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Article
Frequency of HLA Antigens in a Sample of Iraqi Brucellosis Patients
تكرار مستضدات خلايا الدم البيض البشرية لعينة عراقية من مرضى داء البروسيلا

Authors: Ammna N. Jasim آمنة نصيف جاسم --- Aaiad H. A. Al-Rikaby أعياد حميد عاجل الركابي --- Ali H. Ad'hiah علي حسين أدحية
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2012 Volume: 9 Issue: 1 Pages: 86-92
Publisher: Baghdad University جامعة بغداد

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Abstract

Fifty one patients with serologically confirmed brucellosis and 70 healthy controls were phenotyped for HLA-A, -B, -DR and -DQ antigens by using standard microlympho-cytotoxicity method, and lymphocytes defined by their CD markers (CD3, CD4, CD8 and CD19). The results revealed a significant (Pc = 0.001) increased frequency of HLA-DR8 (41.18 vs. 10.0%) in the patients . A significant increased percentage of CD8+ lymphocytes was also increased in the patients (25.15 vs. 22.0%; P = 0.006), while CD3+ lymphocytes were significantly decreased (75.1 vs. 79.4%; P = 0.02).

نمط مظهريا احدى وخمسون مريضا من مرضى داء البروسيلا المشخصين مصليا وسبعين من الأصحاء لمستضدات خلايا الدم البيض البشرية A و B و DR و DQ باستخدام الطريقة القياسيةMicrolymphocytotoxicity test ، وفضلا عن توصيف الخلايا اللمفية في ضوء بعض الواسمات (CD3 و CD4 و CD8 و CD19). أوضحت النتائج زيادة معنوية(الاحتمالية المصححة = 0.001) بتكرار المستضد HLA-DR8 (41.18 مقابل 10.0%) في المرضى. كما ارتفعت في المرضى ايضا وبفرق معنوي النسبة المئوية للخلايا اللمفية الحاملة للواسم CD8 (25.15 مقابل 22.0%؛ الاحتمالية = 0.006)، في حين انخفضت معنويا الخلايا الحاملة للواسم CD3 (75.1 مقابل 79.4%؛ الاحتمالية = 0.02).

Keywords

Brucellosis --- HLA --- CD markers


Article
Abnormal Lymphocyte Subsets in Children with Type 1 Diabetes Mellitus

Authors: Majed Al-Jelawy ماجد الجيلاوي --- Nidhal Abdul Mohymen نضال عبد المهيمن --- Eman M. Saleh
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2008 Volume: 7 Issue: 1 Pages: 9-14
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

This study was designed to investigate the cellular changes of peripheral blood lymphocytes (PBL) in children with type 1 diabetes mellitus (T1DM) by determining the surface antigens (CD markers). Sixty T1DM patients who were newly diagnosed as type1diabetetics (duration of their illness is less than five months) were selected from the National Diabetes Center at Al-Mustansiriya University during the period May 2004 to October 2005. All the patients were treated with daily replacement doses of insulin. Their age ranged from (3-17) years. Fifty apparently healthy control subjects, matched with age (4-17) years and sex underwent the PBL phenotyping. Phenotyping of lymphocyte surface antigens was done by direct Immunoflurocent (IF) technique using mouse antihuman CD3, CD4, CD8, CD19 and CD56.T1DM patients showed a remarkable lowering in CD3+, CD8+, and CD56+ cells but the decrease in CD4+ cells percentage was not significant in patients in comparison to healthy controls. In contrast, a significant elevation of CD19+ cell percentage and CD4+: CD8+ ratio were observed in the patients.

Keywords

T1DM --- CD markers --- Immunophenotyping


Article
Activated Peripheral Blood Lymphocyte Subpopulation in Newly Diagnosed Type 1 Diabetes Mellitus Children

Author: Eman Mahdi Saleh
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 2 Pages: 112-120
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

