research centers


Search results: Found 25

Listing 1 - 10 of 25 << page
of 3
>>
Sort by

Article
Open Access Esophagogastroduodenoscopy

Authors: Tawfiq J. Al Marzook --- Zuhair B. Kamal --- Riyadh M. Hassan
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 3 Pages: 268-271
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Summary:
Background: Open access gastroduodenoscopy allows general practitioners to request gastroduodenos-copy without prior referral to a specialist. Endoscopy of the upper gastrointestinal tract in experienced hands has definite advantages over conventional barium-meal examination.
Patients and Methods: A total of 266 patients who were referred directly from general practitioner or a specialist attending for esophagogastroduodenoscopy (EGD) to the Endoscopy Unit At Al-Kindi Teach-ing Hospital from September- 2008 to Feb-2010 as an open access policy. Six inclusion criteria were used to include patients in our study group , while 136 patients had underwent EGD were referred from outpatient clinics of the hospital by specialist after screening and filtration were included in the study. Data were obtained from patients include chief complaint and duration and full history of present illness with special emphasis on age, gender, symptoms (abdominal pain, vomiting, loss of weight or appetite, hematemesis, melena, dysphagia), and history of present medications. EGD was done for all patients with gastroscope Pentax EG-2985K2.8.
Results: Two hundred sixty six patients were included in the study and underwent EGD . One hundred thirty EGDs were done in this study as an open access EGD policy while 136 EGD were done for patients who were referred from outpatient clinics of the hospital. In open access EGD policy, 66.15% of patients were males and 33.85% patients were females. The most commonly affected age group which showed abnormal endoscopic findings were in the second decade of life (20-29 years) 22.31% of cases; the chief complaint was epigastric pain in 87.69% of patients. Normal EGD was found in 23.07% of patients while pathological lesions were seen in 76.93% of patients.
Gastro esophageal reflux disease (GERD) was the most common condition encountered by EGD (33.08%). While 136 patients referred from outpatient clinics of the hospital underwent EGD, 68.38% of patients were males and 31.62% of patients were females, most of the patients were in the third decade of life (28.67%), normal EGD was found in 44.12% of patients. Chronic active DU and GERD were the most common diagnoses 12.5%, 11.76% respectively.
Conclusions: The clinical assessment and the strict application of the six inclusion criteria in open ac-cess EGD policy increase the yield of diagnosis of pathological lesions and decrease the number of un-necessary EGDs in our study.

Keywords

Gasteroscopy --- gastritis --- endoscope


Article
Increase serum leptin level in Helicobacter pylori infection in Iraqi gastritis patients

Author: Sana’a Khudhur سناء خضر
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 74-77
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: H.pylori colonized gastric mucosal epithelium will virtually develop gastritis and had the capacity to persist for decades. Pathogenesis is dependent upon strain, virulence host genetic susceptibility, and environmental cofactors. Leptin is a member of the class 1 cytokine family so altered leptin production during ifnect and inflammation that leptin part of the cytokine cascade ,which orchestrates the defense mechanism. Objective: Examin the effect of H.pylori infection on serum leptin level. Methods: One hundred and thirty(130) Patients attending the Endoscopic Unit at "Gastroenterology and Hepatology Teaching Hospital/ Baghdad Medical City"were included in this study with ages range from 18 years to 65 years are the source of specimens to undergo oesophageal gastroduodenoscopy (OGD) compared with twenty healthy control the study began from April 2009 to the end of March 2010 were eligible for this study.Tow types of samples were taken, biopsy for rapid urease test and histopathological examination to detect H.pylori and blood sample for estimation of serum leptin by ELISA test. Results: The results show significant increase in serum leptin concentration(P<0.001)in gastritis patients caused by H.pylori compared with patients control and healthy control. Conclusion: Increase of serum leptin concentration explained the role of leptin in the immune response to H.pylori infection that leptin consider as member of cytokine.

