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Article
Prevention of preeclampsia using low dose Aspirin: A randomised controlled trial
الوقاية من تسمم الحمل باستخدام جرعة صغيرة من الأسبرين: باختبار عينة عشوائية

Author: Aseel Mosa Jabber اسيل موسى جابر
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2016 Volume: 6 Issue: 1 Pages: 39-44
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Objectives: To test the effectiveness of aspirin in low doses to prevention PE in high risk . Study design: Prospective randomized controlled double blind trial. Setting: Department of Obstetrics & Gynaecology, Al-Habobi teaching hospital, Thi-qar province/Iraq. Patients and methods: 100 participants at high risk of developing preeclampsia were randomly divided into 2 groups. Group I involved 50 pregnant women who received acetyl salicylic acid 75 mg/ day. Group II included 50 pregnant women who received placebo. Primary outcomes included gestational hypertension and pre-eclampsia. Secondary outcomes included development of eclampsia, HELLP syndrome, placental abruption, IUGR, NICU admission, neonatal complications and congenital anomalies. Results: The incidence of preeclampsia was 22% in the Aspirin group and 44% in the control group (P <0.001). A highly significant difference was found when comparing the two groups regarding gestational age at delivery (37.8±1.9 vs. 33.2±3.2 ), development of PE (22% vs. 44%) particularly early onset (14% vs. 34%) and severe form (8 vs. 22%) and occurrence of HELLP syndrome (4 vs. 16%) respectively (P <0.001) . There was a significant difference between cases and controls regarding the development of gestational hypertension (14% VS. 22%) (P 0.05) .There was a significant improvement of neonates delivered to mothers who received aspirin proved by the presence of significant higher birth weight (2989±815 vs. 2062±976), lower occurrence of IUGR (10% vs. 24%), neonatal ICU admission (34% vs. 78%) and respiratory distress syndrome (20% vs. 60%). Conclusion: the use of low-dose aspirin is of significant importance in reducing the risk of gestational hypertension, pre-eclampsia and IUGR in high risk women.

ألهدف: لاختبار فعالية الأسبرين بجرعات منخفضة لمنع PE تحت عوامل خطورة عالية. طرائق ألعمل: اجريت الدراسة في قسم التوليد وألامراض النسائية في مستشفى الحبوبي التعليمي في محافظة ذي قار/ العراق. شملت الدراسة 100 مشاركة في خطر كبير من تسمم الحمل تم تقسيمهن عشوائيا إلى مجموعتين. المجموعة الأولى من 50 امرأة حامل حصلوا على أسيتيل الساليسيليك بجرعة 75 ملغ / يوم. تضمنت المجموعة الثانية 50 امرأة من النساء الحوامل الذين تلقوا العلاج الوهمي. وشملت النتائج الأولية ارتفاع ضغط الدم الحملي وتسمم الحمل. وشملت النتائج الثانوية تطور تسمم ألحمل متلازمة هيلب، انفصال المشيمة ألباكر تأخر النمو داخل ألرحم وقبول نيكو , مضاعفات حديثي الولادة والتشوهات الخلقية. ألنتائج: كان معدل حدوث تسمم الحمل 22٪ في مجموعة الأسبرين و 44٪ في المجموعة الضابطة تحت مستوى احتمالية (P <0.001). تم الحصول على فرق معنوي كبير للغاية عند المقارنة بين المجموعتين فيما يتعلق بعمر الحمل عند الولادة (37.8 ± 1.9 مقابل 33.2 ± 3.2)، وتطور PE (22٪ مقابل 44٪) ولادة مبكرة وخاصة (14٪ مقابل 34٪) و شكل حاد (8 مقابل 22٪) وحدوث متلازمة هيلب (4 مقابل 16٪) على التوالي (P <0.001). كان هناك فرق معنوي بين الحالات السريرية ومجموعة السيطرة فيما يتعلق بتطور وارتفاع ضغط الدم الحملي (14٪ مقابل 22٪) (P 0.05) كما حدث تحسنا كبيرا لحديثي الولادة الذين ولدوا للأمهات اللاتي حصلن على الأسبرين من خلال زيادة اوزان المواليد عند الولادة مقارنة بالمجموعة الاخرى (2989 ± 815 مقابل 2062 ± 976) مع قلة حدوث حالات تأخر النمو داخل الرحم (10٪ مقابل 24٪)، و دخول حديثي الولادة الى وحدة العناية المركزة (34٪ مقابل 78٪) ومتلازمة الضائقة التنفسية (20٪ مقابل 60٪) . ألاستنتاج: استخدام جرعة منخفضة من الاسبرين له أهمية كبيرة في الحد من مخاطر ارتفاع ضغط الدم الحملي، تسمم الحمل وتأخر النمو داخل الرحم عند النساء اللاتي يتعرضن الى مخاطر عالية لتطور هذه الحالات.