SUMMARY:BACKGROUND:In Type 1 Diabetes Mellitus (T1DM), numerous changes in the cellular as well humoral immune response have been identified. However, it is not known whether both the CD4+ and CD8+ subpopulation or only one of these or CD19+contains increased numbers of activated cells.OBJECTIVE:The aim was to study the activated lymphocyte subpopulation by use of monoclonal antibodies to T-cell and B-cell antigens which is known to be expressed on activated cells.METHODS:A total of 60 T1DM patients who had newly onset of the disease (diagnosed was from one week up to five months) were included in the present study, all the patients were treated with daily replacement doses of insulin. Fifty apparently healthy control subjects underwent the PBL phenotyping. Phenotyping of surface antigens was done by direct Immunoflurocent (IFT) technique using mouse antihuman CD3, CD4, CD8, CD45RA, CD19, and activated markers CD45RO, DR-antigen and CD38.RESULTS:T1DM patients showed a remarkable lowering in CD3+, CD8+, and CD45RA+ cells (p<0.0001), but the decrease in CD4+ cells percentage was not significant. In contrast, a significant elevation of activation markers includes (CD45RO+, HLA-DR+ and CD38+ cells) were observed in patients in addition to a significant increase of CD19+ cell percentage and CD4+: CD8+ ratio in the patients.CONCLUSION:This study provides evidence that abnormalities of T-cells regulation are detectable in patients with T1DM.

Keywords

T1DM --- CD markers --- immunophenotyping


Article
Lymphocyte subsets phenotype in patients with infectious mononucleosis

Author: Shahlaa M. Salih
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 2 Pages: 227-231
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Infectious mononucleosis (IM) is a lymphoproliferative disease caused primarily by theEpstein-Barr virus (EBV) infection. The initial viral infection by EBV occurs in B lymphocytes and isfollowed by an extensive proliferation of T lymphocytes. Previous studies on immunity to EBV(including IM) have mainly focused on activation of peripheral blood T cells, which are responsible forthe lymphocytosis in blood during acute IM.Patients and Methods: Indirect immunofluorescence technique analysis was performed to detect thepercentage of CD3, CD4, CD8, CD19, and CD56 positive lymphocytes.Results: Our results on the phenotype of T cells in samples from patients with infectious mononucleosisshowed that there is a significant increase in percentage of CD8+ T-cells when compared with healthygroup. In addition, increased in percentage of CD3 T-cells and moderately increase in CD56 (NK) cells.CD4 and CD19 percentage were significantly decrease in comparison with healthy control.Conclusion: Acute infectious mononucleosis is characterized by a marked increase in the percentage ofCD3 and CD8 T- cells with a slight increase in CD56 percentage. A marked decrease in CD19 percentageand CD4/CD8 ratio was noticed.


Article
The effect of Cd substitution in PbS thin film on the optical properties
تأثير استبدال الكادميوم Cd على الخواص البصرية للغشاء الرقيق PbS

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Abstract

Abstract:Thin films of Cd¬x¬Pb¬1-x S were prepared by chemical spray pyrolysis with
( x=0.6 , 0.7 , 0.8 , 0.9 , 1 ) .The optical properties of prepared thin films were studied by UV-VIS spectrophotomer . From the measurement of absorption and transmission , the optical parameters and the optical energy gap (Eg) were calculated .The optical energy gap (Eg) was increased with increasing the value of Cd from 1.2 eV when x=0.6 to 2.4 eV when x=1 . The maximum value of refractive index (n) is equal to 2.5 and the maximum value of extinction coefficient is varied between 0.2 to 0.45 depending on the value of x . The film with x=0.7 was doped by Ag in the ratio 1% ,3% and 5% . The film after dopping have a direct energy gap also and the value of Eg were increased with increasing (Ag) ratio , these values increased from 1.2 eV for absent Ag to 1.74 eV for 5% Ag .

وقد درست الخواص . x = بطريقة الرش الكيميائي الحراري لقيم 0.6,0.7,0.8,0.9,1 CdxPb1-xS تم تحضيراغشية رقيقة منمن قياسات طيف الامتصاصية والنفاذية تم حساب الثوابت البصرية . UV-VIS البصرية للاغشية المحضرة باستخدام مطيافx= 1.2 عندما 0.6 eV من Cd حيث كانت قيمة فجوة الطاقة البصرية تزداد بزيادة نسبة الكادميوم . Eg وفجوة الطاقة البصريةتتغير بين k تساوي 2.5 ، وكذلك فان قيمة معامل الخمود (n) وقد وجد ان اعلى قيمة لمعامل الانكسار . x= الى 2.44 عندما 11,3,5 .وقد وجد ان الغشاء wt% بعنصر الفضة وبنسب x = تم تطعيم الغشاء عند قيمة 0.7 . x 0.2 الى 0.45 معتمدة على قيمة1.2 في حالة غياب الفضة الى 1.74 eV بعد تطعيمه يمتلك فجوة طاقة مباشرة تزداد بزيادة نسبة الفضة هذا القيمة تزداد من. % عندما تكون نسبة الفضة 5 eV


