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Article
Diagnostic Value of C Reactive Protein Measurement in Patients with Acute Appendicitis

Author: Maitham H. Kenber
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 4 Pages: 347-351
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:OBJECTIVES :To evaluate the role of crude measurement of C-reactive protein in the diagnosis of acute appendicitis.BACKGROUND:Appendicectomy for suspected acute appendicitis is a common procedure. The rate of normal appendices unnecessarily removed remain high(15%-30%) ; despite several techniques and investigations used to improve the diagnostic accuracy . Many studies investigated the role of raised C-reactive protein (CRP ) in improving the diagnosis of acute appendicitis, but with conflicting results.PATIENTS AND METHODS :This is a randomized prospective study from February to July 2006 . A total of 100patients were included in this study that presented to our hospital with acute right iliac fossa pain and later on operated and had appendicectomy .Blood for the measurement of serum C-reactive protein(CRP) was collected preoperatively from all the patients. The patients divided in to two groups ,those who are positive appendicitis proved by operative finding and histopathological examination and those with negative appendicitis proved by histopathological examination.RESULT:A total of 100 patients were included in this study, and out of these 16 (16%) had normal appendix giving an over all negative appendicectomy rate of 16% out of these 5 were males and 11 were females ,the age range was (6-47 years) with a median age of ( 25.92) years . Among the 84 who had appendicitis, 64 patients had obstructive type of appendicitis which were noticed during the operation ,and CRP was positive in all patients, but only 9 of them were with CRP negative . 4 perforated appendicitis were found in which all of them were CRP positive, and 16 patients with catarrhal appendicitis were diagnosed by histopathological examination and only 3 patients out of those had negative CRP while the remainder were positive.CONCLUSION:The positivity of CRP was related to the severity of inflammation; but it is more reliable to depend on negative results to postpone the operation and observe the patient .Thus unnecessary removal of normal appendices may be reduced.


Article
The association of C-reactive protein in the pathogenesis of meconium stained amniotic fluid in Al- Najaf city

Author: Basima Sh. Alghazali
Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2015 Volume: 2 Issue: 2 Pages: 65-69
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

The objectives of this study is to study the association of C-reactive protein in the pathogenesisof meconium stained amniotic fluid in women presented in labour. A case control study, 90women presented in labour 45 with meconium stained amniotic fluid (MSAF) and 45 clearamniotic fluid (CAF), from March 2013 to July 2013 in the labour room and operative theater.Data collected regarding their age, gestational age, mode of delivery, neonatal outcome, parityand maternal blood for C- reactive protein. Complete physical examination of the neonateregarding Apgar score, color of baby, response to a catheter in the nostril, muscle tone, heart rate and breathing was done. There was a significant increment in the level of C- reactive protein in women with MSAF. We concluded that C- reactive protein may be involved in the pathogenesis of MSAF.

Keywords

C-reactive protein --- MSAF --- CAF


Article
The Role of Serum C - reactive protein in Leukemic and Lymphomic Patients

Author: Sawsan Ahmed Hussein
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2010 Volume: 3 no.1 Issue: 6 Pages: 784-787
Publisher: Kerbala University جامعة كربلاء

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Abstract
Background : C-reactive protein is a sensitive major acute phase reactant in humans, whose synthesis in the liver is regulated by different cytokines . C-reactive protein is a common marker of inflammation plays a key role in the progression of human cancer.
Objective: To detect the level of C - reactive protein in sera of patients with leukemia and lymphoma (infected and uninfected with fungus).
Methods: Ninety six patients and hundred and fourteen control patients attended Medical city in Baghdad over period from Oct. 2005 to Dec.2005 were included in the study. Patients were divided into 2 groups according to the infected or uninfected with fungi, also 20 healthy volunteers were included in this study.
Results: The level of C - reactive protein in sera of patients was significant higher than the healthy control group (248.6+70.5) and (3.72+1.61) respectively with (p~0.05). Also the level of C - reactive protein in sera of patients was significant higher than the patients control group (54.3+28.14) with (p~0.05).
Conclusions: There was a significant increase in mean serum level of C - reactive protein in patients with fungal infections.
Key Words: C-reactive protein, fungi, leukemia, lymphoma.