Keywords

Leptin --- H.pylori --- gastritis


Article
The Detection of Neutrophiles in Gastric Mucosa of Patients Suspected to be Infected with Helicobacter Pylori Using Leukostix

Authors: Nassir Enssief Mohsun --- Raji H AL-Hadithi --- Suhaila Saadallah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 480-483
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Helicobacter pylori has been detected in many populations and associated with inflammation of gastro duodenal mucosa. Colonization of the stomach by Helicobacter pylori occurs in more than half of human population worldwide. It is the principle cause of chronic active gastritis, peptic ulcer and gastric cancer.OBJCTIVE:To detect neutrophiles in homogenates biopsied gastric mucosa semiquantitatively using rapid leukocyte strip test (leukostix).METHODS:A total of 115 patients (74 males, 41 females) referred to The Gastrointestinal Tract Center and Gastroscopy Department of Baghdad Medical City and subjected to gastroscopy were included in this study during the period from November 2004 to May 2005.RESULTS:The sensitivity and specificity of leukostix at the initial examination were 95.8%, 88.23% respectively.CONCLUSION:The leukostix test, using biopsied samples of gastric mucosa was excellent for quantitative determination of neutrophils in patients infected with H pylori


Article
The Detection of Neutrophiles in Gastric Mucosa of Patients Suspected to be Infected with Helicobacter Pylori Using Leukostix Nassir Enssief Mohsun*,

Authors: Suhaila Saadallah *** --- Raji H AL-Hadithi**,
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 480-483
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Helicobacter pylori has been detected in many populations and associated with inflammation ofgastro duodenal mucosa. Colonization of the stomach by Helicobacter pylori occurs in more thanhalf of human population worldwide. It is the principle cause of chronic active gastritis, peptic ulcerand gastric cancer.OBJCTIVE:To detect neutrophiles in homogenates biopsied gastric mucosa semiquantitatively using rapidleukocyte strip test (leukostix).METHODS:A total of 115 patients (74 males, 41 females) referred to The Gastrointestinal Tract Center andGastroscopy Department of Baghdad Medical City and subjected to gastroscopy were included in thisstudy during the period from November 2004 to May 2005.RESULTS:The sensitivity and specificity of leukostix at the initial examination were 95.8%, 88.23%respectively.CONCLUSION:The leukostix test, using biopsied samples of gastric mucosa was excellent for quantitativedetermination of neutrophils in patients infected with H pylori.


Article
ASSOCIATION OF ATG16L1 T300A GENETIC VARIANT WITH H. PYLORI AND NONE H. PYLORI ATROPHIC GASTRITIS

Author: Haider F. Ghazi حيدر فيصل غازي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 1 Pages: 75-79
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Background: Helicobacter pylori persistence may develop atrophic gastritis, gastric ulcer or cancer.Objectives:To determine the association between the presence of autophagy related gene 16 like 1 and thrionin 300 alanine mutation and H. pylori infection among atrophic gastritis patients.Methods:Gastric biopsy was taken from eighty patients and tested for urease, and blood samples were taken for serum separation for detection of Anti-H. pylori IgG by ELISA and DNA extraction from whole blood were used for sequence specific primer – polymerase chain reaction for autophagy related gene 16 like 1 and thrionin 300 alanine mutation allelic discrimination.Results:Among 40 H. pylori positive cases, the carriers of mutated allele were 62.5% compared with 36.25% in H. pylori negative cases (p = < 0.001, OR = 1.72, CI = 1.23-2.42).Conclusions:Among Iraqi atrophic gastritis, there is an association between H. pylori infection and mutated autophagy related gene 16 like 1 and thrionin 300 alanine mutation allele. Thrionin 300 alanine may confer higher risk for infection with H. pylori.Key words: Autophagy, H. pylori, atrophic gastritis.


