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Article
The Role of Some Inflammatory Markers (IL-6 and CRP)in the Pathogenesis of Acute Coronary Syndrome in IraqiCCU for Heart Diseases

Authors: Amal N. Almarayati --- Mohamed A. Taher محمد عباس طاهر --- Nadia GH. AbdulKarim
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 1 Pages: 43-49
Publisher: Baghdad University جامعة بغداد

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Abstract

In this work an enzyme linked immunosorbent assay (ELISA) technique has been used for detection of some inflammatory markers in serum of acute coronary syndrome (ACS)-Patients Admitted to the cardiac care unit (CCU) o f Iraqi Centre For Heart Diseases and Ibn AlNafees Teaching Hospital. The present method includes quantitative measurement of interleukine-6 (IL-6) and Creactive protein (CRP), as their increase during symptoms may be responsible for identifying the mechanism of myocardial damag, in addition to their best performance than other quantitative tests perhaps due to their association with atherosclerotic process that belongs to the endothelial dysfunction. Aim of this study is to estimate the prevalence and correlation of IL-6 with CRP in ACSpatients presented with unstable angina/ non-ST elevation myocardial infarction (UA/NSTEMI) symptoms to be as new diagnostic parameters in Iraqi CCU. Seventy (70) ACS- patients with mean age(58.55 year ± 9.98), from Jun.2009 to Feb. 2010 with diagnosis of UA/NSTEMI were included in this study. Proper history, physical examination, electrocardiograph (ECG), and Echocardiography (ECHO) were performed for all patients in addition to the routine laboratory works including fasting blood glucose, lipid profile, assay of transaminases activity (Aspartate and Alanine transaminase),and biomarkers analysis as cardiac troponin I and T, creatine kinase (CK and CK-MB) and myoglobin. Blood sample was collected from all patients for quantitative assay of IL-6 and CRP. All patients underwent diagnostic coronary angiography, were 66 of them with abnormal coronary outcome and four patients have normal coronary arteries, study include 39- male and 31 female. Seventeen of 67 patients (25.4%) had elevated serum level of IL-6 and fifty four of 62 patients (87.1%) had elevated serum level of CRP. Statistically found strong and significant (SS) correlation between IL-6 and CRP (assessed by Spearman's rho correlation coefficient, P<0.01). The significant proportion of UA/NSTEMI patients that had elevated serum levels of IL-6 and/or CRP, in addition to the strong correlation with coronary angiographic findings make tbrhese inflammatory markers to be considered as risk stratification factors and good predictors for coronary artery disease independent of other traditional risk factors for cardiovascular disease (CVD).

