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Article
In vitro, Study of The Effect of Four Plant Aqueous Extracts on The Growth of Some Candida Species recovered from the stool samples of infants

Authors: Intesar.M.Juma --- Ahmed Ali Mhawesh/
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2012 Volume: 2 Issue: 3 Pages: 30-40
Publisher: University of Kufa جامعة الكوفة

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Abstract

A total of (32) stool samples of infants, complaining from diarrhea were included in this study. All of them diagnosed as fungal infections by making a routine and confirmative diagnostic processes, after primary isolation of Candida species, the results reveal that : 12 (37.5%) of isolates were Candida albicans, 11 (34.4%) of isolates were Candida tropicalis and 3 (9.4%) of each isolate of Candida globrata, Candida cruzei and Candida parapsilosis. Five isolates from each one of C. albicans and C. tropicalis were chosen randomly for studying of sensitivity of these isolates to four plant’s aqueous extracts, the extracts which were (Pimpinella anisum leaves, Matrecaria chamomilla flowers, Camellia sinensis leaves and Citrus aurantifolia fruits peels), their Minimal Inhibitory Concentration (MIC) and Minimal Fungicidal Concentration (MFC) were studied by using the dilution method by Sabouraud Dextrose Broth .The results show the MIC of Pimpinella anisum (Leaves) aqueous extracts was (6.25 ) mcg / ml., and the MFC were (12.5) mcg / ml., the MIC of Matrecaria chamomilla (Flowers) aqueous extracts was (12.5) mcg / ml., and the MFC were (25) mcg/ml , While the rest plants aqueous extracts of (Camellia sinensis (Leaves), Citrus aurantifolia (Fruit Peels) ) were results have no or very little antifungal activities in all the isolates, so there were not MIC and MFC for it .A second method was used to test the antifungal activity of the same four plant’s aqueous extracts by the agar well diffusion method, and the results showed that the diameters of inhibition zones were increased when the concentrations of extracts were increased .This method was the best in explanation of results of sensitivity tests. Results demonstrated that the aqueous extracts of P. anisum (Leaves) and M. chamomilla (Flowers) Produced inhibition zone against C. albicans at (25, 50 and100 mcg /ml ) concentrations, While the other aqueous extracts of plant under study reveal a very little or no inhibition zones at (25, 50 and100 mcg /ml ) concentrations. When comparison of the plant aqueous extracts with both standard antifungal drugs of Ketoconazole and Amphotericin B under study, I found that the aqueous extracts of P. anisum (Leaves) and M. chamomilla (Flowers) were more antifungal effective than other aqueous extracts of plants under research at (100 mcg /ml) concentration for both, and detected also that aqueous extracts of M.chamomilla (Flowers) followed by P.anisum (Leaves) were more antifungal effective than other aqueous extracts of plants under research at (25 mcg /ml) concentration for both. In comparison with Amphotericin B, I detected that the aqueous extracts of M. chamomilla (Flowers) was more antifungal effective than other aqueous extracts of plants under research at (50 mcg /ml) concentration for both. And in comparison with ketoconazole, I found that the aqueous extract of M. chamomilla (Flowers) was more antifungal effective than other aqueous extracts of plants under research at (50 mcg /ml) concentration for both.

