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Article
Asymptomatic Pyuria In Diabetic Females

Author: Hussein Aziz Nasir*
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 3 Pages: 274-276
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The goal of this study was to determine the prevalence and the risk factors of asymptomatic pyuria in diabetic female patients.
Methods: The study included 100 diabetic female patients and 100 non diabetic females attending the outpatient in the period from Sep.2001 to Sep.2002.Patients with symptoms of urinary tract infection were excluded. Asymptomatic pyuria was defined as the presence of more than 10 leukocyteshigh power field in an uncentrifuged random urine sample.
Results: Diabetic women more often had asymptomatic pyuria than non diabetic women. The prevalence of asymptomatic pyuria was significantly higher in patients with duration of diabetes exceeding 15 years than those below. Diabetic females with asymptomatic pyuria more often had diabetic retinopathy, neuropathy, nephropathy, cerebrovascular disease, and ischemic heart disease than those without asymptomatic pyuria. As the degree of neuropathy increases it is accompanied by an increase in the prevalence of asymptomatic pyuria. The prevalence of asymptomatic pyuria was significantly increased in patients with proliferative diabetic retinopathy. As degree of nephropathy increases, it is accompanied by an increase in the prevalence of asymptomatic pyuria,
Conclusion: There is an increase in the prevalence of asymptomatic pyuria among diabetic females with complications of retinopathy, neuropathy and in nephropathy. The prevalence of asymptomatic pyuria increased with long duration of diabetes as diabetic microangiopathy becomes sever

Keywords

Asymptomatic pyuria --- DM --- Females


Article
The Relationship Between Hyperglycemia and the Rheumatoid Factor in the Serum of Diabetic Patients
العلاقة بين ارتفاع السكر والعامل الرثوي في مصل مرضى السكري

Author: Ali M. Al-Gharawi علي محمد الغروي
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2009 Volume: 6 Issue: 1 Pages: 99-105
Publisher: Baghdad University جامعة بغداد

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Abstract

This study was conducted to determine the relationship between two most common diseases in Iraqis patients , which are Diabetic mellitus (DM) and Rheumatoid Arthritis (RA); seeking rheumatoid factor in hyperglycemic sera. The results revealed that ; 62.5% of hyperglycemic (HG) patients had positive rheumatoid factor (RF) . No difference in number between both gender of HG patients (20 males and 20 females ) , RF reaction was nearly similar in males and females of HG patients ( 12 &13 respectively ) . Only 40% out of patient controls had positive RF . None of the apparently healthy subjects had positive RF .

يعد مرض السكري من أمراض العصر المزمنة والمقيتة , ومن مسببات الالتهابات. لذا تمت دراسة علاقة هذا المرض بداء التهاب المفاصل الريثاني (Rheumatoid Arthritis RA) من خلال دراسة عامل الالتهاب (rheumatoid factor RF) في مصول مرتفعي السكر( hyperglycemia). تم انتقاء (40) مريضا"يعاني ارتفاع السكر على أساس الفحص السريري والمختبري وعشرة أشخاص يعانون أمراضا" مختلفة غير السكري كمجموعة سيطرة وعشرة متبرعين من السويين ظاهريا" ولأعمار مضاهية للمرضى . تم الفحص السريري في العيادة الخارجية لمدينة الطب / بغداد . اجري العمل في المختبرات التعليمية لمدينة الطب . ومن هذا العمل المحدود لوحظ ما يلي : اظهر 62.5% من المرضى مرتفعي السكر(hyperglycemic HG) قيمة موجبة للعامل (RF) بينما اظهرفقط 40% من مجموعة السيطرة القيمة الموجبة للعامل ولم تظهر في نفس الوقت أي قيمة موجبة للعامل (RF) لمجموعة المتبرعين من السويين ظاهريا". كان عدد الرجال والنساء من مرضى مرتفعي السكر متساويا" ( 20 : 20 ). وقد اظهر الجنسين تفاعلا" ايجابيا" +ve للعامل الرثوي (RF) متقاربا" ( 12 رجلا" : 13 أمرأة ) .