Keywords

C-reactive protein --- fungi --- leukemia --- lymphoma


Article
C-Reactive Protein and Cholesterol level In Male Type 2 Diabetic Patients.
مستوى C-Reactive Protein والكولسترول في المرضى الذكور المصابين بداء السكري نوع 2

Authors: Noor A. Abood نور عادل عبود --- Majid A. Naseif AL-Bayati ماجد احمد نصيف البياتي --- Samal H. Kareem سامال حكيم كريم
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2012 Volume: 9 Issue: 1 Pages: 113-119
Publisher: Baghdad University جامعة بغداد

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Elevated C-Reactive Protein (CRP) level in serum is a risk factor for type 2 diabetes ,this relationship is likely to be the cause it means elevated CRP leads to T2D in future . Our objective was to examine CRP in male Type 2 Diabetes(T2D) patients in different age ,we studied 120 male subjects divided to two groups according to their age. First group A age (31 - 40) year old ,60 person )30 control & 30 T2D patients(,3 person for each same age: second group B age (41 – 50) years old ,60 person )30 control & 30 T2D patients(,3 person for each same age. We examined blood sugar ,cholesterol and CRP in each group. and we toke the mean of samples in the same age in each data in all the 4 groups. Our data shows that CRP raised significantly P≤0.05 in group A(T2D) and in group B(T2D) comparing with control group of each .And cholesterol levels, and sugar levels raised significantly P≤0.05 in group A(T2D) and in group B(T2D) comparing with control group of each. CRP ,Cholesterol and sugar are higher in group B(T2D) than in group A(T2D),and in group B (control) than in group A (control). CRP level can predict diabetes but not causal, diabetes may cause a kind of inflammation (showed by high CRP) by its effect on body and this effect (inflammation) may cause rising CRP level.

ارتفاع مستوى C-Reactive Protein (CRP)هو احد العوامل التي ترافق مرضى السكري نوع 2 ٫هذا الترابط بين مستوى CRP ومرض السكري نوع 2 يمكن أن يفسر كعلاقة سببية أي أن ارتفاع CRP يؤدي بالنهاية إلى الإصابة بمرض السكري نوع 2 مع الأخذ بالاعتبار الاختلافات الجينية وأسلوب المعيشة اللذان يؤثران على مستوى CRPهذه تؤدي مجتمعة إلى أعراض مرض السكري .كان الهدف من الدراسة تقييم مستوى CRPوالكولسترول في دم المرضى الذكور المصابين بداء السكري نوع2 ٫تمت هذه الدراسة على 120 ذكر قسموا على مجموعتين عمريتين الأولى مجموعة A (60 شخص) من عمر (31-40 )سنة وتشمل سيطرة 30 شخص غير مصابين ,3 أشخاص لكل عمر (3 تكرارات) ومجموعة مصابين Type 2 Diabetes (T2D) عدد 30 شخص ,3 أشخاص لكل عمر (3 تكرارات):ومجموعة ثانية مجموعة B من عمر (41 -50)سنة وتشمل أيضا مجموعة سيطرة غير مصابين 30 شخص بواقع 3 أشخاص لكل عمر (3 تكرارات) ,ومجموعة مصابين من 30 شخص بواقع 3 أشخاص لكل عمر (3 تكرارات). أعطت النتائج ارتفاع معنويا P≤0.05 بمستوى CRP في مرضى السكري نوع 2 في مجموعةِA ومجموعة B بالمقارنة مع مجموعة السيطرة لكلا المجموعتين وكان هذا الارتفاع موازيا للارتفاع المعنوي P≤0.05 بمستوى سكر الدم والكولسترول في كلا المجموعتين Aو B المصابتين (T2D) بالمقارنة مع مجموعة السيطرة لكلا المجموعتين . إن مستوى CRP في الدم يمكن إن يعتبر كمؤشر لحدوث مرض السكري نوع 2 كما إن ارتفاع CRP لا يسبب مرض السكري نوع 2 وهذا يوضح من خلال, إن مرض السكري نوع 2 يشبه من حيث طبيعة تأثيره على الجسم تأثير الالتهاب إي يعتبر كنوع من أنواع الالتهاب وهذا الأخير يسبب ارتفاع مستوى CRP في هؤلاء المرضى كما وان حدة المرض ومستوى السكر في الدم وCRP والكولسترول يزداد مع تقدم العمر.