الخلاصة: شملت هذه الدراسة ( 32 ) عينة خروج جمعت من أطفال رضع يعانون من إسهال , كل العينات شخصت على أنها تحوي إصابات فطرية بواسطة العمليات التشخيصية التأكيدية والروتينيـة , بعد العزل الأولي لأنواع المبيضات أظهرت النتائج أن 12 (37.5%) من العزلات كانت Candida albicans , 11 (34.4%) من العزلات كانت Candida tropicalis و3 (9.4%) لكل من العزلات: Candida globrata, Candida cruzei andCandida parapsilosis. تم اختيار ( 5 ) عزلات عشوائيـــاً مـن كـل من Candida albicansو Candida tropicalis لدراسة حساسية تلك العزلات إلى اربع مستخلصات مائية نباتية وهذه المستخلصات كانت: ( Pimpinella anisum leavesاوراق الينسون), , Matrecaria chamomilla) flowers ازهار البابنج Camellia sinensis leaves) (اوراق الشاي الاخضر) Citrus aurantifolia) fruits peels قشور زهرة النومي بصرة) وتم دراسة التركيز المثبط الأدنى والتركيز القاتل الفطري الأدنى باستخدام طريقة التخفيف في وسط ال (Sabouraud Dextrose Broth) أظهرت النتائج أن التركيز المثبط الأدنى للمستخلص المائي لكل من أوراق الينسون كان (6.25 ) مايكروغرام / مل والتركيز القاتل الفطري الأدنى لهما كان( 12.5) مايكرغرام / مل ., و أن التركيز المثبط الأدنى للمستخلص المائي لكل من زهور البابونج كان )12.5) مايكروغرام / مل والتركيز القاتـل الفطري الأدنى لهما كان (25) مايكروغرام / مل, بينما وجد أن المستخلصات المائية لباقي النباتات وهي( أوراق الشاي الأخضر وقشور زهرة الليمون (النومي بصرة) ) بأنها ليس لها أو لها القليل جداً من التأثير ضد الفطري على جميع العزلات , لذا ليس لها تركيز مثبط أدنى ولا تركيز قاتل فطري أدنــى. استخدمت طريقة ثانية لاختبار الفعالية ضد الفطرية لنفس المستخلصات المائية النباتية الاربع بواسطة طريقة الانتشار عبر الحفر, وأظهرت النتائج أن أقطار مناطق التثبيط تزداد بزيادة تركيز المستخلص وكانت هذه الطريقة هي الأفضل في التعبير عن النتائج في اختبارات الحساسية.أظهرت النتائج أن المستخلصات المائية لكل من( أوراق الينسون وزهور البابونج) أنتجت منطقة تثبيط للمبيضات البيضاء (Candida albicans) في كل من التراكيز التالية ( 25, 50 و 100 مايكرو غرام /مل ), بينما باقي المستخلصات المائية النباتية قيد الدراسة أظهرت بأنه ليس لها أو لها منطقة تثبيط قليلة جدا عند التراكيز التالية ( 25, 50 و 100 مايكرو غرام /مل ).عن مقارنة المستخلصات المائية النباتية مع كلا المضادين الفطريين القياسيين وهي الامفوتريسين ب والكيتوكونازول قيد البحث, وجدنا بان المستخلصات المائية لكل من أوراق الينسون, زهور البابونج لها تأثير ضد فطري أكثر من باقي المستخلصات المائية النباتية قيد الدراسة عند التركيز( 100 ) مايكرو غرام / مل لكلاهما , وكذلك وجـد أن المستخلصات المائية لكل من زهور البابونج وتليها أوراق الينسون لها تأثير ضد فطري أكثر من باقي المستخلصات المائية النباتية قيد الدراسة عند التركيز (25) مايكرو غرام / مل لكلاهما .عند المقارنة مع الامفوتريسين ب اكتشف أن المستخلص المائي لزهور البابونج لهما تأثير ضد فطري أكثر من باقي المستخلصات المائية النباتية قيد الدراسة عند التركيز (50 ) مايكرو غرام / مل .


Article
MEDIUM OPTIMIZATION FOR BIOMASS PRODUCTION AND PROTEIN CONTENT OF CANDIDA UTILES K50
وسط زرعي مثالي لانتاج الكتلة الحيوية وتحسين المحتوى البروتيني لخميرة Candida utitlis K50

Author: Abdul W. Baqir. عبد الواحد باقر
Journal: Bulletin of the Iraq Natural History Museum مجلة متحف التاريخ الطبيعي العراقي ISSN: Print ISSN: 10178678, Online ISSN: 23119799 Year: 1990 Volume: 8 Issue: 3 Pages: 85-93
Publisher: Baghdad University جامعة بغداد

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Abstract

Molasse medium containing different concentrations of (NH4)2 SO4, (NH4)3 PO4, urea, KCI, and P2O5 were compared with the medium used for commercial production of C. utilis in a factory south of Iraq. An efficient medium, which produced 19. 16% dry wt. and 5. 78% protein, was developed. The effect of adding various concentrations of micronutrients (FeSO4, 7T20, MnSO4. 7H20, ZnSO4. 7E20) was also studied. Results showed that FeSo4. 7H20 caused a noticeable increase in both dry wt. and protein content of the yeast.

