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Article
Gastric Cancer Staging Comparism and Role of EUS

Authors: Aqeel Shakir Mahmmod --- Talib A.Majid --- Waseem Mohammed Shakir
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 1 Pages: 36-40
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:The tumor stage of gastric cancer in the preoperative period must be evaluated to choose the type of therapy so the preoperative imaging diagnosis is the basis for a tumor–stage –adapted therapy of each patient .OBJECTIVE:Is to compare between the preoperative staging of gastric cancer which includes the ultrasound scan, CT scan and EUS findings and the postoperative staging which include the histopathological finding and to assess the efficacy of EUS in determining the tumor and lymph node stage of tumor.PATIENT AND METHODS:Prospective study of 32 patients with gastric cancer admitted to the surgical word in the gastroenterology and hepatology teaching hospital, medical city, Baghdad over the period from Nov. 2005 to Nov. 2007 who underwent gastric resection , all the cases were proved to be gastric cancer by endoscopic biopsy or by histopathological examination of the gastric specimen after operative resection, and all the cases radiologically investigated in the preoperative period by abdominal ultrasound, endoluminal ultrasound and abdominal CT scan.RESULTS:Show that there is increase in the staging in 18 (56.25%) cases and same staging in 8 (25%) cases and decrease staging in 6 (18.75%)cases.CONCLUSION:Endoluminal ultrasound is most accurate preoperative investigation to determine staging of gastric malignancy. Ultrasound and CT scan although it is important in the assessment but they downstage the tumor in about half of cases. So we recommend that EUS is done for all patients with gastric cancer for accurate planning for surgery


Article
Association of Helicobacter Pylori Infection and Gastric Cancer

Author: Shurooq A. Lafta, Abdul Hussein M. ALFaisal
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 1 Pages: 1-9
Publisher: Baghdad University جامعة بغداد

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Abstract

Helicobacter pylori (H. pylori) is the most important etiologic factor for gastric cancer. It is one of the most common human pathogens, which colonizes in the mucus layer of the gastric epithelium in more than 50% of the population. The study include 78 samples of gastric cancer in addition to 42 blood samples. The results from 78 gastric cancer samples showed that gastric cancer can occur red at any age, but it increases in older ages and the incidence of H. pylori infected positive gastric cancer (HIP-GC) is higher than of H. pylori infected negative gastric cancer (HIN-GC). Male is the predominant in both groups and female affected by H. pylori more than male and the intestinal type was the predominant type.


Article
Study the relation of gastric cancer with helicobacter pylori infection among dyspeptic patients

Author: Wasan Hatem Rzooqi , Muna Turkey Al-Mossawei
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 3 Pages: 159-168
Publisher: Baghdad University جامعة بغداد

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Abstract

Helicobacter pylori (H. pylori) is the main causative agent of gastrointestinal diseases including chronic gastritis, peptic ulcer associated disorders, gastric and duodenal carcinomas leading to morbidity and mortality in humans. This research was conducted to study the relation of gastric cancer with H.pylori infections through some invasive methods(Histology, Direct biopsy smear, Biopsy urease test and culture methods). One hundred and twenty five dyspeptic patients were subjected to esophageal gastroduodenoscopy in Baghdad Teaching Hospital/ Endoscopy unit from10/1/2013 to 8/1/2014, gastric biopsy samples were applied for microbiological analysis. The results showed that there was a relationship between H. pylori infection occurrence and endoscopically diagnosed Gastric cancer (3.2%); it was recorded highest H. pylori isolation (45.45%) from gastric ulcer patients followed by (25%) from gastric cancer patients. Histological examination recorded that active gastritis is found to be the most infected case (93.75%) with H. pylori followed by gastric adenocarcinoma (66.66%) gastric lymphoma (50%), so the study recorded a significant association between H .pylori infection and gastric cancer.