Article
Frequency of Metabolic Syndrome in a Sample of Adult Diabetics in Baghdad
نسبة انتشار المتلازمة الايضية في عينة مرضى السكر البالغين في مدينة بغداد

Author: Faisal Gh. Al-Rubaye د. فيصل غازي الربيعي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2011 Volume: 24 Issue: 1 Pages: 12-16
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: The metabolic syndrome (MS) which is characterized by risk of developing diabetes mellitus and cardiovascular disease (CVD) is becoming an increasingly recognized disorder with an age- adjusted prevalence of 23.7%. In Iraq, there is little data concerning metabolic syndrome hence this study come to add some information about MS and to find the frequency of metabolic syndrome among Iraqi sample of patients with type 2 diabetes attending National Diabetes Centre of Al-Mustansiriya University.Method: This is a cross sectional study on 400 cases of diabetes mellitus who attended the National Diabetic centre/ Al-Mustansiriya university for a period of 6 months. All cases were examined by a consultant physician. All the patients were interviewed and blood pressure is examined, BMI was calculated and lipid profile measuring TG and HDL was done.Results: The prevalence of MS among diabetics in this study was 38.7%. The main factor of metabolic syndrome was diabetes followed by hypertension, obesity and dyslipidemia. Females in this study were more prone to have metabolic syndrome; male: female ratio 1:2. Those in the age group 60-69 had the highest frequency of metabolic syndrome. Those with BMI 30-40 had the highest frequency of metabolic syndrome.Conclusion: This study concludes that early diagnosis and aggressive treatment is needed for metabolic syndrome to avoid cardiovascular complications. Key word: DM, metabolic syndrome.

الملخص: الخلفية: المتلازمة الايضية والتي تتميز باضطراب السكري وامراض القلب و جهاز الدوران اصبحت مرضا معروفا بازدياده مع نسبة انتشار تصل الى 23.7% . في العراق هناك القليل من المعلومات حول المتلازمة الايضية ولهذا هذه الدراسة وجدت لاضافة معلومات حول المتلازمة الايضية وايجاد نسبة انتشارها في عينة من المصابين البالغين بمرضى السكري.طريقة العمل: دراسة مقطعية تمت على 400 حالة من المصابين البالغين بمرضى السكري والذين كانوا يراجعون المركز الوطني لعلاج السكري – الجامعة المستنصرية لمدة 6 أشهر. جميع الحالات تم فحصهم من قبل الاختصاصي، وتم مقابلة جميع المرضى، وتم قياس ضغط الدم الشرياني، وتم حساب دليل كتلة الجسم، وتم قياس نسبة الدهون لدى جميع المرضى.النتائج: كانت نسبة انتشار المتلازمة الايضية في هذه العينة 38,7%. كان اضطراب السكري في الدم متبوعا بارتفاع ضغط الدم متبوعا بالسمنة وزيادة الدهون في الدم اكثر شيوعا في هذه المتلازمة. كانت النساء اكثر عرضة للاصابة بالمتلازمة الايضية حيث كانت نسبة الذكور : الاناث =2:1. كان المرضى ضمن عمر 60-69 هم الاكثر في هذه المتلازمة الايضية. وكان حلول الكتلة الجسمية 30-40 ممن لديهم المتلازمة الايضية الاكثر انتشارا.الاستنتاج: تخلص هذه الدراسة الى ضرورة التشخيص المبكر والعلاج الشديد لحالة المتلازمة الايضية لتجنب المضاعفات على جهاز الدورة الدموية.

Keywords

DM --- metabolic syndrome.


Article
Serum Fetuin-A, A New Potential Biomarker For Diagnosis Of IHD In Menopausal Women.
استخدام فيتوين ا (Fetuin-A) كمؤشر حيوي لتشخيص مرض القلب الأقفاري لدى النساء في سن اليأس.

Authors: Safaa Ali Khudhair --- Arshad N. AL-Dejaly --- Mohammed Emad
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2013 Volume: 3 Issue: 3 Pages: 119-123
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: The role of inflammation in atherogenesis would suggest, a great deal of work looking for inflammatory markers that are risk factors for IHD. The most extensively examined markers are fibrinogen, C-reactive protein, IL-6, homocysteine, and fetuin-A.Aim of the study: The present study is focusing on role of biomarker fetuin-A in the diagnosis of IHD in menopausal female.Method: This study involved 76 menopause women suffering from IHD (42 patients with AMI and 34 with angina) and 20 healthy menopause women as control. Patients were divided into subgroups according to the presence of DM and hypertension. Serum Fetuin-A level is estimated in each group. Results: There is significant reduction in serum fetuin-A levels in menopausal women with IHD. Diabetes mellitus and hypertension associated with significant decrease in serum fetuin-A levels in menopausal women with IHD.Conclusion: Serum fetuin-A can be used as biomarker for diagnosis of angina and AMI in menopausal women. Both DM and hypertension have detrimental effect on serum fetuin-A levels.

