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Article
Association between periodontitis and acquired coronary heart disease

Author: *Nadia Aftan AL Rawi M.Sc., Ph.D. **Athra M. Al. Waheb M.Sc.
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2016 Volume: 12 Issue: 1 Pages: 10-15
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The association between oral microbial infection and systemic disease is not a new concept. A major confounding issue is that oral infections often are only one of the many important factors that can influence systemic diseases .Objective: This study was conducted to evaluate the periodontal health status of patients with acquired coronary heart disease. Type of the study: Cross-sectional study.Methods: The study group consisted of 200 patients with an age range (35-70) years, having coronary heart disease .This study group were compared to a control group of non-coronary heart disease (200 individuals ) matching with age and gender. The oral parameters were examined including the periodontal conditions, assessment of periodontal loss of attachment as well as the missing teeth according to the World Health Organization criteria (1997)(1) were followed for diagnosis and recording of oral health status.Results: Results of the present study show that the total sample had a highly significantly periodontitis and periodontal loss of attachment with advancing age (P<0.01), while no statistically significant differences were found between males and females with periodontal condition and periodontal loss of attachment among the study group (P>0.05), while there was significant differences among their corresponding controls (P<0.05). High percentage of missing teeth was recorded among the study and control group. Highly statistically significant differences were seen between study and control groups in all the degree of severity related with periodontal conditions (P<0.001).Conclusion: The data showed that 50.5%, 35% of the control group were with periodontal disease and loss of attachment respectively compared with study group 68%, 58.5% . The present study indicate that periodontal disease more common among patients with CHD than among controls matched for age and gender. Thus the possibility that chronic oral infection or similar factor may he positively associated with CHD at least in form patients susceptible to CHD.Although causality cannot be inferred from the present data, the observed association between chronic oral infections and CHD for susceptible patients in the present study can not be excluded.


Article
Hypercholesterolemia as a risk factor for coronary heart disease

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Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of a defect in the gene that is responsible for the production of LDL-C receptor. The current study was designed to determine the FH patients in the city of Sulaymaniyah for both sexes. The study included 213 samples, the number of males was 99 and the number of females was 114, both sexes ranged from (30-79) years.The results of cholesterol, triglyceride, high density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in patients with hypercholesterolemia showed highly significant (P ˂ 0.01) for cholesterol and the concentration level in patients with hypercholesterolemia compared to the level of concentration of healthy.As concerns the effect of hypercholesterolemia on coronary heart disease, the results showed a significant increase (P ˂ 0.01) in cholesterol, triglycerides and LDL-C with a significant decrease in HDL-C concentration in people with heart disease compared with healthy people. triglyceride in patients with compared healthy people. (HDL-C and LDL-C) showed a significant decrease (P ˂ 0.01) in the concentration of HDL-C in patients with hypercholesterolemia compared to their level of concentration in healthy individuals, in relation to low-density lipoprotein (LDL-C) -C is the other (P ˂ 0.01) in.

فرط كولسترول الدم العائلي FH) Familial Hypercholesterolemia) هو إضطراب وراثي وهو تعبير عن خلل في الجين المسؤول عن إنتاج مستقبلReceptor البروتين الدهني منخفض الكثافة ( Low – Density – Lipoprotein (LDL-C . صممت الدراسة الحالية لمرضى فرط كولسترول الدم العائلي (FH) في مدينة السليمانية لكلا الجنسين ، وشملت الدراسة (213) عينة وكان عدد الذكور (99) وعدد الأناث (114) وتراوحت أعمار كلا الجنسين من (30-79) سنة .أشارت نتائج قياس تركيز كل من ( الكولسترول ، الدهون الثلاثية ، البروتينات الدهنية عالية الكثافة HDL-C والبروتينات الدهنية واطئة الكثافة LDL-C ) لدى المرضى المصابين بفرط كولسترول الدم ارتفاعاﹰ عالي المعنوية ملحوظاﹰ (0.01 ˂ P) ﹰللكولسترول والدهون الثلاثية لدى المرضى مقارنةﹰ بالأصحاء ، في حين أظهرت نتائج البروتينات الدهنية ( HDL-C و LDL-C) إنخفاضاﹰ معنوياﹰ كبيراﹰ (0.01 ˂ P) في مستوى تركيز البروتينات الدهنية العالية الكثافة HDL-C لدى مرضى فرط كولسترول الدم مقارنةﹰ بمستوى تركيزه لدى الأصحاء ، أمـﱢــا بالنسبة للبروتين الدهني المنخفض الكثافة LDL-C فهو الأخر عالي المعنويةﹰ (0.01 ˂ P) في مستوى تركيزه لدى مرضى فرط كولسترول الدم مقارنة بمستوى تركيزه للاصحاء . أمــﱢـا عن تأثير العامل المرضي على المصابين بفرط كولسترول الدم وهو مرض القلب التاجي coronary heart disease ، فقد أظهرت النتائج وجود زيادة معنوية (P ˂ 0.01) في الكولسترول والكليسيريدات الثلاثية TG و LDL-C مع أنخفاض ملحوظ لتراكيز HDL-C لدى الأشخاص المصابين بأمراض القلب مقارنةﹰ بالأصحاء .


