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Article
Total Laryngectomy outcome of 36 cases after 5 years at Mosul Centre

Authors: Daoud S. Allos داود الوس --- Youis Sultan يونس سلطان --- Nafi M. Shehab نافع محمود شهاب
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2008 Volume: 34 Issue: 1 Pages: 16-20
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To evaluate results of treating laryngeal cancer by total laryngectomy.
Methods: A prospective study of 36 patients with squamous cell carcinoma of the larynx treated with total laryngectomy over five years period.
Results: The age range of the patients was between 34-72 years with a male to female ratio of 11/1. After five years follow up of patients , 100%, 84% & 14% were free of disease for T2, T3 & T4 respectively. Results of treating cases at T3 stage seems to be better when surgery preceded radiotherapy than when radiation given before.
Conclusion: Combination of surgery and radiotherapy gives relatively high cure rates if stage of tumour was still within the larynx ( T3 or less). The results of this study shows that this was better when surgery preceded radiotherapy.

الهدف: تهدف هذه الدراسة لتقييم نتائج علاج ورم الحنجرة الخبيث بعملية استئصال الحنجرة.التصمبم: دراسة لسلسلة من الحالات.الطريقة: ستة وثلاثون مريض بسرطان الحنجرة عولجوا بعملية استئصال الحنجرة خلال فترة خمسة سنوات. النتائج : تراوحت اعمارالمرضى بين 34-72 سنة وكانت نسبة الذكور الى الاناث 11/1. بمتابعة المرضى لمدة خمسة سنوات على الاقل وجد ان 100% و 84% و14% كانوا خالين من المرض للمرحلة T2و T3 T4 بالتسلسل . ووجد ان النتائج كانت افضل نسبيا اذا سبقت العملية العلاج بالاشعاع.الاستنتاج: استخدام الجراحة و العلاج بالاشعاع معا يعطي نسبة شفاء عالية نسبيا اذا عولج المرضى في مراحل غير متقدمة للمرض. وكانت النتائج افضل اذا سبقت الجراحة العلاج بالاشعة.

Keywords

Laryngectomy --- carcinoma


Article
Colorectal Carcinoma Presentation and Management

Authors: Talib A.Majid --- Wasem Muhamed Shakir --- Aqeel Shakir Mahmmod
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 3 Pages: 204-211
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACTBACKGROUND:Colorectal carcinoma is the most common gastrointestinal tract cancer worldwide. In men, it is the third cancer after lung and prostate cancer, while in women; it is the third common cancer after lung and breast cancer. Despite the clear relationship with aging, colorectal carcinoma is not strictly a disease of elderly and 6-8 % of cases occur in patients below 40 years of age. Colorectal cancers are of favorable prognosis provided they are diagnosed and treated in early stage.OBJECTIVE:This study aims to assess the patterns of presentation, distribution, and management of colorectal carcinoma in Gastroenterology and Hepatology Teaching Hospital.METHODS:From November 2005 to November 2007, 80 patients with colorectal carcinoma 50 males and 30 females were admitted to the Gastroenterology and hepatology center. The age, sex, presentation, modes of investigation, stage of the cancer, treatments as well as complications have been described.RESULTS:Male: female ratio about 1.6:1 with peak age of incidence is 60-69 year age group, 17.5% of cases are below age of 40 most of them were with worse histopathological types and advanced stage. The main presenting symptom was bleeding per rectum 63%.The mean period between onset of presenting symptoms and final diagnosis was 7 months .The most common sites were rectum 35% . Fiftythree percent were moderately differentiated ,47.5% were Duke's-C.CONCLUSION:The study highlights the distribution of colorectal carcinoma, presenting symptoms, modalities of treatment, keeping in mind the increasing incidence of colorectal carcinoma in younger age groups.


