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Article
PREDICTORS OF HYPOXEMIA IN BRONCHIOLITIS IN ASAMPLE OF IRAQI INFANTS

Authors: Cawes Omar Hamad --- Muhi K. AL-Janabi --- Numan Nafie Hameed
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2008 Volume: 50 Issue: 2 Pages: 145-153
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Bronchiolitis is the first episode of wheezing associated with low grade
fever, rhinitis, tachypnea, and increasing respiratory effort in a previously healthy
infant during the winter months, and it is the most common lower respiratory tract
infection in infancy.
Objectives: This study is designed to analyze the clinical signs and symptoms alone
or as combinations as possible predictors of severe hypoxemia in infants with
bronchiolitis.
Patients and methods: This is a prospective study, which was carried out on 96
infants with a mean age of 7.74 ،ہ3.72 months who were admitted to Children
Welfare Teaching Hospital in Medical City-Baghdad with bronchiolitis during the
period from 1st
October 2006 to the 15th
March 2007. They are divided into two
groups: group one 46 cases (oxygen saturation (SaO2<90) and group two, 50 cases
(SaO2،ف90).Complete history taken from care taker and full examination done for each
patient. A portable oximeter was used to measure oxygen saturation.
Results: Forty nine (51%) of patients were males and 47 were females (49%), with
male to female ratio of 1.04:1. The mean age was (7.745،ہ3.7) months. The mean
oxygen saturation was (90%), with a median of (84.7%) and a range of (76%-89%) in
group one (SaO2<90), while it was (95.32%) with a range of (90%-99%) in group two
(SaO2،ف90).
Conclusions: Reduced ability to feed, sleep disturbances, hypotonia and clinical
signs as suprasternal retractions, continuous nasal flaring, tachypnea, grunting, head
nodding and cyanosis appeared to be statistically highly significant in this study as
predictors of severe hypoxemia. Combinations of signs and symptoms that showed
statistically significant association with severe hypoxemia were: grunting or head
nodding, cyanosis or head nodding, tachypnea or sleep disturbance, tachypnea or
suprasternal retractions, and tachypnea or head nodding (p.value <0.0001) for all
mentioned combinations, So we recommend to use these combinations of signs and
symptoms as significant predictors of severe hypoxemia especially when pulse
oximetry is not available.


Article
Incidence of Bronchiolitis in Breast Fed Infants Below 2

Author: Haider Nadhim Abd
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 1-5
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Acute viral bronchiolitis is a common respiratory infectious disease of children.OBJECTIVE:To study the relationship between bronchiolitis and breastfeeding in children below 2 years of age.MATERIAL AND METHODS:A prospective study was carried out with100 child aged up to 24 months to evaluate theirbreastfeeding status as possible risk factors for unfavourable evolution in department of pediatricin AL-Kahdimiya Teaching Hospital during the period from first of October 2008 to the end ofMarch 2009.RESULTS:Hundred cases of bronchiolitis were included in this study. Most of them ( 78 %) were below oneyear. Male children were 70%, female children were 30%. Fifty-four of the children wereexclusively breastfeeding. Eighty of the children were admitted to the hospital because of severeattack. The median length of hospital stay was four days and of oxygen-use was three days.CONCLUSION:The duration of exclusive breastfeeding was inversely related to the length of oxygen-use and thelength of hospital stay. Shorter exclusive breastfeeding was observed in children who wereassigned to a pediatric ward or to an intensive care unit. Longer duration of breastfeeding wasassociated with better clinical outcomes.


Article
Hypoxemia among infants with bronchiolitis in Al-Anbar governorate
انخفاض الأوكسجين في الدم لدى عينة من الأطفال المصابين بالتهاب القصيبات في محافظة الانبار

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Abstract

Abstract:Objective: To study the predictors of hypoxaemia In a sample children with bronchiolitis admitted to maternity and children hospital in Al-Ramadi, Al-Anbar governorate.Materials & Methods: A total of 154 infants with bronchiolitis were admitted during the period 1st Dec. 2002 to 1st March 2003, inclusive. Information about infant's feeding and sleeping was taken from mothers. All infants were examined for cynosis, level of consciousness, hypotonia, use of accessory muscles of respiration and respiratory rate. The heart rate and the arterial oxygen saturation (SaO2) were measured by pulse oximetry. SaO2 less than 95% was regarded as hypoxaemia.Results: SaO2 was significantly associated with level of consciousness, use of accessory muscles of respiration, ability to feed, ability to sleep, hypotonia, and cynosis. A significant negative association was found between SaO2 and respiratory rate. Similar association was demonstrated between SaO2 and heart rate.Conclusion: Studied signs and symptoms reflect the SaO2 level. Health care worker could assess them for proper selection of patients for oxygen therapy.Key words: Bronchiolitis, hypoxaemia, infants, predictors

