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Article
The effect of toxoplasmosis infection in the concentration of interferon-ɣ and complementary proteins C3,C4 for parasite infected woman Toxoplasma gondii
تأثير الخمج بداء المقوسات في تركيز الانترفيرون كاما والبروتينات المتممة C3,C4 للنساء المخمجات بطفيلي Toxoplasma gondii

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Abstract

The current study deals with measuring the level of interferon-ɣ for 96 sample of infected women with Toxoplasma gondii , whose attended Salah- El-Deen Teaching Hospital in Salah- El-Deen Governorate from 13/10 /2016 to20/4/ 2017. The samples have been divided into 50 infected pregnant women with Toxoplasma gondii and 46 women as a control group which included 23 pregnant women and 23 non – pregnant whose as not infected. The study shows significant difference in the level of interferon ɣ between the infected women group and control group .The level of interferon ɣ in infected women was higher compared with the control group 1.658± 0.977 and 0.765 ± 0.524 pg. / ml, respectively, at the level of probability p< 0.01. concerning on to the measurement of the level of the complementary proteins C3, C4, It was shown the result exist variances moral if were valued in infection women of 0.3708± 0.0107 and 0.3851± 0.0306 mg/dl, respectively, compared to the valued in non-infection women 0.2528± 0.0463 and 0.2142±0.0608 mg/ dl, respectively, at the level of probability p< 0.01.

تناولت الدراسة الحالية قياس مستوى الانترفيرون كاما ل 96 عينة من النساء المخمجات بطفيلي المقوسات الكوندية المراجعات لمستشفى صلاح الدين التعليمي في محافظة صلاح الدين للفترة 2016/10/13 لغاية 2017/4/20 وقد قسمت العينات الى 50عينة من النساء الحوامل المخمجات بطفيلي Toxoplasma gondii و46 عينة كمجموعة سيطرة. اشتملت على 23عينة من النساء الحوامل و23 عينة من النساء غير الحوامل من غير المخمجات ب T.gondii. واظهرت الدراسة وجود فرق معنوي في مستوى الانترفيرون كاما بين النساء المخمجات ومجموعة السيطرة اذ ارتفع مستوى الانترفيرون كاما في النساء المخمجات مقارنة بمجموعة السيطرة 1.658 ± 0.977 و0.765 ± 0.524 بيكوغرام / لتر على التوالي عند مستوى احتمالية 0.01>p. وفيما يتعلق بقياس مستوى بروتينات المتمم C3,C4 فقد اظهرت النتائج وجود فروق معنوية اذ كانت قيمها في النساء المخمجات 3708± 0.0.0107 و 0.0306 ± 0.03851ملغرام / ديسلتر على التوالي مقارنة بقيمها بالنساء غير المخمجات 2528± 0. 0.0463 و0.2142 ± 0.0608 ملغرام / ديسلتر على التوالي عند مستوى احتمالية 0.01>p .

Keywords

Toxoplasmosis --- Toxoplasma gondii --- C3 --- C4 --- proteins C3


Article
Study the Relationship of Toxoplasma IgG Titer with Some Other Immunoglobulin and Complement Components
دراسة علاقة المعيار الحجمي لضد داء المقوسات القندية IgG وبعض الضدات وعوامل المتمم

Author: Ekram Abbas Abood Al-Samarrae اكرام عباس عبود السامرائي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2010 Volume: 23 Issue: 2 Pages: 127-129
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract: Background: Toxoplasmosis is caused by intracellular protozoan parasite; it is difficult to distinguish between the recently acquired infection and the chronic infection because of the frequent presence of Toxoplasma antibodies in the general population.Objective: This study was conducted to estimate the relationship between the Toxoplasma antibodies titers and other immunoglobulin and complement componentsStudy design: Sera from 40 Iraqi blood donors of different ages (18-45 years) during first of February- first of December /2008 in Baghdad city, were screened for Toxoplasma antibodies titers (28 positive and 12 negative). Agglutination method was used according to the kit procedure (Toxo Cell Latex) and single radial immunodiffusion plates were used for estimation of IgM, IgA, C3 & C4.Results: The results showed a significant differences (P<0.01) in the all means of IgM in all titers compared to controls, and the highest titer of IgM (197±21.27 mg/dl) has been shown at a titer of IgG 160 IU/ml. There was no significant differences (P>0.05) shown between IgA titers compared with IgG titers, while there were a high significant differences (P<0.01) of C3 & C4 compared with the IgG titers at level 10, 20&10 IU/ml respectively. Conclusion: The results indicated that there is a relationship between titers of IgG and titers of IgM and complement components (C3 & C4) during the course of Toxoplasma infection especially at the beginning and chronic infection when the level at IgG titers was low.Key wards: Toxoplasmosis, IgG, IgM, C3, C4