تم في هذا العمل استعمال اختبار الامتصاص المناعي الإنزيمي للكشف عن بعض المؤشرات الالتهابية في أمصال مرضىمتلازمة الشرايين الإكليلية الحاد الراقدين في وحدات العناية بالقلب. واشتملت الدراسة على الطرق الكمية لقياس الحريك الخلوي6(أوالبين ابيضاضي) وبروتين الطور الحاد (أو بروتين سي الفعال) ٬ حيث إن زيادتهم بالدم أثناء حدوث الأعراض محتمل أن يكونالمسؤول عن التعريف بالية الضرر بعضلة القلب ٬ هذا بالإضافة إلى أدائهم المفضل عن بقية الاختبارات الكمية وذلك لعلاقتهم بتصلبالشرايين الذي يعود الى الاختلال الوظيفي للبطانة. الهدف من الدراسة لتقدير انتشار وارتباط الحريك الخلوي6و بروتين سي الفعالST- في مرضى متلازمة الشرايين الإكليلية الحاد مع أعراض الذبحة الغير مستقرة واحتشاء العضلة القلبية الغير مصحوبة بارتفاعلتكون هذه الاختبارات كأدوات تشخيص جديدة في وحدات العناية بالقلب في العراق. شملت الدراسة سبعون مريضا" segment58.55 ) ابتداء" من حزيران 2009 ولغاية شباط 2010 . تم اخذ التاريخ المرضي وإجراء year ± بالمتلازمة معدل أعمارهم ( 9.98الاختبارات الفيزيائية ٬ تخطيط كهربائية القلب وتخطيط صدى القلب للمرضى. عينات الدم جمعت من كافة المرضى لقياس الحريكالخلوي6و بروتين سي الفعال. جميع المرضى خضعوا للقسطرة الإكليلية التشخيصية التي أظهرت نتائج غير طبيعية للشرايينالاكليلية ل( 66 ) مريض و أربعة مرضى لديهم شرايين إكليلية طبيعية. شملت الدراسة 31 ذكر و 39 أنثى. 17 مريض ( 25.4 %) مناصل 67 لديهم ارتفاع بمستوى الحريك الخلوي6(اعتبر التركيز 25 بيكوغرام/مل كنقطة قطع لارتفاع مستوى الحريك الخلوي6بالدم) و 54 مريض ( 87.1 %) من اصل 62 لديهم زيادة بمستوى بروتين سي الفعال (باعتبار التركيز 3.83 ملغم/لتر كنقطة قطع(P< لزيادة مستوى بروتين سي الفعال بالدم). احصائيا" وجد ارتباط معنوي قوي بين الحريك الخلوي6و بروتين سي الفعال ( 0.01لعموم مرضى المتلازمة وكذلك بين ال 66 مريض ذوي الإصابات الإكليلية. النسبة المعنوية من مرضى الذبحة الغير مستقرة واحتشاءالذين لديهم زيادة بمستويات الحريك الخلوي6و/ او بروتين سي الفعال ST-segment العضلة القلبية الغير مصحوبة بارتفاعوارتباطهم القوي بنتائج القسطرة الإكليلية يجعل هذه المؤشرات الالتهابية كعوامل خطورة وتوقع جيدة لأمراض الشرايين الإكليليةمستقلين عن عوامل الخطورة المتعارف عليها في أمراض القلب الوعائية.

Keywords

ACS. IL-6. CRP.


Article
PREPARATION OF C-REACTIVE PROTEIN LATEX REAGENT OF HUMAN SERUM
تحضير محلول لاتكس لبروتين Cالمنفعل من مصل الإنسان

Authors: سحر عبد الوهاب الشالجي --- ليلى خالد مهدي --- منى صبار
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2006 Volume: 5 Issue: 1 Pages: 112-122
Publisher: Baghdad University جامعة بغداد

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Abstract

ABSTRACTC-reactive protein (CRP) is an acute phase reactant the concentration ofwhich increases significantly following tissue injury or inflammation. It ispresent in the albumin fraction of the serum of patients and is antigenic uponinjection into rabbits. We report here the development of a local latex reagentcoated with rabbit anti-CRP. For this purpose CRP was isolated from pooledsera of patients and injected into rabbits. CRP rabbit antiserum was purified byusing ammonium sulfate precipitation. Followed by passing on ion exchangechromatography (Diethylaminoethyl "DEAE" cellulose). Then, latex particleswere coated with purified antisera. The prepared CRP latex reagentagglutination was observed upon the addition of patients' sera and comparedwith that of normal sera. In addition, it was evaluated against a standard CRPlatex reagent. The prepared reagent gave positive results (100%) with patients'sera and the positive control of the standard kit. While, the negative control ofthe standard kit and 30% of the normal sera gave negative results.