تمت مقارنة وسط المولاس الحاوي على تراكيز مختلفة من كبريتات الامونيوم، فوسفات الامونيوم، يوريا، كلوريد البوتاسيوم، وخماس اوكسيد الفسفور مع الوسط المستخدم لانتاد خميرة التوريلا في مصنع يقع جنوب العراق.امكن تطوير وسط زرعي ذو كفاءة انتاج عالية وذلك عندما ازداد الوزن 19.16% والمحتوى البروتيني 5.78% عن الوسط المستخدم في المصنع. كما وردس تاثير املاح التغذية الثانوية (املاح الحديد والمنغنيز والخارصين) على كل من الوسط المطور في


Article
Candida Vulvovaginitis in pregnancy

Authors: Sawsan A. Hussien --- Eman E. Yousif
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 2 Pages: 185-187
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Vulvovaginal candiddiasis is an opportunistic mucosal infection caused by Candida albicans that affects large number of otherwise healthy women of child bearing age. Acute episodes often occur during pregnancy.Patients and methods: This study was done on 50 pregnant women with Candida vulvovagnitis who were diagnosed by direct microscopic examination, culture technique, germ tube production, chlamydospore, and Api 20 candida system, at Baghdad Teaching Hospital in the period between October 2008 to February 2009.
Results: The study group included 50 pregnant women with Candida vulvovaginitis . The percentage of pregnant women with Candida albicans infection who their age is higher than 30 years old is 100 %( 23cases), while the percentage is high as 100 % (36cases) in pregnant women whom their gestational age more than 37 week gestation. On the other hand the percentage of pregnant women who have children more than 3 (100%) (12cases). Candida albicans was occurred more frequently when pregnant women suffered from diabetes mellitus 100 %( 14cases). Conclusion: Direct relationship was detected between the percentage of infection and the age of the mother, gestational age, parity, and the presence of diabetes mellitus, the higher the age of the mother, gestational age, parity, and the presence of diabetes mellitus, the higher percentage of infection with Candida albicans during pregnancy.

Keywords

Candida --- vulvovaginitis --- pregnancy.


Article
Glucose Tolerance in Pregnant Women Inflictedwith Candida Albicans

Authors: Fatma Haider K. AL-Mulla فاطمة حيدر الكلا --- Tarik Hovthy A.T. AL-Khayat طارق مفتي الخياط
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2009 Volume: 5 Issue: 1 Pages: 8-10
Publisher: Baghdad University جامعة بغداد

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Background: Many previous studies were concerned with the relationship between gestational diabetes and the development of vaginal candidiasis in pregnant women. In this study, our aim is directed to uncover glucose tolerance status in non-diabetic pregnant women inflicted with candida albicans.Methods: Thirty-four pregnant women with vaginal condidiasis (as demonstrated by microscopy) were enrolled in this study. The patients were nearly similar in their anthropometric and demographic criteria with those of the healthy pregnant women (control group, forty –two women). Fasting plasma sugar and glucose tolerance test were alone for all patients and control group.Results: fasting plasma sugar was significantly higher in the candidiasis-positive pregnant women in comparison to those of candidiasis-negative subjects (5.09 mmol/L vs. 4.71, p <0.02). Plasma glucose level after 30 minutes of performing oral glucose tolerance test was also significant (8.47mmol/Lvs. 7.84, P <0.04). The same trend of significance was noticed after 60 minutes and 120 minutes of performing the corresponding test.The results were (8.13 mmol/L vs. 7.10, P <0.02) and (6.90mmol/L vs. 6.15, P<0.05) respectively.Conclusion: the results reveal an impaired oral glucose tolerance test in pregnant women with candida albicans


Article
Prevalence of Candida Species and Oral Candidiasis during Menstrual Cycle in a Sample of Women in Baghdad City