Article
Evaluation of CD14 expression in Helicobacter pylori positive and Helicobacter pylori negative gastritis
تقيم التعبير البروتيني للمعلم المناعي 14 عند الاشخاص المصابين وغير المصابين ببكتريا الملويات البوابية

Author: Manar Mustafa Ibraheem منار مصطفى ابراهيم
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 4B Pages: 2070-2075
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Monocytes are considered a key mediator of inflammatory cytokine secretions during inflammation. This study evaluates CD 14 expression in gastritis tissue biopsies of H. pylori and none H. pylori gastritis. This cross-sectional study involved 60 gastritis patients that have been classified into H. pylori positive (n=30) and H. pylori negative (n=30). Formalin fixed paraffin embedded tissue blocks were sectioned and immune-peroxidase staining with anti-CD14, then compared between study groups and clinical parameters. The results showed a marked difference in the percentage of expression in mild and severe intensity of inflammation sub-groups, the results showed a higher percentage of CD14 immunoreactivity (18.29±5.84 vs. 10.2±3.89, p=0.005) and (42.84±19.43 vs. 32.98±9.83, p=0.007) respectively. In conclusion, the percentage of CD14 immunoreactivity may closely related to the inflammatory gastritis induced by H. pylori bacterium.

تعتبر الخلايا وحيدة النواه المفتاح الأساسي لإنتاج النواقل الحركية الالتهابية خلال العملية الالتهابية. تهدف هذه الدراسة الى تقييم التعبير البروتيني للمعلم المناعي ١٤ في المقاطع النسيجية لالتهاب المعدة المأخوذة من اشخاص مصابين وغير مصابين ببكتريا الملويات البوابية. صممت الدراسة بصورة مقطعيه تتضمن ٦٠ شخص مصاب بالتهاب المعدة مقسمين الى مجموعتين احداها تضم ٣٠ شخص مصاب ببكتريا الملويات البوابية والمجموعة الأخرى تضم ٣٠ شخص من غير المصابين بتلك البكتريا. تم اخذ عينات خزعيه من معدة الأشخاص اثناء الفحص الناظوري بعدها تمت معاملتها لتصبح مطموره بشمع البرافين. تم فحص المعلم المناعي ١٤ على المقاطع النيسجية من المرضى بواسطه طريقة التصبيغ المناعي النسيجي الكيميائي وتم مقارنة النتائج للمجموعتين وكذلك المتغيرات السريرية. اشارت النتائج الى وجود فرق في نسبة تعبير بروتين المعلم المناعي ١٤ بين المجموعة الطفيفة والشديدة الالتهاب مما يدل على ان نسبة التعبير البروتيني للمعلم المناعي ١٤ مرتبطة بشدة الالتهاب الناتج عن وجود بكتريا الملويات البوابية.


Article
IDENTIFICATION OF HELICOBACTER PYLORI IN GASTRIC BIOPSIES OF PATIENTS WITH CHRONIC GASTRITIS: HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
تحديد ملوية بيلوري في خزعات المعدة للمرضى الذين يعانون من التهاب المعدة المزمن: د ا رسة نسيجية، كيميائية مناعية

Authors: AZAD M. BAIZEED ازاد باييزد --- INTISAR S. PITY انتصار سالم بتي
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2011 Volume: 5 Issue: 1 Pages: 69-77
Publisher: University of Dohuk جامعة دهوك

Loading...
Loading...
Abstract

Background and objectives Different methods have been used for detection of Helicobacter pylori in patients with chronic gastritis but a little has been written about immunohistochemistry. The study done was to identify Helicobacter pylori in gastric biopsies of patients with chronic gastritis using the routine stains and immunohistochemistry.Methods In a twelve month period, from April 2008 to May 2009, 105 cases of chronic gastritis were studied. The routine hematoxylin and eosin stain and modified Giemsa stains “Sheehan’s modified may method” and immunohistochemistry “automated staining machinefrom Ventana Company” were performed.Results Chronic gastritis cases (n=105) included 35 (33.3%) mild, 51 (48.6%) moderate, and 19 (18.1%) marked inflammation. Active form gastritis was detected in 76 (72.4%) cases, glandular atrophy in 40 (38.1%) cases, and intestinal metaplasia in 19 (18.1%) cases. Theroutine hematoxylin- eosin and modified Giemsa stains gave 20 (19%) false positive and 13 (12.4%) false negative results. The sensitivity and specificity of the routine stains were 77.6% and 57.4% respectively while their positive and negative predictive values were 69.2% and 67.5 % respectively with 68.6% accuracy.Conclusion Although Helicobacter pylori can be readily demonstrated by the routine hematoxylin-eosin/modified Giemsa stains, the high rates of false negative and false positive results necessitate the routine application of immunohistochemistry for all chronic gastritis cases.