Article
Immunohistochemical detection of estrogenreceptor ل in endometrial carcinoma

Authors: Wahda MT Al- Nuaimy وحدة محمد طيب النعيمي --- Abeer H. Ahmed عبير أحمد
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2010 Volume: 36 Issue: 1&2 Pages: 130-137
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To evaluate the immunohistochemical expression of estrogen receptor alpha (ERα) in patients with endometrial carcinoma in Mosul city and to correlate it with various clinical and pathological parameters.Methods: Sixty cases of endometrial carcinoma were collected from Al-Batool Teaching Hospital, Al-Khansaa Teaching Hospital, private laboratories during a period extending from January 2007 – to January 2009. The tumors were typed according to the World Health Organization classification system and graded according to FIGO grading system. The expression of ERα was evaluated immunohistochemically; the findings were correlated with the age of the patients, type and grade of the tumor and the extent of myometrial invasion. ERα status was assessed immunohistochemically on formalin fixed paraffin embedded (FFPE) tissue of tumor, using monoclonal mouse antibody (IgG1) clone ID5. A semi-quantitative score was used to record the results of ERα staining according to the system established by Carcangiu et al.Results: The patients age ranged from 31 to 70 years (mean = 56.5). Histopathological typing revealed that 55 cases (91.7%) were endometrioid carcinoma which included [46 cases (83.6%) typical, 5 cases (9.1%) villoglandular, 3 cases (5.5%) adenosquamous and 1 case (1.8%) secretory type] and 5 cases (8.3%) were non-endometrioid carcinoma [2 cases (40%) papillary serous and 3 cases (60%) with clear cell type]. The overall expression of ERα in endometrial carcinoma is 60%, ERα was failed to show a statistically significant correlation with the age (P value = 0.9). A statistically significant association was found between ERα expression and types of endometrial carcinoma (P value = 0.004). In endometrioid carcinoma, the ERα expression was detected in 65.5%, whereas non-endometrioid carcinoma failed to demonstrate positivity (0.0%). There was a significant inverse relation between ERα expression and the grade of the tumor (P value = 0.001). There was a significant inverse relation between ERα expression and the extent of myometrial invasion (P value = 0.004). Conclusions: ER α is expressed in 60% of endometrial carcinoma in Mosul city. ERα is significantly expressed in endometrioid carcinoma, while it is negative in non-endometrioid carcinoma. ERα expression is inversely correlated with the grade of endometriod carcinoma and the extent of myometrial invasion.Keywords: ERα , endometrial carcinoma, endometrioid carcinoma, non-endometrioid carcinoma.

