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Article
Relation between Serum Leptin, Lipid Profiles and other biomarkers levels in patients with type 2 diabetic nephropathy
علاقة مستوى اللبتين مع شاكلة الدهون وبعض المتغيرات الكيمياحياتية في مصل دم مرضى السكري من النمط الثاني المصاحب بأعتلال الكلى

Authors: Sahar Abdul W- Shaban سحر عبد الواحد شعبان --- Esam Noori Al-Kirwi عصام نوري --- Khitam Abdul W. Ali ختام عبد الوهاب
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2010 Volume: 7 Issue: عدد خاص بمؤتمر العلمي النسوي 1 Pages: 678-686
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: In advanced diabetes mellitus, serum levels of the most hormones are altered due to several interplaying mechanisms.Objective: To assess the relation of serum leptin and lipid profile in type 2 diabetic nephropathy.Patients and Method: Serum leptin levels and its relation to lipid profile were estimated in 62 patients with type 2 diabetic nephropathy attending the National Diabetes Center in Al- Mustansiriya University, and (26) healthy individuals considered as control group. The diabetic patients were classified into three groups, (24) pathients with normoalbuminuria (21) patients with microalbuminuria and (17) patients with macroalbuminuria.Fasting plasma glucose, serum creatinine, Hb A1c %, lipid profile (Total cholesterol, LDL- Cholesterol, HDL- Cholesterol and Triglyceride) and urinary albumin, were measured to establish the possibility of using these biomarkers as a supplementary to serum leptin to be a diagnostic test for type 2 diabetic nephropathy.Results: Serum leptin levels showed a significant elevation in microalbuminuria (20.08± 4.50 ng/ml) and macroalbuminuria groups (22.35± 6.89 ng/ml) as compared to nondiabetic normal control group (10.64 ± 3.17 ng/ml). There was no significant differences observed in serum leptin levels between the normoalbuminuria group (13.96 ± 5.73 ng/ml) and healthy controls, but a significant positive differences were noticed in the levels of fasting plasma glucose, serum creatinine, Hb A1c% and lipid profile in the three patient groups in comparison with the control group. While no significant correlation was observed between these biomarkers levels and serum leptin values.Conclusion: It might be concluded that serum leptin levels were elevated in type 2 diabetic patients with microalbuminuria and macroalbuminuria, suggesting that renal leptin degradation is impaired in early stage of kidney damage and this impairment increase with the progression of this disease. Leptin hormone may consider according to these results as a risk factor for progression of kidney disease in diabetic patients.

1-( المقدمة) : في المراحل المتقدمة لمرضى السكري يحدث تغير في مستويات معظم الهورمونات نتيجة لتداخل ميكانيكية التفاعلات الحيوية المختلفة.2- (هدف البحث) : دراسة العلاقة بين مستوى اللبتين مع شاكلة الدهون لدى مرضى السكري من النمط الثاني المصاحب بأعتلال الكلى.3- (طريقة البحث) : تم قياس مستوى اللبتين وعلاقته مع شاكلة الدهون في مصل (62) مريض يعانون من مرض السكري النمط الثاني والمصاحب بأعتلال الكلى والذين حضروا الى مركز السكري في الجامعة المستنصرية.وشملت الدراسة كذلك (26) شخص سوي (كمجموعة ضابطة) لغرض المقارنة.قسمت اعداد المرضى الى ثلاثة مجاميع (24) مريض (نسبة تركيز البومين البول الى الكرياتين اقل من 30 ملغم/ غم ) كمجموعة اولى ، (22) مريض (نسبة تركيز البومين البول الى الكرياتين يتراوح بين 30-300 ملغم/ غم) كمجموعة ثانية ، اما المجموعة الثالثة فتضمنت (17) مريض (نسبة تركيز البومين البول الى الكرياتين اكثر من 300 ملغم/غم). تم قياس تراكيز كل من الكرياتين ، شاكلة الدهون والتي تشمل (الكوليسترول الكلي ، كوليسترول البروتينات الدهنية واطئة الكثافة ، كوليسترول البروتينات عالية الكثافة وثلاثي الكليسرول) في مصل الدم مع قياس تركيز البومين البول كمتغيرات كيمياحياتية مساندة لامكانية اعتماد قياس مستوى هرمون اللبتين في مصل الدم كفحص مختبري مساعد في تشخيص مرضى السكري النمط الثاني المصاحب لاعتلال الكلى.4- (النتائج) : مستوى اللبتين اظهر زيادة واضحة في مصل دم المجموعة الثانية للمرضى (4.50 ± 20.08 ng/ml ) وكذلك في مصل دم المجموعة الثالثة (6.89 ± 2.35 ng/ml ) مقارنة بالمجموعة الضابطة (3.17 ± 0.64 ng/ml ) بفرق ذي دلالة احصائية (P< 0.05 ) ولم يلاحظ فرق احصائي موجب في مستويات هرمون اللبتين بين المجموعة الاولى من المرضى (5.73 ± 13.96 ng/ml ) والمجموعة الضابطة ، ولوحظ ان هناك فرق احصائي موجب (P< 0.05 ) في مستوى الكلوكوز ، الكرياتين في مصل الدم ، الهيموكلوبين وكذلك عند مقارنتها مع المجموعة الضابطة. ولم تظهر دلالة احصائية بين مستوى هذه المتغيرات الكيمياحياتية ومستويات هرمون اللبتين في مصل الدم.5- (الاستنتاج) : يستنتج ان مستوى هرمون اللبتين يرتفع بصورة واضحة عند مرضى السكري النمط الثاني المصاحب بأعتلال الكلى ، وخاصة في مراحله المتقدمة نتيجة لضعف قابلية الكلى على تجزئة هذا الهرمون وتحلله في مراحل المرض المختلفة ، وان هذا الارتفاع يزيد من تطور المرض.من نتائج هذه الدراسة يمكن اعتماد هرمون اللبتين كعامل قياس لمدى تطور وخطورة امراض الكلى.