Article
Sclerotic Aortic Valve and Coronary Heart Disease
تصلب الصمام الابهر وقصور الشرايين ألتاجيه

Author: Abdul-Kareem Al-Shamari د. عبد الكريم الشمري
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2010 Volume: 23 Issue: 4 Pages: 277-281
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Summary:Background: Aortic valve sclerosis, is considered to be a manifestation of coronary atherosclerosis, and is associated with an increased incidence of cardiovascular events.Method: Echocardiographic study of 52 patients with aortic valve sclerosis associated with ECG finding of ischemic heart disease.Result: Ischemic changes were positive in 31(59.6%).Conclusion: Aortic valve sclerosis should be considered a potential marker of coexisting coronary disease.Key words: Aortic valve sclerosis, Coronary heart disease

الملخص:ألمقدمه: يعتبر تصلب الصمام الابهر علامة وإشارة إلى وجود وقصور الشرايين ألتاجيه، وهو يتزامن مع زيادة نسبه الاصابه بأمراض القلب والشرايين.طريقه العمل: تم دراسة 52 مريض بواسطة فحص الأمواج فوق الصوتية للقلب (الايكو) مع علامات قصور الشرايين التاجية في تخطيط القلب الكهربائي.النتائج: تبين وجود نسبه 31 (59.6%) إصابة قصور الشرايين ألتاجيه لدى المرضى المذكورين.الاستنتاج: يجب اعتبار تصلب الصمام الابهر علامة مهمة لتزامنها مع إصابة قصور الشرايين ألتاجيه.


Article
Changes of Liver Enzymes in Coronary Heart Disease

Authors: Salman K. Ajlan --- Yasin A. Baqir
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 1 Issue: 9 Pages: 994-1001
Publisher: Kerbala University جامعة كربلاء

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Abstract

background : Coronary heart disease is one of the leading causes of morbidity and mortality elsewhere in the world . An association between liver enzymes and coronary heart disease is suggested.Objective: To evaluate the changes in liver enzymes, Alanine aminotransferases andaspartate aminotransferases in patients with coronary heart disease.Methods: The study included 60 patients with coronary heart disease (41 males and 19 females), and 40 control subjects (25 males and 15 females) from Basrah, Iraq. Alanine aminotransferase, aspartate aminotransferase, lipid profile and fasting blood glucose levels were determined.Results: alanine aminotransferase , aspartate aminotransferase, fasting blood glucose, totalcholesterol, triglycerides, and low density lipoprotein- cholesterol levels were significantlyhigher among coronary heart disease patients compared to controls (P<0.001), while highdensity lipoprotein- cholesterol level was significantly lower among patients with coronaryheart disease in comparison to controls (P<0.001). Alanine aminotransferases revealed asignificant positive correlation with triglycerides (P=0.006), and significant negativecorrelation with high density lipoprotein- cholesterol (P= 0.031) and no significantcorrelations with body mass index, blood pressure, and other biochemical parameters(P>0.05). On the other hand, aspartate aminotransferases showed significant positivecorrelations with total cholesterol (P=0.009), triglycerides (P=0.025) and low densitylipoprotein- cholesterol (P=0.042), and no significant correlations with other physiologicaland biochemical parameters (P>0.05).Conclusions: A strong association exists between changes in liver enzymes, alanine aminotransferase and aspartate aminotransferase and coronary heart disease. These enzymes could be included within the increasing list of coronary heart disease risk factors. Also, they might have prognostic significance and a predictive value in coronary heart disease complications.Key words: Coronary heart disease, liver enzymes, lipid profile.