Keywords

Preeclampsia --- Aspirin


Article
The effects of aspirin and fenugreek seed on the testes of white mice

Authors: Musheer H. Gassim --- Hadeel M. Qasim --- Amal K. Chaloob
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 3 Pages: 347-349
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Fenugreek seeds are used as food ingredient in traditional medicines; also aspirin is an incredible chemical with many useful benefits in the medical field. The objective was to study the effect of aspirin and fenugreek on testes of mice.
Method: 20 white male mice weighing (18-23gm) were divided into four groups 5 each. Group 1, represented control, group 2, mice treated with fenugreek seed (100mg/KgB.W), group 3 mice treated with aspirin (10mg/Kg B.W), group 4 mice treated with aspirin and fenugreek seed for 21 days. Body weight and testes weights were recorded. Histopathological examination of testes was carried out. Results: a significant decrease (P<0.05) in body weight of mice treated with aspirin when compared to the other groups. A significant decrease (P<0.001) in testicular weight of mice treated with aspirin as compared to control and other groups was noted. Structural changes in testes have shown that: aspirin administration caused a decrease in seminiferous tubules diameter associated with increase in connective tissue between them and basement membrane thickness of seminiferous tubules. While fenugreek seed reverse these changes.Conclusion: fenugreek seeds exhibited antioxidant property that could ameliorate the alternations induced in mice treated with aspirin. Further studies are needed to be done on mammals to support our findings.

Keywords

aspirin --- fenugreek --- testes mice


Article
The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy

Author: Estabraq M. Mahdi Msc
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 1 Pages: 11-13
Publisher: Baghdad University جامعة بغداد

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Abstract

Objective: To investigate and prove that aspirinprotects, or at least attenuates amikacin ototoxicity inhumans.Method: This study was conducted in 60 patients thatcompleted allrequirements .The patients were divided into twogroups:• Control group: receive placebo treatment.• Drug–treated group: They receive aspirincoated tablets (1.5gm/ day), 500mg 8 hourly.Both groups had similar aspects regarding the gender,age and weight. The duration of therapy was 7 daysand dosage of amikacin was 1gm/day (500mg 12hourly).Results: Comparison of Audiometry test inEar/Nose/Throat (E.N.T.) Department (Pure ToneAudiometry) at 1000 Hertz (Hz), 2000 Hz, 4000 Hz,and 8000 Hz showed significant differences betweenmean Audiometry at 250Hz was significantly differentonly at 8th and 15th day while at the frequency of 500Hzthe difference was significant at the 15thday only.Conclusion: In present study, we had shown thataspirin can protect the patients who are receivingamikacin therapy from it' s ototoxicity.