Article
Role of Antioxidant on Nephropathy in Alloxan Induced Diabetes in Rabbits

Authors: Israa F. Jaffar Alsamaraee --- Huda Arif Jasim
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 4 Pages: 398-402
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:The development and progression of diabetic nephropathy is dependent on glucose homeostasis and many other contributing factors. Diabetic nephropathy is a leading cause of end-stage renal failure, accounting for 35 to 40% of all new cases that require dialysis therapy worldwide. Recent clinical studies clearly demonstrated that hyperglycemia and oxidative stress is an important causal factor in mediating the development and progression of diabetic kidney disease.OBJECTIVE:To evaluate the therapeutic effect of levamesole in diabetic nephropathy .METHODS:The study included 10 rabbits Weight (1kg ±20 gm); they were followed up for 7months. Blood was aspirated from marginal ear vein after agitation with xylol for estimation of fasting blood glucose and malondialdehyde (MDA) which is used as marker of oxidative stress. Rabbits were given 110 mg / kg alloxan to induce diabetes. In the second month rabbits became diabetic without development of nephropathy. After 1 month from being diabetic a bosture dose of alloxan was given (125 mgkg). After 1 month of the bosture dose blood glucose level further increased and rabbits developed albumin urea. Once rabbits developed albumin urea they received levamesole 2 mgkg EOD for 6 weeks.RESULTS:The study results showed that diabetic nephropathy is associated with high blood glucose level (300-400mgdl) and oxidative stress (significant increase in MDA level). The nephropathy (albumin urea) and oxidative stress can be reversed by levamesole.CONCLUSION:The antioxidant effect and immune modulating properties of levamesole provided a protective therapy against the development of diabetic nephropathy.KEY WORDS: diabetic nephropathy, levamesole, MDA.


Article
Prevalence of Microalbuminuria

Author: Assist. Prof. Safaa Ali Khudhair
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 1 Pages: 462-467
Publisher: University of Kufa جامعة الكوفة

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Abstract

AbstractBackground: Diabetic nephropathy accounts for a significant reduction in life expectancy of diabetic patients, approximately 80% of Type 1 diabetic patients and 30% of type 2 diabetic patients with microalbuminuria progress to overt nephropathy after 10–15 years.Objective: To determine the prevalence of micro- and macro-albuminuria in diabetic patients in AL-Najaf city and the predictive value of some risk factors.Method: Urinary albumin-creatinine ratio (ACR) in a spot early morning urine sample was used and the patients were categorized as normo-albuminuric when ACR<30 mg/g, micro-albuminuric when 300>ACR≥30 and macro-albuminuric when ACR≥300 mg/g.Results: Prevalence of albuminuria among Type1 patients was 4(67%) microalbuminuria, 0% macroalbuminuria, i.e. 67% had abnormal urinary albumin-creatinine ratio (ACR). The corresponding prevalence for Type 2 patients was 26(52%) micro-albuminuria, 4(8%) macro-albuminuria and total of 30(60%) for abnormal urinary albumin-creatinine ratio (ACR).Conclusion: The occurrence of microalbuminuria detected in this study was much higher than previously reported in other studies and the duration of diabetes was the strongest predictor.