Article
Lymphocytes Subset Phenotypes in Patients with Visceral Leshmaniesis
التنميط المظهري لبعض الخلايا اللمفاوية في المرضى المصابين بالشمانيا الحشوية

Author: Jabbar Resen. Zangor Al-Autabbi د. جبار رسن زنكور العتابي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2011 Volume: 24 Issue: 4 Pages: 308-313
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Visceral leishmaniasis is an endemic protozoan disease in Iraq Recovery from this disease confers a solid and permanent immunity.Objective: Determining the type of lymphocyte phenotype by using; monoclonal antibodies against (CD 4, CD8).Patients and methods: Indirect immunofluorescence technique analysis was performed to detect the percentage of CD4, CD8 and CD4/CD8 ratio positive lymphocytes.Results: Our results showed that the patients groups have decrease in both the percentage of CD4 cells &CD4/CD8 ratio and increase in the percentage of CD8. Follow up of patients after treatment showed a significant increase in the percentage of CD4, CD4/CD8 ratio but they were still lower than their normal range.Conclusion: CD4/CD8 ratio is reversed in VL infection then increase after treatment but it was less than its normal range.Key words: CD-Markers profile, leishmania donovani, amastigote form.

اللشمانيا الحشوية هي مرض وبائي مستوطن في العراق وعند الشفاء منه يحصل المريض على المناعة الدائمة. أظهرت الدراسة المناعية لهؤلاء المرضى بان هنالك نقصان معنوي في نسب الأنماط المظهرية (CD4) وكذلك (CD4/CD8) بينما ظهرت زيادة معنوية في نسبة CD8 مقارنة مع مجموعة السيطرة.المواد وطريقة العمل:استعملت طريقة الومضان غير المباشر (IFAT) وقد لوحظ إن النسبة المئوية لعدد T cell CD8 في مجموعة المرضى المصابين باللشمانيا الحشوية قد اتخذت التفاعل العكسي وأبدت ارتفاعاً معنوياً حاداً عند المقارنة مع المجموعة الضابطة. كما أظهرت فرقاً معنوياً حاداً في هبوط معدل النسب CD4 Tcell و CD4/CD8 .النتائج: أظهرت النتائج إن هناك انخفاضا ملحوظا في النسبة المئوية للمعلومات الخاصة بالخلايا اللمفية المساعدة والنسبة بين الخلايا التائية المساعدة والخلايا السمية لمرضى اللشمانيا الحشوية . كما أظهرت ارتفاعاً بالخلايا اللمفية السمية (P < 0.01) . عند متابعة معلومات هذه الخلايا بعد العلاج نلاحظ إن هناك ارتفاعاً في النسبة بين الخلايا التائية المساعدة والخلايا اللمفاوية السمية مع بقاء هذه النسبة اقل من معدلاتها الطبيعة (P < 0.01). الاستنتاجات: إن نسبة الخلايا اللمفية المساعدة إلى الخلايا اللمفية السمية معكوسة في مرض اللشمانيا الحشوية ولكن هذه النسبة ترتفع بعد العلاج ولكن تبقى اقل من المعدل الطبيعي للنسبة


Article
CD-Markers as an immunological aspect in patients with visceral leishmaniasis

Author: Jabbar R. Zangor Al-Autabbi* VM, PhD د. جبار رسن زنكور
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 4 Pages: 411-415
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Back ground: Visceral leishmaniasis is an endemic protozoan disease in Iraq. Recovery from this disease confers a solid and permanent immunity. Immunological assessment of our patients was carried out and the results showed a significant reduction in the percentage of CD3, CD56 and a significant increase in the percentage of CD19 in the peripheral blood lymphocyte of VL in comparison with control group.Patients and methods: Indirect immunofluorescence technique analysis was performed to detect the percentage of CD3, CD19and CD56 positive lymphocytes.Results: Our results in the patients groups showed decrease in the percentage of CD3, CD56 and increase in the percentage of CD19. Follow up of patients after treatment showed a significant increase in the percentage of CD3, CD56, but they were still lower than their normal range . Conclusion:- CD3,CD56, were decreased in VL infection then increased after treatment but it was less than its normal range, while CD19 was increased in VL when compared with control group.Key words: CD-Markers profile, leishmania donovani, amastigote form


Article
Immunohistochemical Expression of Ki 67 &CD31 in Iraqi patients with Astrocytomas, A clinicopathological Studies