المقدمة: دراسة المؤشرات الحيوية ومساراتها الكيميائية سمح بتطور العديد من الاستراتيجيات الجديدة في تشخيص النساء المصابات بمرض القلب الأقفاري في سن اليأس. احد هذه المؤشرات الحيوية هو .(Fetuin-A)هدف الدراسة: دراسة اهمية المؤشر الحيوي (Fetuin-A) في تشخيص مرض القلب الأقفاري لدى النساء في سن اليأس.منهجية العمل: شملت الدراسة 76 من النساء المصابات بمرض القلب الأقفاري بالإضافة الى 20 من النساء الاصحاء. تم تقسيم المريضات الى عدة مجاميع بناءً على وجود مرض السكري و ارتفاع ضغط ألدم ثم تم قياس مستوى (Fetuin-A) في الدم لدى كافة النساء.ألنتائج: اظهرت الدراسة انخفاض معنوي في مستوى (Fetuin-A) في الدم لدى النساء المصابات بمرض القلب الأقفاري.الاستنتاج: يمكن استخدام (Fetuin-A) كمؤشر حيوي لتشخيص المصابات بمرض القلب الأقفاري.التوصيات: دراسة المؤشر الحيوي (Fetuin-A) في تشخيص مرض القلب الأقفاري لدى الرجال و النساء و في اعمار مختلفة

Keywords

Fetuin-A --- IHD --- DM --- menopause


Article
Use of Silymarine as Adjuvant in Type 1 Diabetes Mellitus Patients Poorly Controlled with Insulin

Authors: Saad A. Hussain سعد حسن --- Nasreen Sh. Mohammed نسرين محمد --- Naseer A. Hadi نصير عبد الامير هادي --- Ahmad T. Numan احمد نعمان
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 1 Pages: 74-78
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Glycemic control and prevention of secondary complications are the most important aims of using pharmacological treatments in diabetes mellitus. Due to the high incidence of inadequate response to insulin and, we try to evaluate the effects of adjunct use of silymarin with insulin on glycemic control, lipid profile and renal function in type 1 diabetes mellitus patients. Patients and Methods: Placebo-controlled, doubled blinded clinical trial method is utilized through which 60 type 1 DM patients allocated into two groups, 30 patients treated with insulin and silymarin 400 mg/day in two divided doses, while the other 30 patients treated with insulin and placebo for 60 days. Fasting serum glucose, HbA1c, C-peptide, lipid profile and microalbuminuria were evaluated at base line and after 60 days. Results: Compared with placebo, silymarin significantly improves the effects of insulin through the reduction of fasting serum glucose, HbA1c and increase C-peptide level, associated with improving lipid profile and renal function. Conclusion: Adjunct use of silymarin with insulin improves glycemic control associated with improving lipid profile and renal function, an effect that may be related to increased insulin sensitivity in peripheral tissues.Keywords: Silymarin, Type1 DM, Glycemic control


Article
Percutanous revascularization of chronic total occlusion of diabetic patients at Iraqi center for heart diseases, a single center experience 2012

Author: Hassan Abdul Amir Al-Daghir
Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2015 Volume: 2 Issue: 2 Pages: 76-82
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

We aimed to evaluate the influence of DM on the results of PCI of patents with CTO and to compare that with the results in non-diabetic patients. Prospectively studied 150 consecutive cases of CTO with PCI at Iraqi center for heart diseases- Baghdad/Iraq for the period January– December 2012. Success of revascularization of chronic total occlusion by percutaneous coronary intervention was similar in both sexes (male 69.4%, female 72.4%). Intervention was successful in (40) out of (55) patients with diabetes mellitus (72.7%) which was identical to those without diabetes mellitus (66 patients out of 95 patients 69.47%). The success in diabetic and non- diabetic groups in the absence of other risk factors was (64.2%) and (62%) while in the presence of these risk factors it was (73.1%) and (71.2 %) respectively. In (11) out of the (15) patients with diabetes failed intervention was attributed to inability to pass the wire (73.3 %) compared to (23) out of the (29) non-diabetic patients (79.3%). While failure to pass the balloon was identical in both groups (13.3%) compared (13.7) and failure to pass a stent while it was not reported compared to (3.4%) in both diabetic and non-diabetic patients respectively. As far as failure of procedure, passing the wire into a false lumen occurred in one patient (6.6%) of diabetic group, while creation of perforation had occurred in one patient (6.6%) in diabetics. Successful revascularization has led to a prompt relieve of symptoms; angina and improved exercise tolerance as well as enhanced left ventricular function equally in both groups. Regarding CTO- PCI, there was no much difference between success in diabetic and non-diabetic.