Article
Screening for Diabetic Nephropathy in Teenage Diabetes
التحري عن الاعتلال الكلوي لدى المراهقين المصابين بداءالسكري

Author: Abdul Munem Al Dabbagh د.عبد المنعم يونس الدباغ
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2009 Volume: 22 Issue: 1 Pages: 9-17
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background: Diabetic nephropathy is the leading known cause of end-stage renal disease (ESRD). Epidemiological studies have demonstrated that diabetic nephropathy occurs in approximately one-third to one half of all diabetes and, today, diabetes is the most important cause of renal failure in the industrialized world. Recent studies have demonstrated that the onset and course of diabetic nephropathy can be ameliorated to a very significant degree by several interventions but these interventions would have their greatest impact if instituted at a point very early in the course of the development of this complication.Objective: To screen the problem of diabetic nephropathy in teenage patients with type I diabetes Mellitus (TIDM), by detection of Microalbuminuria (MA) which consider the best predictor of high risk for developing diabetic nephropathy.Patients and Methods: A cross-sectional design and a convenient sampling procedure were adopted to enroll 230 patients (118 males and 112 females) who met the inclusion criteria, from those attending the National Center for Treatment & Research of Diabetes in Al-Mustansirya Collage of Medicine-Baghdad during the period from the 1st of September 2006 to the end of December 2007. Micral test II was used to screen early morning (spot) urine samples for increased albumin excretion rate while the Schwartz formula made possible estimating the glomerular filtration rate (GFR) from serum creatinine and demographic characteristics. The results were used for evaluating the relationship between microalbuminuria and GFR. Some important risk factors including patient's age, disease duration, body mass index, and hypertension have also been evaluated with reference to the impact of hyperglycemia measured as the prevailing (HbA1c). -Conclusion: Micro-albuminuria manifested by increased urinary albumin excretion was encountered in 47.82% of our teenage DM patients showing significant association with hyperfiltration state, increasing level of HbA1c, and hypertension. But not gender or body mass index. Key words: Screening, Diabetic nephropathy, Teenage diabetes

المقدمة: يعتبر الاعتلال الكلوي بسبب السكري من الاسباب الرئيسية للاصابة بالعجز الكلوي .اثبتت البحوث الوبائية ان الاعتلال الكلوي يحدث لحوالي ثلث الى نصف المصابين بداء السكري .من الممكن التقليل من الاعتلال الكلوي بسبب السكري الى حد كبير اذا ما تم التدخل بشكل مبكر من بداية حدوث هذا الاعتلال .اهداف البحث:التحري عن الاعتلال الكلوي بسبب السكري لدى المرضى المراهقين المصابين بداء السكري من النوع الاول بالتحري عن الالبومين المجهري في الادرار.طريقة البحث:دراسة مقطعية على عينة مناسبة مكونة من 230 مريض (118 ذكر و 112 انثى) من المرضى الذين يراجعون المركز الوطني لعلاج وبحوث السكري في كلية الطب في الجامعة المستنصرية في بغداد . تم استخدام فحص Miscal test 2 للتحري عن الالبومين في الادرار ومعادلة شوارتز لحساب معدل التنقية الكلوي .النتائج: كانت نسبة الالبومين المجهري لدى المرضى 47.82% . معدل التنقية الكلوي كان 18.69% والذي يمثل 60.46% من المرضى المصابين بالادرار المصحوب بالالبومين المجهري و39.53% لغير المصابين.كان خطر الاصابة بالادرار المصحوب بالالبومين المجهري مرتبط بمستوى HbA1c وطول الفترة الزمنية للاصابة بالسكري وارتفاع ضغط الدم التقلصي والانبساطي .الاستنتاج:الادرار المصحوب بالالبومين المجهري تم اكتشافه في 47.82% من المرضى المراهقين المصابين بالسكر وكانت له علاقة بمستوى التصفية الكلوي وزيادة نسبة HbA1c وارتفاع ضغط الدم ولم تظهر له علاقة مع جنس المريض ومؤشر كتلة الجسم .