الخلاصةاحد بروتينات الطور الحاد الذي يزداد تركيزه بشكل ملحوظ بعد اصابة C يعد البروتين المنفعلالنسيج والالتهاب. يوجد هذا البروتين في جزء الالبومين من مصل المرضى وذو فعالية مستضدية عندC حقنة في الارنب. تم في هذا البحث تطوير محلول لاتكس محلي مغلف بالاضداد النوعية لبروتينمن خليط امصال مرضى و تم C المنفعل المحضر في الارنب ولهذا الغرض تم عزل البروتين المنفعلالمحضرة في الارنب C حقنة في الارنب, و من ثم تمت تنقية الاضداد النوعية للبروتين المنفعلبعد ذلك تم تغليف محلول الاتكس ,DEAE باستخدام الترسيب بكبريتات الامونيوم ثم بالمبادل اللايونيبالاضداد النوعية النقبة. لوحظ حدوث التلازن مع محلول الاتكس المحضر بعد اضافة مصل المرضى لهبالمقارنة مع المصل الطبيعي. قييست بعد ذلك العدة المحضرة مع محلول لاتكس قياسي, اذ اعطىالمحلول المحضر محليا تفاعلا ايجابيا مع امصال المرضى والسيطرة الايجابية للعدة القياسية بنسبة%100 بينما اعطت تفاعلا سلبيا مع امصال المرضى بنسبة 30 % وكذلك مع السيطرة السالبة للعدةالقياسية.PDF created


Article
Assessment of High Sensitivity C.Reactive Protein

Author: Dr.Faris Abdul Kareem Khazaal M.B.CH.B., CABM ,FRCP Dr.Safaa HassanFadhil M.B.Ch.B,
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 12-17
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: syndrome X or metabolic syndrome is a collection of multiple diseases mainly visceral obesity , hypertriglyceridemia , decrease HDL level, hypertension and elevated fasting blood glucose that lead to accelerated atherosclerosis through multiple mechanisms, one of the most important is increase inflammation of the vessels manifested by elevated high sensitivity C reactive protein (hs-CRP).Objective: The aim of the study was to assess the prevalence of elevatedhs CRP in people with metabolic syndrome and atherosclerosis complication (IHD, Cerebrovascular disease, peripheral vascular disease) and metabolic syndrome without these complication.Patients and methods:;This is a cross sectional study carried out in Diabetic referral center in Baghdad al-rusafa extended from November 2009 to March 2010 for 84 male patients with metabolic syndrome ,aged 40-70 years, clinical features ,anthropometric and biochemical measurement (BP, Waiste circumference, BMI, HDL, LDL, TG, BG, hs CRP) were recorded and metabolic syndrome diagnosis was made according to IDF definitionResults: The 84 patients with metabolic syndrome divided in to two groups the first 35 patients clinically complicated atherosclerotic group were 30 patients high risk 85% and 5 patients low risk 15%. The second 49 patients (clinically uncomplicated atherosclerotic) group were 30 patients high risk 61% and low risk 19 patients 39%, and tabulated with the p.value was (0.014).These results tabulated with the following parameters ,waist circumference (abnormally high p.value was 0.05, normal p.value was 0.49) ,blood pressure (hypertension p.value was 0.05 and normal blood pressure p.value was 0.58),age(middle age p.value was 0.007 and elderly age p.value was 0.29) and BMI(less than 25g/kg p.value was 0.39 and more than or equal to 25 g/kg p.value was 0.08).Conclusion: The values of hs-CRP are high in most patients with metabolic syndrome but are higher in patients with atherosclerotic complications than those without .specially elevated in those with hypertension ,middle age group, increasing waist/hip ratio with significant p.value,and in high BMI but with insignificant p.value.Key words : (HS-CRP metabolic)

Keywords

HS-CRP metabolic


Article
C- Reactive protein and iron status in Iraqi patients with acute myeloid leukemia before and after treatment