الملخص:الخلفية العلمية: داء المقوسات القندية يتسبب عن الاصابة بالاوالي المتطفلة داخل الخلايا وان من الصعب التمييز بين الاصابة الحديثة المكتسبة والاصابة المزمنة بسبب ظهور معايير لأضداد داء المقوسات القندية في الاشخاص بشكل عام.اهداف الدراسة: هدفت هذه الدراسة معرفة العلاقة بين مستويات الاضداد الخاصة بداء المقوسات القندية والاضداد الاخرى وعوامل المتمم.تصميم التجربة: جمعت 40 عينة مصول من اشخاص متبرعين باعمار مختلفة (18-45 سنة) خلال المدة 1- شباط الى 1-كانون الاول/2008 في مدينة بغداد. وتم فحصها لمعرفة وجود الاضداد لداء المقوسات القندية وظهرت 28 عينة موجبة و12 عينة سالبة باستعمال عدة التلازن الخاصة بداء المقوسات القندية وتم فحص اطباق الانتشار المناعي الشعاعي.النتائج: اظهرت النتائج ان هناك فروقات معنوية (P<0.01) لكافة معدلات الضد IgM مفارنة مع الضد IgG وكان اعلى معدل للضد IgM (197±21.27 ملغرام/ديسي لتر) عند مستوى الضد IgG 160 وحدة دولية/مل. ولم تلاحظ فروقات معنوية (P>0.05) ما بين مستويات الضد IgA وIgG، في حين هنالك فروقات معنوية (P<0.01) ما بين مستويات C3 و C4 مقارنة مع مستويات الضد IgG 10، 20 و10 على التوالي.الاستنتاجات: اظهرت النتائج ان هناك علاقة مابين مستويات الضد IgG ومستويات الضد IgM وعوامل المتمم C3 و C4 خلال مدة الاصابة بداء المقوسات القندية وخاصة في بداية الاصابة والاصابة المزمنة التي يكون فيها مستوى الضد IgG واطئة.

Keywords

Toxoplasmosis --- IgG --- IgM --- C3 --- C4


Article
Evidence of Correlation between Some Auto Antibodies with Complement Component in Lupus Nephritis

Author: Nawar Abass Abud Noor
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 1 Pages: 54-57
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:lupus nephritis is a fatal complication of systemic lupus erythematosus (SLE), the serological hallmark of SLE is the presence of circulating autoantibodies directed against a wide variety of nuclear, cytoplasmic and plasma membrane antigens among which are anticardiolipin (ACL),anti-B2glycoprotein and anti-C1q antibodies, together with the consumption of complement component (C3 &C4) by immune complex mediated reaction.AIM OF STUDY:To shed light on the relations among these autoantibodies and with complement component in lupus nephritis patients.METHODS:Tthe study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritia and 25 healthy controls.Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP, anti-C1q, while single radial immundiffusion plates used for the estimation of C3& C4.RESULTS AND CONCLUSION:Anticardiolipin antibodies correlated significantly with anti-B2GP IgG & IgM (P<0.05), anti-C1q antibodies (P


Article
The relevance of serum complement C3 with fasting blood glucose levels in obese type 2 diabetics

Author: Sura Muhsin Abood
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2010 Volume: 13 Issue: 2 Pages: 18-29
Publisher: University of Kufa جامعة الكوفة

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Abstract

AbstractThe aim of the present study was to verify the relevance of complement, C3 & C4 with fasting blood glucose level (FBGL) in type 2 obese diabetics. To achieve this aim, 22 obese diabetic patients (12 females & 10 males) with ages of 45.23±13.83 and body mass index (BMI) of 34.52±2.15 Kg.m‾² were enrolled. To compare the results, 20 healthy individuals (10 females & 10 males) of ages 36.55± 5.36 were also included. Serum C3 and C4 levels were measured in the patients & the control group by a single immune-diffusion method. Fasting blood glucose level was estimated by the glucose-oxidase method. In the diabetic patients, serum C3 level was found to be significantly (P<0.01) elevated when compared with those of healthy individuals whereas C4 didn't show such variation. The linear regression analysis exhibited a significant positive correlation for C3 (r= 0.45, P< 0.05) with FBGL in diabetics but not in healthy subjects. Such correlation was also significant (r=0.60, P< 0.001) with the BMI values. In conclusion, C3 was found to direct the levels of FBGL in type 2 obese diabetic patients.