Keywords

Aspirin --- amikacin --- Pure Tone


Article
Antiatherosclerotic potential of aspirin: Antioxidant and anti-inflammatory approaches

Authors: Najah R Hadi نجاح رايش هادي --- Hussam H Sahib حسام حسن صاحب --- Bassim I Mohammad باسم ارحيم محمد
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2013 Volume: 9 Issue: 16 Pages: 11-21
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Objective: this study was undertaken to evaluate the effect of aspirin on the progression of atherosclerosis. Materials and methods: A total of 28 local domestic rabbits were assigned to four groups: Group I (normal control), Group II (atherogenic control), Group III (vehicle control),Group IV (aspirin 10 mgkg daily). Blood samples were collected at the end of experiment (8 weeks) for measurement of serum triglycerides (TG), total cholesterol (TC), HDL-C, plasma high sensitive C-reactive protein (hsCRP), plasma malondialdehyde (MDA) and plasma reduced glutathione (GSH). Immunohistochemical analysis (VCAM-1, MCP-1, and TNF-α) and histopathologic assessment of aortic atherosclerotic changes were also performed.Results: Compared to NC, levels of lipid profile, atherogenic index, hsCRP, and MDA are increased while GSH were decreased in animals on atherogenic diet (p< 0.05). Immunohistochemical analysis showed that aortic expression of VCAM-1, MCP-1, and TNF-α were significantly increased in AC group compared to NC group (p<0.001). Histopathologic finding showed that animals on atherogenic diet have significant atherosclerotic lesion compared to NC group. Compared to AC group aspirin don’t have significant effect on lipid profile. Aspirin causes statistically significant reduction in hsCRP and MDA (p<0.05). Aspirin treatment causes significantly increase the level of GSH. Aspirin treatment significantly reduced aortic expression of VCAM-1, MCP-1, and TNF-α (p<0.05). Histopathologic examination of aortic arch showed that aspirin significantly reduced atherosclerotic lesion (p<0.05).Conclusions: It thus can conclude that aspirin reduces lipid peroxidation, systemic inflammation and aortic expression of inflammatory markers used in this study and hence reduce the progression of atherosclerosis.

أجريت هذه الدراسة لتقيم تأثير الاسبرين على تقدم تصلب الشرايين. تم استخدام 42 ذكر من الأرانب في هذه الدراسة.وقسمت هذه الحيوانات بشكل عشوائي إلى 6 مجموعات ( 7 أرانب في كل مجموعة)واعطيت الحيوانات في المجموعة الأولى غذاء طبيعي قياسي واعتبرت مجموعة سيطرة في حين الأرانب في المجموعات الثلاثة الباقية أعطيت غذاء عالي الدهون (2% كوليستيرول) و عولجت كالتالي لمدة 8 أسابيع. 1. مجموعة السيطرة (عالية الدهون) لم تعطى أي علاج 2. مجموعة المذيب (الايثانول) 10% 3 .مجموعة عقار الاسبرين أعطيت اسبرين 10 ملغم لكل كغم يوميا. في نهاية ألثمان أسابيع تم التضحية بكل الحيوانات وتم جمع عينات من الدم لقياس المؤشرات التالية: صورة الدهون, مؤشرات الأكسدة (المدي أي و الجي أس أج ( و مؤشر الالتهاب السي ا ربي عالي التحسس. كما أخذت عينة نسيجية من الشريان الابهر لمعرفة مدى درجة تصلب الشرايين حسب تصنيف الجمعية الأمريكية لأمراض القلب بالإضافة إلى ذلك جرى فحص مؤشرات الالتهاب في النسيج حيث تم فحص مدى ظهور كل من في كام -1, ام سي بي -1, تي ا ناف الفا في طبقات الشريان الابهر.مقارنة بمجموعة السيطرة عالية الدهون,لم يكن للاسبرين تأثير مميز على صورة الدهون في الدم مقارنة بمجموعة السيطرة عالية الدهون, بينما أظهرت التحاليل أن كل من الاسبرين يقللان بصورة واضحة مؤشر الالتهاب في الدم ( السي ا ربي عالي التحسس)كما أظهرت النتائج أن الاسبرين تقلل بصورة واضحة مؤشرات الأكسدة ( ألجي أر أس و والمدي أي), كما أظهرت الدراسة أن كل من الاسبرين والكلوبيدوكريل والخليط من الاسبرين والكلوبيدوكريل يقللان بصورة واضحة علامات الالتهاب في النسيج ( في كام -1, التي ا ناف ألفا, ا مسي بي _1).واخيرا اظهرت الدراسات ان الاسبرين يقلل بصورة واضحة من تقدم تصلب الشرايين .مماسبق يمكن ان نستنتج ان بغض النظر عن عدم تأثير الاسبرين على مستوى الدهون فانه يقلل من تقدم تصلب الشرايين بصورة واضحة.