Article
Role of serum IL-18 in type 2 diabetic patients with and without microalbuminuria

Authors: Ali Naser Mohammed Ali AL-Alglani --- AbduladheemYaseen Abbood --- Hazim Abdul Razak Abdul Wahab --- Abbas Mahdi Rahma
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2015 Volume: 14 Issue: 1 Pages: 58-63
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Microalbuminuria is a well-known indicator of poor renal outcomes in patients with type 2 diabetes that leads to diabetic nephropathy (DN), but there are many proinflammatary markers that are elevated during injury to the nephrons which lead to chronic kidney disease, one of those is interleukin - 18 (IL-18). Objective: To confirm the role of serum IL-18 as a novel predictor before DN onset. Patients and Methods: The microalbuminuria levels were measured by immunoturbidimetric method, serum IL-18 levels were measured by ELIZA sandwich method, both serum and urine creatinine levels were measured by colorimetric method and hemoglobin A1c (HbA1c) levels were measured by ion exchange - high performance liquid chromatography (HPLC) in 90 individuals, 20 individuals apparently healthy (group I), 40 diabetic patients without microalbuminuria (urinary albumin to creatinine ratio (UACR) ˂ 30 mg/g) (group II) and 30 diabetic with microalbuminuria (UACR 30 -300) (group III).Results: The mean of serum IL-18 in group I, II and III was 189.30 pg/ml ± 3.269 S.E., 220.83 pg/ml ± 0.900 S.E. and 246.67 pg/ml ± 22.341 S.E. respectively. The difference between group I and II, group I and III, and group II and III was significant (P=0.000 for all). The mean of UACR in group I, II and III was 4.25 mg/g ± 2.359 S.E., 4.20 mg/g ± 1.518 S.E. and 34.17 mg/g ± 0.629 S.E. respectively. The difference between group I and II was not significant (P=1. 000) but between group I and III, and group II and III were significant (P=0. 000 for both). The mean of serum creatinine in group I, II and III was 0.885 mg/dl ± 0.0302 S.E., 0.883 mg/dl ± 0.0240 S.E. and 0.933 mg/dl ± 0.0237 S.E. respectively. The difference between group I and II, group I and III, and group II and III was not significant (P=0.998, 0.331 and 0.145 respectively). The mean of hemoglobin A1c (HbA1c) in group I, II and III was 5.9 % ± 0.0211 S.E., 7.7 % ± 0.0445 S.E. and 8.135 % ± 0.0519 S.E. respectively. The difference between group I and II, group I and III, and group II and III was significant (P=0.000 for all). The correlation between urinary albumin to creatinine ratio (UACR) and IL-18 in group III was significant (r=0.983 with P=0.000). The correlation between hemoglobin A1c and IL-18 was significant (r=0.641 with P=0.000) in group II. The correlation between serum creatinine and IL-18 in group III was not significant (r=0.041 with P=0.830). Conclusion: while the increased IL-18 levels were positively correlated with both HbA1c and UACR that leads to the progression of the diabetic nephropathy and it can be one of the cytokines which opens the possibility of its application in clinical treatment in the future.


Article
Elevated ceruloplasmin and leucocyte count in Type 2 diabetic nephropathy

Authors: Huda Mundher Mahdi --- Khaleed J. Khaleel --- Waleed H.Yousif
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 82-90
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background : Type 2 diabetes mellitus is chronic disorder that requires proper medical careand education of patients to reduce long term complication like nephropathy .Patients and methods: Forty-five Type 2 diabetic nephropathy patients in early stage wererecruited for this study. Twenty-nine control subjects matched for age were also included.Results : this study demonstrated a significant increase in glycosylated hemoglobin ,randomblood glucose , blood urea , creatinine and total White blood cell count while a significantdecrease in , estimated glomerular filtration rate in Type 2 diabetic nephropathy patientscompared with healthy control . Urine markers including microalbumin and ceruloplasminshowed a significant increase in level in Type 2 diabetic nephropathy patients when comparedwith the healthy control.Conclusion: leucocyte count can be considered as indicator for an inflammatory marker and aceruloplasmin a good urinary marker.