خلفية واهداف البحث: تم استخدام أساليب مختلفة للكشف عن ملوية بيلوري في المرضى الذين يعانون من التهاب المعدة المزمن ولكن كتب قليلا عن الكيمياء المناعية أجريت الد ا رسة لتحديد ملوية بيلوري في خزعات المعدة من المرضى الذين يعانون من التهاب المعدة المزمن باستخدام الاصباغ الروتينية و الكيمياء المناعية.طرق البحث: خلال فترة اثني عشر شه ا ر، من أبريل 2008 إلى مايو 2009 ، تمت د ا رسة 105 حالة من التهاب المعدة و “Sheehan’s modified may method” المزمن باستخدام صبغة الهيماتوكسيلين الروتينية و صبغة غيم ا ز المحورة ."Ventana الكيمياء المناعية بطريقة "تلطيخ الآلي من شركة 48.6 ٪) حالة ) 33.3 ٪) حالة التهاب خفيفة, 51 ) النتائج: شملت الد ا رسة 105 حالة من التهاب المعدة المزمن: 35 72.4 ٪) حالة، ) 18.1 ٪) حالة التهاب شديدة. وقد مثلت التهابات المعدة المنشطة في 76 ) التهاب متوسطة، 19 18.1 ٪) حالة. وقد سببت صبغة الهيماتوكسيلين ) 38.1 ٪) حالة، وحؤول المعوية في 19 ) وضمور غدي في 40 12.4 ٪) سلبية كاذبة سلبية. وكانت حساسية ) 19 ٪) نتيجة إيجابية كاذبة و 13 ) الروتينية و صبغة غيم ا ز المحورة 20 % وخصوصية الصبغة الروتينية: 77.6 ٪ و 57.4 ٪ على التوالي بينما قيمها التنبؤية الإيجابية والسلبية كانت 69.2 .٪ و 67.5 ٪ على التوالي مع دقة 68.6 الاستنتاج: على الرغم من أنه يمكن أثبات رؤية ملوية بيلوري بسهولة من قبل الهيماتوكسيلين الروتينية و صبغة غيم ا ز المحورة، ولكن وجود معدلات نتائج سلبية وإيجابية كاذبة عالية يستلزم التطبيق الروتيني للكيمياء المناعية لجميع حالات التهاب المعدة المزمن.


Article
Association between Helicobacter pylori infection& atrophic gastritis

Author: Hayfaa S. AL-Hadithi *
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 4 Pages: 461-462
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Helicobacter pylori (H. pylori) infection is associated with gastritis and may induce atrophic gastritis have specific circulating immunoglobulin G (IgG) antibodies.
Aim of the study: To confirm the correlation between Helicobacter pylori infection and gastric atrophy.
Patient and Method: A study was conducted in the period between December 2005 and March 2006 on 25 patients with atrophic gastritis attending Gastroenterology and Hepatology Teaching Hospital in Baghdad, and 25 healthy volunteers who agreed to donate blood. Sera were tested for H. pylori IgG Ab by ELISA test.
Results and Conclusions: detection of H. pylori IgG Ab were applied to each individual, showed that (92 %) of patients with atrophic gastritis had positive H. pylori IgG Ab were as only 4 (16 %) of normal healthy individuals had positive H. pylori IgG Ab.


Article
Determination of Enzymatic Antioxidant in Iraqi Patients with Chronic Gastritis