Article
Uses of CD31 monoclonal Antibody for the Assessment Of Angiogenesis as a prognostic Factor in Gastric Adenocarcinoma

Author: . Ikbal A.H.AI-Kaptan
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 1 Pages: 51-59
Publisher: Baghdad University جامعة بغداد

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Abstract

Background &objectives: Angiogenesis plays an important role in the growth, progress and the metastasis of solid tumors. This study was done to determine the significance of angiogenesis as another prognostic factor in gastric carcinoma in an attempt to identify the patients at high risk of recurrences after surgical therapy who may benefit from postoperative adjuvant therapy.In this study the correlation between the microvessel count(MVC) and the various clinicopathological factors was investigated. A highly significant statistical correlation was found between the mean microvessel count in different histological grades and the stage of gastric adenocarcinoma .No correlation was found between the MVC and the age and sex of the patients , the size, location and the macroscopical appearances of the tumorsPatients and Methods: Fifty seven cases of gastric adenocarcinoma were reviewed from private pathology laboratories during the period between 2000-2002 , including 33 males and 24 females. The age ranged between 20-80 years ,the peak incidence was in the sixth decade . The specimens were formalin- fixed paraffin embedded, and the 5 microns thick sections were stained with Haematoxylin & Eosin stains .Immunohistological staining with CD 31 was performed on all sections. The microvessel count (MCV) was performed on the areas of the highest neovascularization i.e. hot spots. Five hot spots were selected the MVC was done under X200 magnification in light microscope .The relationship between the MVCand the variousclinicopathological factors were assessed. ( Statistical analysis was done using SPSS system version 10.0 computer software. Student “T” and “F” test were used and the differences were regarded as significant when the P value was less than 0.05.Result:: Using CD 31 an endothelial cells marker monoclonal antibody shows that the MVC was 35 in well differentiated adenocarcinoma and 48.22 in the poorly differentiated tumors. In tumors with no serosal invasion the MVC was 26.5 while in case s with serosal invasion the MVC was 87.7. In cases of negative lymph nodes metastasis the MVC was 27.7 while in cases with positive lymph nodes metastasis the MVC was 43.56.Conclusion : Evaluation of angiogenesis by counting the microvessels using the monoclonal antibody CD 31 as an endothelial cell marker on tissue sections proved to be a helpful and a useful prognostic factor to predict the poor prognosis in gastric cancer patients.


Article
Experience Of Gastric Cancer In Al- Sadder City in Baghdad

Author: Maytham Hatam Shahid, Saad Ramadan Jawad, Asaad Abdullah Abbas
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 2 Pages: 129-137
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: The aim of the study is to assess the following points among the patients with gastric cancer admitted to the surgical wards in Imam Ali Hospital- Al- Sadder City- Baghdad.•Sex and age distribution. •Mode of presentation.•Results of endoscopic findings and histopathology.•Risk factors and tumour staging.•Treatment options.PATIENTS AND METHODS:A prospective study was done in Imam Ali Hospital for a period of six years from (January 2009 to December 2014) where fifty cases with biopsy proved gastric cancer had been assessed. The age and sex distribution, mode of presentation, site of the tumour, macrosopical appearances histopathological findings, risk factors and treatment options were analysed.RESULTS: The male to Female ratio was 1.4:1, peak age incidence was 60-70 years, non-specific symptoms such as vague epigastric pain, dyspepsia, anorexia, weight loss were the most common symptoms; esophagogastric junction was the commonest site, polypoid type was the commonest endoscopic finding (44%); upper gastrointestinal endoscopy with biopsy was the most accurate method of diagnosing gastric cancer; Adencarcinoma was the most frequent histopathological type (96%); cigarette smoking is the predominant risk factor (64%) (32, 33, 34, 35); In the majority of those patients the disease was advanced and the curative measures were not possible.CONCLUSION: Gastric cancer remains a significant problem in Iraq, it's one of the most popular malignancies (ninth most common in Iraq) (37). No age group of both sexes can be excluded. Late presentation is a stigmata of the disease and the gloomy prognosis can only be improved by early detection based on a more vigorous diagnostic approach following a high risk index of suspicion in individuals at risk.