الملخص:هدف الدراسة: دراسة مؤشرات انخفاض الأوكسجين في الدم لدى الأطفال المصابين بالتهاب القصيبات الذين ادخلوا إلى مستشفى النسائية والأطفال في الرمادي.طريقة الدراسة: ادخل 154 طفلا مصابا بالتهاب القصيبات إلى المستشفى خلال الفترة من الأول من كانون الأول 2002 لغاية نهاية آذار 2003 . تم اخذ المعلومات عن قابلية الطفل للرضاعة والنوم من آلام. وتم فحص الأطفال لتحديد وجود ازرقاق، ومستوى وعي الطفل، وارتخاء العضلات، واستعمال العضلات المساعدة للتنفس، وسرعة التنفس. وتم قياس سرعة النبض ومستوى التشبع الشرياني بالا وكسجين باستعمال قياس الأوكسجين النبضي. مستوى التشبع بالأوكسجين اقل من 95% اعتبر انخفاضا لمستوى أل أوكسجين بالدم.النتائج: كان مستوى التشبع الشرياني بالا وكسجين ذا علاقة إحصائية معنوية مع مستوى الوعي واستعمال العضلات المساعدة للتنفس وصعوبة الرضاعة وصعوبة النوم وارتخاء العضلات والازرقاق. كانت هناك علاقة عكسية معنوية بين مستوى تشبع الدم الشرياني بالا وكسجين وسرعة التنفس وعلاقة مماثلة بين مستوى التشبع الشرياني بالا وكسجين وسرعة نبض القلب.الاستنتاج: العلامات والأعراض السريرية المدروسة مؤشرا لمستوى تشبع الدم الشرياني بالأوكسجين وممكن للعامل الصحي أن يحددها بدقة لاختيار المرضى للعلاج بالأوكسجين.


Article
Effect of treatment with subcutaneous epinephrine versus nebulized salbutamol on O2 saturation and rate of admission in patients with bronchiolitis

Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2016 Volume: 3 Issue: 1 Pages: 5-9
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

Despite wide spread use of epinephrine β2-agonists in infants with bronchiolitis since the late 1950s, the efficacy of these drugs remains unproven. The objective of the study is to determine the effective treatment with subcutaneous (s.c) epinephrine versus nebulized salbutamol on O2 saturation and rate of admission to hospital in patients (age 2 years or less) with bronchiolitis. Single dose of epinephrine (0.01 mg/kg) has been used across various age groups of 2 years or less (maximum dose used was 0.15 mg) and no complications were reported suggesting that the dose is safe; however the maximum safe dose cannot be interpreted from this study. The response to sc epinephrine in patients younger than 12 months was significantly better than in older patients, suggesting a useful role of s.c epinephrine in bronchiolitis in this age. The s.c epinephrine relieves clinical manifestations of respiratory distress (wheezing, chest retractions, flaring of alanasi, cyanosis) and improves parameters of respiratory distress (oxygen saturation, respiratory rate) in infants treated for acute bronchiolitis with maximal effectiveness at 30-60 minute. For s.c epinephrine, every patient had his own disposable syringe; while for nebulized salbutamol, all patients share the same nebulizer. So that, s.c epinephrine may decrease the likelihood of transmission of infection between the patients. The s.c epinephrine reduces the admission rate (13%), compared to nebulized salbutamol (24%). The observation that peak action of s.c epinephrine occurs 30-60 minutes after administration suggests the need for caution in repetitive administration during this period.