صممت الدراسة الحالية للتحقق من العلاقة بين البروتينات C3 و C4 مع مستوى السكر الصيام في الدم (FBGL)لدى الذين يعانون من السمنة من مرضى السكري النوع الثاني.لانجاز هذا الغرض تم دراسة 22 من مرضى السكري ذوي البدانة (12اناث و 10ذكور) معدل اعمارهم 45.23±13.83 ومعدل معيار الكتلة الجسمية BMI لديهم .34.52±2.15 Kg.m‾² ولغرض المقارنة بين النتائج تضمنت الدراسة 20 شخصا صحيحاً (10اناث و 10ذكور) معدل اعمارهم36.55± 5.36 .قيست مستويات C3 وC4 بطريقة الانتشار المناعي المنفرد بينما قدر مستوى السكرالصيامي بالدم بطريقة. Glucose-oxidase بينت النتائج زيادة معنوية (P<0.01) في تركيز C3 عند مقارنته مع أمثاله في الأشخاص الأصحاء بينما لم يلاحظ مثل هذا التغيير في مستوى C4. اظهر تحليل الارتباط الخطي علاقات ارتباطيه معنوية بين مستوى ,P<0.05) C3 (r=0.45 مع FBGL في المصابين بالمرض.وكذلك مثل هذه العلاقة كانت واضحة معBMI اذ لوحظت علاقة معنوية موجبة (r=0.60, P<0.001) لمستوى C3مع BMI في مرضى السكري عند مقارنتهم بالأصحاء.تشير هذه النتائج إلى إن C3 يوجه مستوى FBG في مرض السكري النوع الثاني وبالأخص المصابين بالسمنة منهم.

Keywords

C3 --- C4 --- FBGL --- BMI --- Diabetes mellitus --- DM


Article
Detection of Serum Hs CRP and C3 Complement Levels Following Immunization with Measles Containing Vaccine in Iraqi Young Adults

Authors: Ismail Ibrahim Latif --- Salwa S. Abdul –Wahid --- Arwa Mujahid Abdullah --- Zena Jassim Mohammed
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 7 Issue: 1 Pages: 50-56
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Measles remains a major cause of worldwide childhood mortality, and has been targeted by the WHO for global eradication following the eradication of poliomyelitis. Despite the implementation of mass school catch-up campaigns for measles, an outbreak of measles occurred mostly affecting the adult population.Objectives: To measurement of Highly Sensitive C Reactive Protein (Hs CRP) and C3 Complement levels in adult volunteers after vaccination with live attenuated measles containing vaccine, and to compare the results with that following vaccination. Subjects and methods: A sero-surveys for serum Hs CRP and C3 complement levels was conducted among [190] healthy young adults aged 18-25 years, randomly selected, and to compare after a national campaign with measles containing vaccine. Hs CRP and C3 complement were detected in volunteer’s sera prior to, 1, and 4 weeks after vaccination, measured by Enzyme Linked Immunosorbent Assay and Single Radial Immunodiffusion Assay respectively. Results: There was a significant differences (p ≤ 0.05) in the concentration of serum Hs CRP and C3 complement at week one following vaccination with measles containing vaccine, and returned to normal after four weeks. Conclusions: Raising Highly Sensitive C Reactive Protein and Complement C 3 Levels in the sera of adult volunteers after measles containing virus vaccine administration could play a role in increasing innate immune response against measles virus infection and may explain some mechanisms of immune response associated with measles infection.