Article
Immunohistochemical assessment of Cox-2, and ki-67 expression in gastric cancer
التقييم المناعي الكيميائي النسيجي لتعبير Ki-67 و Cox–2 في سرطان المعدة

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Abstract

Cell proliferation characteristics may reflect the aggressiveness of gastric cancer and their eventual prognosis. The aim of this study was to evaluate whether the proliferative activities determined by Ki-67 labeling index (LI) could be used as a predictor in patients with gastric cancer, and examine the relation between COX-2 and Ki-67 expression and gastric cancer. The expression of COX-2 and Ki-67 were detected in 40 patients with gastric cancer and 30 healthy individuals were assessed by immunohistochemistry. The biopsies were fixed in 10% buffered formaldehyde solution, embedded in paraffin and stained immunohistochemically with anti-human COX-2 and Ki-67 antibodies. Expression of Ki-67 andCOX-2was significantly higher in tumor compared with control samples.A significant correlation was found between COX-2 and Ki-67 protein expression. In conclusion,the expression of COX-2 and Ki-67 proteins was closely connected with gastric cancer.

خصائص تكاثر الخلايا ربما تعكس خطورة اورام المعدة . الهدف من هذه الدراسة هو تقييم فيما اذا كانت الانشطة التكاثرية التي تحدد بواسطة Ki-67 ربما تستخدم كمؤشر في المرضى الذين يعانون من سرطان المعدة وتحديد العلاقة بين Ki-67 و Cox–2 في هؤلاء المرضى. تم الكشف عن تعبيرKi-67 و Cox–2 في 40 مريض يعانون من سرطان المعدة و 35 شخص سليم بواسطة تقنية التحليل المناعي الكيميائي. ثبتت الخزعة النسيجية في 10 % من محلول الفورمالين وطمرت بالبرافين وصبغت بواسطة التحليل المناعي الكيميائي مع مضادات وحيدة النسيلة منKi-67 و .Cox–2 ظهر تعبير Ki-67 و Cox–2 اعلى في الورم مقارنة بمجموعة السيطرة ووجد هناك ارتباط بينهما. الاستنتاج: تعبيربروتينKi-67, Cox–2 يرتبط بصورة قوية بسرطان المعدة.

Keywords

COX-2 --- Ki-67 --- gastric cancer --- COX-2 --- Ki-67 --- gastric cancer


Article
IL-10 serum level estimation in Iraqi colorectal and gastric cancer patients
قياس مستوى IL-10 في مصل المرضى العراقيين المصابين بسرطان القولون والمستقيم وسرطان المعدة

Author: Ahmed R. Abdulla احمد رشدي عبد الله
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2012 Volume: 54 Issue: 2 Pages: 167-171
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Gastrointestinal cancers (GITc) is a worldwide problem. In Iraq , Gastric cancer is the 9th commonest of the top cancers while colorectal cancers it is considered as the 7th commonest ten cancers.IL-10 appears to be more of a pro-tumor than anti-tumor properties in both colorectal and gastric cancers.Objective:is to estimate the serum level of IL-10 in the Iraqi colorectal and gastric cancer Patientsand its relation to the progress of disease.Patients and Methods:In ourstudy ,54 serum samples werecollected starting from the 1st of January to mid of March 2011, to investigate the IL-10 serum level by using ELISA kit. 38colorectal and gastric cancer patients (H.Pylori +ve) and 16 of healthy control group.Results: The results showed that IL-10 serum levels of both GIT tumors were increased significantly (p<0.05) comparing with the healthy control group.Conclusion:In conclusion, the high serum level of IL-10 in colorectal cancers is due to the pro-tumor properties of IL-10 while in gastric cancer while the association of IL-10 genotypes specifically the single nucleotide polymorphism of the IL-10 promoter region may be the source of its serum increasing level. Keywords: IL-10, Colorectal Cancer, Gastric Cancer.