Authors: Aws Waleed Abbas --- Rafil H. Rasheed --- Jasim M. Karhoot
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 1 Pages: 73-78
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Menstrual cycle define and reflect the women internal endocrine environment. Ovarian hormones, estrogens and progesterone, are not secreted in constant amounts throughout the cycle. Estrogen and progesterone have been shown to inhibit aspects of both innate and acquired immunity at the systemic or local level furthermore they have been shown to influence on maturation and keratinization of oral mucosa. So there may be possible influence of the menstrual cycle on the adherence of Candida to human oral epithelial cells, and may implicate hormonal factors in the aetiology of oral Candidiasis.OBJECTIVE:The purpose of this study was to estimate the prevalence of Candida albicans and other different Candida species in the oral cavity during different periods of menstrual cycle.METHODS:One hundred and seventy six oral swabs were taken from 44 females’ patients attending dental clinic during the period from May to September2007 with age range 14-49 years old at different periods of menstrual cycle on days 5, 13, 22 and 28, which represent menstrual phase, ovulatory phase, mid-luteal phase and premenstrual phase respectively.Swabs were taken from the tongue for isolation of Candida species. The swabs were inoculated on Sabouraud’s glucose agar incubated at 37º for 72 hours; Candida species were identified by gram stain method, germ tube method and fermentation of sugar set.RESULTS:The prevalence of Candida in the oral cavity at 5th, 13th, 22nd and 28th days of menstrual cycle were 31.8%, 22.7%, 40.9% and 25% respectively. The study shows that the prevalence of Candida in the oral cavity was non-significantly higher at 22nd day of menstrual cycle.CONCLUSION:There was no significant influence of menstrual cycle on the prevalence of Candida in the oral cavity during different periods.The prevalence of Candida albicans was higher during different periods of menstrual cycle in comparison to Candida tropicalis and Candida parapsilosis


Article
THE USE OF SOLID AND LIQUID MEDIUM TO STUDY THEEFFECTS OF HEAVY METALS ON THE GROWTH OF CANDIDA ALBICANS
استخدام الوسط الزرعي الصلب والسائللدراسة تاثير العناصرالثقيلة على نمو الخميرة candida albicans

Author: Mohammed H.Khudor , **iMakia M.Al-Hejuje محمد حسن خضر مكية مهلهل خلف فوزية علي عبد الله
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2006 Volume: 5 Issue: 2 Pages: 170-182
Publisher: Basrah University جامعة البصرة

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Abstract

Sabouraud's dextrose (solid and liquid) medium has been used to examine the response ofCandida albicans to Cobalt , Nickel , Silver , Copper and Lead in three doses per each (10 , 25 and50) mg/l in different exposure periods . In the solid medium the number of colonies was noteffected by all metals ions , except Ag ions'(25 and 50) mg/l which completely inhibited thecolonies numbers . In the liquid medium the effect of these metals on the growth was in thefollowing sequence Co , Ni . Ag , Cu and Pb respectively: 'Most elements studied: showed increase in- the ‘inhibition effect on the growth with Aincreasing the ions concentration in the medium , whilethe inhibition effect decreased with theincreasing periods of exposure


Article
Efficacy of Three Denture Cleansers on Candida-Related Denture Stomatitis

Author: Lamia T Rejab
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2013 Volume: 13 Issue: 22 Pages: 235-240
Publisher: Mosul University جامعة الموصل

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Aim: The aim of the study is to evaluate the efficacy of three dentures cleanser on Candida related denture stomatitis through assessing their ability to reduce the number of colony forming unit (CFU) of Candida on palate of the patient for different times. Materials and methods: Group of 12 patients who have denture stomatitis were divided into four groups according to the type of denture cleaners (Protefix, sodium hypochlorite solution 0.02%, saturated sodium chloride salt solution and control wa-ter). The microbiological examination was done to determine the efficacy of the cleansers that used by assessing the number of (CFU) at different times (day before treatment and after 14, 28days of treat-ment). The data were statistically analyzed, (ANOVA) followed by Duncan's multiple Range test to assess the significant difference between the groups at P≤0.05. Results: The results showed that there was a significant effect of three cleansers on reducing number of (CFU) of Candida species in the treatment of denture stomatitis after 14 and 28 days of treatment, but it was not significant for control water group. Sodium hypochlorite showed the highest efficacy. Conclusions: Result showed that there was no significant difference in the efficacy between the three cleansers indicating that all cleansers are effective in the treatment of denture stomatitis .