Authors: Khitam Abdul Wahab Ali --- Alaa Fadhil Alwan --- Hiba Ammar Mohammed
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 101-118
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Acute Myeloid Leukemia (AML) is a clonal hematopoietic disorder, leading to apremature arrest of the normal differentiation of stem cells. C - reactive protein (CRP) is a markerof inflammation. Serum level of C-reactive protein may be increase in patients with AML. Thisassociation between CRP levels and acute myeloid leukemia influenced by multiple factors.Acute myeloid leukemia commonly associated with iron overload. Many factors are participatingto the hyperferritinemia associated with AML, inflammation chemotherapy, blood transfusionand ferritin hepatic clearance disordersObjectives: To assess serum C-reactive protein (CRP) and iron status (serum Iron, Total ironbinding capacity, serum ferritin levels) in patients with acute myeloid leukemia (AML) beforeand after chemotherapyMaterials and Methods: A prospective cohort study included 58 patients (30 male and 28female) with acute myeloid leukemia with age range (15-65 years). Patients divided into twogroups: Group (1) Patients with AML before starting chemotherapy. Group (2) the patients after 4weeks of chemotherapy In addition to 43 healthy subjects (24 male and 19 female) wereincluded. They were age and sex matched to patients group and considered as controls as(Group 3). This study conducted at the National Center of Hematology and Baghdad TeachingHospital in the Medical City from February 2014 to June 2014. All patients were subjected tocomplete history and physical examination. Diagnosis as AML patients was established bycomplete blood count and blood film, bone morrow aspiration and biopsy. C-reactive proteins.iron, s.total iron binding capacity and s. ferritin were estimated for all .Results: Serum CRP levels increased in AML patients before and after treatment , while therewere a significant increase in mean serum ferritin levels observed in (Group 2) compared tonewly diagnosis patients (Group 1)(P<0.002) and the levels were significantly higher in newlydiagnosis group compared to healthy controls (P<0.015). Patients with (AML) during remissionshow significant decrease in iron levels compared to newly diagnosis group (P<0.0001), whilelevels in healthy controls recorded higher values than both (Group 2) and (Group 1) (P<0.0001).Serum total iron binding capacity (TIBC ) levels showed a significant decrease in (Group 2) aftertreatment compared to (Group 1) before treatment(P<0.0001) but the levels were significantlyhigher in healthy controls compared to (Group 1) and (Group 2) (P<0.0001)Conclusion: CRP does not predict response to chemotherapy while it may be of benefit inpredicting infection or inflammation in patient with AML post chemotherapy. Regarding Ironstatus: s.ferritin increase significantly post chemotherapy while s.iron and TIBC decrease.

Keywords

CRP --- iron status --- AML


Article
Relation of Follicular Fluid C-Reactive Protein Level to Intracytoplasmic Sperm Injection Outcome at Al-Najaf Fertility Centre

Authors: Ban Dhahir Thabbah --- Sami Raheem Al-Katib --- Basima Shamki Al-Ghazali
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 948 -955
Publisher: Babylon University جامعة بابل

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Abstract

C-reactive protein is a protein that act as a sensitive marker in inflammatory processes, rises following hormonal stimulation it may affect fertility and intracytoplasmic sperm injection (ICSI) outcome. this study aimed to measure follicular fluid proinflammatory mediator as C-reactive protein and their relation controlled ovarian hyperstimulation protocols and to interpret these findings according to the cause of subfertility and subfertility treatment outcome. This study was carried out on 110 subfertile women aged between 18-45year (30.01±6.02), referred to fertility clinic in Al-Sadder teaching hospital at AL-Najaf city who classified into four group according to the cause of subfertility, estradiol(E2) also measured on day of HCG and CRP were measured in follicular fluid collected on day of pickup using special ELISA kit then correlate the result to ICSI outcome. The Result of this study reported that the pregnancy rate was 34.55% for embryo transferred after 48-72 hours, there was non-significant increment in pregnant than non-pregnant women regarding FF-CRP (P>0.05), also non-significant difference in FF- CRP in subfertile women according to cause of subfertility(p=0.303), higher FF-CRP value were in ovulatory factor female. Regarding ICSI parameters, there was positive non-significant correlation between FF- CRP and embryo number, Grade I, Grade II, embryo transferred, fertilization rate. so conclusion of this study minimal increment in these inflammatory markers would aid and share in success ICSI outcome.