Article
Clinical evaluation of wheezy chest in children below 2 years of age in Hawler governorate
التقييم السريري للصدر الصفير عند الأطفال أقل من عامين في محافظة هولير

Authors: Kawes O. Hamad Zangana --- Dlair AbdulKhalik Chalabi --- Parween N. Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 1 Pages: 23-30
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objectives: Acute respiratory tract infection is a leading cause of childhood morbidity & mortality in developing countries .respiratory distress with wheezing in infants is quite common & presents substantial diagnostic problems. The aim is to determine the clinical characteristics of wheezy chest in children below 2 years of age in Raparin pediatric hospital in Hawler GovernorateMethods: a prospective study conducted between 1st of January till 1st of June 2007 in Raparin hospital , three hundreds children of 1-24 months old admitted with respiratory distress & acute wheezing were recruited & 62 children with no respiratory distress were also studied as control cases. Chest x-ray, total & differential WBC counts were undertaken for all of them.Results: of the 300 cases, 191 were due to bronchiolitis. thier age were between 1-6 months (47.23 %), male was the most common gender affected (67.67%).Fever with temperature above 37.7 Cᵒ indicate pneumonia (68.9%) more likely rather than other 2 diseases (asthma ,bronchiloitis). One hundred percent of cases of asthma had history of previous attack of wheeze & +ve family history of atopy.Among bronchopneumonia patients, 77% had opacity in chest x-ray (CXR) while 39.9% of bronchiolitis cases had normal CXR. In 84.8 % of cases with bronchiolitis WBC count were normal with only 4.2% had lymphocytosis, while 11.5% of bronchopneumonia patients had leukocytosis with 24.6% of these cases had neutrophilia.Conclusion: It can be concluded from this study that bronchiolitis, bronchopneumonia & asthma can be differentiated up to reasonable extent on the basis of clinical features supported by simple available investigations..


Article
Risk Factors For Respiratory Syncytial Virus (RSV) Bronchiolitis in Children. A hospital Based Study

Author: Muneera Fadhil Rida
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 305-310
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT :BACKGROUND:Respiratory syncytial virus (RSV), historically being the major causative agent. RSV causes respiratory disease in young children worldwide and by the age of two years most children have been infected.OBJECTIVE:The aim of this study was to investigate the effect of passive smoking alone and in conjunction with breastfeeding and Crowding index and Family history of atopy in determining the risk of bronchitis in Children under of 5 years of age .METHODS:We studied 100 consecutive Children aged from (1)day to (60)months (56boys and 44 girls),median age 30 months, who required hospital admission for acute bronchiolitis at the Pediatric Department ,Children Welfare teaching hospital ,medical city complex - Baghdad.The cases were compared with 100 patients at the same age groups with no history of Bronchilolitis .The following parameters was studied in both groups: Exposure to passive smoking, type of feeding (Breast, Bottle, and Mixed), Family history of atopy, and crowding index.RESULTS:High level of exposure to passive smoking on the other hand significantly increase the risk of having bronchiolitis by (2.3) times compared to those with negative exposure. Breast feeding significantly decrease the risk of having bronchiolitis by 5 times compared to those on mixed and bottle feeding.A positive family history of atopy significantly increase the risk of bronchiolitis by (9.5 )times . Subjects with moderately high crowding index (interquartile range )has 6.3 times of having increase the risk of bronchiolitis compared to those of living in uncroweded residence (first quartile crowding index).Highly crowding index (forth quartile)significantly increase the risk by 101 times compared to the those in un crowded (first quartile )residence.CONCLUSION:Although Smoking , Lack of Breast feeding and family history of atopy are important risk factors for RSV bronchiolitis But Crowding seems to be the most important risks factors for RSV bronchiolitis in this study.


Article
Treatment options of acute viral bronchiolitis in two Iraqi pediatric hospitals with a recent montelukast treatment option.

Authors: Afrah, G. Salih, افراح جعفر صالح --- Kassim, J. Al-shamma قاسم الشماع --- Mahir, M.Hassan ماهر حسن
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2013 Volume: 13 Issue: 2 Pages: 87-94
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Bronchiolitis is a virally induced acute bronchiolar inflammation. It is the mostcommon lower respiratory tract infection in infants with ages less than 1 year.The most common virus responsible for bronchiolitis is respiratory syncytial virus(RSV). The mainstay of management is oxygen and fluid administration. Pharmacologicalinterventions including corticosteroids and bronchodilators have not been shown to improveoutcome.Is to evaluate the effect of montelukast and to verify the efficacy of bronchodilatorsand anti-inflammatory drugs among infants presenting with acute viral bronchiolitis in twoIraqi pediatric hospitals.This was a randomized, prospective study in two Iraqi pediatric hospitals. Sixtyinfants with age range (2-24months) with a first episode of acute bronchiolitis were randomlydivided into four treatment groups: oxygen plus intravenous fluid, montelukast pediatricchewable tablet, salbutamol given in combination as oral plus nebulized salbutamol, anddexamethasone IV injection. Control infants with non respiratory diseases were also studiedfor comparisons. The measured outcomes included: respiratory rate, heart rate, oxygen bloodsaturation, and times to resolution of illness, duration of oxygen & intravenous fluid therapy,and length of hospital stay.These parameters were measured for each infants from hospital admission untildischarge.All groups were comparable at baseline. There are significant improvements in therespiratory rate, heart rate, blood oxygen saturation and rapid resolution of illnesses in thepatients group that received oxygen plus IV fluid &the patients group that receivedmontelukast tablet compared to other treatment options.Length of hospital stays was shorter in these two treatment options compared to othertreatment options.The results observed effect of montelukast & oxygen plus intravenous fluid on themeasured parameters compared to other treatments options in these two hospitals.