Article
PCR in Comparison with Culture Methods for The Diagnosis of Candida albicans Responsible for Candidemia in Leukemic Patients
طريقة تفاعل البلمرة المتسلسل في تشخيص تعطن الدم بداء المبيضات البيضاء بالمقارنة مع طريقة الزرع لتشخيص فطر المبيضات البيضاء

Authors: Saba Sabeeh صبا صبيح --- Azhar A. F. Al-Attraqhchi ازهار عبد الفتاح الاطرقجي --- Elham Al-Aswad الهام الاسود
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 5 Issue: 2 Pages: 29-35
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Currently, candidemia infections represent an increasing cause of morbidity and mortality in seriously ill hospitalized patients. Because the accurate diagnosis of candidiasis remains difficult, fast and reliable assay for characterization of fungal pathogens is critical for the early initiation of adequate antifungal therapy and/or for introduction of preventive measures.Objective: To detect candidemia in leukemic patients by molecular methods in comparing with golden standard method(culture method).Materials and methods: A total of 60 leukemic patients were included in this study. Clinical type and other demographic data were recorded. Blood samples were taken from each patient, culture; germ tube formation and carbohydrate fermentation were done for each sample. DNA extraction and polymerase chain reaction (PCR) were used for detection of Candida albicansin cultured bottles. This study was conducted on leukemic patients admitted to four different hospitals in Baghdad city from September 2010 to March 2011. Sixty patients suffering from acute lymphoid (ALL) and myeloid (AML) leukemia were included in this study. The age of patients were ranging between 3-46 years old. Twenty five apparently healthy individuals were enrolled in this study as control group. Three milliliters of blood were collected from each patient; 1.5 ml was inoculated in 20 ml Brain heart infusion broth (Cruikshank. 1975). The rest of blood (1.5ml) was stored in -20ᴼC for further analysis. Blood cultures were incubated at 37°C for 10 days, and examined daily for growth. DNA purification kit was purchased from QIAGENE®Company. This method was used for the purification of genomic DNA from fresh or frozen samples of 1 ml overnight yeast cultures by using the GentraPuregene Yeast/Bact. Kit. PCR was performed to detect Candida albicans species through the amplification of specific gene (αINT1) Results: Only one positive culture result out of 60 samples was obtained for Candida sp., (1.7%). PCR results showed that there were only three out of sixty were positive for C. albicans (5%). In this study we obtained only one positive sample according to culture, while three samples only gave positive results according to PCR method. These results suggest that molecular analysis of candidemia is more sensitive and less time consuming than culture and other conventional methods.Conclusions: From this study, we concluded the following:1.The rate of candidemia was 1.7% among leukemic patients, according to culture results.2.Only 5% of blood cultures was positive according to PCR.3.PCR results showed 100% sensitivity and 96.6% specificity and it is rapid, easy, reliable and also applicable in clinical laboratory for identification of medically important

حالياً الإصاباتَ بداء المبيضات منتشرةوبنسب متزايدةبالاخص للمرضى الراقدين في المستشفيات. ولأن التشخيصَ الدقيقَ لداءفطرالمبيّضاتِ يَبْقىصعبَ ,لذلك يتطلب اجراء فحوصات سريعة وموثوقة لمعرفة الأسباب المرضية الفطريةِ لغرض العلاج المبكر او لغرض الوقاية.لقد تم شمل 60 مريضا بسرطان الدم في هذه الدراسةِ. اخذت عينات دم مِنْ كُلّ مريض، وتم زراعته بوسط Sabourauds agar الفطري،وتم اختبار تشكيل الإنبوبِ الفطري وإختمارِ الكربوهيدراتِ. تم أستخلاص الحامض النووي الرايبي منقوص الاوكسجين وتفاعل البلمرةالمتسلسل (PCR) لفطر المبيضيات البيضاء.أظهرت النتائج بأنّ هنالك عينةِ دمّ وحيدةِ إيجابيةَ للزرع الفطري. وبواسطة عينات اخذت من القناني المزروعة، كان هنالك 3 عيناتَ ايجابية لأستخلاص الحامض النووي الرايبي منقوص الاوكسجين وتفاعل البلمرةالمتسلسل (PCR) لفطرِالمبيّضات البيضاء. وكانت الطريقة الاخيرة(PCR) هي الاكثر حساسية لكشف داء المبيضيات في الدم .نقترح استخدام طريقة البلمرة في تشخيص مرض اللوكيميا او اي مرض داخلي تسسببه هذه الفطريات بدل طريقة الزرع الكلاسيكبة كونها غير دقيقة نتيجة حدوث التلوث بالجراثيم الاخرى عند زرع عينة الدم كما انها تستهلك موادا كثيرة لان كل عينة يجب ان يعاد زرعها يوميا ولمدة شهر كامل الى ان يتم الحصول على النتيجة النهائية.