Keywords

DM --- PCI --- CTO --- HTN --- HLP


Article
The Possible Role of Peripheral Blood Lymphocytes in the Pathogenesis of Diabetes Mellitus…..

Author: Haider Sabah Kadhim
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 599-603
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Diabetes mellitus (DM) is disorder with world wide distributionwith severe complications and high mortality rate.Aim: Our study shed light on the possible role of peripheral bloodlymphocytes (PBL) B-cells and T-cells and subsets (T-helper (CD4) and T-cytotoxic(CD8)) in the pathogenesis of DM.Patients and Methods: In this study, 40 patients with type-1 DM, and 40 patientswith type-2 DM, with 22 age matched control group were included.Immunocytochemistry for PBL for each group were done to detect the level of B-cell(CD19), T-cell (CD3), T-cell subsets CD4 and CD8.Results: The results showed a significant difference between control group and DM-1in CD8, while DM-2 showed a significant differences in CD3, CD8 and CD19. Asignificant difference also seen between type-1 and type-2 DM in CD3 and CD19markers, while CD4 and CD8 were not significant.Conclusion: This study may explore the role of the immune cells, T-cells (CD3, CD4and CD8) and B-cells in the pathogenesis of DM especially type -1 DM as it is theprototype of autoimmune disease.

Keywords

Diabetes mellitus --- DM --- type-1 DM --- type-2 DM --- T-cell --- B-cell --- T-helper


Article
Novel Insulin & Better Glycemic Control in Type 2 Diabetics

Author: Hazim A. Abdulwahab
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2009 Volume: 8 Issue: 1 Pages: 8-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background Recently a new premixed insulin analogue has been introduced with good results achieved in different parts of the world particularly regarding good glycemic control and safety. Objective This clinical study was conducted to evaluate the effectiveness and safety of introducing new insulin (biphasic insulin aspart 70/30)for the treatment of type 2 diabetic patients. Methods This prospective follow up study included 68 type 2 diabetic patients who has been randomly selected from those attending the National Diabetes Centre (NDC)of Almustansiria University during the period between 1st of oct.2004 to 31st of march 2005.Each patient had been followed for an average period of 6 months. Detailed history had been recorded and thorough physical examination has been performed for each patient. Readings of fasting and postprandial plasma glucose (FPG,PPPG), HbA1c,body mass index (BMI), and the frequency of hypoglycemic attacks had been recorded at the baseline ,interim, and the final visit which had been separated by 3 months between each other. At the baseline visit , each patient has been instructed how to use insulin pen properly and biphasic insulin aspart 70/30 had been supplied to the patients included in this study freely. Statistical analysis using students t-test had been used to assess the difference between different means using a p value of less than 0.05 as the level of statistical significance. Results This study showed that there was significant difference between the mean human insulin dose used before the study(48.3u/day) and the mean premixed insulin Aspart (36.88u/day) P value less than 0.05.The use of insulin analogue was associated with significant reduction in FPG (130.5mg/Dl in the last visit ,compared with 216mg/Dl in the 1st visit )P value less than 0.001,and the PPPG (160.2mg/Dl compared with 280mg/Dl in the 1st and last visit respectively)P value less than 0.001, and the mean HbA1c (7.1% compared with 9.41%)P value less than 0.001.There was no significant difference between the 1st and last visit recordings of BMI (27.9Kg/m2 compared with 28.1Kg/m2 respectively )P value more than 0.05 ,and in the average incidence of mild hypoglycemic episodes (1.01 compared with 0.42 episode respectively)P value more than 0.05. Conclusion This study showed that the use of this type of insulin analogue for type2DM lead to marked and statistically significant improvement in the glycemic control ,mainly in the PPPG. In addition the use of this type of insulin was associated with only mild elevation in the BMI and slight lowering in the incidence of hypoglycemic episodes ,both non-significant statistically.