Article
The Impact of Inflammation on Adiponectin, IL-6 and CRP in Acute Myocardial Infarction Patients

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi.
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: supplement Pages: 616-622
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity. Adiponectin is adipocyte derivate hormone that has important effect as anti-inflammatory factor. Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. IL-6 is one of the most important mediators of fever and of the acute phase response. C-reactive protein (CRP) is a protein found in the blood, the levels of which rise in response to inflammation (an acute-phase protein). Myocardial Infarction (MI) or Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.OBJECTIVE:To investigate the level of adiponectin and its effect on IL-6 and CRP in patients with Acute Myocardial infarction.SUBJECTS AND METHODS:The study included 50 patients with Acute Myocardial infarction and forty healthy subjects as control group. Levels of adiponectin , CRP and IL-6 were measured.RESULTS:The levels of adiponectin, IL-6 and CRP were significantly elevated with (p<0.001), there was negative correlation between adiponectin with CRP and IL-6 in acute myocardial infarction patients.CONCLUSION:The significant increase in adiponectin in AMI may be related to inflammation. Adiponectin inversely correlated with inflammatory marker (CRP and IL-6) so it has anti-inflammatory properties and that make us consider it as cardiovascular protective factor


Article
Study of Some Serological Tests on Patients with Visceral Leishmaniasis
دراسة بعض الاختبارات المصلية على مرضى اللشمانيا الاحشائية

Author: Israa Salim Musa إسراء سالم موسى
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 1C Pages: 645-648
Publisher: Baghdad University جامعة بغداد

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Abstract

This study aimed to measure the alterations in serum zinc (Zn) and acute phase proteins ( C-reactive protein and Ceruloplasmin) concentrations in patients with visceral leishmaniasis (VL). A total of 62 individuals were enrolled in this study : 52 individuals were infected with visceral leishmaniasis and 10 individuals as healthy control. Serum zinc levels were significantly (p<0.05) decreased in patient group(76.25 ± 4.59 µg/dl ) when compared with healthy control (103.75 ± 3.77 µg/dl ) . C-reactive protein , as a mediator of innate immunity, removed damaged cells by activating the classical complement pathway revealed elevated levels in patients (4.36± 0.23mg/l ) when compared with the healthy control (2.50 ± 0.28mg/l ). The level of Ceruloplasmin was also significantly (p<0.05) increased in VL patients (0.82±0.05 mg/dl) as compred with healthy subjects (0.43±0.03mg/dl). These results showed that serum essential trace elements Zn, C-reactive protein and ceruloplasmin concentrations have been changed in VL patients. This may be a part of defense strategies of organism

الهدف من الدراسة الحالية هو قياس التغيرات الحاصلة في تركيز كل من الزنك والسي رياكتف بروتين والسيريلوبلازمين .شملت الدراسة 62 شخص ,52 منهم مصاب باللشمانيا االحشوية و10 أشخاص أصحاء. أظهرت النتائج ان تركيز الزنك في المرضى المصابين 76.25 ± 4.59 µg/dl )) انخفض بصورة معنوية بالمقارنة مع الأشخاص الأصحاء ( 103.75±3.77µg/dl). السي رياكتف بروتين الذي يعمل على إزالة الخلايا المحطمة عن طريق تنشيط المسار الاعتيادي للمتمم أظهرت النتائج ارتفاع معنوي(P<0.05 ) لمستوى هذا البروتين في المرضى المصابين (4.36± 0.23mg/l) بالمقارنة مع الأشخاص الأصحاء (2.50 ± 0.28 mg/l ). أظهرت النتائج أيضا ارتفاع مستوى السريلوبلازمين في الأشخاص المصابين ( mg/dl 0.82±0.05) بالمقارنة مع الأصحاء ( mg/dl 0.43±0.03) عند مستوى معنوية (P<0.05). بصورة عامة وضحت هذة الدراسة حصول تغير في تركيز كل من الزنك و السي رياكتف بروتين والسيريلوبلازمين في المرضى المصابين باللشمانيا وهذا التغير يمكن أن يعتبر كوسيلة دفاعية من قبل الشخص المصاب.


