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Article
Evaluation of the hematological and histopathological effects of Teucrium polium on experimental hyperthyroidism rats

Author: Adaay*1 M.H., jaata 2 , T.A.l., Al-hindawi 2 ,S. H.
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 2 Pages: 273-281
Publisher: University of Kufa جامعة الكوفة

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Abstract

Mature Albino rats of both sexes were given 5mg/kg/day carbimazole orally for 15 days for experimental induction of hyperplasia. The animals divided to four groups, G1 served as a positive control and G2, G3 and G4 treated orally with 50, 100 and 200 mg/kg/day respectively of the aqueous extract of Teucrium polium for 45 days to evaluate its effects on Hb, RBCs, differential leukocytic count and thyroid gland after 15, 30 and 45 days of treatment. The results showed a decrease in Hb and RBCs values during the first two periods and an increase during the last period of the experiment, no significant changes on the differential leukocytic count whereas T4 and T3 revealed a significant increase during the first two periods and a significant decrease during the last period. histopathological preparations of the thyroid gland revealed a remarkable amelioration on the follicular cells in which they were refilled with colloid materials and become look like normal especially in the group treated with 100mg/kg.

عوملت الجرذان البالغة من كلا الجنسين بعقار الكاربمازول 5ملغم/كغم/يوم عن طريق الفم لمدة 15 يوم للتحفيز التجريبي لفرط التنسج . قسمت الحيوانات الى مجموعة سيطرة ايجابية وثلاثة مجاميع عوملت عن طريق الفم بالمستخلص المائي لنبات الجعدة وبجرع 50و 100 و200 ملغم/كغم/يوم لتقييم التاثيرات المحتملة على الهيموغلوبين وكريات الدم الحمراء والحساب التفريقي لكريات الدم البيضاء والغدة الدرقية بعد 15و30 و45 يوم من المعاملة. اظهرت النتائج انخفاض في قيم الهيموغلوبين وتعداد كريات الدم الحمراء خلال الفترتين الاوليتين من التجربة وارتفاع في تلك القيم للفترة الاخيرة من التجربة، لم تظهر تاثيرات تذكر على الحساب التفريقي لكريات الدم البيضاء بينما ارتفعت قيم هورمونات الثايروكسين والثايرونين ثلاثي اليود بشكل ملحوض خلال الفترتين الاوليتين من التجربة وانخفضت تلك القيم خلال الفترة الاخيرة من التجربة. التحضيرات النسيجية للغدة الدرقية اظهرت تحسن ملحوظ للخلايا الحوصلية حيث اعيد امتلائها بالمواد الغروية واصبحت تبدو مشابهة للطبيعية وخاصة في المجموعة المعاملة بجرعة 100ملغم/كغم/يوم.


Article
Oral manifestation biochemical and IgA analysis of saliva in hyperthyroid (Grave’s disease) patients (Comparative study)

Authors: Fawaz D. Al-Aswad فواز الاسود --- Fatma A. Abdulkareem Al-Naif فاطمة عبد الكريم النايف
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 1 Pages: 82-86
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Hyperthyroidism occurs due to over production of thyroid hormones, one types of hyperthyroidism wasGraves, disease. Hyperthyroidism is characterized by high level of serum thyroxin, triiodothyronine and low level ofthyroid stimulated hormones.Material and Methods: fifty two hyperthyroid patients, thirty patients under treatment with carbimazole and othertwenty two patients under treatment with radioactive iodine, and sixty healthy control group. The average salivaryflow rate was calculated as ml/5mint.The concentration of calcium, potassium, and total protein were determined inthe salivary supernatant sample. This is done through different biochemical tests. Determination of salivary IgA isdone by ELIZA.Results: The most prevalence oral manifestation was dry mouth; there were highly significant differences in salivaryflow rate between the two studied groups. There were differences in concentration of total salivary protein andsalivary IgA between the two studied groups although statistically non-significance. However there a significantdifferences in calcium concentration between the two studied groups, also there was a sequential decrease inpotassium concentration between the two studied groups and control group.Conclusions: Those type of patients need dental evaluation especially those who are taking radioactive iodine

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