الهــدف: تهدف هذه الدراسة إلى تقيم حالات مستقبلات الاستروجين ألفا لسرطان بطانة الرحم في مدينة الموصل ولإيجاد أي علاقة بينها وبين مختلف الصفات المرضية للورم ومقارنة النتائج مع نتائج دراسات أخرى.الحالات والطرق: لقد تم إجراء دراسة تضمنت ستين حالة سرطان بطانة الرحم ولقد تم تجميع الحالات من مستشفى البتول التعليمي، مستشفى الخنساء ومن بعض المختبرات الخاصة خلال فترة امتدت بين شهري كانون الثاني ٢٠٠۷ وكانون الثاني ٢٠٠٩. ولقد تم تصنيف سرطان بطانة الرحم وفقا لتصنيف منظمة الصحة العالمية ولقد تم تقسيم درجة التمايز الخلوي وفقا لمنظمة الدولية الفدرالية للنسائية والتوليد. تم التحري على مستقبلات الاستروجين ألفا بطريقة الكيمياء النسيجي المناعي باستخدام المضادات أحادية النسل (المضاد أحادي النسل نوع نوع١دي٥) ونظام اظهار نوع المعلم تي ام جي/1 أي دي، فأر(احمر دائم). وتم تحليل النتائج بطريقة شبه كمية، وإيجاد العلاقة مع عمر المريض، نوع النسيج الخلوي للورم، درجة التمايز الخلوي و نسبة الانتشار إلى العضلة الرحمية طبقا للنظام المستخدم من قبل كاركينجو.النتائج: لقد تراوحت أعمار المرضى بين واحد ثلاثين وسبعين سنة وكان المعدل ٥, ٥٦ سنة. حيث وجد فشل في العلاقة بين مستقبلات استر وجين ألفا وبين العمر (٠٫٩= P). لقد وجدت مستقبلات استروجين ألفا في ٦٠% من سرطان بطانة الرحم. ولقد اظهر الفحص النسيجي (نوع النسيج الخلوي للورم) وجود ٥٥ حالة (٩١٫۷ %) سرطان من بطأني الرحم ألغدي، كما وجدت علاقة بين مستقبلات استروجين ألفا وبين نوع النسيج الخلوي للورم (٠٫٠٠٤ p=). تضمنت درجة التمايز الخلوي ٣١ حالة (٤,٥٦ %) من نوع سرطان جيد التمايز الخلوي ١٨ حالة (٣٢٫۷%) من نوع سرطان متوسط التمايز الخلوي و٦ حالات (١٠٫٩%) من نوع سرطان غير متمايز خلويا . حيث وجد علاقة عكسية بين مستقبلات استروجين ألفا وبين درجة التمايز الخلوي (٠٫٠٠١p=). نسبة الانتشار إلى العضلة الرحمية قسمت إلى ثلاث أقسام حسب مستوى الانتشار. حيث ظهرت ٥ حالات عدم وجود انتشار للورم بالعضلية الرحمية و٢٠ حالة وجود انتشار للورم بالعضلية الرحمية اقل أو يساوي (٥٠%) من التثخن الكلي للعضلة الرحمية و٢٠ حالة وجود انتشار للورم بالعضلية الرحمية أكثر من (٥٠%) من التثخن الكلي للعضلة الرحمية. حيث وجد علاقة عكسية بين مستقبلات استر وجين ألفا وبين نسبة الانتشار إلى العضلة الرحمية (٠٫٠٠٤P=). الاستنتاجات:-وجدت نسبة مستقبلات استر وجين ألفا في (٦٠%) من سرطان بطانة الرحم في مدينة الموصل.-وجود علاقة بين مستقبلات استروجين ألفا وبين سرطان بطاني الرحم الغدي بالمقارنة مع الورم اللابطاني لسرطان بطانة الرحم.-وجود علاقة عكسية بين مستقبلات استروجين ألفا وبين كل من درجة التمايز الخلوي ونسبة الانتشار إلى العضلة الرحمية.


Article
Breast tumors in females: A Review Of 500 Malignant Cases.

Author: Lubab F.Talal
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 456-459
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women, with more than 1,000,000 cases occurring worldwide annually.(1) as a matter of fact , the mortality rate for breast carcinoma changed very little from the 1930s to the early 1990s, because of the combined action of earlier diagnosis and improved therapy .
Materials and methods: The prospective study included 500 cases of breast carcinoma who went total mastectomy , between October 2006- April 2007, where taken from private pathology laboratory , sections(4microns) are taken and stained with H&E stain and over-reviewed.
Results: Clinicopathological analysis of the 500 cases of breast carcinoma, including the age, clinical presentation, the site of the tumor, the mammography results, the microscopic morphology, the stage and the grade of the tumor. The age in relation to the morphological classification also analyzed.
Conclusion: The commonest breast carcinoma in women is invasive ductal carcinoma, followed by lobular carcinoma, with mean age 44.5 year, mainly in the left breast, and that mammography approach is so useful in early detection of breast carcinoma.


Article
Evaluation of Staging of Carcinoma of Breast as anIndicator for Presentation of Patients

Authors: Mahdi Jasim Moosa --- Najeeb Sleiwah Jabbo
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2006 Volume: 3 Issue: 1 Pages: 52-55
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The type of treatment of carcinoma
of the breast depends on its stage at presentation. Its
early detection is important.
Objective: Analysis of treated patients for
carcinoma of breast in regards to their stages,
considering it as an indicator for patient's presentation
and discusses the results in this collection.
Methods: A review study of cases treated surgically
for the last 10 years by the authors. Their stages were
recorded in addition to their age, gender and type of
histopathology.
Results: A collection of 110 patients was studied.
Those in the 5th decade were affected more. Females
were 107 and males were only 3. The right breast was
affected more than the left one. Infiltrative ductal
carcinoma was the commonest type of pathology
followed by the lobular carcinoma. Stage 2 was the
commonest stage at time of diagnosis and treatment.
Conclusion: In our collection, more than half of
our patients present during stage 2. This is a late
presentation. Earlier detection is necessary. An
important Program for early detection directed by the
authorities, using the periodic physical examination
and self breast examination and considering the start
of mammography screening program for those with
age range of (40-60). Programs for educating women
in regards to the risk factors and other information
about this disease through the internet should be
considered.
Keywords: Breast carcinoma, stage, presentation.