Authors: Noah A. Mahmood --- Shalal M. Hussein --- Wasan A. Bakir
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2008 Volume: 17 Issue: 2 Pages: 26-31
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Infection of the gastric mucosa with Helicobacter pylori is strongly associated with chronic gastritis, peptic ulcer and gastric cancer. Helicobacter pylori virulence factors include a variety of proteins that are involved in its pathogenesis, such as VacA and CagA. Another group of virulence factors is clearly important for colonization of H.pylori in the gastric mucosa. These include urease, motility factors (flagellin), and Superoxide dismutase (SOD). Because of this organism's microaerophilic nature and the increased levels of reactive oxygen in the infected host, we expect that other factors involved in the response to oxidative stress are likely to be required for virulence. Superoxide dismutase is a nearly ubiquitous enzyme among organisms that are exposed to toxic environments. In this study, we measured the SOD in serum of 80 patients complain from chronic gastritis and infected with H.pylori. 37 patients infected with H.pylori have the CagA gene, and 13 patients are not and also measured the SOD in 30 control groups that not infected with H.pylori. Serum level of SOD was significantly (p<0.05) higher in patients with chronic gastritis compared to controls. Also significantly higher (p<0.001) in patients with chronic gastritis infected with H.pylori positive CagA than patients infected with H.pylori negative CagA.

إصابة الغشاء المخاطي للمعدة ببكتريا الHelicobacter pylori تترافق مع التهاب المعدة المزمن والقرحة المعدية وسرطان المعدة. عوامل الضراوة الخاصة بهذه البكتريا تتضمن أنواع من البروتينات التي تشارك في أحداث في المراضية وهي ال CagA و VagA . مجموعة أخرى من عوامل الضراوة تكون مهمة في تكوين المستعمرات في الغشاء المخاطي المعدي منها اليوريز و عامل الحركة وأنزيم ال (SOD) Superoxide dismutase الذي يتواجد في الكائنات التي تتعرض إلى وسط سام. في هذه الدراسة تم قياس مستوى الـ SOD في مصل 80 مريض كانوا يعانون من التهاب المعدة المزمن ومصابين ببكتريا ال H.pylori منهم 37 مريض مصابين ال H.pylori الحاملة لل CagA و13 مريض مريض مصابين ال H.pylori لكن غير حاملة لهذا الجين . وكانت مجموعة السيطرة تتكون من 30 شخص بحالة صحية سليمة وغير مصابين بالبكتريا. وجد أن مستوى الـ SODيزداد معنوياً (p<0.001) في المرضى المصابين بالتهاب المعدة المزمن مقارنة بمجموعة السيطرة ويزداد معنويا في مرضى التهاب المعدة المزمن المصابين ببكتريا ال H.pylori والحاملة للـ CagA (p<0.05) مقارنة بمرضى التهاب المعدة المزمن المصابين بالبكتريا ولكن غير حاملة للـ CagA.


Article
Gastrintestinal Manifestation and Alcoholic

Author: Aswad Ai Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 1 Pages: 17-20
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Alcohol remains the single most significant Cause of liver disease throughout the Western World, responsible for between 40 and 80% of cases of cirrhosis in different countries. Many of the factors underlying the development of alcoholic liver injwy remain unknown, and significant questions remain about the value of even very basic therapeutic strategies.Patients and Methods: A total number of 113 patients with ALD attending the Gastroenterology and Hepatology teaching hospital between December 2001 and December 2003 were studied for the gastrointestinal, esophagogastroduodenoscopic manifestation of alcoholic liver disease.Results.'The most common presenting symptom was jaundice (62.8%), anorexia, weight loss (39.8-54%) followed by hematemesis and malena (46.9%) and encephalopathy (40.7%). The pattern of the bowel motion was predominantly diarrhea (47.8%>), constipation (16.8%). The most common physical finding was hepatomegaly in (70.8%) followed by jaundice and ascites. The most common EGD jinding was esophageal varieses in (77%>), PHT gastropathy (52%), hemorrhagic gastritis (10.6%), GERD and lax cardia (8.8-15%) and esophageal candidiasis (4.4%).Conclusion: In Iraqi patients with ALD, the most common clinical manifestations were jaundice and hepatomegaly. The pattern of the bowel motion was predominantly diarrhea. The most common EGD finding was esophageal varieses, hemorrhagic gastritis was prevalent and esophageal candidiasis may be a manifestation.

Listing 1 - 10 of 25 << page
of 3
>>
Sort by
Narrow your search

Resource type

article (25)


Language

English (23)

Arabic and English (2)


Year
From To Submit

2019 (3)

2018 (1)

2017 (2)

2016 (1)

2014 (1)

More...