Keywords

Candidemia --- PCR --- Candida albicans.


Article
Inhibitory effect of Cinnamon cassia against Candida albicans growth in vitro and in vivo

Authors: Bushra J .Mohamed --- Rasha Abdlhussain
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2014 Volume: 22 Issue: 9 Pages: 2370-2361
Publisher: Babylon University جامعة بابل

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The inhibitory effect of Cinnamon cassia against Candida albicans which isolated from cases of sore mouth in vitro and in vivo was studied. The results of determining inhibitory effect of alcohol and aqueous extract of Cinnamon against C.albicans according to well diffusion method showed that Cinnamon extract had the best effect at 50% concentration with inhibition zone reached to (23) millimeter in aqueous extract and (20) millimeter in alcohol extract while the less effect was observe at 10% concentration which reached to (11) millimeter in aqueous extracts and (9) millimeter in alcohol extract. The out come of in vivo study (histological examination ) clarified that C.albicans caused clinical pathological effect in mice tissue organs ( liver , intestine, and kidney) when administrated orally by 1.5x 10 8 cfu/ml C. albicans that effect decrease by orally inoculated with 5 mg/ml of the aqueous Cinnamon extract .The results reflect the ability of cinnamon to reduce certain clinical pathological change in mice organs, with promising encourage to use the Cinnamon as biotherapeutic agents against C.albicanas infections.

تم دراسة التأثير التثبيطي لنبات القرفة للحد من نمو خميرةCandida albicanis و المعزولة من حالات القرح الفموية خارج و داخل الجسم الحي. أوضحت نتائج التأثير التثبيطي للمستخلص المائي والكحولي للقرفة بطريقة الانتشار عبر الحفر أن مستخلص القرفة ذو تأثير تثبيطي عالي يصل إلى23)) مليمتر للمستخلص المائي و(20) ملم للمستخلص الكحولي عند تركيز 50% بينما اقل تأثير تثبيطي كان عند تركيز10% حيث وصل الى (11) مليمتر للمستخلص المائي و(9) مليمتر للمستخلص الكحولي .أما عند إجراء الدراسة داخل الجسم الحي( الفحص النسيجي) بينت النتائج أن خميرةC.albicanis سببت تأثيرات مرضية واضحة في أنسجة الأعضاء ( كبد, أمعاء, كلية ) عندما جرعت الفئران بمقدار 0.1 مل 1.5 ) ×108 خلية حية ( هذا التأثير تناقص عند تجريع الفئران 5 mg/ml من المستخلص المائي للقرفة مما يعكس قابلية القرفة في التقليل من التغيرات المرضية في أنسجة الفئران وهذه النتائج تشجع على استخدامه كعلاجات حيوية للحد من التأثيرات المرضية لخميرة C. albicans.


Article
The effect of inhaled corticosteroid on oral conditions among asthmatic children

Authors: Meen O. Abdul Wadood --- Zainab A.A. Al-Dahan زينب عبد الرضا الدهان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 1 Pages: 169-174
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Inhalation therapy has been employed as the mainstay of the treatment in chronic respiratory diseasessuch as asthma, Patients who taking asthma medication may be at risk of many health problems including oralhealth .The purpose of this study was to assess the local effect of ICS on oral tissue by measuring Candida albicanscount colonies in saliva among12 years old asthmatic children who were collected from AL- Zahra Center Advisoryfor Allergy and Asthma, and compares them with non asthmatic children of the same age and gender.Material and Methods: The total sample involved sixty children of 12 years old, thirty asthmatic children who receivedmedium dose of ICS/day (200-400 microgram/day) for 2 years and 30 non-asthmatic children. The unstimulatedsaliva was collected under standard condition and then analyzed for Candida albicans colony counts assessment.Results: The mean rank of the colony counts were found to be higher among asthmatic than non- asthmatic childrenwith statistically significant difference (P<0.05). Concerning each gender, the results illustrated that the difference forboys was statistically non significant (P>0.05), while for girls the difference was statistically significant (P<0.05).Concerning gender differences, data analysis showed that the mean rank of Colony counts were found to be higheramong girls than boys in both groups with statistically non-significant difference (P>0.05)Conclusions: The findings of the present study showed that the asthmatic disease and ICS treatment play animportant role in elevation of the candida prevalence in oral cavity

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