الخلاصة :التھاب القصیبات الحاد عند الاطفال ھو مرضشائع یصیب المجاري التنفسیة الصغیرة في الجھاز التنفسي، وھویحدث خلال السنتین الأولیین من الحیاة، وذروة حدوثھ في الأعمار الصغیرة ذات الستة شھور، ویكثر في فصل الشتاءوأوائل الربیع، واحیانا یحدث في الفصول الأخرى ولكن بشكل أقل ویمكن ان یكون بشكل وباء نتیجة لتفشي ذلك الفیروس6 اشھر والذین لم یتغذوا من اثداء امھاتھم - المسبب لھ. أكثر ما یحدث التھاب القصیبات عند الرضع الذكور بین اعمار 3والذین یعیشون في المناطق المزدحمة، عادة ما یكون مصدرالالتھاب الفیروسي ھو من أحد افراد العائلة المصابین بمرضتنفسي بسیط، حیث ان الأطفال الأكبر سنا والبالغین یتحملون ھذا الالتھاب بشكل أفضل من الرضع الذین یعانون الكثیر من


Article
Prevalence of IgM and IgA Antibodies for the Respiratory Syncytial Virus in Infants and Young Children in Baghdad
انتشار الاجسام المضادة المناعية IgM وال IgA لفايرس المخلوي التنفسي Respiratory Syncytial Virus في الاطفال الصغار والرضع في بغداد

Authors: Hassan. M. Naif حسن محمد نايف --- Zaineb. M. Ahmad زينب معين احمد --- Faisal. G. Al hamadani فيصل غازي الحمداني
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 1C Pages: 689-692
Publisher: Baghdad University جامعة بغداد

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Abstract

Respiratory Syncytial Virus is the most common cause of acute viral bronchiolitis and pneumonia in infants and young children. This study is designed to examine the presence of anti-RSV IgM and IgA antibodies in infants and young children aged between 2 months up to 5 years old. ELISA was used to examine the levels of IgM and IgA antibodies in the serum samples from 90 individuals (60 are with respiratory symptoms and 30 healthy as controls). The results were analysed by systematically dividing those individuals into two groups according to their age and clinical status. The age groups included infant between 2 months and 1 year of age and young children between 2-5 years whereas the clinical grouping includes the severity of infection of those hospitalized with acute respiratory symptoms and /or with chest pain from two main children hospitals in Baghdad. ELISA results revealed that anti-RSV IgM levels were 80% and 72% for those with acute infection and those with chest pain, respectively, whereas the levels of IgA were 45% for both groups. On the other hand, the level of IgM for individuals from group I and group II of age distribution were 63% and 35%, respectively; while the levels of IgA were only 27% for group I and 8% for group II. This study showed that the level of IgM antibodies for RSV is indicative of early detection of viral infection and it is more likely to be associated with the onset of recent infection with RSV regardless of the severity of infection. By including another test together with IgM detection may significantly improve early detection of RSV infections. These results may contribute for better understanding for the prevalence of RSV among infants and young children as well as the status of respiratory infection with RSV in children from Baghdad areas which may eventually lead to better rationale for the unnecessary prescription of antibiotics in community.