سرطانات الجهاز الهضمي تعتبر من المشاكل الصحية العالمية. في العراق يعتبر سرطان المعدةبالمرتبة التاسعة ضمن قائمة العشر من حيث الترتيب للتسجيل السرطانيأما سرطان القولون والمستقيم فهو في المرتبة السابعة.الغاية من الدراسة :هذه الدراسة لغرض معرفة مستوى IL-10فيمصلالمرضىالعراقيينالمصابينبسرطانالقولونوالمستقيموسرطانالمعدة وعلاقته بتطور السرطان.طريق البحث :في هذه الدراسة كان هناك 54 عينة مصل جمعت إبتداءا من الأول من كانون الثاني والى حد منتصف آذار 2011 للكشف عن مستوى IL-10 و باستخدام تقنية ELISA وقد قسمت إلى 38 عينة للمصابين بسرطان القولون و المستقيم وسرطان المعدة (موجب الإصابة ببكتريا H.Pylori ) و16 عينة اعتبرت مجموعة سيطرة .النتائج أظهرت زيادة معنوية (P<0.05) في مستوى IL-10 لكلا النوعين من السرطانات مقارنة بمجموعة السيطرة . الاستنتاج :استنتجنا من خلال هذه الدراسة أن الزيادة المعنوية (P<0.05) لمستوى IL-10 في كلا نوعي السرطانات مقارنة بمجموعة السيطرة ممكن أن يكون بسبب قابليته على مساندة استمرار النمو السرطاني في سرطان القولون والمستقيم و ارتباط هذه الزيادة بتركيبه الوراثي في سرطان المعدة. مفتاح الكلمات: سرطان القولون، سرطان المعدة


Article
Increasing serum level of transforming growth factor beta 2 (TGF-β) in patients with colorectal and gastric cancer in Iraq
إرتفاع مستوى Transforming growth factor beta2 (TGF-β) في مصل مرضى سرطانات القولون والمستقيم والمعدة في العراق

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Abstract

Gastrointestinal cancers (GITs) are worldwide problem particularly in highly developed countries. In Iraq, gastric cancer(GC) is the 9th most common cancer while colorectal cancers (CRC) is considered as the 7th most common cancer among all cancer patients in both males and females. The Objective of this study was to estimate the serum level of transforming growth factor beta 2 (TGF-β) in Iraqi patients who are complying from gastric and colorectal cancers. Fifty four serum samples were collected starting from the 1st of March till the mid of May of 2011 to investigate the TGF-β serum level by using ELISA technique. Thirty eight samples were gastric (H.pylori +ve) and colorectal cancer patients (GC=17, CRC=21) while the other 16 samples considered as a healthy control group. The results showed that TGF-β serum levels of both GIT tumors were increased significantly (p<0.05) compared to the healthy control group. In conclusion, the presented study showed elevated serum level of TGF-β in Gastric cancer patients which could point out to use this elevation as a biomarker for tumor prognosis; while in colorectal cancer it may evade the immune system cancer killing mechanisms. We recommend further studies concerning the correlation between serum level of TGF-β in Gastric cancer patients with staging and grading, and more immunological techniques can be implied to know the exact immunological evading mechanism of colorectal cancer cells.

يعتبر سرطان الجهاز الهضمي من أكثر المشاكل الصحية في العالم خاصة في البلدان المتقدمة أو ما يسمى ببلدان العالم الأول . أما في العراق وحسب احصائيات مجلس السرطان التابع لوزارة الصحة فيحتل سرطان المعدة الترتيب التاسع وسرطان القولون والمستقيم الترتيب السابع ضمن قائمة العشر اورام الأكثر انتشارا بين الرجال والنساء المصابين بمرض السرطان . كان الهدف من هذه الدراسة هو قياس مستوى 2TGF-β في مصل المرضى العراقيين المصابين بسرطان المعدة والقولون والمستقيم ، وقد جمعت 54 عينة مصل إبتداءا من الأول من اذار وانتهاءا بمنتصف مايس من سنة 2011 لقياس مستوى 2TGF-β باستخدام تقنية الاليزا ELISA ، 38 منها كانت لمرضى سرطان المعدة (H.pylori +ve) وسرطان القولون والمستقيم ( سرطان المعدة :17 حالة ، سرطان القولون والمستقيم : 21 حالة) و الباقي (16عينة) تم جمعها من أفراد أصحاء رجال ونساء والتي اعتبرت مجموعة سيطرة . أظهرت النتائج ارتفاعا في مستوى TGF-β في مصل المرضى المصابين بكلا نوعي السرطان وبشكل معنوي (p<0.05) مقارنة بمجموعة السيطرة . من خلال هذه الدراسة استنتجنا ان ارتفاع مستوى β TGF- في مصل مرضى سرطان المعدة قد يعكس مآل سيء اوخطير لحالة المريض بالمقارنة مع الدراسات الدولية المشابهة ، بينما في سرطان القولون والمستقيم قد تكون هي احدى آليات هروب الخلايا السرطانية من الفعاليات القاتلة لجهاز المناعي .


