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Article
M1 TRANSITIONS IN ER ISOTOPES
الانتقالات ثنائية القطب لنظائر Er

Author: A. M. ASHIJ عبد المنعم مصلح عاجج
Journal: Journal of university of Anbar for Pure science مجلة جامعة الانبار للعلوم الصرفة ISSN: ISSN: 19918941 Year: 2007 Volume: 1 Issue: 2 Pages: 95-101
Publisher: University of Anbar جامعة الانبار

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Abstract

We presented the results of schematic calculations of Magnetic dipole transitions in Erbium isotopes from 158 to 168 by considering the Hamiltonian of the neutron- proton Interacting Boson Model (IBM-2). New idea for counting bosons number at N=64 has been used. A comparison with available M1 experimental data is presented.

في هذه الدراسة تم تقديم نتائج الحسابات النظرية لعناصر مصفوفة الأنتقال المغناطيسي بين مستوياتالطاقة في نظائر الأريديوم من 158 الى 168 وذلك باستخدام نموذج البوزونوتات المتفاعلة رقم – 2 . لحسابعدد البوزونات تم استحداث فكرة جديدة وهي استخدام القشرة شبه المغلقة عند عدد النيوترونات 64 . قورنتجميع النتائج المستحصلة مع النتائج العملية المتوفرة.


Article
IL-2 and IL-4 Serum Levels in Breast Cancer

Author: Batool H. Al-Ghurabi* BSc, MSc, PhD (Clinical Immunology) د. بتول هاشم الغرابي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 300-303
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Background: The role of cytokines in cancer immunity and carcinogenesis in general has been well established, which play an important role in the pathogenesis of many solid cancers.This study aimed to estimate serum levels of IL-2 and IL-4, and to shed light on the correlation of these interleukins with progression of breast cancer. Patients and Methods: The study included 80 women, it comprised of 45 breast cancer patients, 12 patients with benign breast lesions and 23 apparently healthy controls. ELISA method has been used for estimation the level of IL-2 and IL-4 in serum of three studied groups.Results: This study showed elevation of IL-4 level in the sera of breast cancer patients with significant differences between breast cancer and controls (p<0.001), this elevation was correlated with progression of the tumor. In addition, the elevation of serum level of IL-4 was found to be inversely related to ER and PR expression (P=<0.05). On the other hand, there was a significant decrease in the median of serum level of IL-2 in patients as compared with control groups. Conclusions: There was association between elevated serum level of IL-4 and breast cancer and this elevation was correlated with advanced stage of disease. In addition, there was no association between the statistical significant decrease of IL-2 serum level and the advanced stage of breast cancer. Keywords: Breast cancer, Cytokines, ER

Keywords

Breast cancer --- Cytokines --- ER


Article
The effect of ER: YAG laser on enamel resistance to caries during orthodontic treatment: An in vitro study

Authors: Noor M.H. Garma نور محمد حسن --- Esraa S. Jasim
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 1 Pages: 182-188
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: One common undesirable side effect of orthodontic treatment with fixed appliances is thedevelopment of incipient caries lesions around brackets, particularly in patients with poor oral hygiene. Differentmethods have been used to prevent demineralization; the recent effort to improve the resistance against thedemineralization is by the application of lasers.Materials and method: Thirty human premolars extracted for orthodontic purposes were used to test the effect of twoenergy level of ER-YAG laser on enamel resistance to demineralization. The brackets were bonded on the teeth andall the labial surface excluding 2 mm area gingival to the brackets were painted with acid resistance varnish. Threegroups were generated. The first group was the control group (A) with no treatment was performed. In the second(group B) and third (group C) groups; teeth were irradiated by ER-YAG laser of 200, 60 mj energy respectively. All theteeth were individually subjected to acid challenge cycle for 30 days. After debonding longitudinal sections weretaken and examined under stereomicroscope. The enamel demineralization evaluation was done by taking theaverage of three depths at the centre of the artificial lesion. Also the enamel surface was classified by anexperienced investigator according to acid etch pattern. Comparisons of the average depth values of the groupswere performed with ANOVA and LSD tests. The statistical significance level was set at p ≤ 0.05.Results: The results revealed that average lesion depth was significantly deeper at the control group than the lasergroups, and it was significantly deeper in group (B) with 200 mj than in group (C) with 60 mj. Enamel surfaces showeddeeper pits and craters than in control group.Conclusions: The decrease in artificial caries lesion depth associated with use of the two laser energy level supportthe ER-YAG laser as a tool to increase enamel resistance to demineralization and white spot lesion prevention