فايروس المخلوي التنفسي Respiratory Syncytial Virus (RSV) هو الأكثر شيوعا في اصابات التهاب القصيبات الفيروسي الحاد والالتهاب الرئوي عند الرضع والأطفال الصغار. صُممت هذه الدراسة لفحص وجود الاجسام المضادة IgM وIgA ضد فايروس RSV عند الرضع والأطفال الصغار الذين تتراوح أعمارهم بين 2 أشهر وحتى 5 سنوات من العمر. تم استخدام فحص ELISA لقياس مستويات الأجسام المضادة (غلوبولينات) المناعية في عينات مصل الدم من 90 طفلاَ، من بينهم 30 طفل غير مصاب كسيطرة ,وقد تم تحليل النتائج وفقا لتقسيم منهجي لهؤلاء الأفراد إلى مجموعتين وفقا للأعمار والأعراض السريرية. وشملت الفئات العمرية الرضع بين 2 شهر - 1 سنة من العمر والأطفال الذين تتراوح أعمارهم بين 2-5 سنوات في حين شملت الاعراض السريرية شدة العدوى من الذين نقلوا الى المستشفيات يعانون من أعراض الجهاز التنفسي الحاد و/أو آلام في الصدر في اثنين من المستشفيات الرئيسة في بغداد. كشفت نتائج ELISA أن الاجسام المضادة لفايروس RSV IgM للمرضى بأعراض حادة هو 80% ولذوي آلام الصدر 72%، اما مستويات IgA فكانت 45% لكلا الحالتين السريريتين. اما قياس مستويات الاجسام المضادة حسب التوزيع العمري IgM فكانت 63٪ من المجموعة الأولى و 35٪ من المجموعة الثانية ، و مستويات IgA كانت 27٪ فقط من المجموعة الأولى و 8٪ من المجموعة العمرية الثانية. تظهر الدراسة مستويات عالية للأجسام المضادة IgM لفايروس RSV لكل المجاميع قيد الدراسةونسبة أقل لـ IgA مما يدل على الكشف المبكر عن الأصابة الفيروسية حيث أنه من المرجح أن تترافق مستويات ارتفاعه مع بداية الإصابة الاولية بالفيروس RSV بغض النظر عن شدة الإصابة. يمكن أن تسهم هذه النتائج لفهم أفضل لأنتشار RSV بين الرضع والأطفال الصغار، وكذلك نسبة عدوى الجهاز التنفسي لفايروس RSVمما قد يؤدي أيضا إلى الأساس المنطقي لأفضل وصفة طبية من المضادات الحيوية غير الضرورية في المجتمع.

Keywords

RSV --- respiratory infection --- bronchiolitis --- ELISA --- IgM --- IgA --- children.


Article
The Effect of Hypertonic Saline in Treatment of Moderate Bronchiolitis in Children

Author: Alaa Jumaah Nasrawi علاء جمعة النصراوي
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2017 Volume: 17 Issue: 1 Pages: 77-91
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: Airway oedema and mucus plugging are the predominant pathological features in infants with acute viral bronchiolitis. Nebulized hypertonic saline (HS) solution may reduce these pathological changes and decrease airway obstruction.Aim: To assess the effects of nebulized hypertonic (3%) saline solution in infants with acute viral Bronchiolitis of moderate severity.Methods: This study was conducted in Al Zahraa teaching hospital for maternity and pediatric in the period between December 2013 till November 2014 at which 165 patients with acute viral bronchiolitis were included. The inclusion criteria were; Infants aged ≤18 months presented with a prodromal history consistent with viral upper respiratory tract infection followed by wheezing and/or crackles on auscultation. Patients were excluded from the study if they have the following criteria: born at ≤ 34 weeks’ gestation, previous history of wheezing, steroid use within 48 hours of presentation, history of apnea within 24 hours before presentation, oxygen saturation ≤85% on room air at the time of recruitment, history of a diagnosis of chronic lung disease,congenital heart disease, or immunodeficiency, consolidation or atelectasis on a chest X-Ray and infants with bronchiolitis severity score <4 or > 8. Result: We found that nebulized 3% HS decreases bronchiolitis severity score after 12h of treatment and its effect subsided after more than 48 h. In regard to hospital stay, the study shows a decrease in mean of hospital stay length from 42.2 to 36.3 h. Conclusion: Nebulization with 3% hypertonic saline is safe, can be widely generalized, and may be superior to current treatment for early outpatient treatment of bronchiolitis.Recommendation: Planning for a multicenter trial to explore the clinical benefit of this therapy with a large sample size is essential.


