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Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients

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Abstract

Background: Periodontitis is a bacterial infection of tooth-supporting tissues; the immunopathologic mechanismsinclude inflammatory cells and chemical mediators, which persist inflammation and develop a local autoimmune.The presence of autoantibodies against extracellular matrix components, anti-neutrophil cytoplasmic antibodies(ANCA) and anti-DNA was detected. This study aimed to provide evidence of altered humoral immune response inchronic periodontitis, as well as to determine the presence of auto-antibodies in this disease.Subjects and Methods: Blood samples were collected from 35 patients with chronic periodontitis (20 with severperiodontitis and 15 with moderate periodontitis) and from 30 healthy age and sex matched individuals served ascontrols. Clinical periodontal parameters used in this study were plaque index, gingival index, probing pocket depth,clinical attachment level and bleeding on probing. The levels of serum IgG-antinuclear antibody were determinedusing enzyme-linked immunosorbent assays, whereas serum immunoglobulin (IgG, IgM and IgA) were estimated bysingle radial immune diffusion method.Results: Serum levels of IgG-antinuclear antibody and IgG were significantly higher in sever chronic periodontitis thanin moderate chronic periodontitis and healthy controls (p<0.05). On the other hand, the serum levels of IgM and IgAshowed no significant differences among three studied groups (p>0.05). Concerning the correlation between serumIgG-antinuclear antibody and clinical periodontal parameters, the level of this autoantibody did not show anycorrelation with clinical parameters of periodontitis (p>0.05).Conclusion: The production of antibodies against self structures could be involved in the pathogenic mechanism ofchronic periodontitis


Article
Using Anti-Nuclear Antibody and Rheumatoid Factor to Evaluation of Immune- Pathogenic Link of Rheumatoid Arthritis and Hepatitis C Virus in Iraqi Patients

Author: Mohammed A. Saleh
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2012 Volume: 15 Issue: 2 Pages: 126-131
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This study was aimed to assess immune- pathogenic association of HCV infection among RA patients. A cross sectional study was conducted on the following groups: patient group includes forty patients with RA. Their age range was between (20-70) years with (7) (17.5%) males and (33) (82.5%) females. Healthy Group: thirteen serum samples were collected from apparently healthy individuals they served as a control group.Their age range was between (23-59) years. Results of this study reveals that the majority of RA patients are females (82,5 %) with females to males ratio of 4.7: 1. Moreover, the mean of age for RA and control groups are (46.83 ± 12.06) and (45.23 ± 12.58), respectively. The prevalence of RA among RA females was (82.5%) and (17.5%) for male and the frequency of rheumatoid Factor positivity among RA patients was (70%) in comparison with (0.0%) for apparently healthy control group with significant differences (P ≤ 0.001). Also, ANA positivity was higher (27,5%) than that for healthy control group (0.0%) with significant differences (P≤ 0.005). Results showed that, the frequency of positivity anti-HCV Ab was (5%) among RA patients in comparison with apparently healthy control group (0 %). Our results sustain the possible contribution of HCV infection in the pathogenesis of RA.

هدفت هذه الدراسة إلى أثبات العلاقة مابين التهاب الكبد الفيروسي نمط (ج) ومرض الحمى الرثوانية وذلك من خلال قياس العلاقة المناعية-الأمراضية مابين التهاب الكبد الفيروسي نمط (ج) والحمى الرثوانية.تم أجراء هذه الدراسة على المجموعات التالية: مجموعة المرضى والتي تضمنت أربعين مريض مصابين بمرض الحمى الرثوانية وكان مدى أعمار المرضى مابين (20-70) سنة وعدد الذكور (7) (17.5 %) والإناث (33) (82.5%). مجموعة الأصحاء: جمعت ثلاثة عشر عينة مصل من أفراد أصحاء ظاهريا وكان مدى أعمار لأصحاء مابين (23-59) سنة. أظهرت نتائج الدراسة بان أغلبية المرضى من الإناث (82.5 %) ونسبة الذكور إلى الإناث 4.7:1، علاوة على ذلك كان متوسط العمر لمجموعتين المرضى والسيطرة ( 46.38 ± 12.06)،(45.23 ± 12.58) على التوالي. أكدت الدراسة بان نسبة انتشار مرض الحمى الرثوانية في الإناث (82.5%) وفي الذكور (17.5%) وبينما معدل موجبيه العامل الرثواني في مرضى الحمى الرثواني كان (70%) بالمقارنة مع مجموعة السيطرة (0.0%) مع وجود فرق معنوي ، من ناحية أخرى أوضحت الدراسة بان نسبة موجبيه الأجسام المضادة ضد النووية عالية (27%) بالمقارنة مع مجموعة السيطرة (0.0%) مع وجود فرق معنوي ، فضلا على ذلك أكدت الدراسة بان نسبة الايجابية للإصابة بفيروس التهاب الكبد الفيروسي نمط (ج) في مرضى الحمى الرثوانية كانت (5%) بالمقارنة مع مجموعة السيطرة. نتائج الدراسة أثبتت احتمالية مساهمة فيروس التهاب الكبد نمط (ج) في أمراضية الحمى الرثوانية.

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