Article
Diagnostic Value of C - Reactive Protein and Other Hematological Parameters in Neonatal Sepsis

Authors: Hafadh Jaleel Hussein --- Yusra Fayyadh Alwan
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 3 Pages: 370-375
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:There have been many attempts to develop screening tests or scoring systems that can identify infected infants at the time of initial assessment, sparing others from invasive diagnostic procedures, intravenous antibiotics therapy, mother-infant separation and parental anxiety.OBJECTIVE:Is to analyze hematological parameters and C - reactive protein so as to evaluate their diagnostic value in neonatal sepsis.PATIENTS AND METHODS:A cross-sectional study was performed in the neonatal care unit (N.C.U) at the Central Teaching Hospital for Pediatrics and Al-Habibiya Maternity and Children Teaching Hospital during a period from the first of June 2005 to the first of January2006One hundred neonates having clinical features of sepsis and 100 normal asymptomatic neonates were evaluated with a set of investigations including C-reactive protein(CRP), White Blood cellsCount(WBC), Absolute Neutrophil count (ANC), Platelets count (thrombocytopenia), Immature to Total neutrophil ratio (I/T ratio) and Erythrocyte Sedimentation Rate (ESR) to diagnose neonatal sepsis.RESULTS:C-reactive protein (CRP) was positive in (82.4%) of group-A and (81.8%) of group-B and had a specificity of 93.0%. ANC was the second most sensitive test having sensitivity of 61.8% for group-A and 48.5% for group-B and specificity of 86.0%.The sensitivities of platelets count (thrombocytopenia), WBC, I/T ratio and ESR for group-A were: 55.9%, 29.4%, 17.6% and 26.5% respectively, with specificities of 91.0%,89.0%, 92.0% and 81.0% respectively. While group-B had sensitivities of 42.0%, 33.3%,15.2% and 22.7% respectively with specificities of 91.0%, 89.0%, 92.0% and 81.0%respective ly.CONCLUSION:The implementation of CRP and other hematological parameters (ANC, Platelets count and WBCs) are useful in early detection of neonatal sepsis and diagnosis of neonatal sepsis in those who have false negative blood cultures


Article
Evaluation of C-reactive protein titer in patients with acute hepatitis B virus infection
تقييم بروتين ( C ) المنشط في مرضى التهاب الكبد الفيروسي نمط (B ) الحاد

Author: Nazar Shiaa Al-Azawi د.نزار العزاوي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2008 Volume: 21 Issue: 3 Pages: 241-245
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Objective: to evaluate the serum C-reactive protein (CRP) titer as a predictive diagnosis of acute hepatitis B virus (HBV) infection.Materials and methods: One hundred and five patients with acute HBV infection and 117 apparently healthy individuals as a control group were enrolled in this study. The patients include 37(35.2%) females and 68 (64.8%) males with mean age (27±16.5) years. The control group includes 57 (48.7%) females and 60 (51.3%) males with mean age (26±5.8) years. Blood samples were collected, sera were separated and stored at -20 0C. The diagnosis of acute HBV infection was based on detection of HBS Ag and anti-HBc IgM and standard liver function tests. Determination of CRP titer was assessed by semi-quantitative tube agglutination test. All data were statistically analyzed.Results: Based on 95% percentile, the baseline CRP titer in healthy individuals was 1:8 (16 mg/l) and for patients 1:512 (1024 mg/l). There was a statistically significant increase in the mean CRP titer in patients with acute HBV infection compared to healthy individuals (P< 0.001). The validy of CRP titer 1:64 as a cut-off value to predict HBV infection provide a sensitivity and specificity 100% and 96% respectively. The positive and negative predictive values were 95% and 100% respectively with an accuracy of 98%. Furthermore, there was a significant correlation between CRP titer and liver function test values.Conclusion: In conjunction with clinical suspicions, CRP titer may be of value for predictive diagnosis of acute hepatitis B infection. Key words: C-reactive protein, Hepatitis B virus.