Keywords

Demineralization --- ER-YAG --- laser


Article
Estrogen and Progesterone Receptors (ER and PR) Status of Breast Cancer Cases in Kurdistan and Their Correlation with Pathologic Prognostic Variables

Author: Mayada I. Yalda
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 1 Pages: 75-84
Publisher: Babylon University جامعة بابل

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Abstract

Background: breast cancer shows different clinico-pathological features according to geographic and ethnic groups' variation. The ER and PR positive status is an indication that the patient is a good candidate for hormone therapy. Furthermore, the high percentage and intensity of ER and PR positive cells are important predictive markers for this cancer.Aim To assess breast cancer-specific features for patients diagnosed in the north of Iraq and to assess the hormone receptors status and their relation to other pathological prognostic factors.Patients and Methods: This study included 324 breast cancer cases diagnosed and reviewed by histopathology in the central lab of Duhok/ Iraq, from May 2007 to March 2012. Immunohistochemical markers were used to identify the ER and PR status and scoring according to Allred scoring guideline. Results: About 68.2% of the patients included in this study were younger than 50 years. Most of them presented at stage II and III. Negative stain for ER was seen in more than half of the patients. The score proportion was decreasing with the increase in the stage, but the correlation was statistically insignificant; on contrary the correlation of ER and PR scoring with lymph node involvement was statistically highly significantConclusion: The young onset of breast cancer among Kurdish patients, the high stage at first presentation and the relatively high percentages of hormone insensitive cancers in both young and old patients could be attributed to the genetic predisposition modified by the revolution in life style and required additional study and analysis.

يشكل سرطان الثدي مشكلة كبيرة للنساء ويظهر تتغيرا في صفاته بحسب التغير الجغرافي والعرقي , وللمُستقبِلات الهرمونيه للاستروجين و البروجسترون و لشدة ايجابيتها دور ليس في التنبئ بتطورالمرض فقط بل في التنبئ باستجابة المريض للهرمونات العلاجيهتهدف الدراسة الحالية الى التعرف على مميزات حالات سرطان الثدي عند المرضى المصابين في شمال العراق مع دراسه مناعيه للمُستقبِلات الهرمونيه للاستروجين و البروجسترون و علاقتهم بالمميزات الأخرى في سرطان الثدي.تم جمع 324 عينه من مرضى مصابين بسرطان الثدي من المختبر المركزي في مدينة دهوك و مستشفيات أربيل و السليمانيه منذ مايس 2007و حتى آذار 2012. لقد تم تحليل صفات السرطان من نواحي مختلفه مع التركيز على درجة تميزه , مرحلة الورم , انتشاره في العقد اللمفاويه. وتم استخدام النسيج المُضَمَّن في البرافين لقياس المُستقبِلات الهرمونيه للاستروجين , البروجسترون وشدة ايجابيتهاالنتائج: أضهرت الدراسه أن حوالي 68.2% من المرضى في هذا البحث كانوا بعمر يقل عن الخمسين , كما أن معظمهم كانوا في مرحله متطوره نسبيا (المرحله 2 و 3) و بدرجة تمييز قليله .كانت المُستقبِلات الهرمونيه ذات نتائج سلبيه في اكثر من نصف الحالات, ولوحظ أن شدة الصبغ المناعي كانت تتناقص مع تقدم مرحلة الورم . لقد ارتبطت بعلاقه ذات مغزى احصائي مع الانتشار في العقد اللمفاويه, وكانت عاليه في درجة التمييز العاليه نستنتج من هذه الدراسه أن سرطان الثدي سجل بأعمار صغيره مقارنة بالدراسات من بعض مناطق العالم العربي, وأصغر بكثير من الدراسات من العالم الغربي. ان الاعمار الصغيره نسبيا بالاضافه الى النسبه العاليه من التشخيص الأولي بدرجة تميز قليله و في مرحله متطوره و نسبه متدنيه من المُستقبِلات الهرمونيه للاستروجين و البروجسترون قد يعزى الى تأثيرات جينيه معدله بتأثيرات انماط الحياة المعاصره وتحتاج الى المزيد من التحليل و الدراسه.