Article
DETECTION OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN A SAMPLE OF INFANTS IN IRAQ
التحري عن الاصابة بفايروس الخلية العملاقة التنفسي في مجموعة من الاطفال في العراق

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Abstract

Background: Human Respiratory syncytial virus (HRSV) is one of the major causes of bronchiolitis and pneumonia in infants.Objective: detection of Anti HRSV antibodies in infants and children by using indirect ELISA, and detection of HRSV antigen by using Respi- RSV test. Materials and Methods: Hundred and eighty four serum samples (104 with respiratory tract infection, 54 without Respiratory tract infection, and 26 with cancer) also 100 nasal and throat swabs were collected from infants and children from Central Pediatric Hospital in Baghdad in year (2005-2006). Indirect ELISA test and rapid test used for detection Human RSV antibodies and Human RSV antigen respectively Results: Detection of anti HRSV antibodies using ELISA in children without respiratory tract infection was 26% with mean titer 494, but the antibodies was higher in patients with cancer which were 96% with mean titer 580, however anti HRSV was detected in79% in infants with respiratory tract infection (bronchiolitis and pneumonia), their mean titer (1411) was, higher than that of the previous two groups.Human RSV viral antigen was detected by RSV-Respi kit in 45% of nasal and throat secretion collected from children with respiratory tract infection, detection of HRSV antigen samples was compatible with the detection of antiHRSV antibodies in 50%. Conclusion: The highest percentage and titers of antiHRSV antibodies were detected in infants with respiratory tract infection than in others suffering from different cancers or without respiratory tract infection. Human RSV antigens were detected in nasal/throat swabs in infants with bronchiolitis and pneumonia. Keywords: Respiratory syncytial virus, bronchiolitis, Respi-RSV.

خلفية الدراسة : فايروس الخلية العلاقة التنفسي من المسببات الرئيسة لالتهاب القصبات الحاد والتهابات الرئوية في الاطفال الرضع. هدف الدراسة : الكشف عن اضداد فايروس الخلية العملاقة في الاطفال باستعمال اختبار الاليزا الغير مباشر وكذالك الكشف عن المستضد الفايروسي باستعمال التشخيص السريع RSV-Respi . المواد وطرق العمل : تضمنت الدراسة الكشف عن اضداد الفايروس في 184 نموذج مصل لاطفال يعانون من اعراض تنفسية شديدة واطفال يعانون من عدة انواع من السرطان كما شملت الدراسة 100 نموذج مسحات من الأنف والحنجرة للكشف عن المستضد الفايروسي تم الحصول عليها من مستشفى الطفل المركزي في بغداد. النتائـج : شملت الدراسة184 نموذج مصل جمعت من (104 لاطفال يعانون من اصابات الجهاز التنفسي, 54 لاطفال لا تظهر عليهم اصابات تنفسية و26 نموذج لاطفال مصابون بالسرطان) حيث تم الكشف عن اضداد فايروس الخلية العملاقة التنفسي واستعمال فحص الاليزا في أطفال لا يعانون من اعراض تنفسية حيث سجلت في 26% من النماذج وبمعدل معيار 494. كما كشفت اضداد فايروس الخلية العملاقة التنفسي في 96% من النماذج لأطفال يعانون من مختلف انواع السرطان وبمعدل معيار 580. كما ان اضداد فايروس الخلية العملاقة التنفسي البشري سجل في 79% من النماذج لأطفال يعانون من اعراض تنفسية شديدة وبمعدل 1411 والذي تفوق على المجموعتين السابقتين. تم تشخيص مستضد فايروس الخلية العملاقة التنفسي البشري باستعمال Respi-RSV للتشخيص السريع حيث سجلت في 45% من النماذج المرضية في افرازات الانف والحنجرة لأطفال يعانون من اصابات تنفسي شديدة ، حيث كان تشخيص مستضد فايروس الخلية العملاقة التنفسي في النماذج التي تم فحصها متزامناً مع تشخيص الاضداد وبنسبة 50% من نماذج المصول المفحوصة. الاستنـتاج :الكشف عن الاضداد لفايروس الخلية المعلاقة لاطفال يعانون اعراض تنفسية شديدة وبمعيار عال مقارنة مع المجاميع التي لم تظهر عليهم اصابات تنفسية. الكشف عن المستضد الفايروسى في افرازات الانف والحنجرةلاطفال يعانون من التهاب القصبات والتهابات رئوية. مفتاح الكلمات: فايروس الخلية العملاقة التنفسي ,التهاب القصبات الحاد ,Respi-RSV .

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