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Article
Gorlin - goltz syndrome: a case report
متلازمة غورلين غولتز: تقرير حالة

Authors: Layla Muhammad --- Amera Kamal Khaleel --- Ahmad Haidar
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 2 Pages: 157-161
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Gorlin-Goltz syndrome, also known as basal cell nevus syndrome, is an uncommon, autosomal dominant inherited disorder, which is characterized by numerous basal cell carcinoma, odontogenic keratocysts and musculoskeletal malformations. However, medical literature documents both common and lesser known manifestations involving the skin, central nervous system, craniofacial anomalies etc. A case of Gorlin –Goltz syndrome with no family history has been reported here, the patient have multiple odontogenic keratocysts, tiny pits involving the palms and soles, rib anomalies, numerous nevi and nodes predominantly present on his face, chest and back. Histopathological study confirms the presence of multiple keratocysts in the jaws and the absence of basal cell carcinoma of the skin. Immunohistochemical study showed negatively p53 staining result. Early diagnosis and treatment is important to prevent long term sequelae including malignancy and oromaxillofacial deformation and destruction.


Article
Epidermal Skin Cancers: Anatomical and Pathological Distribution

Author: Rana Aasim Abdul-Kareem Azooz
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 273-278
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND : There are three major types of skin cancer; basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma.The distribution of these tumors on the face follows particular anatomical regions which may be related to histological subtypes of the tumor.OBJECTIVE: To describe and compare the clinicopathological characteristics of epidermal skin cancers regarding facial distribution of these tumors and their histological correlations.METHODS: Data sources for this retrospective case-series study included all pathological reports of patients with epidermal skin cancers diagnosed at histopathology laboratory of Al-Jamhuri Teaching Hospital in Mosul city between the years 2008 and 2010.RESULTS: There were 117 patients with different facial epidermal skin cancers. BCC represented the highest frequency (68.3%) among all facial epidermal skin cancers (and the most frequent eyelid malignancy), followed by SCC (28.5%) while malignant melanoma was the least frequent skin cancer (3.2%). There was no difference in the frequency of distribution of both BCC and SCC between nose and cheek (p=1, p=1, respectively) but the nose was the most frequent region of involvement of the nodular variant of BCC. Preexisting mole, xeroderma pigmentosa, actinic keratoses and scar of previous burns were found to be associated with different epidermal skin cancer.CONCLUSION: BCC was the most frequent epidermal skin cancer of the face followed by SCC. Histological variant of BCCs followed variable facial distribution , while no difference in facial involvement was found regarding BCCs and SCCs.


Article
Immunohistochemical evaluation of actin expression in basal cell carcinoma and oral squamous cell carcinoma

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Abstract

Background: Basal cell carcinomas (BCCs) are generally slow-growing tumours. They have been classified as aggressive (A-BCC) and non-aggressive (NA-BCC).Oral squamous cell carcinoma (OSCC) is a major cause of cancer morbidity worldwide, this is due to the characteristics of invasion. The microenviroment or stroma of neoplastic tissues plays an active role in tumour progression. Trans-differentiation of fibroblast to myofibroblast is a crucial and early event in tumourigensis. Alterations of contractile tension generated by the actin–myosin complex are of central importance in the development of the phenotype of morphologically transformed neoplastic cells with invasive behavior. Actin is the predominant component of contractile microfillament and it may be associated with increase contractility and invasiveness of tumour cells.Objective: This study aimed to investigate the presence of myofibroblasts in the stroma of basal cell carcinoma and oral squamous cell carcinoma, evaluated by the immunohistochemical expression of actin.Materials and methods: Twenty four formalin –fixed, paraffin -embedded tissue blocks (14 cases basal cell carcinoma, 10 cases oral squamous cell carcinoma) were included in this study. An immunohistochemical analysis was performed using anti alpha - smooth muscle actin (α- SMA) monoclonal antibody.


Article
A Clinicopathologic Correlation of Basal Cell Carcinoma in A Sample of Iraqi Population.