Keywords

Immunohistochemistry --- ER --- PR --- Breast --- Cancer --- Prognosis


Article
Evaluation of the effect of ER: YAG laser on apical microleakage (in vitro study)

Authors: Anas F. Mahdee --- Ali H. Abbas --- Salah A. Issmaeel
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 4 Pages: 66-71
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Apicoectomy and retrograde filling is indicated when conventional endodontic treatment is impossibleor failed to achieve apical seal. The aim of this study was to evaluate the effect of ER: YAG laser on apicalmicroleakage.Materials and Methods: Sixty extracted single-rooted teeth were used in this study. The roots were divided into sixgroups. Group 1: apicoectomy by fissure bur, and apical cavities prepared by round bur, then cavities were filledwith MTA. Group 2: the roots preparations and fillings were the same as group 1, then the apical areas were treatedby Er:YAG Laser. Group 3: apicoectomy by fissure bur, and apical cavities prepared by ultrasound retrotip andcavities were filled with MTA. Group 4: the roots preparations and fillings were the same as group 3, then the apicalareas were treated by Er:YAG Laser. Group 5: the roots obturation with gutta percha, then the apices were resectedusing Er:YAG Laser. Group 6: the roots apices were resected with Er:YAG Laser, then the canals were obturates withgutta percha. Apical microleakage was measured by methylene blue dye penetration technique.Results: Significant difference between the groups. Group 1 shows the best apical seal, while group 5 shows theworse apical sealing ability.Conclusion: Apicoectomy by bur is better than apicoectomy by laser, and apical cavity prepared by bur is betterthan prepared by US. The use of ER: YAG laser in apicoectomy is preferred to be done before obturation of the rootcanal with gutta percha


Article
Immunohistochemical Study of Estrogen, Progesterone Receptor and Her-2neu Oncogene with Her-2neu Biomarker Estimation by ELISA Technique in Primary Breast Cancer before Chemical Therapy
دراسة نسيجية مناعية لمستقبل هرمون الاستروجين والبروجستيرون والهير 2 نيو الورمي مع حساب العلامات البايولوجية للهير 2 نيو عن طريق تقنية اللايزا في مريضات مصابات لسرطان الثدي قبل العلاج الكيمياوي

Authors: Ali H. Al-Khafaji علي حسين الخفاجي --- Ayad M.A. Fadhil اياد محمد علي فاضل --- Mohammed A. Hameed محمد اياد حميد
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2014 Volume: 55 Issue: 1 Pages: 132-144
Publisher: Baghdad University جامعة بغداد