Article
Thromboprophylaxis in women with unexplained consecutive recurrent ‎miscarriages
موانع تخثر الدم في النساء المصابات بالاجهاض المتكرر غير المفسر

Author: Maysoon Sharief, Teshreen Sabri Ali د.ميسون شريف، د.تشرين صبري
Journal: The Medical Journal of Basrah University المجلة الطبية لجامعة البصرة ISSN: 02530759 Year: 2014 Volume: 32 Issue: 1 Pages: 37-42
Publisher: Basrah University جامعة البصرة

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Abstract

Objective: To compare the effect of low dose aspirin and enoxaparin on pregnancy in women with recurrent ‎miscarriage.‎Patients& Methods: Randomized controlled trail, conducted in Basrah Maternity and Child Hospital during the period ‎from January 2012 till April 2013. Participants were 221 pregnant women aged 18-41 years with history of at least 2 ‎previous miscarriage without apparent causes. They were divided into 2 groups; the first group included 111 were given ‎enoxaparin and the second group involved 108 which were given aspirin.‎Results: In both groups (75%) of patients had negative serological test for thrombophilia. Enoxaparin group had higher ‎significant incidence of term delivery (86%) with less incidence of preterm delivery (4.5%) and less early pregnancy ‎loss (8%).‎No significant differences in obstetrical complication but higher incidence of abdominal delivery in both groups.‎Higher incidence of postpartum hemorrhage in the enoxaparin group in comparison with aspirin group and no significant ‎systemic adverse effect of enoxaparin were noticed on the first group.‎Conclusion: Since postpartum hemorrhage is treatable, low molecular weight heparin is safe and effective for treating, ‎preventing thrombosis and achieving successful pregnancy.‎

الهدف: دراسة مقارنة بين استعمال الجرع القليلة من دواء الاسبرين ودواء الاينوكسابارين اثناء الحمل للوقاية من الاجهاض المتكرر من الحوامل.‏المرضى وطرق العمل: اجريت دراسة سرية عشوائية في مستشفى الولادة والطفل في البصرة خلال الفترة بين كانون الاول 2012 ونيسان 2013. ‏المشاركون221 امرأة حامل ذوات الاعمار 18-41 سنة ويعانون من اسقاطين سابقة بدون وجود اسباب واضحة. تم تقسيمهم الى مجموعتين؛ ‏تشمل المجموعة الاولى 111 مريضة اعطين دواء الاينوكسابارين بينما اعطيت المجموعة الثانية (108 مريضة) دواء الاسبرين.‏النتائج: لقد تبين ان 75% من النساء الحوامل لديهن نتائج ايجابية لعدم وجود اضطراب في عمل الصفيحات الدموية وقد لوحظ كذلك ان ‏مجموعة الاينوكسابارين هي الاعلى نسبة في الولادة في الشهر التاسع (86%) والأقل نسبة في فقدان الحمل اثناء الاشهر الاولى (8%). لايوجد ‏فرق في مضاعفات الحمل والولادة بين المجموعتين. سجلت اعلى نسبة في الاصابة بنزف مابعد الولادة أي مجموعة الاينوكسابارين اكثر من ‏مجموعة الاسبرين.‏الاستنتاجات: نظراً لامكانية معالجة النزف بعد الولادة ، لذا يعتبر دواء الاينوكسابارين امين في الاستعمال وله تأثير جيد في معالجة ومنع حدوث ‏تخثر الدم وبالتالي المحافظة على الحمل ‏