Author: Haider Latteef Mohammed, Farah Falah Hassan Abu Deka
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 3 Pages: 266-273
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: BCC is a malignant epithelial neoplasm constitutes 70%-75% of all skin cancers .It arises from basal cells layer of the epidermis. It has a higher degree of invasive potential with an extremely rare ability for distant metastases so the mainstay treatment is surgical excision.OBJECTIVE: To study histological types of BCC, age and gender preference, size, anatomical location and find a correlation between various clinical and histological parameters.MATERIALS AND METHODS: In this retrospective study all histologically proven cases of BCC during two years period, in the period from October 2014 to February 2017 (in the pathology lab of Alwasity teaching hospital for plastic and orthopedic surgery in bagdad) were collected .The microscopic features of these tumors were carefully reviewed including histological types and surgical margin status and compared with the related clinical information.RESULTS: This study enrolled 76 excisional biopsies of basal cell carcinomas include 34 (44.74%) for males and 42(55.26%) for females, with mean age of 55.64 ±14.613. 63 (82.89%) were above forty years old. 72(94.73%) were located in the sun exposed areas. Regarding histological types, 64(84.21%) were mixed, 6(7.89%) were nodular, 3(3.95%) were pigmented and 3(3.95%) were superficial. According to the size of the excised tumors, those above two cm were 22(28.95%). Regarding surgical margin status, 28(36.84%) were margin positive and 48(63.16%) were margin negative. The study found that there is a significant statistical relationship between histological type and surgical margins status with P value 0.030(<0.05) .By Analyzing histological type in regard to age, gender, locations and size, the study find that there is no statistical relationship between them with P value (>0.05) , also there is no significant statistical relationship between tumor size and age ,gender , tumor location with P value (>0.05).CONCLUSION: Basal cell carcinoma is malignant skin tumors most commonly affects older population with a strong association to sun exposure. Commonly present with a size of two cm. and below .There is a significant associations between histological types and completeness of surgical excison highlighting the importance of histological sub typing for prognostic purposes and giving a clue to the surgeon about management decision since the clinical (macroscopic) and histological (microscopic) types of BCC are closely correlated. Otherwise there is no age, gender and location preference of various histological types and there is no significant relationship between tumor size and various clinical parameters.


Article
Histopathologic Study for Skin Basal Cell Carcinoma

Authors: Nazar J. Metib --- Aseel H. Aboud
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3884-3888
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Basal cell carcinoma (BCC) is the most common Worldwide cutaneous cancer; approximately 75% of all skin cancers. It arises from the basal cells of the epidermis and pilosebaceous units. It has a long evolution, slow growth rate with up to 70% of primary BCCs occurring in head or neck region. Although it rarely results in death or metastatic disease, BCC can cause significant morbidity due to destructive local spread.Aims of the study: To determine the frequency of various histopathologic types of BCCs encountered in practice, to delineate the spectrum in setup, anatomical location, site predilection, and annual age and sex incidence each year.Materials and Methods: The analysis included two hundreds and five cases of skin tumors, 88 cases were basal cell carcinoma from Department of Histopathology, Al Hussain Medical City/ Karbala. The study was retrospective and done during the period of January 2012 to June 2016. After careful review of the Hematoxylin and Eosin (H and E) stained sections, statistical analyses were done.Results: Out of (205 cases of skin tumors) only 88 were of BCC and accounted for 42.92% of all the malignant tumors of skin. majority (87.51.%) of the lesions of BCC were located on head and neck region, solid nodular type was most common histopathologic type and average age of cases was 64 5years. Conclusion: In the present study majority (87.51.%) of the lesions of BCC were located on head and neck region, average age of cases of basal cell carcinoma was 64.5years, and solid nodular type of BCC was most common type.