Article
The Value of C- Reactive Protein in Neonatal Sepsis
قيمة البروتين التفاعلي ( CRP ) C في التسمم ألوليدي

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Abstract:Background: Neonatal sepsis occur 1-8 per 1000 live birth. It is mandatory to have a high index of suspicion for the possibility of sepsis since the signs and symptoms are non specific. (C-Reactive Protein) CRP an acute phase protein used as a screening test for inflammation and disease activity and diagnostic adjuvant. Objective: To evaluate the importance of CRP in the diagnosis of neonatal sepsis, sensitivity, specificity and the predictive value of it.Patients &methods: One hundred neonates with suspected sepsis were admitted to the Central Teaching Hospital for Children / Baghdad, between 1st of April and 1st of October 2005, were selected for diagnosis of sepsis by CRP and blood culture. The clinical presentations of these neonates were studied to find the most common signs and symptoms.Results: there were 76% of total cases with positive CRP . 53% of cases had positive blood culture and CRP, and the sensitivity was 96.36%, specificity was 48.8% and the negative predictive value was 91.6% and the positive predictive value was 69.7% Conclusions: CRP show high sensitivity and negative predictivevalue which are helpful in the diagnosis of sepsis. A singlenormal value cant exclude infection and serial measurements will enhance the sensitivity of the test. CRP is not recommended as a sole indicator of neonatal sepsis but may be one of a septic work up.

الملخص:الخلفية: التسمّم ألوليدي يَحْدثُ 8-1 لكلّ 1000 مولود حيِّ. وانه من الضروري أَنْ يَكُونَ هناك نسبة عالية مِنْ الشكِّ لإمكانيةِ التسمّمِ لأن الإشاراتِ والأعراضِ غير محدّدة. البروتين التفاعلي C هو بروتين المرحلة الحادّةِ يستعمل كاختبار فحص لنشاطِ المرضَ والالتهاب وللتشخيصَ. الهدف: لتقييم أهمية البروتين التفاعلي C في تشخيص التسمم ألوليدي وكذلك لتقييم أهمية درجة الحساسية , الخصوصية والقيمة المتوقعة للبروتين التفاعلي C.المرضى والطرق: مئة طفل حديثي الولادة يفترض لديهم تسمم الدم ادخلوا م. الطفل المركزي التعليمي للأطفال / بغداد للفترة بين أولِ مِنْ أبريل/نيسانِ حتى أولِ مِنْ أكتوبر/تشرين الأولِ 2005 , وأكد التشخيص بواسطة البروتين التفاعلي C و زرع الدم. وقد درست العروض السريرية لإيجاد الإشاراتِ والأعراضِ الأكثر شيوعاً. النتائج: من مجموع الحالات %76 لديهم نتائج ايجابية للبروتين التفاعلي C فقط , %53 لديهم نتائج ايجابية لزرع الدم و البروتين التفاعلي C . درجة الحساسية كانت % 96.36 ودرجة الخصوصية كانت % 48.8 أما النتائج السلبية للقيمة المتوقعة فهي % 91.6 والنتائج الايجابية للقيمة المتوقعة % 69.7 .الاستنتاجات: البروتين التفاعلي C اظهر درجة حساسية و قيمة سلبية متوقعة عالية , وهذان مهمان في تشخيص التسمم في حديثي الولادة. قراءة واحدة طبيعية للبروتين التفاعلي C لا تنفي تشخيص المرض , بينما عدد من القراءات قد يزيد من حساسية هذا الاختبار. البروتين التفاعلي C لَيسَ مؤشر وحيد للتسمّمِ ألوليدي لكن قَدْ يَكُون جزء من عمل متكامل .


