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Article
Glucose 6 phosphate dehydrogenase deficiency among neonates with hyperbilirubinaemia in western Iraq

Author: Sahar J Al-Hiali
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 431-434
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Glucose -6-phosphate (G6PD) deficiency seems to be a major cause of neonatal hyperbilirubinaemia. This study was carried out to determine the prevalence of G6PD deficiency among icteric neonates in western Iraq and to evaluate its association with hemolysis in neonatal jaundice.
Patients and Methods: All icteric neonates admitted to Al-Ramadi Maternity and Paediatrics hospital, Al-Anbar governorat, for the period from 1st Feb. to 1st Dec. 2006 were included in the study. Data collected from case records and includes age, sex, total serum bilirubin hemoglobin level, reticulocyte count, blood group and Rh of the mothers and neonates, direct coomb's test and peripheral smear. G6PD enzymewas measured also.
Results: eight out of 100 icteric neonates had G6PD deficiency, with male to female ratio of 7:1. A significant higher total serum bilrubin (TSB) level was among G6PD deficient icteric neonates than that among non deficient icteric neonates. Reticulocytes count and haemoglobin level was not significantly differ between G6PD deficient and non deficient icteric neonates.
Conclusion: Neonatal screening for G6PD deficiency is a need in order to control genetic blood diseases.

Keywords

G6PD deficiency --- haemolysis --- TSB


Article
G6PD Deficiency in Syria: Identification of the Mediterranean Mutation Amongst Hemolytic Anemia Patients

Author: Ghalia Aboualchamat
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2019 Volume: 18 Issue: 2 Pages: 193-200
Publisher: Baghdad University جامعة بغداد

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Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked genetic disorder. More than 400 million individuals are affected globally. The most common clinical manifestations are neonatal jaundice and acute hemolytic anemia. Numerous mutations have been described in the G6PD gene, many exhibit region-specific distributions. The G6PD Mediterranean mutation is frequently found in the Mediterranean region. However, in Syria no previous studies were conducted on G6PD deficiency disorder on its molecular basis. The aim of this study was to screen for the Mediterranean mutation amongst hemolytic anemia patients, as a preliminary search to determine the frequency of G6PD mutations in the Syrian society. A total of 265 children with hemolytic signs presented to Children's University Hospital in Damascus, were enrolled in this study. Genomic DNA was extracted from 197 patients for genotyping, and the Mediterranean mutation has been determined by PCR-RFLP method. Our result showed that 30% of cases have a positive family history for G6PD deficiency. The Male to female ratio was 1.6:1. Mediterranean mutation was detected in 164 case (83%) with an allele frequency of 0.65. High prevalence of Mediterranean mutation in our study strongly suggests the need for nationwide screening to determine the prevalence of the deficiency in the Syrian society. Further expanded studies are needed to evaluate other mutations in the G6PD gene.


Article
Glucose-6-Phosphate Dehydrogenase Deficiency among Neonate with Jaundice in Baquba city
نقص انزيم الغلوكوز 6 فوسفات ديهيدروجيناز بين حديثي الولادة مع اليرقان في مدينة بعقوبة

Authors: Hadeel Ahmed Jasim هديل احمد جاسم --- Nadhim Ghazal Noaman ناظم غزال نعمان --- Shefaa Mansour Hemza شفاء منصور حمزة
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2019 Volume: 16 Issue: 1 Pages: 55-62
Publisher: Diyala University جامعة ديالى

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Abstract

Background:Glucose -6-phosphate dehydrogenase (G6PD) deficiency is the commonest genetic disorder and is one of the most frequent red cell enzymopathies worldwide, Individuals with this disorder are prone to jaundice and hemolysis upon exposure to certain triggers, including fava bean consumption & certain drugsObjective:To determine the rate of G6PD deficiency among neonate with jaundice and in relation to certain epidemiological character in Baquba city.Patients and Methods: This cross sectional study includes (155) neonates from both sex, males (106) and females (49) From 1st February to 30th July 2018, in neonatal care unit in Albatool Teaching Hospital in Baquba city, the diagnosis was done by ELISA test to detect G6PD deficiency among neonate with jaundice.Results: Out of 155 neonates, showed male neonates & female neonate, 39 (97.5%), 1 (2.5%) respectively were found to have G6PD deficiency, the mean age among G6PD deficient and normal 3.0±1.6; 4.3±2.4 days respectively, with significant difference (P 0.001), the mean TSB level among G6PD deficient neonate, normal neonates were 17.4±3.55, 15.9±3.19 (mg/100 ml) respectively with significant difference (P 0.014).Conclusion: The rate of G6PD deficiency was (25.8%) among the studied neonates, It was discovered more among first, second and third age of life and it was more among male than female.

خلفية الدراسة: يعتبر فقر الدم الانحلالي (G6PD) هو أكثر الأمراض الوراثية شيوعًا وهو أحد أكثر أنواع نقص إنزيمات الخلايا الحمراء في العالم ، فالأفراد الذين يعانون من هذا الاضطراب معرضون لليرقان وانحلال الدم عند التعرض لمحفزات معينة ، بما في ذلك استهلاك الفول. بعض الأدوية.اهداف الدراسة: هدفت هذه الدراسة إلى تحديد معدل نقص انزيم G6PD بين الاطفال حديثي الولادة المصابين باليرقان في مدينة بعقوبة. المرضى والطرائق: تشمل هذه الدراسة المقطعية (155) طفل حديث الولادة من كلا الجنسين ، الذكور (106) والإناث (49). للفترة من 1 فبراير إلى 30 يوليو 2018 ، في وحدة العناية بالأطفال حديثي الولادة في مستشفى البتول التعليمي في مدينة بعقوبة ، تم إجراء التشخيص بواسطة اختبار ELISA للكشف عن نقص انزيم G6PD بين الاطفال حديثي الولادة المصابين باليرقان.النتائج: من أصل 155 مولود ، أظهرت الدراسة ان نسبة نقص انزيم G6PD بين الاطفال حديثي الولادة من الذكور و الاناث كانت ، 39 (97.5 ٪) ، 1 (2.5 ٪) على التوالي، متوسط العمر بين الاطفال المصابين بنقص انزيم G6PD والاطفال الغير مصابين كان 3.0 ± 1.6 ؛ 4.3 ± 2.4 يومًا على التوالي ، مع وجود فرق معنوي (P 0.001) ، متوسط مستوى TSB بين الاطفال حديثي الولادة المصابين بنقص انزيم G6PD والغير مصابين كانت 17.4 ± 3.55 ، 15.9 ± 3.19 (مجم / 100 مل) على التوالي بفرق كبير (P 0.014).الاستنتاجات: معدل نقص انزيم G6PD بين الاطفال حديثي الولادة كان ((25.8 ٪ ،وان معدل نقص الانزيم تم اكتشافه أكثر بين الاطفال في اليوم الأول والثاني والثالث من العمر وكان أكثر شيوعا بين الاطفال الذكور من الإناث.

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