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Abstract

Breast cancer is one of the comments malignant tumors worldwide especially in Iraq; it is a leading cause of death in Iraqi women. Determination of estrogen and progesterone receptors status is helpful in selecting the patients most likely to receive benefit from endocrine therapy, and provide prognostic information on recurrence and survival since their expression is related to the degree of the tumor differentiation. From November 2012 to March 2013, 150 breast cancer patients at Al-Amal Hospital in Baghdad were attended to start treatment of disease for the first time. All patients included in this study did not receive chemotherapy. Patients were asked to bring their paraffin embedded tissue blocks to participate in estrogen, progesterone and Her-2/nue receptors estimation. Blood samples were also collected from the patients to estimate positive Her-2nue cases in serum. Age distribution in women with breast cancer showed that 44%of cases at age group (40 – 49) years. 23% of the patients had a positive family history (first and second degree). Histological types of breast carcinoma showed that 82%, 14% and 4% were ductal, lobular and mixed carcinoma respectively. The Makee classification showed that Grade I, II, and III were detected in 10%, 64% and 26% respectively. TNM staging revealed that 16% of the patients were recorded in stage I, 44% in stage II, 32% in stage III and 8% in stage IV. It was demonstrated that 72% and 70% of breast carcinomas were positive for ER and PR respectively; both markers correlated with age, family history, type, histological grade and stage of the disease. Her-2/neu showed 28% expression in Iraqi breast cancer cases. HER2/neu over-expression (>15 ng/ml) was observed in 36 out of 150 patients (24%) Her-2/neu serum level at ELISA diagnosis and in 42 out of 150 (28%) at immunohistochemistry method (IHC).There were significant (P <0.001) association between tissue HER-2/neu and serum HER-2 levels. Detection Her-2/neu in serum by ELISA technique could be used as a method for detection with high rate reached to 78% after mastectomy, also it considered as an excellent method for follow up.

يعد سرطان الثدي احد اكثر انواع السرطان شيوعا في العالم واحد اهم اسباب الوفاة بين نساء العراق ولقد كان لاكتشاف مستقبلات الهرمونات (استروجين و بروجستيرون) فضل كبير في اختيار المريضات للخضوع للعلاج الهرموني ولتوقع فترة العيش بعد العلاج وامكانية رجوع الورم مرة اخرى وذلك للعلاقة بين درجة الورم ونسبة تمثيل مستقبلات الهرمون على سطح الخلايا, يقوم البحث على اساس قياس نسبة ER, PR &HER2neu في النسيج ومصل الدم وملاحظة العلاقة بين مستوى المستقبلات والحالة الاكلينيكية في نساء عراقيات مصابات بسرطان الثدي قبل وبعد الخضوع للعلاج الكيميائي, تم بدأ الدراسة من تشرين الثاني 2012 الى اذار 2013 في مستشفى الامل وتم اختيار المشخصات حديثا بالاصابة بسرطان الثدي وقبل بدأ العلاج الكيميائي للمشاركة في الدراسة , تم اخذ النسيج المنطمر في البارافين وعينة من الدم من 150 مريضة لمعرفة نسبة الHER2neu الموجبة (اهم بارامتر في الدراسة) 44%من النساء المشمولات في الدراسة كن بين 40-49سنة, 23% لهن اقارب من الدرجة الاولى والثانية مصابات بالمرض, 82% كان من نوع سرطان القنوات,14% من نوع قصيبي و 4% من النوع المختلط, 64% من الدرجة الثانية,10% من الدرجة الاولى و16% من الدرجة الثالثة حسب تصنيف SBR, باستخدام تصنيف TNM 16% في المرحلة الاولى 44% في المرحلة الثانية.32% في المرحلة الثالثة و8% في المرحلة الرابعة وكلاهما علامات مرتبطة مع التقدم في العمر والتاريخ العائلي ونوع ودرجة النسيجية ومرحلة المرض. التحليل المناعي immunohistochemistry over expression) ( كشف عن 42(28%)حالة زيادة او افراط في التعبير للجين الورمي HER2neu وباستخدام تقنية الفحص المناعي المرتبط بالانزيم ELISA كانت نسبة فرط التعبير 22% بمتوسط يبلغ 17.9 نانوغرام/مل بمدى 12.8_29.9نانوغرام/مل P value<0.001, r=0.53. هناك فروقات معنوية (P <0.001) مرتبطة ما بين مستويات HER-2/neu اللنسيجية و HER-2 مصل الدم. الكشف عن مستقبلات ال Her-2neu في مصل الدم بواسطة تقنية ELISA يمكن أن تستخدم كوسيلة للكشف مع نسبة عالية وصلت إلى 78٪ بعد عملية استئصال الثدي، كما أنه تعتبرها وسيلة ممتازة لمتابعة العلاج(follow up). تعد تقنية التحليل المناعي اختبار سهل نسبيا ويمكن استخدامه لمراقبة فعالية انسجة الثدي.