Article
Effects of different doses of aspirin on the liver and kidney functions of the female albino rats

Author: Nuha SH. Ali
Journal: Al-Qadisiyah Journal of Veterinary Medicine Sciences مجلة القادسية لعلوم الطب البيطري ISSN: 18185746 23134429 Year: 2017 Volume: 16 Issue: 1 Pages: 31-37
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

The confer study was carried out to examines in detail the effect of Aspirin on the liver and kidney function of the female albino rats. (15) mature female albino rats (150-170 gm)were divided in to three groups :1st group which treated as negative control group ,it was drenched only 0.2 ml of PBS.2nd group was drenched with Aspirin (10mg/kg of B.W once daily for 30 days).3rd group was drenched with Aspirin (20mg/kg of B.W once daily for 30 days).Our results showed that 2nd and 3rd groups demonstrated significantly increased (P≤0.05) in the values of plasma GOT and GPT enzymes compared with control group. In the values of plasma total protein, the 2nd and 3rd groups showed meaningfully decreased (P≤0.05) in the relation with the control group. The values of plasma creatinine and uric acid, the 2nd and 3rd groups showed significantly increased (P≤0.05) as compared with control group. On the other hand, the microscopic examination of the histopathological sections of livers of all the treated and control groups showed that the 2nd group demonstrated congestion of central vein and presence of radially arrangement of hepatocyte around the central vein ,mild dilation of sinusoids ,mild hemorrhage and mild infiltration of inflammatory cells. In 3rd group, the histopathological examination of livers showed infiltration of inflammatory cells mainly macrophage and lymphocytes, congestion and hemorrhage in the hepatic tissue and vaculation of hepatocyte. In kidneys of 2nd group showed high cellularity of the glomeruli, mild infiltration of inflammatory cells, mild hemorrhage in the renal tissue and few dilation of renal convoluted tubule. The kidneys section of 3rd group showed atrophy and small in size of the glomeruli with marked dilation in the renal convoluted tubules. In addition, there is degeneration in the epithelial cells which lining the renal tubules and hemorrhage along the renal tissue.

Keywords

Aspirin --- liver --- kidney


Article
Synthesis, characterization and biochemical study of novel ester prodrugs containing aspirin and ibuprofen
تحضير ودراسة بايوكيميائية وتشخيصية لادوية مصاحبة استرية تحتوي الاسبرين والايبوبروفين

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Aspirin and ibuprofen are aryl acids of nonsteroidal anti inflammatory drugs with goodanalgesic. For reducing the gastrointestinal toxicity associated with presence free carboxylicacid functional group in aspirin and ibuprofen, therefore the present work is aimed tosynthesize a novel ester prodrugs of these two drugs. These two novel prodrugs were preparedby the reaction of aspirin or ibuprofen acid chloride with 1,2:5,6-di-O-isopropylidene-α-Dglucofuranose,then deprotection of ester prodrug of aspirin was also accomplished using 70%acetic acid. The purity of the synthesized compounds was established by (TLC), columnchromatography, while their structures were confirmed by (FT-IR, 1HNMR, 13CNMR). Then36 rabbits has been obtained and divided to six groups to show the bioavailability of theprepared prodrugs at some biochemical parameters and compared with the parent drugs andcontrol group. Statistical analysis revealed significant increases in the levels of creatinekinase, alkaline phosphatase, aspartate aminotransferase, alanine amino transferase,glutathione, malondialdehyde, creatinine, uric acid, concentration of Cu, and significantdecreases in the levels of choline esteras, total protein, Zn concentration, while the resultsshowed no significant increases in the activity of lactate dehydrogenase, acid phosphataseand no significant decreases in the levels of albumin, globulin, and iron concentration for theprepared prodrugs compared with the control group. Finally, to ensure the release of parentdrugs(aspirin or ibuprofen), hydrolytic studies of the ester prodrugs were obtained at differentpH (2, 4, 10 and 12) at 25οC, the results showed that the hydrolysis at basic pH were fasterthan acidic pH, so it means that the most hydrolysis will obtain at intestine not at stomach.