Article
Determination the Level of Complement Protein C3 and C4 in Gastric UlcersPatients in Baqubah City, Iraq
تحديد مستوى البروتين التميلي C3 و C4 في المرضى الذين يعانون من قرحة المعدة في مدينة بعقوبة ,العراق

Authors: Maha Falh Nazzal د.مها فالح نازل --- Ashwaq MuthannaWhaeeb أشواق مثنى وهيب
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2017 Volume: 13 Issue: 2 Pages: 87-90
Publisher: Diyala University جامعة ديالى

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Background: Gastric ulcer is common and serious diseases caused by imbalances between naturally occurring defensive factors such as mucus, prostaglandins and aggressive factors such as hydrochloric acid, usually found in gastrointestinal juices Objective: To evaluated the level of complement protein C3 and C4 for infected patients with gastric ulcer in Baqubah city, Iraq. Patients and Methods: In this case- control study (57) blood samples were collected from patients with gastric ulcer and (32) blood samples from healthy individuals has been accredited as a control group and the study has continued during the period between October 2016 and April 2017.Results: The results showed that there was a decrease in the level of C3 in patients with gastric ulcers by (25.168 ± 182.173) mg/dl compared to the control group and (501.565 ± 481.418) mg/dl and found that an increase in the level of C4 in patients with gastric ulcer was (34.978 ± 91.252) mg/dl compared to control group and (7.493 ± 17.403) mg/dl in (p value < 0.001). Conclusion: We conclude from this that the complemental protein plays an important role in the localized response to gastric ulcer and gastrointestinal diseases. The presence of neutrophil cells leads to an increase in the production of the C4 complement in patients and that IL-10 has a role in regulating the complemental product in general .

خلفية الدراسة: قرحة المعدة هي من الأمراض الشائعة والخطيرة والتي تحدث نتيجة إختلال التوازن بين العوامل الدفاعية (defensive factors) التي تحدث بشكل طبيعي مثل المخاط ، والبروستاجلاندين ، والعوامل الضارة (aggressive factors) مثل حمض الهيدروكلوريك وأنزيم البيبسين الموجود عادة في العصائر الهضمية. اهداف الدراسة: هدفت هذه الدراسة الى تقييم مستوى بروتينات المتمم C3 و C4 للمرضى المصابين بالقرحة المعدية في مدينة بعقوبة في العراق..المرضى والطرائق : في هذه الحالة، تم جمع (57) عينة دم من المرضى الذين يعانون من قرحة المعدة و (32) عينة دم من أفراد أصحاء تم اعتمادهم كمجموعة سيطرة واستمرت الدراسة خلال الفترة بين أكتوبر 2016 ونيسان 2017.النتائج: وأظهرت النتائج أن هناك انخفاض في مستوى C3 في المرضى الذين يعانون من قرحة المعدة بمعدل (25.168 ± 182.173) مقارنة مع مجموعة السيطرة بمعدل (501.565 ± 481.418) dl/ mgووجد هناك أرتفاع في مستوى C4 لدى المرضى الذين يعانون من قرحة المعدة وكانت بمعدل (34.978 ± 91.252) mg/dl مقارنة مع مجموعة السيطرة وبمعدل (7.493 ± 17.403) mg/dl عند مستوى أحتمالية (P <0.001).الاستنتاجات : نستنتج من هذه الدراسة وجود أنخفاض في مستوى بروتين المتمم الثالث C3وأرتفاع بروتين المتمم الرابع C4بروتين المتمم يلعب دورا هاما في الاستجابة الموضعية لقرحة المعدة وأمراض الجهاز الهضمي, ووجود خلايا العدلات يؤدي إلى زيادة في إنتاج بروتين المتمم الرابعة C4 في المرضى الوسيط الخلوي IL-10 أثره الفعال في تنظيم انتاج المتمم عامةً.


Article
Assessment of Immunopathological Response of Serum Immunoglobulins and Protective Role of Complement Components in Iraqi Patients with Hydatidosis

Author: Ra'ad F. Al-Awadi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 4 Pages: 322-326
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Hydatid disease is a widely distributed disease caused by the larval stage of the Cestode Echinococcus. Inflammation increases the synthesis of immunoglobulins and complement components (C3 and C4) presumably through the action of interleukin 1& gamma interferon.OBJECTIVE:Assessment of immunopathotogical response of scrum immnnoglobulins and complement components fC3 and C4)in Iraqi patients that might be a fleeted as inflammatory response to hydatid disease.SUBJECT AND METHOD:A total number of 50 patients with radiological diagnosis of HD wore studied. Surgical interference had been done to 20 out of 50 patients and the results of surgery gave a clinical confirmation of the diagnosis of HD. Sera from patients with HD and 38 apparently healthy controls were obtained for measurement of immunoglobulins (lgG. IgM and IgA) and complement components (C3 and C4) by Radial Immunodiffuision Assay ( Biomaghreb).RESULTS AND DISCUSSION:Hydatid patients showed increases of IgG (P value < 0.001) IgM and IgA levels (p value <0.05) in comparison to the control group, but these variables start to decrease after surgical treatment that is significant only in case of IgM (P value <0.05). and this might be due to activation of humoral immunity against HD. Complement components were found to be insignificantly lower in patients with HD in comparison to control group (P value > 0.05) and higher in one week postoperative period in comparsion preoperative period (P value > 0.05). This might mean consumption of complement and it's activation or it might be due to anticomplementary action of the hydatid cyst.CONCLUSION:The picture that has emerged from this study is that HC wall might have anticomplementary action. And serum complement component tend to increase in postoperative period.