أهداف الدراسة : تقييم استخدام عياريه بروتين (C ) المنشط في التشخيص التنبؤي لالتهاب الكبد الفيروسي نمط (B ) الحاد.المواد وطرائق العمل: شملت الدراسة 105 من المرضى المصابون بالتهاب الكبد الفيروسي نمط (B ) الحاد و 117 شخصا من الاصحاء ظاهريا كمجموعة سيطرة. تضمنت مجموعة المرضى 37 (35.2%) إناث و 68 ( 64.8%) ذكور وبمعدل عمـر ( 27 ± 16.5) سنة.مجموعة السيطرة تألفت من 57 (48.7%) إناث و 60 (51.3%) ذكور وبمعدل عمر ( 26 ± 5.8) سنة. جمعت نماذج الدم وتم فصل الأمصال وتجزئتها في أنابيب صغيرة (500 مايكروليتر) وحفظت في درجة حرارة – 20 0م. تشخيص حالات التهاب الكبد الفيروسي نمط (B ) الحاد اعتمد على وجود المستضد السطحي (HBsAg ) والضدات النوعية للب الفيروس نوع IgM (Anti-HBc IgM) وأجراء فحوص وظائف الكبد. تحديد عياريه بروتين المنشط اجري بطريقة التلازن شبه الكمية.جميع البيانات حللت إحصائيا.النتائج: اعتمادا على نسبة 95% فان المستوى الأساسي لعيارية بروتين (C ) المنشط بين الاشخاص الاصحاء كان 8:1 (16 ملغرام/لتر) وبين المرضى 512:1 (1023 ملغرام/لتر). أظهرت النتائج أن الوسيط الحسابي لعيارية بروتين (C ) المنشط كان أعلى بشكل معنوي إحصائيا مقارنة بالأشـخاص الاصحاء (P< 0.001 ). إن صلاحية عيارية بروتين (C ) المنشط عند القيمة الفاصلة 64:1 للتنبؤ بالتهاب الكبد الفيروسي نمط (B ) الحاد أعطت حساسية وخصوصية 100% و 96% على التوالي، وان نسبة الصواب كانت 98%. فضلا عن ذلك فقد أظهرت النتائج وجود ترابط معنوي إحصائيا بين عيارية بروتين (C ) المنشط وبين قيم فحوص وظائف الكبد.الاستنتاج: عيارية بروتين (C ) المنشط يمكن أن يكون ذا قيمة في التشخيص التنبؤي لالتهاب الكبد الفيروسي نمط (B ) الحاد عندما يشكل التشخيص ألسريري 50%.الكلمات المفتاحية: بروتين (C ) المنشط، التهاب الكبد الفيروسي نمط (B ).


Article
Effect of typical and atypical antipsychotic drugs on serum C-reactive protein and lipid profile in schizophrenic patients

Author: Faris A Ahmed فارس عبدالموجود احمد
Journal: Iraqi Journal of Pharmacy المجلة العراقية للصيدلة ISSN: 16802594 Year: 2012 Volume: 12 Issue: 1 Pages: 33-40
Publisher: Mosul University جامعة الموصل

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Objectives: To assess the effect of quetiapine and fluphenazine on serum high sensitivity C-reactive protein (hs-CRP) and serum lipid profile in schizophrenic patients.Patients and methods: The subjects comprised two groups of twenty seven newly diagnosed schizophrenic patients for each group. The first group was treated orally with quetiapine at a dose 200-500 mg/day. The second group was treated with fluphenazine intramuscularly at a dose 25 mg every 4 weeks. Twenty seven healthy volunteers were also included as a control group. The patient and the control groups were age and sex matched. The patients were diagnosed by a psychiatrist on the basis of semi-structured interview to determine DMS-IV diagnosis. Clinical symptoms were assessed in 14 of the 18 Brief individual Psychiatry Rating Scale (BPRS) items in order to measure the severity of schizophrenia. Fasting blood samples from the patients were taken for analysis before the beginning of quetiapine or fluphenazine treatment and after 8 weeks of the study. Other blood samples were taken from healthy subjects as a control group.Results: Serum hs-CRP was significantly (p  0.01) higher in the schizophrenic patients before treated by quetiapine or fluphenazine (difference = 382.9% and 395.1% of control, respectively) than controls. The measurement of hs-CRP decreased significantly (p  0.01) after quetiapine treatment by 19.1%, while it was increased significantly (p  0.01) after fluphenazine by 12.3% compared with before treatment values. In the schizophrenic patients, serum total cholesterol (TC) and triglycerides (TG) were significantly higher (p  0.01) than controls, while high density lipoprotein cholesterol (HDL-C) was lower than controls. Quetiapine caused significant increase (p  0.01) in serum TC and TG, while serum HDL-C decreased significantly (p  0.01) compared with the results before treatment. Fluphenazine did not cause any significant change in the lipid parameters. Quetiapine treatment significantly increased (p  0.05) body mass index (BMI), whereas fluphenazine did not change BMI compared with before treatment values. Base time and after 8 weeks of quetiapine or fluphenazine treatment showed significant decrease in the score of BPRS by quetiapine and fluphenazine.Conclusion: Quetiapine depressed CRP and caused dyslipidemia. Fluphenazine raised CRP but it had no effect on lipid profile.