Article
Invasive lobular carcinoma versus duct carcinoma of the breast

Author: Shoroq M.Abbas Al-Temimi شروق محمد عباس
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2007 Volume: 3 Issue: 4 Pages: 178-184
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Lobular carcinoma of the breast uncommon compared to duct carcinoma .77 specimens with breast carcinoma in the Diwania teaching hospital were examined in the period from feb.2000 to feb.2006.Thirteen out of 77 specimen were proved to be invasive lobular carcinoma of the breast and out of these 13 specimen 5 were from a patients with bilateral disease and two specimen proved to be lobular carcinoma insitu.All the specimen were examined for multifocality and compared with duct carcinoma. Aim of this studyTo confirm that invasive lobular carcinoma present bilaterally and it is multifocal

Keywords

breast --- carcinoma --- lobular


Article
Hepatocellular Carcinoma Presentation & Management , A Prospective Study in the Medical City Baghdad - Iraq

Author: Wissam Jaffar Altaee
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 253-260
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND :The development of HCC is a major global health problem , It's incidence has increased world wide and nowadays it constitute the 5th most frequent cancer representing around 5% of all cancers, and estimated to rank 4th in terms of mortality of cancers incidence world wide , it accounts for 80 –90% of all primary liver tumors . The Etiology of this tumor is multifactorial , certain viral, environmental & hereditary causes of cirrhosis have a strong correlation with HCC . HCC is a highly malignant tumor with poor prognosis .OBJECTIVE:To evaluated the Etiological , Epidemiological , Patho physiological , Diagnostic series , Therapeutic approaches & Advanced studies in detection and prevention of HCC .PATIENTS AND METHODS :Across sectional study of (57) patients with HCC ( 43 males , 14 females ) during the period from January 2000 to December 2002 . The patients were collected from medical & surgical units of Baghdad teaching hospital & the gastroenterology & hepatology teaching hospital .History taken from these patients & physical examination , Lab investigation ,CBP, liver function test ,Virology study , serum AFP. Titer ,U/S study , MRI , CT scan . Ascitic fluid tapping , Liver biopsy.Modalities of treatment : Palliative Treatment, Chemotherapy, Injection of Alcohol , Hemilobectomy ,Segmental resection , Debulking resection of tumor in the liver, Conservative treatment , any complications or hazards during surgical procedures were recorded.RESULTS :Male to female ratio is approximately (3:1), The mean age of (57.1) yr . more common between (51-60) yrs old ( 28.25% ) , Most of the patients were from Baghdad ( 47.4% ) . Increasing no. of patients from 2000 ( 21.1 % ) to 2002 ( 45.6 % ). (84% ) have previous history of chronic liver disease & (16%) haven't such a history . Most of chronic liver diseases are due to previous history of hepatitis B- infection (41.6%) . High level of AFP ( 66.6% ), all of them are of standard type of HCC. Ascitic fluid cytological study bloody (14%) & positive malignant cells (17.2%) . Liver biopsy (82.7%) had chronic liver diseases, and (96.5%) moderate to poorly differentiated type of standard HCC,(3.5%) fibrolamellar type .Outcome of treatment , Conservative (35%), Injection therapy (3.5%) , Chemotherapy (28%), Surgical procedures (16%) , Segmental & Right lobectomy (3.5%) for each , Debulking (9%) .CONCLUSION :AFP and U/S study are very important in the early detection and follow up of the patient with HCC , Liver biopsy - very important study to detect various type of HCC , Surgical resection is the only potentially curative treatment of HCC