Authors: Zainab Khalid Shehab Almukhtar --- Mohammed Subhi Kamal --- Saba Ali Abd Alkareem
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2019 Volume: 12 Issue: 1 Pages: 4077-4086
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Astrocytomas are the most common primary tumor of the central nervous system, the diagnosis absolutely based on histology has a high interobserver variations and remains problematic even for an experienced neurological pathologist.The objective of this study: To assess the immunohistochemical expression of Ki67 as proliferative markers and CD31 as an endothelial cell marker in astrocytomas interrelated with some clinicopathological parameters (age, gender, site of the tumor, and tumor grade) in Iraqi patients.Materials and methods: In this retrospective study, 41 formaline–fixed paraffin –embedded tissue blocks represent cases of Astrocytomas, The histopathologic diagnosis had been revised and all cases were stained by immunohistochemical technique with Ki 67 & CD 31 antibodies and assessed independently by three pathologists. Values were considered statistically significant when p<0.05.Results: Fibrillary astrocytoma (WHO grade II) was found to be the most common type among astrocytic tumors with the peak age incidence in the second and sixth decades of life, and a slight male predominance had been identified. Parietal location of tumor consider most common site ,There was a significant correlation between the age of the patients and the grade of the tumor on one side & Ki-67 labeling indix, and microvessel density (MVD) detected by CD31 on other side (p<0.05). While no significant correlation with the site and gender. Conclusion: A significant correlation was found between Ki67 labeling indices, and MVD (microvessel density) in one side, and the clinicopathological variables of astrocytomas in other side, Could be used as ancillary methods in the differentiation of borderline grades of astrocytomas.


Article
The effect of a weak axial magnetic field on a He-Cd laser
تأثير حقل مغناطيسي ضعيف محوري على الليزر وهو المضغوط

Author: Gailan Asad Kazem كيلان اسعد
Journal: Journal of Research Diyala humanity مجلة ديالى للبحوث الانسانية ISSN: 1998104x Year: 2009 Issue: 39 Pages: 186-197
Publisher: Diyala University جامعة ديالى

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Abstract

By experimenting on a He-Cd laser in a weak axial magnetic field (WAMF), some new phenomena was observed. the polarization characteristics of the laser beam varied, the main polarization axis of the laser beam rotated and the laser out¬put was modulated with the strength of the WAMF varied. Calculations according to Lamb's theory are in good agreement with experimental results obtained .

تم اختبار خواص ليزر He-Cd في المجال المغناطيسي المحوري الضعيف WAMFوتم ملاحظة بعض الظواهر الجديدة و منها ان خواص الاستقطاب لحزمة الليزر قد تغيرت وان محور الاستقطاب الرئيسي لحزمة الليزر قد تم تدويره وكذلك حدوث تعديل في القدرة الخارجة مع تغير شدة WAMF.الحسابات التي تم الحصول عليها باستخدام نظرية لامب كانت قريبة و متطابقة مع النتائج العملية التي تم الحصول عليها.


Article
Temperature Dependence of AC Conductivity and Complex Dielectric Constant of Cd2Si1-xGexO4 Compound
اعتماد التوصيلية المتناوبة وثابت العزل المركب على درجة الحرارة لمركب Cd2Si1-xGexO4

Author: Salma M. Shaban سلمى مهدي شعبان
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 2B Pages: 1409-1415
Publisher: Baghdad University جامعة بغداد

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Abstract

In this work, samples of Cd2Si1-xGexO4 prepared by powder technology for (x = 0, 0.3, 0.6) were studied. The effect of (Ge) additives at different ratio of Ge (x=0, 0.3, 0.6) on the behavior of dielectric constant, dielectric loss and a,c conductivity were measured as a function of temperature at a selected frequencies (0.01 – 10) MHz in the temperature range 298 K to 473 K. The dielectric constant and dielectric loss obtained different behavior with the additives of (Ge). The activation energy for the electrical conduction process was studied.

في هذا العمل , درست نماذج Cd2Si1-xGexO4 المحضرة بتكنولوجيا المساحيق للنسب (x = 0, 0.3, 0.6) . درس تاثير اضافة Ge لنسب مختلفة من Ge (x = 0, 0.3, 0.6). على ثابت العزل , فقد العازل والتوصيلية المتناوبة كدالة لدرجة الحرارة ولترددات مختارة (0.01 – 10) MHz في مدى درحات الحرارة 298 كلفن الى 473 كلفن. اكتسب ثابت العزل وفقد العازل سلوك مختلف باضافة Ge . تم دراسة طاقة التنشيط لعملية التوصيل الكهربائي.

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