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The Effect of Amoxicillin-Clavulanate and Actifed Versus Actived Only in treatment of Otitis Media with Effusion

Authors: Ahmed Muhei Rasheed*,FIBMS(Otolaryngology) --- Yusra Hayder Taha**, FICMS(Otolaryngology احمد محي رشيد
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2008 Volume: 50 Issue: 3 Pages: 327-331
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Otitis media with effusion(OME)is a common cause of deafness in childrenwith subsequent impairment of speech development and scholastic difficulties.Treatmentremains controversial.Aim: To study the effect of amoxicillin-clavulanate in treatment of OMEPatients and methods: A prospective study of a target sample consisting of sixty childrenunder the age of 12 years presented with chief complaints duration for at least 6 weeks andon examination there were bilateral red and retracted tympanic membranes withoutoversized adenoids and no underlying causes require surgical correction e.g cleft palate.Thepatients were divided into two groups;group A which received Actifed for 4 weeks andgroup B which received Actifed +Amoxicillin-clavulanate for 4 weeks treatmentcourse.After complete history and otolaryngological examination,all the patients were sent tox-ray of postnasal space( to exclude oversized adenoids),audiometry andtympanometry.Assessment was repeated at the end of 2 and 4 weeks of treatment courseincluding audiometry and tympanometry.The response to treatment in group B wascompared to that in group A at the end of 4 weeks treatment course.In this study,we referedto improvement in otoscopic findings and tympanometry results to show the response to 4weeks treatment course.Results: Eight patients(25.81%)in group A have shown response to treatment at the end of 4weeks treatment course,while the response in group B was seen in 15 patients( 51.72%).Conclusion: Amoxicillin-clavulanate has statistically significant effect in treatment of otitismedia with effusion(OME)in short term follow-up and the clearance of middle ear efussionin response to amoxicillin-clavulanate indicates that bacterial infection may play a role in theaetiology of OME.Keywords: Otitis media with effusion,Amoxicillin-clavulanate,Tympanometry.

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