Article
TP53 Over expression In Colorectal Carcinoma By Immunohistochemistry

Author: Maather Baqer Hussein. M.B.Ch.B, MSC pathology, Faculty of medicine, Al-Qadysia university
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2012 Volume: 15 Issue: 1 Pages: 25-36
Publisher: University of Kufa جامعة الكوفة

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Abstract

Abstract:-Fifty paraffin blocks of colorectal carcinomas cases included in this study were randomly selected from January 2007 to Juan 2007 from the histopathological department in AL-Sadr Teaching Hospital.Of the fifty paraffin blocks of the studied colorectal carcinomas' cases; 29 cases (58%) were males and 21 cases (42%) were females. Their ages range was (16-80) years with an overall mean age (56.44±13.558) years , (58%) cases in distal colon (26%) cases were rectal , well differentiated carcinoma in (40%) cases , their stages by Dukes they were (36%) Dukes C followed by (30%) Dukes B then (18%) Dukes D and (16%) Dukes A. Fifty cases were submitted for immunohistochemical stain for P53 antibody, 39 cases (78%) were positive , and positive cases classified as weak positive in 18 cases (36%) and strong positive in 21cases (42%) ,also as faint staining pattern in 15 cases (38.4%) and dense staining pattern in 24 cases (61.6%).TP53 expression was more in distal colon cases (82.7%) , higher stages Dukes C (83.3) and D ( 88.8%) and poorly differentiated cancer (94.7%) , With no significant correlation of TP53 expression and site and stage of tumor but with significant relationship with grade of tumor

اهدف الدراسة هو البحث عن التعبير المناعي النسيجي الكيميائي لجين أل P53 كمؤشر للتغيرات الجينية الطارئة في ألخلايا السرطانية لأورام القولون ومقارنته في النسيج الحميد ولمعرفة ترابط هذا التغير مع ثوابت أخرى مثل درجة تمايز الورم، موقع الورم في الأمعاء الغليضه وأخيرا درجة انتشاره. منذ بداية كانون الثاني 2007 وحتى حزيران 2007 تم جمع 50 عينة من مرضى مصابين بسرطان القولون (21أنثى و 29 ذكور) تراوحت أعمارهم بين 16 و80 سنه مع معدل عمر 56,44 سنه ،وقد قورنت هذه المجموعة مع مجموعه أخرى (عشرون حاله) مصابين بأمراض القولون الحميدة. أظهرت الدراسة المناعية النسيجية أن تعبير أل-TP53 كان موجبا في 78% من سرطان القولون, بينما لم يلاحظ أي تعبير لهذا ألجين في النسيج الطبيعي (قيمة ألفا < 0,05). كان تعبير أل-TP53 أكثر في المرضى في القولون البعيد أكثر منه في القولون المستقيم والقولون القريب ، وفي أعلى مراحل الانتشار[Dukes C&D] و في الأورام ذات التمايز الضعيف (الدرجة الثالثة ) عنه في الأورام ذات التمايز القوي والمتوسط (الدرجة الأولى والثانية). مع عدم وجود ترابط بين ألتعبير المناعي النسيجي ل TP53 مع موقعه ودرجة انتشاره (قيمة ألفا > 0.05) كما انه توجد علاقة واضحة لتعبير أل-TP53 مع درجة التمايز (قيمة ألفا < 0.05).


Article
Orphan Annie eye nuclei versus Psamomma bodies as a diagnostic microscopical feature for the papillary carcinoma of the thyroid gland

Author: Dr.Shoroq Mohamed Abbas Al-Temimi
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2008 Volume: 11 Issue: 2 Pages: 239-245
Publisher: University of Kufa جامعة الكوفة

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Abstract

A 450 specimen of thyroid gland were examined histopatholoically in the Labrotaries of the college of Medicine and Diwannia Teaching Hospital for the period from Feb.2004 to Feb.2008 prospectively. All the spicemen were formalin embedded and paraffin fixed and all were sectioned randomly and serially.32 of the spicemen were proved to be papillary carcinoma of the thyroid gland depending on the presence of branching papillae as a general microscopical feature for all and the presence of the Orphan Annie eye nuclei(ground glass optically clear nuclei with heterochromatin all pushed to the edge)in 28 of the cases(87.5%) as the most diagnostic microscopical feature compared to 13(40.6%) specimen showed Psamomma bodies while randomized and serial section examination of the specimen showed 6(18.7%) and 26(81.2%) multifocal growth respectivelly.Only one specimen(3.1%) showed the cytoplasmic invaginatin and nuclear grooves . Aim of the study To confirm the diagnosis of the papillary carcinoma of the thyroid gland depending on the most important microscopical features