Article
Expression of Cyclooxygenase-2 (COX-2) in Helicobacter Pylori Premalignant and Malignant Gastric Lesion, the Association with Tumor Angiogenesis.
ظهور انزيم الاكسدة الحلقية (COX-2) في ورم المعدة وماقبل ورم المعدة بوجود بكتريا الملويات البوابية وعلاقته بورم تكوين الاوعية الدموية

Author: Wasan A. Bakir وسن عبدالاله باقر الطائي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2013 Volume: 26 Issue: 1 Pages: 56-62
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: Cyclooxygenase-2 (Cox-2) is a central mediator in inflammation and cancer. Expression of the Cox-2 gene is up-regulated in the gastric mucosa during H. pylori infection.Vascular endothelial growth factor (VEGF) has a potent angiogenic activity and cyclooxygenase-2 (COX-2) promotes angiogenesis by modulated production of angiogenic factors including VEGF.Aim: investigate the distribution and intensity of COX-2 and VEGF expression in premalignant and malignant gastric lesions with H. pylori.Material and Methods: Gastric biopsies from patients with chronic active gastritis and gastric adenocarcinoma, and control group were studied. Immunohistochemical analysis was used to examine the expression of COX-2 and VEGF in 81 cases of patients, including 30 cases with chronic gastritis infected with H. pylori, 51 cases of gastric cancer, 42 cases from GC have H. pylori and 30 cases with normal mucosa and none infected with H. pylori as control group.Results: In H. pylori-infected patients, COX-2 expression was predominantly found in the epithelium and, to a lesser extent, in the lamina propria. In the non infected group, few cases demonstrated weak COX-2 expression. Intensity of COX-2 was significantly different between the chronic active gastritis, gastric adenocarcinoma groups and control group. The positive rate of COX-2 was increased from chronic gastritis (60%), to gastric cancer (88.09%) in patients with H. pylori, compared with negative ones (22.58%). COX-2 was expressed in 23 of 24 intestinal types and in 14 of 18 diffuse types' carcinomas. The negative VEGF carcinomas have turned positive for COX-2 only for 76.92% of the cases. Different from those, the positive VEGF carcinomas have associated COX-2 immunoreactivity in 93.10% of the cases. Conclusions: These results suggest that COX-2 may play an important role in carcinogenesis by stimulating tumor angiogenesis. Also, show a relation between the expressions of COX-2 and VEGF in gastric carcinomas and the value significantly higher in the positive COX-2 carcinomas, suggesting an intense angiogenesis activity in that group of tumors.Keywords: Gastric cancer, Cox-2, H. pylori, tumor angiogenesis, VEGF