Article
Evaluation of the Complement (C3) in Patients with Acute Coronary Syndrome

Authors: Basil Najeeb --- Ali Hiad --- Ebtsam A. Saleh --- mnther A Tlair Haider --- et al.
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 40-45
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT: BACKGROUND: To evaluate complement activation (C3) levels in all forms of acute coronary syndrome (ACS) and to find whether there is any significant changes in C3 concentration at the 1st and 4th day after admission and its relation to clinical outcome. OBJECTIVE: Comparing the degree of complement activation (C3 level) between ACS and stable pectoris.To know whether there is any significant difference between the level C3 at first and fourth day. Any correlation between CRP and C3 in patients with ACS. PATIENT AND METHODS: 129 subjects (94 male and 35 female) age range (41-72 years, mean age 57 ± 10.6) were admitted in this study over the period of Feb 2009-Jan 2010 categorized into three groups; 76 patients with acute coronary syndrome (group A), 25 patients with stable angina (group B) and 28 healthy control (group C). Full clinical, biochemical, electrocardiographic and echocardiographic studies liveredone. All patients were followed to the fourth day of admission, Blood samples from peripheral veins were collected centrifuged and Serum C3 levels were measured using immunokit based on single immunodiffusion. RESULTS: The sample of patients was (129) subjects (94 male 72.9%) and (35 female 27.1%). Troponin (I) was positive in 35.7% and negative in 64.3% of the study sample (p. value 0.0005). C-reactive protein (CRP) was significantly correlated with different groups (p. value 0.0004).the same with diabetes mellitus (p. value 0.0003) but not in hypertensive and smokers (p. value 0.486 and 0. 368 respectively).C3levels was significant in correlation to clinical status in both STEMI and NSYEMI 1st and 4th day. Correlation between C3 and C-reactive protein level was insignificant with different groups. CONCLUSION: C3 levels was significantly elevated in correlation between ACS compared to patient with stable angina and healthy control subjects. Also C3 level was significant at the fourth day of admission in patients with NSTEMI in correlation to its level at the first day. However no significance associations between C3 levels and CRP in different studied groups


Article
EVALUATION OF SOME IMMUNE RESPONSE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
تقييم الإستجابة المناعية في مرضى إبيضاض الدم اللمفي المزمن 1: المناعة المتأصلة

Author: محمد عبد الجبار حمودي الدباغ
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2011 Volume: 10 Issue: 1 Pages: 116-125
Publisher: Baghdad University جامعة بغداد

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ABSTRACT Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by the accumulation of mature-appearing lymphocytes in the blood, marrow, and lymphoid tissues. This study aimed to evaluate innate immunity in patients with CLL via estimation of serum levels of Interleukin-1α (IL-1α) and interleukin 8(IL-8), and complement components C3 and C4. Blood samples were collected from 48 patients with CLL (28 treated and 20 untreated). Other 20 blood samples were collected from healthy appearing individuals as control group. Enzyme linked immunosorbent assay (ELISA) was used to estimate serum concentration of IL-1α and IL-8. Single radial immune-diffusion assay was used to estimate the serum levels of C3 and C4. Total white blood cells and absolute lymphocyte count in each blood sample were determined. The study showed a significant decrease in serum concentration of IL-1α and complement components C3 and C4 in treated and untreated patients, whereas, serum concentration of IL-8 and blood absolute lymphocyte count showed significant increase in untreated patients. These data collectively indicated the aberration in innate immunity in CLL patients which can used as a prognosis for the disease.