Keywords

Breast Cancer --- ER --- PR --- Her2/neu


Article
Er :YAG Laser Skin Resurfacing for Perioral Wrinkles

Author: Bahir Sabah Abood Allawi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 1 Pages: 202-214
Publisher: Babylon University جامعة بابل

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Abstract

During the last decade, resurfacing lasers advanced from relative obscurity to the forefront of cosmetic and aesthetic surgery, and many surveys revealed that most plastic surgeons performing aesthetic surgical procedures incorporated laser resurfacing in their practices.The introduction of short-duration Er:YAG lasers in the mid-1990s offered another option for resurfacing, The objective of this study Was to evaluate the use of 2940nm Er:YAG laser system for the rejuvination of perioral wrinkles..A total of 20 patients with perioral wrinkles were selected for Er:Yag 2940 nm (Contour, Sciton Inc., St Palo Alto, CA) Laser resurfacing. The erbium square scan was used, with 30 to 50 percent pattern overlap at 15 to 20 J/cm2 , if wrinkles are still apparent, use a single 3-mm spot, at 7 J/cm2 and 5 Hz, to further decrease the wrinkle shoulders.The results was The range of the average grades of the wrinkles before treatment was between 4-2.1 while after treatment was between 1.2-2.7.There was 1.5 total average grade improvement in the perioral wrinkles after Er:Yag laser skin resurfacing. The Erbium:YAG laser is safe and effective it can be recommended for perioral skin resurfacing, with noticeable improvement in wrinkles, it causes tissue ablation with minimal tissue desiccation and minimal residual thermal damage. The Erbium:YAG laser associated with a shorter duration of posttreatment erythema than with carbon dioxide laser.


Article
Evaluation of PIK3CA Status in Breast Cancer and their Correlation with ER, PR, and HER-2 expressions in Iraqi female patients
تقييم حالة PIK3CA في سرطان الثدي وعلاقتها بالتعبير الجيني لـجينات ER ، PR و HER-2 في مريضات عراقيات

Author: Rand Muhammed Abdul-Hussain Al-Hussaini
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2014 Volume: 13 Issue: 2-2 Pages: 134-143
Publisher: Baghdad University جامعة بغداد

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Abstract

The present study revealed that the PIK3CA, catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is mutated in breast cancer. This study was carried out in the laboratory of molecular biology in the Department of Biology in the College of Science – Kufa University, during the period from July 2013 through March 2014. Paraffin blocks of thirty one patients with breast carcinoma were included in this study. These samples were collected from laboratory of histopathology in Alsader Teaching Hospital in Al-Najaf governorate. Six samples with normal breast tissues were considered as control group for this study. Their ages ranged from 30 to 65 years, with a mean age of 49.9 years. Carcinoma tissue samples were evaluated previously for ER, PR and HER-2 by Immunohistochemical analysis. The diagnosis was under the supervision of pathologist in the hospital. The clinicopathological assessment revealed that 14 (45.16%) were hormone dependent carcinoma: ER+PR+, 3 (9.67 %) and 9 (16.12%) were probably hormone dependent carcinoma: ER+PR-; ER-PR+, and 5 (29.03%) were hormone independent carcinoma: ER-PR-. HER-2 expression was found in 7(22.58%) of cases. Mutational analysis of PIK3CA was done in 31 breast cancers and, finally, 11 (35.48%) mutations were identified in total. The frequency of PIK3CA mutations in ER-positive tumors was significantly (p < 0.05) higher than that in ER- negative tumors , and the frequency of PIK3CA mutations in PR-positive tumors tended to be higher than that in PR-negative tumors. HER2 expression was not significantly associated with PIK3CA mutations.