الخلاصة: انزيم الاكسدة الحلقية-2(COX-2) يعتبر وسيطا رئيسيا في الالتهاب والسرطان. اظهار جينات COX-2 يتم تنشيطها في الغشاء المخاطي للمعدة نتيجة للاصابة بخمج الملويات البوابية. عامل نمو بطانة الاوعية الدموية (VEGF) تمتلك نشاط فعال على الاوعية الدموية وCOX-2 يعزز تولد الاوعية الدموية بواسطة تنظيم انتاج عامل الاوعية الدموية الذي هو (VEGF) . الهدف من الدراسة: فحص توزيع وشدة تعبير COX-2 و VEGF في افات ماقبل تحولها الى سرطان المعدة وسرطان المعدة بوجود بكتيريا الملويات البوابية وعلاقته بورم الاوعية الدموية.المواد وطرائق العمل: اخذت خزع من المرضى المصابين بألتهاب المعدة المزمن وسرطان المعدة وكذلك من مجموعة السيطرة. استخدم التحليل المناعي الكيميائي لفحص اظهار COX-2و VEGF الدموية في 81 حالة من المرضى تضمنت 30 حالة لديها التهاب المعدة المزمن ومصابة بالملويات البوابية، 51 حالة من حالات الاصابة بسرطان المعدة منها 42 حالة مصابة بالملويات البوابية، 30 حالة تملك غشاء مخاطي طبيعي وغير مصابة بالملويات البوابية والتي اعتبرت مجموعة سيطرة. النتائج: في المرضى المصابين بالملويات البوابية، وجد في الغالب ظهور COX-2في الخلايا الطلائية للمعدة والى حد اقل في الصفيحة المخصوصة. اما المجموعة الغير مصابة بالملويات البوابية لوحظ ظهور COX-2في حالات قليلة وبشكل ضعيف. شدة ظهور هذا الانزيم يختلف معنويا بين التهاب المعدة المزمن و سرطان المعدة و مجموعة سيطرة. النسبة الموجبة COX-2 تزداد في التهاب المعدة المزمن بنسبة60% الى سرطان المعدة 88.09% المصابين بالملويات البوابية، مقارنة بالاشخاص الغير مصابين بالملويات البوابية 22.58%. COX-2يظهر ب23 من 24 شخص لديهم النوع المعدي من سرطان المعدة و14 من 18 شخص مصابين بالنوع المنتشر. السرطانات السالبة VEGF تكون موجبة COX-2فقط بنسبة %76.92 من الحالات، وهذا يختلف في حالة السرطانات الموجبة VEGF حيث تكون النسبة 93.10% من الحالات.الاستنتاج: ان النتائج تشير الى ان COX-2يلعب دورا مهما في حدوث سرطان المعدة بواسطة تحفيز الاوعية الدموية السرطانية. وايضا هناك صلة بين ظهور كل من ان COX-2و VEGF في سرطان المعدة حيث تكون القيمة اعلى معنويا في حالة الاورام السرطانية الموجبة COX-2، مما يشير الى نشاط الاوعية الدموية الشديد في هذه المجموعة من الاورام.


Article
Her 2/Neu Overexpression in Gastric Cancer

Author: Nadwa Subhi Al-Azow
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 268-272
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND :Overexpression of Human epidermal growth factor receptor 2(Her2/neu)Protein has been observed in many human cancers including gastric cancer . Gastric cancer remains the most common cause of cancer –related death worldwide. Her2/neu overexpressionin gastric cancer associated with poor prognosis and shorter survival rate , the assessment of this protein for selection of eligible patients for treatment with trastzumab in addition to conventional chemo therapy.OBJECTIVE: To evaluate the Her2/neu over expression in gastric cancer by immunohistochemicalTechnique and to find the correlation between the protein exopression and clinicopathological Parameters as age ,sex, histological types and grade of the tumor.MATERIALS AND METHODS : This is a pro-& retrospective study conducted at the pathology department of Al-Jamhuri Teaching hospital and some private laboratories . A total of 30 cases of gastric cancer were collected and diagnosed in the period spanning from April 2010 to April 2012, .An immunohistochemical technique was used for the assessment of Her2 against age,sex, histological types and grade of tumor RESULTS : The mean age of the patients was 54.5 years ranging from 30 to 87 years, Her2/neu overexpression was shown in 30% of the cases , in this study there is no relation between Her2 positivity and age or sex, , it was associated with histological types p-value = 0.04,where as 42.6 % of the intestinal type show immunoreactivity and 11.1% of diffuse type,while two cases of mixed types were shown no reactivity(0.0% ). Her2 positivity was associated with moderate differentiated tumor (50%) more than poorly differentiated (20%) but not reaching the statistical significance.CONCLUSION: Her2/neu positivity was found in 30% of gastric cancer , there is no relation between the age or sex of the patient & Her2 positivity while intestinal type and moderately differentiated tumor were associated with high percentage of Her2 positivity.

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