Keywords

Prodrug --- Aspirin --- Ibuprofen --- NSAIDs


Article
HISTOPATHOLOGICAL AND HORMONAL EFFECTS OF DIFFERENT DOSES OF ASPIRIN ON THE FEMALE REPRODUCTIVE SYSTEM OF ALBINO RATS
التأثيرات المرضية النسجية والهرمونية لجرع مختلفة من الأسبرين على الجهاز التكاثري الانثوي في الجرذان البيضاء

Author: SH. Ali , **Zainab I. Mohammed **Khalil G. Chelab
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2016 Volume: 15 Issue: 2 Pages: 211-226
Publisher: Basrah University جامعة البصرة

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The present study was carried out to investigate the effect of aspirin on the female reproductive organs in albino rats. (21) mature female albino rats (150-170gm) were divided into three groups: 1st group which treated as negative control group, it was drenched only 0.2 ml of PBS.2nd group was drenched with Aspirin(10 mg/Kg of B.W once daily for 14 days).3rd group was drenched with Aspirin (20 mg/Kg B.W once daily for 14 days). Our results showed that 2nd group and 3rd group demonstrated significantly decrease (P ≤ 0.05) in the values of plasma LH compared with control group. In values of plasma FSH hormone, the 2nd and 3rd groups showed significantly decreased (P ≤ 0.05) in the relation with the control group. On the other hand, the microscopic examination of the histopathological sections of uteri of all the treated and control groups showed that the 2nd group demonstrated mild hyperplasia and degeneration in the epithelial cells which lining the uterus and there is few numbers of uteri glands. Also marked hyperplasia and vacuolation of the epithelial cells which lines the uterus. In 3rd group, the histopathological examination of uteri elucidates profuse proliferation and irregular hyperplasia of smooth muscles in the wall of uterus, there is high infiltration of inflammatory cells and there is congestion of blood vessels. Also there is marked vacuolation of uterine epithelial cells and fewer and smaller uterine glands than the 2nd group and 1st (control) group. In ovaries of 2nd group showed markedly few follicular growth wave characterized by primary, secondary follicles and there is congestion and thrombi in the ovarian stroma. Also presence of large corpus luteum. But the histopathological changes in the ovaries of 3rd group animals showed more severity than 2nd group animals in which there are primary and secondary follicles with severe congestion and hemorrhage, also there is high numbers of corpus luteum. 1st (control) group was showed normal histological feature of uteri and ovaries. We conclude from the present study that different doses of aspirin can cause histopathological effects and hormonal disturbances in FSH and LH hormones.


Article
Dual effects of aspirin and Garcinia Cambogia on human blood viscosity
الآثار المزدوجة للأسبرين وغارسينيا كامبوغيا على لزوجة دم الإنسان

Authors: Ali Ismai A. Al-Gareeb --- Basim S. N. Al-Mgoter --- Hayder M. Al-kuraishy
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2013 Volume: 17 Issue: 3 Pages: 514-517
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Background and objective: Prevention of bacterial adhesion is an attractive target for the development of new therapies in the prevention of bacterial infection. The aim of this study is to investigate the effects of pomegranate peel extract, vitamin C, combination of pomegranate peel extract and vitamin C & gemifloxacin on adhesion of E.coli to uroepithelial cells. Methods: This study was conducted in the Department of Pharmacology, college of Medicine, AL-Mustansirya University in 2009. Twenty patients with peripheral vascular diseases enrolled in this study. Those patients randomly allocated equally into two groups; group (A) received aspirin oral tablets 300 mg/day and group (B) received aspirin oral tablets 300 mg/day plus Garcinia cambogia oral tablets 500mg/day. The duration of therapy was two weeks. In this study, measurements were done for total blood viscosity, packed cell volume, serum fibrinogen, and serum cholesterol, before treatment as control and after one and two weeks of treatment.Results: After 2 weeks treatment with aspirin there was significant reduction in plasma fibrinogen (p < 0.05). Combined aspirin and Garcinia Cambogica treatment for 2 weeks produce significant reduction in all blood viscosity parameters (p<0.05) except the packed cell volume which was not affected (p >0.05).Conclusion: Aspirin and Garcinia cambogia produced significant and better effects than aspirin alone on blood viscosity.