Article
Initial Recognition and Prophecy of Diabetic Nephropathy in Type I Diabetes

Author: Dr. Wijdan Akram, , FICMs, MBChB
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 94-102
Publisher: Baghdad University جامعة بغداد

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Back ground: Diabetic nephropathy is rapidly becoming the leading cause of end-stage renal disease (ESRD). The onset and course of DN can be ameliorated to a very significant degree if intervention institutes at a point very early in the course of the development of this complication.Objective: The aim of this study was to characterize risk factors associated with nephropathy in type I diabetes and construct a module for early prediction of diabetic nephropathy (DN) by analyzing their risk factors. Methods: Case control design of 400 patients with type I diabetes mellitus (IDDM), aged 19-45 years. The cases were 200 diabetic patients with overt protein urea while the controls were 200 diabetic patients with no protein urea or micro-albumin urea. Results: concurrent occurrence of retinopathy and nephropathy was the main predictors for nephropathy in type I DM patients. Disease duration more than 10 years, uncontrolled hyperglycemia, age more than 30 years and presence of hypertension were the other predictors respectively. Gender and hypercholestremia showed no predictive value in occurrence of DN. Key words: diabetic nephropathy, diabetes mellitus, case control


Article
Assessment of Omentin-1 as a predictor and Renoprotective for type 2 Diabetic Nephropathy
تقدير الاومنتين_1كمؤشر ااستباقي وحماية كلوية للنوع الثاني لاعتلال الكلويالسكري

Authors: Sarah Salim Mohammed Al-Fahdawi ساره سالم محمد --- Isam Noori Al-Karawi عصام نوري سلمان
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2017 Volume: 30 Issue: 1 Pages: 18-23
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background: Diabetic nephropathy is one of the most serious microvascular complications of diabetes, which may lead to chronic kidney disease in diabetic patients.Objective: to explore correlation of omentin-1 and diabetic nephropathy in type 2 diabetic patients.Method: Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 61 type 2 diabetic patients. These patients were classified into two groups according to their albumin/creatinine ratio (ACR), into patients with normoalbuminuria, group C (ACR< 30 mg/mmol), patients with microalbuminuria, group B (ACR=30-300 mg/mmol), twenty five (25) (10 male and15 female) apparently healthy matching the Pearson were selected as a control group (group A).In addition, glucose and lipid profile and morphological characters were assessed.Result: The serum OMT level of group B was much lower than those of group C and group A. While, there was non-difference in OMT level between group C and group A.Conclusion: Detection of serum OMT level may play an important role in early diagnosis and prevention of diabetic nephropathy in T2DM.


Article
Some profiles of diabetic CKD patients with AVF on haemodialysis

Authors: Zainab Abbass Hassan --- Ahmed Abdul-Ameer Daffar --- Riyadh Mohammad Salih
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2016 Volume: 6 Issue: 1 Pages: 30-38
Publisher: Thi-Qar University جامعة ذي قار

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Background: Diabetes mellitus is one of the major chronic non communicable diseases that affect millions globally. Diabetic nephropathy is a serious complication of diabetes mellitus, often leading to end stage kidney disease (CKD). Objectives: The aim of this study was to assess some profiles of diabetic end stage kidney disease patients with AVF on haemodialysis at baseline and adequacy of treatment after three months follow up regarding different clinical and laboratory parameters.Methodology: The current prospective study was carried out in the haemodialysis unit in AL-Hussein Teaching Hospital (Iraq / Thi-Qar) from April to July 2016. The number of patients included in the study was (24) patients.Results: The majority of patients were not educated and 50 % of them were smokers. The adherence rate of the patients with haemodialysis schedule was 50%. The prevalence of HCV infection was significantly higher among adherent than non-adherent patients.Conclusion: The management of diabetic end stage kidney disease patients with AVF on maintenance haemodialysis is considered inadequate and there was a high rate of acquiring viral hepatitis C infection after beginning sessions of hemodialysis.

