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Evaluate the level of Oxidative Stress markers and Lipids Profile in Patients with Bening Prostate Hypertrophy in Al-Khadhmyah Tteaching Hospital

Author: aHanan H. Fleih aWajeeh Y. Al-Ani bSaddam h. Al- ma’adhedy
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2014 Volume: 10 Issue: 1 Pages: 30-33
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Benign Prostate Hypertrophy(BPH)is a common urological problem worldwide which is defined as denomatous hyperplasia of the periurethralpart of prostate gland that occurs especially in men over 50 years old and that tend to obstruct urination by constriction the urethra Objectives: The study was aimed to investigate the level of Malondialdehyde (MDA), Nitric Oxide (NO) and Superoxide Dismutase (SOD) as an antioxidant, besides other factors such as the level of Lipids Profile (Total Chlosterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C), and Triglyceride (TG))in patients suffer from BPH . Methods: In this study ;clinical ,specific prostate antigen and sonongraphy data of 80 persons were prospectively analyzed ; they are divided into two groups (40) male patients with Benign Prostate Hypertrophy (BPH) was previously diagnosed and another (40) healthy males as a control group .The study was performed at Al-Khadhmyah teaching hospital during the period from March 2001 till April 2003Results: The evaluated data recorded a significant increase in the levels of (MDA) and (NO), while a significant decrease in the level of (SOD) (P  0.001) in patients complain from BPH in comparison with the control group. Moreover, the results showed a significant increase in the levels of (TC), (TG) , (LDL-C) and a significant decrease in the level of (HDL-C) (P  0.001) in comparison with the control groupConclusions: Benign Prostate Hypertrophy (BPH) is the most common benign tumor in men and Malondialdehyde (MDA), Nitric Oxide (NO) ,Superoxide Dismutase and Lipid profile are beneficial markers to evaluate patients with BPH in comparison with those without BPH.


Article
LIPID PROFILE IN DETERMINATION OF PROSTATIC PATIENT
تقدير المجموعة الكاملة للدهون في مرضى البروستات

Author: THANA ISMAIL MUSTAFA ثناء اسماعيل مصطفى
Journal: Journal of university of Anbar for Pure science مجلة جامعة الانبار للعلوم الصرفة ISSN: ISSN: 19918941 Year: 2009 Volume: 3 Issue: 2 Pages: 19-22
Publisher: University of Anbar جامعة الانبار

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Abstract

This study was included investigation the effects of prostate gland on lipid metabolismand other parameters Blood sample were collected from (37) male patient ( (20) cancer prostate ,(17)with benign prostate hypertrophy ) and (25) from control serum prostate specific antigen (PSA) wasdetermined by Enzyme linked immunoabsorbent assay (ELISA method) ,C.R.Protein by agglutinationtest and lipid profile include (total cholesterol, triglycerides, high density lipoprotein(HDL), Lowdensity lipoprotein(LDL), Very low density lipoprotein (VLDL) and Risk factors were done.The resultshowed the value of TPSA,CRP,T.cholesterol,Triglycerides and risk factors increase significantly inpatient group compard to control group , while HDL value decrease in patient group. The result of thisstudy explain the relation ship between the incrase of TPSA and risk factor which lead toarterosclerosis in men .

:تضمن البحث التحري عن تأثير غدة البروستات على ايض الدهون وبعض المتغيرات .جمعت عينات الدم من 37 مريضا (20) يعانون من سرطان البروستات و(17) يعانون من تضخم البروستات الحميد و(25) اشخاص اصحاء . وتم اجراء فحص الاليسا المناعي لقياس كمية مستضد البروستات الكلي (TPSA) وفحص اللاتيكس التلازني بروتين التفاعلي سي (C.R.Protein) وفحص المجموعة الكاملة للدهون (Lipid profile) حيث شمل فحص الكولوستيرول T.Cholesterol والدهون الثلاثية Triglycerides والدهون عالية الكثافة (HDL) والدهون منخفضة الكثافة (LDL) وعامل الخطورة .اذ بينت النتائج ارتفاع قيم مستضد البروستات الكلي والبروتين التفاعلي سي والكولوستيرول والدهون الثلاثية وعامل الخطورة في مجموعتي المرضى مقارنة مع الاصحاء وانخفاض الدهون عالية الكثافة في مجموعتي المرضى مقارنة مع الاصحاء ويعد هذا مؤشراً للاصابة بتصلب الشرايين مما يؤدي الى وفاة الكثير منهم بالذبحة الصدرية .

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