Article
The Role of White Blood Cells inAcute Coronary Syndrome

Author: Hilal B. Shawki )
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 4 Pages: 362-368
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:
Inflammation has been shown to play a role in atherosclerosis and acute coronary
syndromes. An elevated total WBC count has been associated with increased cardiovascular
risk, but which leukocyte subtypes carry this risk. is uncertain. This study was designed to
determine the effect of WBC count and other inflammatory markers on severity and
outcome of patients with UA/NSTEMI.
Patients and Methods:
Seventy (70) patients with UA / NSTEMI admitted to CCU at the Iraqi Center for Heart
Diseases were subjected to thorough history and physical examination and WBC indices to
find their relation to clinical severity and outcome for both in-hospital and/month after
discharge. The results were compared with other thirty (30) patients with chronic stable
angina and thirty (30) healthy persons as two control groups.
Fac Med Baghdad
2007; Vol.49, No.4
Received Sept. 2006
Accepted Oct .2007
Results:
High total baseline total WBC was more prevalent in patient with UA/NSTEMI than in
those with stable angina and normal persons (94.1%, 5.9%. and 0%) respectively. High
baseline neutrophil was found only in those with UA./NSTEMI (100%, 0%, and 0%). High
baseline Neutrophil/lymphocyte (N/L ratio) and Positive CRP were more prevalent in
patients with UA/NSTEMI than in other two groups (92.3%. 7.7%. 0%) and (98.5%, 1 .5%.
0%) respectively.
Higher total baseline WBC count was significantly found in more severe Braunwald's
class of those with UA/NSTEMI 6.3%. 31.3%. and 50.5% for patients with class I, II, III
respectively. The same was true for baseline high neutrophil count (6.7%. 33.3% to 60%),
high Baseline N/L ratio (7.7%, 15%. and 21.6%).
Patient in the UA/NSTEMI group with higher baseline WBC count had higher risk for
death as compared to those of low and intermediate WBC count (0.00%. 0.00%. and
100.00%). The same was true for those with higher baseline neutrophil count (0.00%.
1.90%, 20.00%) and those with higher baseline N/L ratio (0.00%. 25.000%. 75.000%)
respectively.
Conclusions:
Total baseline WBC and differential count is simple, cheap and widely available
bedside test that predicted the severity of CAD and one month survival.

Keywords

WBC count --- differential count --- CRP --- UA/NSTEMI


Article
The Role Of Tumor Markers In The Diagnosis And Follow UpIn Patients With Pancreatic Cancer

Author: Ansam Aladdin Al-Bayatti
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 4 Pages: 421-424
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: To shade a light on certain tumor markers and their sensitivity and specificity in determination of pancreatic cancer.
Patients & Methods :- A total of 35 patients with pancreatic cancer were studied between June 2003 and April 2004 in Specialized Surgical - Baghdad Teaching Hospital . These patients were compared with other 25 non malignant G.I diseases patients as well as 35 healthy controls . The serum was estimated for CAI 9-9 , and CEA by ELFA (Enzyme Linked Fluorescent Assay) method and CPR by ELISA method.
Results :- Five patients with pancreatic cancer were excluded from this study because they were beyond surgery.The results show that there is significant differences between serum level of CAI 9-9 in pancreatic cancer patients as compared with the non malignant G.I disease patients group and control (P< 0.05). While for the determination of CEA there is also significant difference between the pancreatic patients group as compared with the non malignant G.I patients group and control group (P< 0.05). As for the result of CRP there is also significant difference between the pancreatic patients group and the non malignant G.I patients group and control group (P< 0.05) .
Conclusion :- Significant differences were found in the result of the tumor markers CA 19-9 , CEA , and CRP studied in patients with pancreatic cancer as compared with the other non malignant G.I patients and controls . The sensitivity for using all the mentioned parameters was 90% were as the specificity was 75%

Keywords

Pancreatic tumors --- CA 19-9 --- CEA --- CRP

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