هدف الدراسة: دراسة تأثير عقار quetiapine وعقار flupheazine على مصل البروتين الفعال نوع C ومصل واجهة الدهون في المرضى المصابين بأنفصام الشخصية.المرضى وطرق العمل: شملت الدراسة مجموعتين من المرضى المصابين بأنفصام الشخصية المشخصين حديثا كل مجموعة مكونة من 27 مريضا . عولجت المجموعة الاولى بعقار quetiapine عن طريق الفم وبجرعة تتراوح بين 500-200 ملغم/اليوم . وعولجت المجموعة الثانية بعقار fluphenazine عن طريق الحقن بالعضلة وبجرعة 25 ملغم كل 4 اسابيع. وشملت الدراسة ايضا على 27 من الاصحاء كمجموعة ضابطة. وكانت مجاميع المرضى ومجموعة السيطرة متجانسة من ناحية العمر والجنس. وتم تشخيص المرضى عن طريق طبيب اختصاص في الامراض النفسية على قاعدة المقابلة شبه الهيكلية باعتماد التشخيص DMS-IV. تم قياس الاعراض السريرية باستخدام 14 من 18 من مقياس BPRS لغرض معرفة شدة المرض. وتم سحب عينات دم من المرضى لاجراء التحليل قبل علاج quetiapine او fluphenazine وبعد 8 اسابيع من العلاج. واخذت عينات اخرى من الدم من الاشخاص الاصحاء. النتائج: كان مصل البروتين الفعال عالي الحساسية في المرضى المصابين بالانفصام قبل علاج quetiapine او fluphenazine اعلى معنويا (p  0.01) من مجموعة السيطرة (الفرق= 382 % و 395 % من السيطرة وعلى التوالي) وقل هذا القياس معنويا (p  0.01) بعد عقار Quetiapine ب19% بينما زاد القياس معنويا (p  0.01) بعد عقار fluphenazine ب 12.3 % مقارنة بالنتائج قبل العلاج. وكان مصل الكوستيرول الكلي TC والشحوم الثلاثية TG للمرضى المصابين بالانفصام اعلى معنويا (p  0.01)من السيطرة بينما كان مصل البروتين الدهني عالي الكثافةHDL-C في المرضى اقل معنوي (p  0.01) من السيطرة. وسبب عقار quetiapine زيادة معنوية (p  0.01) في مصل الكولستيرول الكلي والشحوم الثلاثية. بينما انخفض مصل البروتين الدهني عالي الكثافة معنويا مقارنة بالنتائج قبل العلاج. ولم يسبب عقار fluphenazine تغيير معنوي في قياسات الدهون. وزاد عقار quetiapine مؤشر كتلة الجسم معنويا(p  0.05) بينما لم يؤثر عقار fluphenazine على مؤشر كتلة الجسم مقارنة ما قبل العلاج. ووقلل كل من عقار quetiapine و fluphenazine معنويا من مقياس BPRS. الاستنتاج: ثبط عقار quetiapine مصل البروتين الفعال وسبب في تغيير واجهة الدهون. ان عقار flupheaziine رفع مصل البروتين الفعال نوع C بينما لم يؤثر على واجهة الدهون.


Article
Evaluationof Highly Sensitive C-Reactive Protein in Female Patients with Nodal Osteoarthritis

Authors: Ammar W. Obeid --- Munaf S. Daoud --- Mohammed H. Alosami
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 479-484
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Nodal Osteoarthritis is a subset of OA characterized by polyarticularinterphalangeal and thumb base OA ,Heberden’sand Bouchard’s nodes formation.C-reactive protein (CRP) is one of the first acute phase response proteins to be elevated in an inflammatory processes.OBJECTIVE:The aim of this study is to investigate whether the inflammatory processes have roles in the development of nodal osteoarthritis (NOA) in Iraqi femalepatients using serum highly sensitive C-reactive protein as aninflammatory marker.SUBJECTS AND METHODS:The study included eighty four females, divided into two main groups,sixty were patients with (NOA), and twenty-four represented the control group. Other subdivisions were applied according to body mass index and menopause status. Measurement of serum (hsCRP), wasapplied to all subjects included in this study, by ELISA sandwich method.RESULTS:Serum highly sensitive C-reactive protein (hsCRP) level was significantly higher (18.08±8.15) (P value < 0.05) in patients with NOA in comparison to control group (2.23±1.73) .CONCLUSION:Highly significant elevated level of serum (hsCRP) observed in the NOA patients compared to control suggest that the inflammatory processes have roles in the development of NOA.