أظهرت الدراسة الحالية ان PIK3CA الوحدة الفرعية المحفزة لـ phosphatidylinositol 3-kinase (PI3K) تكون طافر في حالة سرطان الثدي. اجريت هذه الدراسة في مختبر البايولوجي الجزيئي بقسم علوم الحياةص2348 في كلية العلوم جامعة الكوفة، خلال الفترة من تموز 2013 لغاية آذار 2014. تضمنت هذه الدراسة احدى و ثلاثون قالب شمع البارافين لسرطان الثدي. تم جمع هذه العينات من مختبر الامراض النسيجية في مستشفى الصدر التعليمي في محافظة النجف. ستة عينات انسجة ثدي طبيعية اعتبرت كمجموعة سيطرة لهذه الدراسة. تراوحت اعمارهم من 30 الى 65 سنة، بمتوسط عمري بلغ 49.9 سنة، تم تقييم النسيج المسرطن لـ ER، PR، و HER-2 بواسطة التحليل المناعي النسيجي الكيميائي. تم التشخيص باشراف اخصائي علم الامراض في المستشفى. اظهر التقييم المرضي السريري ان 14(45.16%) كانت سرطان معتمد على الهرمون: ER+PR+ ، 3(9.67%) و 9(29.03) كانت من المحتمل سرطان معتمد على الهرمون: ER+PR- ؛ ER-PR+ ، و 5(16.12%) كانت سرطان غير معتمد على الهرمون: ER-PR-. التعبير الجيني لـ HER-2 وجد في 7(22.58%) من الحالات. اجري تحليل طفرة PIK3CA لاحدى وثلاثون حالة سرطان ثدي، و اخيراً 11(35.48%) طفرة تم تشخيصها اجمالاً. كان تكرار طفرات PIK3CA في اورام ER-positive اعلى معنوياً (p < 0.05) من اورام ER- negative، و تكرار طفرات PIK3CA في اورام PR-psitive اعلى نوعاً ما من اورام PR- negative، لم تكن هنالك علاقة معنوية بين الـHER-2 و طفرات PIK3CA .

Keywords

PIK3CA --- Breast cancer --- HER-2 --- ER


Article
Correlation and frequency of HER-2/neu Status With Estrogen and Progesterone Receptors in Breast Carcinomas

Authors: Nazar J. Metib --- Haider Jebur Kehiosh --- Sabah K. Hamzah
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2016 Volume: 9 Issue: 2 Pages: 2588-2599
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Breast cancer is the most common malignant tumor in Iraqi females accounting for a third of registered female cancers. Prognosis and management are influenced by the classic variables such as histologic type and grade, in addition to tumor size, lymph node status, status of hormone receptors of the tumor and HER-2/neu status. HER-2/ neu, also known as c-erb B-2 (HER-2), a proto-oncogene located on chromosome 17, is amplified and/or the protein (HER-2) overexpressed in 15% to 25% of invasive breast carcinomas and is associated with a worse clinical outcome. The interrelationship of ER(estrogen receptor), PR (progesterone receptor), and HER-2 expression in invasive breast cancer has come to have an important role in the management of breast cancer. It has been shown that patients with breast carcinoma overexpressing HER-2 do not respond to tamoxifen therapy.Objectives: To evaluate HER-2/neu overexpression in breast cancer by immunohistochemical study and to study the correlation between HER-2/neu status and expression of ER and PR receptors and other clinicopathological features in invasive breast carcinoma.Patients and methods: Immunohistochemical analyses were performed successfully for ER, PR, HER-2/neu by streptavidin biotin indirect immunohistochemical methods using monoclonal antibodies for 41 specimens of formalin-fixed, paraffin embedded breast cancer tissue.Results:. There was a significant difference in HER-2/neu overexpression between invasive ductal carcinoma of NOS (Not Otherwise Specified) type from other histopathologic types (lobular, and specified type ductal carcinoma). No significant correlation was observed between HER-2/neu overexpression and higher histological grades of invasive ductal carcinoma. The expression of ER or PR was decreased significantly in HER-2/neu positive tumors in comparison with HER-2 negative tumors .Only 7.3 % of all cases (3/41) were negative for estrogen , progesterone receptors (ER/PR) and HER2/neu oncoprotein (Triple negative breast cancers).The two cases of lobular carcinoma and the three cases of the special-type carcinomas were negative for HER-2/neu. Conclusions: HER-2/neu protein was expressed more in ductal carcinoma ( NOS type ) than in lobular or in carcinoma of special type and frequently detected in higher-grade invasive ductal carcinoma tumors.The expression of ER or PR was decreased significantly in HER-2/neu positive tumors. HER-2/neu positivity was not correlated with other clinico-pathological parameters like age of the patient, menopausal state, primary tumor size and axillary lymph nodes status.