Article
Assessing the effects of low dose aspirin on uricacid and renal function in healthy adults

Authors: Yaser Adeep ياسر اديب --- Jonaya Sarsam جنية سرسم
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2009 Volume: 35 Issue: 2 Pages: 154-159
Publisher: Mosul University جامعة الموصل

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Abstract

ABSTRACT
Objective: To evaluate the effects of low daily aspirin doses on uric acid (UA) level and renal functions in healthy adults.
Methods: Healthy adults were randomized to receive 100 mg (n= 33), or 300 mg (n = 31) aspirin daily for one month. Laboratory tests included measurement of blood urea nitrogen (BUN), serum creatinine, and uric acid (UA) levels. Urine creatinine, urea and uric acid excretion were measured in a 24 h collection of urine, 24 hours urine uric acid, creatinine clearance (Ccr), were measured at baseline and then after 4 weeks of therapy.
Results: After 4 weeks of therapy, 100 and 300 mg/d dosage, aspirin caused a 7% and 12% decrease in the rate of UA excretion respectively (P< 0.05). Patients at the dosage 300 mg/d but not the 100mg/day had an increase in serum levels of uric acid (UA), creatinine and urea with a significant decrease in 24 hour creatinine clearance and urinary urea excretion (P<0.05) when compared with the baseline.
Conclusion: Because of the effects of 300 mg dose aspirin, in the lowering of kidney function and the potential of aspirin to cause dose-dependent impairment of renal function, patients taking low-dose aspirin therapy should be monitored for the development of impaired renal function.
Keywords: Low dose aspirin, renal function, healthy adult.

الهــدف: تَقييم تأثيرات جرعات الأسبيرينِ المتدنية اليوميِة على مستوى الحامض البولي ووظائف الكلى في البالغين الاصحّاء. الطريقة: أعطي الأسبيرين عشوائيا (ثلاث وثلاثون شخصا أعطوا 100 ملغم، واحد وثلاثون شخصا أعطوا 300 ملغم) الى البالغين الأصحاء يوميا لمدة 4 أسابيع. شمل الفحص المختبري كمية الحامض البولي، يوريا نتروجين، كرياتينين في مصل الدم، طرح الكرياتينين، الحامض البولي واليوريا نتروجين في الـ 24 ساعة بولِ قبل وبعد 4 أسابيعِ من إعطاء الاسبيرين.النتائـج: ان جرعة الـ 100 ملغم و الـ 300 ملغم أسبيرين يوميا تسبّبت بـ 7% و12% نقصان في نسبة طرح الحامض البولي على التوالي بعد 4 أسابيع. على أية حال، مرضى العينة 300 ملغم وليس 100 ملغم كَان عندهم زيادة في مستويات الحامضِ البولي، الكرياتنين واليوريا في مصل الدم مع نقص معنوي في طرح الكرياتنينِ واليوريا مقَارنة مع ما قبل العلاج.الاستنتاج: بسبب تأثير جرعة الـ 300 ملغم اسبيرين يوميا في ضعف الوظيفة الكلوية وإمكانية الأسبيرين في تسبّب ضعف وظيفة الكلية المعتمد على الجرعةَ. المرضى اللذين يأْخذون جرع منخفضة من علاج أسبيرين يجِب متابعة حالتهم لأي تطور يضعف الوظيفة الكلوية.

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