Article
Non – Melanoma Skin Cancers: A Clinical and Histopathological Study

Authors: Osama N. Al -Hemiari --- Aseel H. Aboud1
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3943-3947
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Non – melanoma skin cancer like basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common cutaneous cancer and are associated with multifactorial causes such as environmental and host factors, hence they are not uncommon skin diseases in Iraqi patients. Aims of the study: This study was conducted to evaluate the topography of lesions and their correlations with gender, age, clinical and histological type and correlation between them. Patients and methods: A total of 159 patients with in non –melanoma skin cancers were studied in Al-Hussain medical city in a retrospective study during the period from January 2012 to June 2016.After diagnosing each patient and a careful histopathological examination, statistical analyses were done. Results: The analysis included 159 patients with non – melanoma skin cancers (NMSCs)Eighty eight patients with basal cell carcinoma were seen (55.34٪). The majority of patients were in the form of nodular and noduloulcerative &the second most type was basosquamous type.Clinically, it was the same of nodular type as the majority of cases were diagnosed with this typeFifty patients with SCCs (31.44 ٪) were seen. Clinically, the patients with SCC presented as a hard indurated plaques or nodules, some were ulcerated.Nearly all the types may be in the form of well differentiated or moderately well differentiated. Discussion:NMSCs comprise a significant proportion of all skin cancer patients in the world. BCC is the commonest NMSC worldwide and various studies have reported SCC as the second most prevalent.Basal cell carcinoma commonly seen on the faces of the middle age or elderly with male to female ratio is about 3: 2 and the incidence increases markedly after age of 40 years.Squamous cell carcinoma was the next common non – melanoma skin cancers of the face forming about 31.44 ٪ of cases as a potentially lethal form of skin cancer, It can arise from actinic keratosis with a slight male predominance in the male to female ratio 1.17: 1.The prevalence and distribution of lesions of SCC correlates well with the exposure to ultraviolet radiation.


Article
Skin Cancers in Baghdad Hospitals
السرطانات الجلدية في مستشفيات بغداد

Authors: Abbas Fadhal Humadi د. عباس فضال حمادي --- Mohammad J. Kadhim د. محمد جواد كاظم --- Jamal R. Al-Rawi د. جمال رشيد عبود الراوي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2013 Volume: 26 Issue: 2 Pages: 99-102
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: Non-melanoma skin cancers are the most common form of skin cancers in the world. Those at risk for skin cancer are fair-skinned individuals who tan poorly and who have had significant chronic or intermittent sun exposure. There were many reports about the increase in the rates of all cancers including skin cancers in Iraq.Objectives: To study the frequency and types of skin cancers in Baghdad hospitals.Patients & Methods: A cross-sectional hospital based study was conducted in seven teaching hospitals from Kurkh and Resafa representing Baghdad city in a period from December 2010 through June 2012. The study includes 577 patients confirmed with various skin tumors. Socio-demographic information, full dermatological examination and skin biopsy was done.Results: The frequency of skin cancer were 246 (42.6%) from Kurkh, 179 (31.1%) from Resafa; and 152 (26.3%) from others (Those patients from near Baghdad or other distant governorates). They include 356 (61.7%) males and 221 (38.3%) female patients. The commonest age group affected by skin tumors were those > 40 years (89.5%) and only 10.5% < 40 years. The outdoor male were more affected than females. The most frequent tumor was basal cell carcinoma 300 cases (52%) then squamous cell carcinoma 144 cases (25%), malignant melanoma 32 cases (5.5%), Kaposi's sarcoma 23 cases (4%), Dermatofibrosarcoma protuberance 19 cases (3.3%) and other rare tumors. Conclusion: The rate of skin cancers were more in men than in women patients (M: F 1.6:1). The outdoor patients were more affected than indoor patients. The rate of skin cancers in Baghdad city was higher than what reported by Ministry of Health. Basal cell carcinoma and Squamous cell carcinoma were the most common skin cancers among patients followed by malignant melanoma and Kaposi sarcoma.Keywords: Skin cancers, Baghdad hospitals, basal cell carcinoma.