Keywords

Breast carcinomas --- HER-2/neu --- ER --- PR


Article
Predictability of the Expression of ER, PR Receptors, HER2 and AgNORs in Breast Carcinoma among Iraqi Women in Thi - Qar Province: Immunohistochemical study
إمكانية التنبؤ عن التعبير الجيني لمستقبلات الاستروجين والبروجسترون ومُــــوسمــــــــــــــات الورم ومناطق التنظيم النووي لسرطان الثدي بين النساء العراقيات في محافظة ذي قار( دراسة نسجيه مناعية )

Authors: Hayfaa Abid Ali هيفاء عبد علي --- Doha Kadhim Najam ضحى كاظم نجم
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2017 Volume: 6 Issue: 2 Pages: 33-38
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

This study is descriptive exploratory in Thi – Qar providence for some breast cancer patients .The study aims of the study to assess the relationship between ER,PR,HER2 and the nuclear regulatory regions Argyrophilic nucleolar organizer region (AgNOR ( in breast cancer. The present study addressed the identification the nuclear organization region in the breast cancer patients in Thi- Qar providence and the extent of their association with ER, PR and HER2 in the occurrence of breast cancer.Fifty tissue samples collected from Hussein Teaching Hospital in Thi Qar and some private laboratories in the province with the province of each case data included the most important factor is age, found that the highest percentage of injuries, age (55-46 years) increased by 38%. And mixed samples. Either partial removal of the tumor or whole breast.The results of the current study showed that there was a clear positive relationship between nuclear organization regions and breast cancer, as it was noted the presence of many of the nuclear regions of the dye-derived tissue sections of tumors while nuclear chromosomal regions did not appear in the sections derived from tumors with negative expression of estrogen receptor and progesterone hormone.

أجریت هذه الدراسة الوصفیة الاستطلاعیة في محافظة ذي قار لبعض مرضى سرطان الثدي , اذ هدفت هذة الدراسة الى تقييم العلاقة بين التعبير الجيني الايجابي لكل من مستقبلات الاستروجينER- Estrogen-receptor والبروجيسترون PR -Progesterone receptor و مٌوسمــــــــــــــات الورمHER2 (Human epidermal growth factor receptor) باستخدام تقنية كيميائيه الاصباغ المناعية وبين مناطق التنظيم النووي Argyrophilic nucleolar organzier region (AgNOR) . تناولت الدراسة الحالية تحديد العلاقة بين مناطق تنظيم النوى والمستقبلات الهرمونية الاستيروجين والبروجيسترون والعامل الوراثي ومدى ارتباطهن بحدوث سرطان الثدي .خمسون عينة نسيجية تم جمعها من مستشفى الحسين التعليمي في محافظة ذي قار وبعض المختبرات الخاصة في المحافظة مع البيانات الخاصة بكل حالة حيث تضمنت اهم عامل وهو العمر,حيث وجد ان اعلى نسبة اصابات بعمر (55-46)سنه بنسبة 38% . وتباينت العينات ،إما باستئصال جزئي للورم او استئصال كلي للثدي. وأظهرت نتائج الدراسة الحالية أيضا أن هناك علاقة إيجابية واضحة بين مناطق التنظيم النووية وسرطان الثدي، كما لوحظ وجود العديد من المناطق النووية من المقاطع الأنسجة المشتقة من صبغ الأورام في حين لاتظهر المناطق تنظيم النوى في المقاطع المأخوذة من الأورام ذات التعبير السلبي لمستقبلات هرمون الاستروجين وهرمون البروجسترون.

Keywords

ER --- PR --- HER2 --- AgNOR --- Breast cancer

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