إبيضاض الدم اللمفي المزمن هو إختلال في عملية تكاثر الخلايا اللمفاوية ويتميز بتجمع خلايا لمفاوية ناضجة ظاهرياً في الدم، نخاع العظم، والانسجة اللمفاوية. هدفت هذه الدراسة الى تقييم مستوى المناعة المتأصلة لدى مرضى إبيضاض الدم اللمفي المزمن من خلال تقدير المستويات المصلية لانترليوكين 1 الفا، انترليوكين 8 ومكوني المتمم الثالث والرابع. جمعت عينات دم من 48 مريضا بإبيضاض الدم اللمفي المزمن (28 معالجون و20 غير معالجين) فضلاًعن 20 عينة من أشخاص أصحاء ظاهرياً مثلوا مجموعة سيطرة. أستعملت تقنية الاليزا لتقدير التراكيز المصلية لانترليوكين1الفا و8 فيما أستعملت تقنية الانتشار المناعي الشعاعي المنفرد لتقدير مستويي المتممين الثالث والرابع. وحسب العدد الكلي لكريات الدم البيضاء والعدد المطلق للخلايا اللمفاوية في كل عينة دم. أظهرت النتائج إنخفاضاً معنوياً في التراكيز المصلية لانترليوكين 1الفا ومكوني المتمم الثالث والرابع في المرضى المعالجين وغير المعالجين فيما أظهرت التراكيز المصلية لانترليوكين8 والعدد المطلق للخلايا اللمفاوية إرتفاعاً معنوياً في المرضى غير المعالجين. تشير هذه النتائج الى مدى التغيرات الحاصلة في المناعة المتأصلة لدى مرضى إبيضاض الدم اللمفي المزمن والتي يمكن إستعمالها في تحديد مآل المرض.

Keywords

: CLL --- IL-1α --- IL-8 --- C3 --- C4 --- Cytokine


Article
Evaluation of serum level of Chromium trace element and complement C3 & C4 in complicated diabetic foot
مستوى الكرم والكومبليت C4, C3 في مضاعفات سكري القدم

Authors: Hameed Mageed Alnaser د. حميد مجيد الناصر --- Estabraq Al-Wasiti
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2007 Volume: 20 Issue: 1 Pages: 77-84
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract Objective: To confirm the importance of Chromium trace element in complicated diabetic foot in addition to complement C3 & C4.Patients & Methods: This study was done in Al-Yarmouk Teaching Hospital “Diabetic Center” and Al-Karama Teaching Hospital throughout a period from November 2002 – July 2003. It included 60 diabetic patients who were divided into two groups, depending on the presence of complications. In addition the study included 20 healthy subjects matched for age and sex as control group. Measurement of F.B.S. was done for each patients. Measurement of serum level of Chromium, by using shimadzu atomic absorption flame emission spectrophotometer and measurement of C3 & C4 complement by using immune diffusion assay kite was also done for each subject.Results: Study reveal that there is lowered Chromium trace element and a lowered level of C3 complement than C4 among complicated diabetic foot more than other groups. Conclusion: We concluded that there is a deficiency of Chromium among a complicated diabetic patient in addition to that this study show deficiency of complement C3 more than C4. Key ward: Diabetes mellitus, chromium trace element, complement C3 and C4.

الملخص:أجريت الدراسة في م. الكرامة التعليمي والمركز الوطني للسكر في م. اليرموك التعليمي للفترة من تشرين الثاني 2002 إلى شهر تموز 2003 حيث تم دراسة عنصر الكروميوم في الدم مع قياس احد الأجزاء المهمة في الجهاز المناعي سي 3 وسي 4 عند المرضى المصابين بالسكر واجريت الدراسة على ثمانون مريض قسموا إلى ثلاثة مجاميع المجموعة الاولى تحتوي على (40) مريض مصابين بالسكر والمجوعة الثانية تحتوي على (20) مريض مصابين بالسكر مع مضاعفاته والتي تشمل التهاب الانسجة الرخوة في القدم مع كانكرين والمجموعة الثالثة تحتوي على 20 شخص غير مصاب وقد تبين ان المرضى المصابين بالسكر مع مضاعفاته هنالك انخفاض في عنصر الكروميوم في الدم بالمقارنة بالمرضى الغير مصابين بالسكر مع انخفاض في احد عناصر الجهاز المناعي سي 3 اكثر من سي 4 وهذا يدل على ان عنصر الكروميوم يعتبر من العناصر المهمة لعمل الأنسولين في الدم.

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