الملخصالخلفية: سرطانات الجلد اللاصبغية هي السرطانات الجلدية الأكثر شيوعا. الذين يحملون خطر الإصابة بسرطان الجلد هم الأشخاص ذوي البشرة الشقراء ذات القابلية على الاصطباغ القليل للجلد والذين يتعرضون لأشعة الشمس بشكل مزمن أو متقطع. اغلب السرطانات الرئيسية والسرطانات المتعلقة بالتدخين تحدث أكثر عند الرجال من النساء بسبب إنهم يدخنون مبكرا وبشكل أكبر.الهدف: دراسة إعداد وأنواع السرطانات الجلدية في مدينة بغداد.طريقة البحث: دراسة مقطعية لمراجعي المستشفيات, جمعت من سبع مستشفيات تعليمية من الكرخ والرصافة في بغداد للفترة من كانون الأول 2010 إلى حزيران 2012 شملت المرضى المشخصين بمختلف السرطانات الجلدية. أخذت المعلومات الشخصية والاجتماعية مع الفحص الجلدي الكامل و خزعه من المرضى. النتائج: بلغت نسبة السرطانات الجلدية بين المرضى الرجال 356 (61.7%) والنساء 221 (38.3%). كانت الفئة العمرية الأكثر شيوعا والمصابة بالسرطانات الجلدية هي >40 سنة (89.5%) وفقط 10.5 % هم < 40 سنة. أكثر الأورام تكرارا هي سرطان الخلايا القاعدية 300 (52%) ثم سرطان الخلايا الحرشفية 144 (25%), سرطان الخلايا الصبغية 32 (5.5%), سرطاني كابوس 23 (4%) وسرطان الجلد الليفي الثاقب 19 (3.3%) وبقية الاورام شكلت اقل تكرارا. الاستنتاج: كانت نسبة السرطانات الجلدية في الرجال أكثر من النساء بنسبة (رجل:امرأة 1.6:1). المرضى العاملين في المناطق المكشوفة هم أكثر عرضة للإصابة بسرطانات الجلد من المرضى العاملين في الظل. معدل السرطانات الجلدية في بغداد هو أكبر مما سجل من قبل وزارة الصحة العراقية. سرطان الخلايا القاعدية وسرطان الخلايا الحرشفية كان الأكثر شيوعا بين المرضى تبعه سرطان الخلايا الصبغية وسرطان كابوسي وبقية الاورام كانت بنسبة اقل تكرارا. الكلمات المفتاحية: سرطان الجلد, مستشفيات بغداد, سرطان الجلد القاعدي.


Article
Retrospective Study of Basal Cell Carcinoma and Related with Different Parameters in Ghazy Al-hariri Hospital for Surgical Specialist
دراسة استرجاعية عن سرطان الخلايا القاعدية و علاقتها بمتغيرات مختلفة في مستشفى غازي الحريري للجراحات التخصصية

Author: Mustafa Mohammed Abdulhussain م.م.مصطفى محمد عبد الحسين
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2015 Volume: 8 Issue: 2 Pages: 32-37
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Basal Cell Carcinoma is a malignant epithelial neoplasm of the skin that can be seen in the area of chronic sun exposure. If it is inadequately treated or left untreated, it can cause local tissue invasion and low death.Objective: To evaluate different parameters of basal cell carcinoma cases referred to Ghazy Al-hariri Hospital for Surgical Specialist.Patients and Methods: Retrospective study done in Ghazy Al-hariri hospital for surgical specialist, medical city, Baghdad during the period from 2009 till 2012, 6579 reports from archives of histopathological laboratories were review of malignant cases,84 cases of Basal cell carcinoma, 54 were men and 30 were women. Confirmatory histopathological re-evaluation of some or incomplete information was done, full information has been taken directly from report and the information was arranged in an informative formula sheet which includes, age, gender, anatomical site of tumor, tumor type and tumor size.Results: In this study the percentage of basal cell carcinoma in relation to the total number is (1.3%), the results showed that 54 (64.3%) were men and 30 (35.7%) were women and the mean age of these patients was (69.9) years. Among basal cell carcinoma lesions, 28 cases were pigmented type, 18 cases were nodular type, 14 cases were ulcerated type, 10 cases were plaque type, 9 cases were basosqumous type and 5 cases were unclear. Conclusion: The present study revealed significant differences in age between male and female, also most basal cell carcinoma lesions were located on the head and neck area.