تمت دراسة 450 عينة من الغدة الدرقية في مختبرات مستشفى الديوانية التعليمي وكلية الطب للفترة من شباط 2004 الى شباط 2008 وتم تقطيع النماذج عشوئيا وبشكل متسلسل وتبين ان 32 عينة هي للسرطان الحليمي اعتمادا على وجود الجريبات الحليمية بشكل عام وتبين وجود النوى الفارغة التي تسمى نوى عين اورفن اني في 28 عينة وهي 87.5% من العينات بينما توجد جسيمات ساموما في 13 عينة أي 40.6% من العينات مما يدل على ان هذه النوى الفارغة هي من اهم العلامات الدالة على تشخيص الاورام الحليمية للغدة الدرقية


Article
13- IMMUNOHISTOCHEMICAL ANALYSIS OF P53 PROTEIN IN COLORECTAL CARCINOMA AND ITS RELATIONSHIP TO CLINICOPATHOLOGIC FEATURES

Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2011 Volume: 17 Issue: 1 Pages: 85
Publisher: Basrah University جامعة البصرة

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Abstract

Hassanain H Khudier* & Daria Ismail Ameen@*MB,ChB, FIBMS Path., Department of Pathology, College of Medicine, University ofSulaimania. @MB,ChB, Pathology lab., gynecological and obstetric SulaimaniaTeaching Hospital.Correspondence to: Dr. Hassanain H. Khudair, Sulaimania teaching hospital, E-mail: hhk1970@gmail.comAbstractColorectal cancer regarded as one of the most widespread malignant tumor in the world.It is considered the second leading death factor among people in some developedcountries. Colorectal cancer comprises several distinct histological types includingadenocarcinoma which forms 85%-95% of all colorectal cancer cases. Pathogenesis ofcolorectal cancer is a multistep process characterized by involvement of many geneticalterations, including p53.The aim of this study is to detect the expression of p53 protein in colorectal carcinomaand to show its relationship with some clinicopathological features including age,gender, histological types, histological grades and staging.Forty paraffin-embedded tissue blocks of colectomy specimens were used in thisretrospective study. They were collected from the Department of Pathology in SulaimaniaTeaching Hospital, Shorsh Hospital and Shehid Saifeddin Private Clinic from January2007 to July 2008.Two sections of 4 micrometer thickness were taken from each paraffin embedded tissueblock. First section was taken for hematoxylin and eosin stain and the other one forimmunohistochemistry [anti-p53 monoclonal antibody] by using DakoCytomationEnvision + Dual Link System-HRP (DAB+). The relationship between p53 over expressionand the dependent variable (age, gender, histological types, histological grades, andstaging) were evaluated statistically using an analysis of variance (ANOVA) with STATA 8soft ware (College station, Tx). A positive reaction for p53 was scored on a semiquantitativebase as score 0 (no staining), score 1+ (weak staining), score 2+ (moderatestaining), and score 3+ (strong staining).Staining was negative for p53 (score 0) in 16 cases (40%). Positive cases were scored as(1+) in 4 cases (10.0%); (2+) in 8 cases (20.0%); and (3+), in 12 cases (30.0%). There wereno significant relationships between p53 over expression and age (p=0.682), gender(p=0.924), histological types (p=0.30), histological grades (p=0.516), and the stage of thedisease (p=0.281). Conclusions: Considering the p53 protein over expression in arelatively high percentage of patients, it seems that p53 mutation may play an importantrole in the development of colorectal carcinoma. There were no significant relationshipsbetween p53 protein expression and some clinicopathologic variables such as age,gender, histological types, histological grades, and the stage of the disease.

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