research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
REPRODUCTIVE EFFICACY IN FEMALE RAT EXPOSED TO BISPHENOL A DURING GESTATION PERIOD
الكفاءة التكاثرية في اناث الجرذان المعرضة للبسفينول خلال فترة الحمل

Loading...
Loading...
Abstract

The study was conduct to determine the effect of exposure to Bisphenol A (BPA) during gestation on serum reproductive hormones levels (Estradiol" E2", Luteinizing Hormone "LH" and follicle- stimulating Hormone" FSH"), age and weight at vaginal opening onset as well as reproductive efficacy in F1 female offspring.Thirty six pregnant female rats (F0) were gavage three doses of BPA suspended in corn oil (50 μg, 50 mg, 250 mg/kg/BW) or corn oil only as control group from gestational day (GD) 6 till gestation day (GD) 21. After delivery, twelve female pups of each group were hold for three months; However, Female rats' offspring, after weaning, were weighed and checked for vaginal opening (VO) every day until completion, then at postnatal day (PND) 90, blood samples were collected from six F1 female of each group to perform hormonal tests and other six females were mated with untreated male rat in a separate cage for 14 days in order to evaluate fertility efficacy. The results showed significant increased (P<0.05) in serum E2 levels, and decrease in LH level, but FSH levels were unchanged in all treated groups compared with control group. The results also revealed significant decrease age at VO onset in all treated groups compared with control group , while body weight at age of VO onset was non-significantly differ between all groups.Fertility rate, number of birth and implantation sites were reduced and resorption sites were elevated in F1 female rats that gestationally exposed to deferent levels of BPA in comparison with control group. From the present study it has been revealed that the BPA exposures during pregnancy adversely affect F1 female reproduction and caused early puberty onset.

Keywords

Estradiol --- BPA --- Female


Article
The Consequences of PCBs and BPA Resulting from Terrorist Operations in Three Regions of Baghdad on Thyroid Function

Authors: Alaa H. Jawad --- Sara J. Kadhim --- Zyad H. Jawad Al-Qaisi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 21 Issue: 3 Pages: 98-104
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Persistent organic pollutants polychlorinated biphenyls (PCBs) and bisphenol-A (BPA) are widely known of being toxicants. Exposure to a variety of dangerous toxic effects has been attached in all humans .in this paper the effect of terrorist operation on thyroid gland functions in a sample of Iraqi individual (AL-karradah and Abo-Gharib) comparison with Al-jadria rejoin as (control). The correlation between sera thyroid hormones thyroxine T4, triiodothyronine T3, Thyrotropin TSH and the levels of polychlorinated biphenyls (PCBs) and bisphenol-A (BPA) have been measured. 75 volunteers from three Iraqi areas were included in this study‎. Their ages ranged between (15-65) years. Our examination proposes an inverse relationship between BPA presentation and thyroid hormones. In this manner, increased persistent organic pollutants exposure might be a factor in the causes of hypothyroidism ‎and thyroid gland function. The result of this study showed that the effect of persistent organic pollutants polychlorinated biphenyls (PCBs) and bisphenol-A (BPA) on thyroid hormones, and the effect of military and terrorist operations on the thyroid gland. In the end we concluded that persistent organic pollutants resulting from the explosions and terrorist operations in the area of (Al-karadah, Abo-Gharib) high compared with the control (Al-jadria) as the lowest percentage of pollution, this leads to many diseases on the health of the human body and also the effect of persistent organic pollutants on the thyroid gland and its negative effect on thyroid hormones and cause thyroid disease.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2018 (1)

2013 (1)