Article
The association of serum Cancer antigen 125 and C-reactive protein level with the severity of preeclampsia

Authors: Warqaa Mahdi Kamel --- Ban Hadi Hameed --- Dr.Miami Abdul Hassan Ali
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2012 Volume: 5 no 1 Issue: 11 Pages: 1322-1327
Publisher: Kerbala University جامعة كربلاء

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Back ground: It has been assumed that the failure in trophoblastic invasion and the induction of an inflammatory process within placenta in patients with preeclampsia may trigger the expression of Cancer antigen 125. C-reactive protein is a marker of tissue damage and inflammation, increased C-reactive protein may reflect endothelial cell dysfunction in preeclampsia and may be a potential marker of preeclampsia. Objectives: To evaluate the association of serum Cancer antigen 125 and C-reactive protein level with the severity of preeclampsia. .Patients & methods: A case control study was carried out in the department of gynecology and obstetrics at Al-Yarmouk teaching hospital (BaghdadIraq) for one year from April 2010 to March 2011. Hundred singleton pregnant women were divided into fifty patients with preeclampsia and fifty healthy pregnant women as control group. Blood samples were taken for measurement of serum cancer antigen-125 and C-reactive protein for both groups.Results :The mean level of cancer antigen-125 in mild, severe preeclampsia and eclampsia groups was 32.57±8.08(IU/ml), 38.04±9.44(IU/ml) and 47.60±12.09(IU/ml) respectively which was significantly higher in comparison to the control group (sampled at the same time) which was 13.70±8.44(IU/ml) the P value was (0.0001). The mean level of c-reactive protein in mild, severe preeclampsia & eclampsia was 15.80±6.69(mg/L), 30.64±15.66(mg/L) and 42.60±13.70(mg/L) which was significantly higher in comparison to the control group which was 7.92±4.05(mg/L) the P value was( 0.0001).Conclusion:Serum cancer antigen 125 and c-reactive protein were significantly higher in preeclampsia groups in comparison to the control group and the increment was directly correlated with the severity of preeclampsia


Article
Oxidative Stress & C – Reactive Protein In

Author: Imad A. Thanoon*Ph.D د. عماد ذوالنون
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 2 Pages: 227-230
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Back ground: Oxidative damage has been suggested to play a key role in accelerating inflammation and to be involved in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). Many studies had shown that those patients have low antioxidants level and are at risk of increased oxidative stress. Objective: This study was designed to examine the levels of serum Total Antioxidant Status (TAS). Malondialdehyde (MDA) as index of lipid peroxidation and C–Reactive Protein (CRP) as a marker of oxidative stress in patients with RA and OA and compared them with healthy control. Method: Serum TAS , MDA and CRP levels were measured in 16 RA and 24 OA patients and compare with those obtained from 25 healthy controls. Results: Serum TAS were significantly lower in RA group than in the OA and control groups (P < 0.05). Serum MDA and CRP levels were significantly higher in patients with RA than in those with OA and healthy subjects (P< 0.05). There were significant negative correlations between TAS and MDA, CRP levels (r = -0.850; p < 0.001) and ( r = -0.498; P < 0.05) respectively and a positive correlation between MDA and CRP levels in the RA group (r = 0.686; P < 0.01) . In OA group, the level of CRP was significantly increased (P< 0.05) and there was significant positive correlation between age and MDA level (r = 0.553; P < 0.01). Conclusion: Our results demonstrated that levels of lipid peroxidation are increased in patients with RA compared to controls and patients with OA , In addition serum TAS levels were decreased in RA. Serum TAS levels may be used as a routine and rapid test to verify the levels of oxidative stress in RA. Furthermore correlating TAS and MDA levels with a cute phase reactants such as CRP may give some clues about disease activity in RA . Keywords: Oxidative Stress, C – Reactive Protein, arthritis

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