Article
Serum ceruloplasmin ,copper and iron levels as a risk factors for coronary heart diseases(CHD)
السيريلوبلازمين والنحاس والحديد كعوامل خطورة لامراض شرايين القلب الأكليلة

Author: Asmaa M. Salih اسماء صالح
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2010 Volume: 7 Issue: عدد خاص بمؤتمر العلمي النسوي 1 Pages: 372-381
Publisher: Baghdad University جامعة بغداد

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Abstract

Ceruloplasmin (Cp) is one of the acute phase protein, in this review ,we studied the level of ceruloplasmin with copper (Cu) and iron in 90 patients with coronary heart diseas ( those patients are divided into three groups, whom are stable angina , unstable angina and myocardial infarction compared with 30 healthy volunteers) and the roles of them as diagnostic and prognostic tools.The diagnosis was attend by a clinical examination carried out by the consult medical staff in Ibn AL-Nafis hospital. The result: ceruloplasmin recorded a significantly(p<0.05)higher level in all patient groups compared with the control, so this result supports the hypothesis that a high serum ceruloplasmin level is a risk factor for coronary heart disease and agrees with immunological theory about tissue damage of myocardial muscle.The same conclusion is reported for serum copper level.

يعد بروتين السيريلوبلازمين احد بروتينات الطور الحاد وفي هذا البحث تمت دراسة مستوى السيريلوبلازمين والنحاس والحديد في مصل المرضى المصابين بامراض شرايين القلب الاكليلية وهي الذبحة الصدرية المستقرة والذبحة الصدرية غير المستقرة واحتشاء العضلة القلبية ودور كل من هذه العوامل كادوات تنبوءية وتشخيصية .شمل البحث تسعين مريضا بامراض شراين القلب الاكليلية وهولاء المرضى تم تقسيمهم الى ثلاثة مجاميع حسب الامراض اعلاه كل مجموعة مكونة من ثلاثين مريضا وتمت مقارنتهم بثلاثين متطوعا من الاصحاء وقام الملاك الطبي الاستشاري في وحدة الطوارئ بمستشفى ابن النفيس بتشخيص الحالات المرضية . اضهرت النتائج ان السيريلوبلازمين سجل ارتفاعا معنويا في مصل دم كل المرضى للمجاميع الثلاثة مقارنة بمجموعة السيطرة والنتيجة هذه توكد فرضية ان المستوى العالي من السيريلوبلازمين يعد كعامل خطورة لامراض شرايين القلب الاكليلية والارتفاع يرافق التغييرات المناعية لتلف نسيج العضلة القلبية وبنفس الوقت رافقه ارتفاع في مستوىالنحاس وبالتالي يمكن استخدام كل منهما كادوات في تشخيص الاصابة المرضية


Article
Postprandial Hyperglycemia as a Significant Risk Factor for Coronary Heart Disease

Author: * Khalid I. Al-Lehibi خالد اللهيبي
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 27-32
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The highest concentrations of blood glucose during the day are usually found postprandialy. Postprandial hyperglycemia (PPH) is likely to promote or aggravate fasting hyperglycemia. Evidence in recent years suggests that PPH may play an important role in functional & structural disturbances in different body organs particularly the cardiovascular system. Objective: To evaluate the effect of (PPH) as a risk factor for coronary Heart disease in Type 2 diabetic patients. Methods: Sixty-three type2 diabetic patients were included in this study. All have controlled fasting blood glucose, with HbA1c correlation. They were all followed for five months period (from May to October 2008). A two hour postprandial glucose (PPG) was done for all. Other risk factors were taken in consideration such as hypertension, obesity, and dyslipidemia. The study was performed on those patients after at least three months of controlled fasting blood glucose. ECG was done to all of them. Results : Out of the 63 type 2 diabetic patients, 20 had normal PPG and HbA1c levels, one of them (5%), has ischemic changes on ECG twenty patients had normal HbA1c & High PPG with 7 (35%) of them showed ischemic changes on ECG 17 patients showed a high PPG and a high HbA1c with four of them showed ischemic changes on ECG P<0.05. The remaining 6 patients had normal PPG but high HbA1c & also only one of them showed ischemic changes on ECG. Conclusion This study showed that PPH is a significant risk factor for ischemic heart disease (IHD).