Article
Orthostatic Hypotension Predicts The Early Morbidity And Mortality In Patients With Ischemic Heart Disease In Coronary Care Unit

Author: dr. Safaa Ali Khudhair د. صفاء علي خضير
Journal: Thi-Qar Medical Journal مجلة ذي قار الطبية ISSN: 19929218 Year: 2009 Volume: 3 Issue: 1 Pages: 33-39
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

ABSTRACTBackground: The mechanism by which the orthostatic hypotension and cardiac autonomic neuropathy increase cardiovascular morbidity and mortality remain to be settled. Some studies found exercise intolerance in patients with cardiac autonomic neuropathy with a reduced response in heart rate and blood pressure and decreased cardiac output during exercise. An association between cardiac autonomic neuropathy and QT prolongation has been shown.Objective: To asses the role of the orthostatic hypotension in the development of the early cardiovascular complications in the patients of the coronary care unit.Patients and method: In this a prospective observational follow up study, (50) patients with ischemic heart diseases were included. Blood pressure was measured with the standard mercury sphygmomanometer, the measurement in supine position was taken after at least 15 minutes of rest and the measurement in standing position was taken at the third minutes of standing, the orthostatic hypotension is said to be present when there was a sustained drop in systolic (≥ 20 mmHg) or diastolic (≥ 10 mmHg) blood pressure at the third minute of standing up.Results: Out of twenty two patients with orthostatic hypotension fifteen patients developed cardiovascular complications and out of twenty eight patients without orthostatic hypotension five patients developed cardiovascular complications, this association is statistically significant Conclusion: Orthostatic hypotension can be used as a prognostic marker for the development of early adverse outcomes in patients with acute coronary syndrome, thus it can be useful tool to screen the high risk patients in the coronary care unit.


Article
Novel Insulin & Better Glycemic Control in Type 2 Diabetics

Author: Hazim A. Abdulwahab
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2008 Volume: 7 Issue: 2 Pages: 8-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Recently a new premixed insulin analogue has been introduced with good results achieved in different parts of the world particularly regarding good glycemic control and safety.Objective: This clinical study was conducted to evaluate the effectiveness and safety of introducing new insulin (biphasic insulin aspart 70/30)for the treatment of type 2 diabetic patients.Methods: This prospective follow up study included 68 type 2 diabetic patients who has been randomly selected from those attending the National Diabetes Centre (NDC)of Almustansiria University during the period between 1st of oct.2004 to 31st of march 2005.Each patient had been followed for an average period of 6 months. Detailed history had been recorded and thorough physical examination has been performed for each patient. Readings of fasting and postprandial plasma glucose (FPG,PPPG), HbA1c,body mass index (BMI), and the frequency of hypoglycemic attacks had been recorded at the baseline ,interim, and the final visit which had been separated by 3 months between each other. At the baseline visit , each patient has been instructed how to use insulin pen properly and biphasic insulin aspart 70/30 had been supplied to the patients included in this study freely. Statistical analysis using students t-test had been used to assess the difference between different means using a p value of less than 0.05 as the level of statistical significance.Results: This study showed that there was significant difference between the mean human insulin dose used before the study(48.3u/day) and the mean premixed insulin Aspart(36.88u/day) P value less than 0.05.The use of insulin analogue was associated with significant reduction in FPG (130.5mg/Dl in the last visit ,compared with 216mg/Dl in the 1st visit )P value less than 0.001,and the PPPG (160.2mg/Dl compared with 280mg/Dl in the 1st and last visit respectively)P value less than 0.001, and the mean HbA1c (7.1% compared with 9.41%)P value less than 0.001.There was no significant difference between the 1st and last visit recordings of BMI (27.9Kg/m2 compared with 28.1Kg/m2 respectively )P value more than 0.05 ,and in the average incidence of mild hypoglycemic episodes (1.01 compared with 0.42 episode respectively)P value more than 0.05.Conclusion: This study showed that the use of this type of insulin analogue for type2DM lead to marked and statistically significant improvement in the glycemic control ,mainly in the PPPG. In addition the use of this type of insulin was associated with only mild elevation in the BMI and slight lowering in the incidence of hypoglycemic episodes ,both non-significant statistically.

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