خلفية الدراسة: سرطان الخلايا القاعدية يعد من الأورام الظهارية الخبيثة التي تظهر في الجلد والتي يمكن رؤيتها في حالات التعرض للشمس بشكل مستمر. إذا كانت الحالات غير معالجة بشكل كاف أو تركت دون علاج، فإنه يمكن أن يسبب غزو الأنسجة المحلي والموت البطيئالهدف من الدراسة: لتقييم انتشار سرطان الخلايا القاعدية وعلاقتها بمتغيرات مختلفة في مستشفى غازي الحريري للجراحات التخصصية.المرضى والطرق العمل: دراسة استرجاعية أجريت في مستشفى غازي الحريري للجراحات التخصصية في مدينة الطب خلال الفترة من 2009 حتى عام 2012، وتم مراجعة 6579 تقرير من التقارير المحفوظة في مختبرات النسيج المرضي في بغداد وتم استعراض الحالات الخبيثة، 84 حالة كانت لسرطان الخلايا القاعدية، 54 من الرجال و 30 من النساء. وقد تم إعادة تقييم الفحوصات النسيجية و استكمال المعلومات المفقودة، اذ اخذت المعلومات بصورة كاملة من التقرير بعدها تم ترتيب المعلومات في ورقة خاصة لكل مريض اشتملت على العمر والجنس والموقع التشريحي للورم، نوع الورم وحجم الورم.النتائج: أظهرت نتائج الدراسة الحالية أن نسبة سرطان الخلايا القاعدية هو (1.3٪) وكان متوسط عمر المرضى (69.9) سنة ,54 (64.3٪) من الرجال، و 30 (35.7٪) من النساء. بين اصابات سرطان الخلايا القاعدية ، كانت 28 حالة نوع المصطبغة، 18 حالة الشكل العقدي، 14 حالة نوع متقرحة، 10 حالات نوع لوحية، 9 حالات نوع حرشفية قاعدية و 5 حالات واضحة.الاستنتاجات: كشفت الدراسة اختلافات كبيرة في السن بين الذكور والإناث،ومعظم اصابات سرطان الخلايا القاعدية كانت في منطقة الرأس والرقبة.


Article
Histopathological Study of BCC in Rizgari Teaching Hospital

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Abstract

This study include (66) case of Basal cell carcinoma (BCC). The age of the patients ranged from (21 – 80) year. The highest percentage of patients was seen related to the age group (61 – 70) year. The total male to female ratio was 1.1:1. The most common histological type was the solid and the most common site of occurrence was the nose. No significant difference was found between site distribution and sex of the patients. The percentage of cases with apparent palisading pattern was (83.1%) and mostly seen related to the solid type. Significant difference was found between peripheral palisading pattern and histological types of BCC. Most cases showed apparent inflammatory reaction, no pigmentation, and involved margin by tumor cells. No significant difference was found between inflammatory reaction, presence of pigmentation, involvement of surgical margins, and histological types of BCC.This study include (66) case of Basal cell carcinoma (BCC). The age of the patients ranged from (21 – 80) year. The highest percentage of patients was seen related to the age group (61 – 70) year. The total male to female ratio was 1.1:1. The most common histological type was the solid and the most common site of occurrence was the nose. No significant difference was found between site distribution and sex of the patients. The percentage of cases with apparent palisading pattern was (83.1%) and mostly seen related to the solid type. Significant difference was found between peripheral palisading pattern and histological types of BCC. Most cases showed apparent inflammatory reaction, no pigmentation, and involved margin by tumor cells. No significant difference was found between inflammatory reaction, presence of pigmentation, involvement of surgical margins, and histological types of BCC.Key wards: Skin cancer, BCC.

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