Article
Serum alpha-1-antitrypsin level in Iraqi patients with coronary heart disease
مستوى بروتين الفا-1-مضاد التربسين في مصل الدم عند مرضى عراقيين مصابين بامراض شرايين القلب الاكليلية

Author: Asmaa M. Salih أسماء محمد صالح
Journal: Jornal of Biotechnology Research Center مجلة مركز بحوث التقنيات الاحيائية ISSN: 18151140 Year: 2011 Volume: 5 Issue: 1 Pages: 53-60
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This study was designed to estimate the level of serum alpha -1- antitrypsin in patients with coronary heart disease. Patients were clinically subdivided into stable angina 25 patients, unstable angina30 patients and myocardial infarction 50 patients. A control sample of 30 individuals was matched with patient for age and sex.Non-significant elevation of serum alpha one antitrypsin were noted in MI cases compared to healthy control individuals, even some MI patients showed decreasing level of alpha one antitrypsin, which may return to hereditary alpha one antitrypsin deficiency in Iraqi patients.The Stable angina patients group showed non-significant decrease in alpha one antitrypsin level compared to healthy control, while unstable angina patients group showed significant decrease in alpha one antitrypsin level that will may facilitate developing disease towards MI. All present results need additional studies to be carried out on larger samples of Iraqi individuals and alpha one antitrypsin deficient patients, furthermore, highlighting on the relationship between alpha one antitrypsin and risk of coronary heart disease.

اجري في البحث الحالي دراسة مستوى بروتين الفا -1-مضاد التربسين في مصل الدم لثلاثة مجاميع من مرضى شرايين القلب الاكليلية وشملت 25 مريضا مصابا بالذبحة الصدرية المستقرة و30 بالذبحة الصدرية غير المستقرة و50 مريضا باحتشاء العضلة القلبية مقارنة بثلاثين فردا من الأصحاء , وقد سجل بروتين الفا-1-مضاد التربسين ارتفاعا غير معنويا في مرضى احتشاء العضلة , ورغم إن بعض مرضى احتشاء العضلة القلبية سجلوا انخفاضا بمستوى البروتين وقد يعزى الى النقص الوراثي له عند هولاء المرضى . المجموعتين الأخريين من المرضى سجلوا انخفاضا غير معنويا لمرضى الذبحة المستقرة ومعنويا للذبحة غير المستقرة في مستوى البروتين. الامر الذي قد يودي الى تفاقم الحلة المرضية وتطورها باتجاه احتشاء العضلة القلبية. نوصي بضرورة إجراء دراسات مستفيضة تشمل عينات اكبر لإلقاء الضوء على حالات النقص الوراثي لبروتين الفا مضاد التربسين عند الإفراد العراقيين، وتوضيح العلاقة بين التركيب الوراثي للبروتين وعلاقته كعامل خطورة بمرض شرايين القلب الإكليليه .


Article
Atherogenic index of plasma (AIP) as a parameter in predicting cardiovascular risk in males compared to the conventional dyslipidemic indices (cholesterol ratios)

Author: Mudhaffar Sami Khazaál
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 1 Pages: 1506-1513
Publisher: Kerbala University جامعة كربلاء

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Abstract

Abstractackground: Several indices had been derived from lipid profiles to establish an index for predicting the risk of having coronary event. The atherogenic index of plasma, is a strongly emerging index that is now fulfilling the criteria to be used as a standalone index for cardiac risk stratification.Objectives: To find out whether the atherogenic index of plasma, was superior to the conventional daily used atherogenic indices in predicting cardiac risk. Subjects and methods: A case-control study in which 119 males with an age range of (43-68) years and with acute myocardial infarction together with 97, apparently healthy males of matched age were enrolled. For each participant, a fasting lipid profile done and the following atherogenic indices were calculated: (total cholesterol / high-density lipoproteins), (high-density lipoproteins / low-density lipoproteins), (low-density lipoproteins / high-density lipoproteins), and the (atherogenic index of plasma). The indices were compared in both groups and then in the patients group to figure out which index has yielded the highest sensitivity in predicting the risk of having coronary artery disease.Results:„X All of the atherogenic indices were found to be significantly different upon comparing these indices in both patients and control groups. Where the P value was (0.0001) for (TC/HDL), (HDL/LDL), and (AIP); and it was (0.0026) for (LDL/HDL).„X AIP was found to have the highest sensitivity for predicting atherogenicity among the other atherogenic indices with a value of 84% versus 68%, 73%, and 76% for (TC/HDL), (HDL/LDL) and (LDL/HDL) ratios respectively.Conclusions: The AIP was a superior index for predicting the coronary arterial disease when compared to the most commonly used indices of atherogenicity in every day practice.Keywords: Atherogenic index of plasma, Coronary heart disease, Atherogenic indices.