الخلفية : يعتبر مرض السكر من الامراض المهمة و غير المعدية و يصيب الملايين في انحاء العالم. عجز الكلية المزمن الناتج عن مرض السكر من المضاعفات التي تنتج عن هذا المرض المزمن.اهداف الدراسة: ان الهدف من هذه الدراسة هو التقييم لبعض ملامح العجز الكلوي الناتج عن مرض السكر المزمن بعد اجراء عملية الربط الدائمي لهم و اجراء الغسل الدموي لهم في البداية و بعد المتابعة لهم لمدة ثلاثة اشهر لتحديد مدى كفاية الغسل الدموي.الطريقة: هذه الدراسية الاستباقية الحالية انجزت في وحدة الكلية الصناعية في مستشفى الحسين التعليمي في الناصرية ( العراق ) من شهر نيسان الى شهر حزيران لسنة 2016. لقد كان عدد المرضى هو 24 مريض.النتائج: اغلب المرضى غير متعلمين و نصف عدد المرضى مدخنين. التزام المرضى بالغسل الدموي كان بنسبة ( 50% ). عدد المرضى المصابين بالتهاب الكبد الفايروسي ( سي ) كان اعلى لدى الملتزمين بالغسل الدموي بالمقارنة مع المرضى غير الملتزمين بالغسل الدموي.الاستنتاج: علاج المرضى المصابين بمرض العجز الكلوي المزمن الناتج عن مرض السكر المزمن و لديهم ربط مزمن في المرفق يعتبر غير كافي بالنسبة للغسل الدموي و هناك عدد كبير من المرضى الذين اصيبوا بالتهاب الكبد الفايروسي ( س ) بعد البدء بعملية الغسل الدموي.

Keywords

AVF --- CKD --- hemodialysis --- diabetic nephropathy --- Iraq


Article
Evaluate the Plasma Iron Levels on Iraqi Type 2 Diabetic Nephropathy
تقييم مستويات الحديد في بلازما الدم لدى العراقيين المصابين بالسكر الكلوي من النوع الثاني

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Abstract

Diabetes is linked with a change of homeostasis for the plasma iron in human, that have the ability to produce reactive oxygen species (ROS) induced by this disease and its microangiopathy complication especially diabetic nephropathy (DN). In addition, iron indicators are associated with obesity and insulin sensitivity as contribute to the development and improvement of oxidative damage. The objective of the study was to measure and evaluate the level of iron in the plasma in diabetic patients with and without DN, and in normal individuals, The current study was conducted on sixty T2D patients diagnosed beforehand, these patients were categorized into two equal groups according to their albumin to Creatinine ratio (ACR), including patient with nephropathy (UAC=30-300 mg/g Creatinine), (I) and patients without nephropathy (UAC<30mg/g Creatinine), (II). Twenty four healthy persons were chosen as a control group. Each group included the same numbers of male and female. The age of patients ranged from (36-65) year . The results showed that the plasma level of iron showed a high significant increasing in patients without DN group (177.10±76.36 μg/dl) compared to patients with DN and healthy control groups (126.77±61.16 vs 116.79±26.16 μg/dl, respectively).

يرتبط مرض السكري مع توازن الحديد في الإنسان. حيث أن له القابلية على توليد الجذور الحرة وأنواع الأوكسجين التفاعلية (ROS) وترتبط مؤشرات الحديد مع السمنة والحساسية للانسولين والتي يمكن أن تسهم في تطور وتقدم الإعتلال الكلوي السكري . الهدف من هذه الدراسة تقدير ومقارنة مستوى بلازما الحديد في الأشخاص الطبيعيين وفي مرضى السكري مع أو بدون اعتلال الكللى السكري. أجريت الدراسة الحالية على ستون مريضاً مصاباً بمرض السكري النوع الثاني حيث كانت تتراوح أعمارهم بين (36-65)سنة لكلا الجنسين تم تشخيصهم مسبقاً. تم تقسيم المرضى الى مجموعتين متساويتين وفقا الى نسبة الألبومين-كرياتينين ضمت المجموعة الأولى المرضى الذين يملكون إعتلال الكلى وسميت مجموعة مرضى إعتلال الكلى السكري في حين إحتوت المجوعة الثانية المرضى الذين لديهم نسبة الألبومين طبيعية وسميت مجموعة المرضى بدون إعتلال الكلى السكري, ولغرض المقارنة تم إختيار أربع وعشرون شخصاً سليماً كمجوعة أصحاء. في المقابل مستوى بلازما الحديد أظهر زيادة معنوية عالية لدى مرضى السكري الذين لايمتلكون إعتلال الكلى السكري ( 177.10± 76.36 مايكرجرام/ديسيلتر) بالمقارنة مع مجوعتي المرضى بدون إعتلال الكلى السكري والأصحاء(126.77 ± 61.16 و 116.79 ± 26.16, مايكرجرام/ديسيلترعلى التوالي).

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