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Article
Oral health status among children re-ceiving chemotherapy

Author: Fayhaa A Al-Mashhadane
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2007 Volume: 7 Issue: 9 Pages: 96-100
Publisher: Mosul University جامعة الموصل

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Abstract

Aim: To investigate the effects of chemotherapeutic agents on the oral health of children and to com-pare the action of two mouth rinses chlorhexidine digluconate 0.2 % and salty water (0.9% NaCl) in relation to their ability in controlling the plaque and gingival inflammation with children treated by cytotoxic agents. Materials and Method: In this clinical trial, the selected children were divided into two groups the first one comprised of 30 healthy children represented as a control group and the second one comprised of 30 children who were receiving chemotherapy for at least 6 months, they were se-lected from patients attended to pediatric wards of public hospitals in Mosul city .All children were of similar age groups and mean age of 5+ 1 years. The plaque and gingival indices were measured accord-ing to silness and lِöe for the six teeth at the baseline. Then the 30 children who were receiving chemo-therapy were randomly divided into two groups; each consisting of 15 children, they were instructed to use mouth rinses twice daily for 30 seconds after breakfast and before the bed time.The plaque and gingival indices were again measured one month after mouth rinsing for the six teeth at the baseline. Results: The results of this study revealed that the chemotherapeutic agents modify oral health and there was significant increase of plaque and gingival indices in children receiving chemotherapeutic agents (at p≤0.05), also results showed that there was a significant reduction after rinsing with chlor-hexidine digluconate for plaque and gingival indices (at p≤0.05), while non significant change for salty water mouth wash. Conclusion: In view of the possible factors that causes increase of the plaque and gingival indices, suggested myelosuppresion that is associated with chemotherapy which has effects on rate and pattern of hard and soft tissues resulting in reduced the ability to repair and maintain the oral health status.


Article
Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis
تأثير علاج اللثة غير الجراحي على مستويات TNF-α في مصل المرضى الذين يعانون من التهاب اللثة المزمن

Authors: Haween T. Nanakaly --- Sazan Sartip Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1167-1174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash).Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjectsat baseline and four weeks after scaling and root planning treatment were quantified fortumor necrosis factor-α levels using ELISA technique.Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed.Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.

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