Article
Coronary Heart Disease in Karbala Population Related to Central Obesity and Other Coexisting Risk Factors – Comparative Study

Author: Amir Omran
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 2 Pages: 1980-1985
Publisher: Kerbala University جامعة كربلاء

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background: Around 6 years ago, a study has been published describing the prevalence of improvement life style behavior in Karbala population in the period between1/12/2004-1/6/2005.Objectives: comparative study is conducted to estimate prevalence of improvement life style behavior in Karbala population and compare it with the previous study.Setting: Coronary care unit (CCU) of Hussein teaching hospital.Design: Prospective study.Methods: one hundred patients participated in this study admitted in CCU during the period from 1/12/2010 to 1/6/2011, all patients newly diagnosed as having acute (MI) by selected criteria in relation to central abdominal obesity (W.C), BMI, age, sex, fat consumption, smoking, physical activity, alcohol, fruit and vegetable consumption.Results: mean age (females 57.5 years, males 63.3 years) males 65%, females 35%, consumed saturated fat 54%, smoking 39%, Alcohol 0%, consumer of fat 54% fruit and vegetables 63%, W.C (males 96.7±12.9, females 99.9 ±16.4)Conclusion: The comparative study shows an adverse results, improvements at certain aspects of life style behavior


Article
Study Effect of Cigarette Smoking on the Liver Functions and Electrolytes
دراســـــــة تأثير التدخين على وظائف الكبد والشوارد الكيميائية

Authors: Nasir Kareem Dhahir ناصر كريم ظاهر --- Aqeel Abbas Noaman عقيل عباس نومان
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 1B Pages: 211-215
Publisher: Baghdad University جامعة بغداد

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Abstract

Smoking have a direct and indirect effects on some organs of the body, this effect is duo to inhaled the smoke and reach the alveoli and in to pulmonary veins. The main objective of this study, to investigate the changes in liver enzymes Alanine aminotransferase(ALT), Aspartate aminotransferase(AST) and Alkaline phosphatase(ALP) and electrolytes like(K+, Na+, Fe+2, Ca+2,Cl- and Po4 -3) in male smokers. In this study collect of (100) blood samples from male smokers and divided in to (3) groups according to period of smoking, and compare with (40) nonsmoker persons (group 4), the age groups are between (25-40) year, in a period between (November 2015-April 2016), within the district of Baqubah in Diyala governorate .The results show increase activity of enzymes ALT, AST and ALP (p<0.001) in smokers compared to control, and no significant differences in the electrolytes (K+, Na+, Cl-) but a significant decrease in Ca+2 level (p<0.001), while the iron concentration increased significantly in all smokers, and the phosphorus concentration increased significantly (p<0.001) in two groups of smokers (10-20) years period of smoking. From this study showed a significant effects on the activity of liver enzymes, Ca+2, Po4-3 and Fe+2in smokers compare to non-smokers while no significant effect on the Sodium, Chloride and Potassium in smokers.

للتدخين تأثيرات مباشرة وغير مباشرة على معظم أعضاء الجسم. هذه التأثيرات يمكن ان تحدث بسرعة عندما تستنشق وتصل الى الحويصلات الرئوية ومن ثم الى الاوردة الرئوية. الهدف من الدراسة هو التحري عن التغير في مستويات الانزيمات الكبدية مثل الانين , اماينوترانسفيريز و اسبرتيت اماينوترانسفيريز و الكلاين فوسفتيز و الشوارد الكيميائية مثل البوتاسيوم والصوديوم و الحديد و الكالسيوم و الكلوريد و الفوسفات في مصل دم المدخنين الذكور. تم جمع 100 عينة من المدخنين الذكور وتم تقسيمها الى ثلاث مجاميع اعتمادا على فترة التدخين. ومقارنتها مع 40 شخص غير مدخن (مجموعة رابعة) والاعمار المختارة هي بين (25 – 40 سنة) من الفترة ما بين (تشرين ثاني 2015 – نيسان 2016) في قضاء بعقوبة في محافظة ديالى.

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