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3.THE RISK FACTORS AND FREQUENCY OF CONGENITAL ANOMALIES IN NEONATES BORN AFTER ASSISTED REPRODUCTIVE TECHNIQUE IN BAGHDAD

Author: Deia K. Khalaf ضياء كاظم خلف
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 4 Pages: 339-344
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Assisted reproductive technique (ART) has helped couples all over the world. There have already been over 3,500,000 births resulting from ART, and with falling fertility in some countries.Objective: To identify the frequency and types of congenital anomalies among neonates born after ART, and to identify the probable fetal and maternal predisposing factors that may associated with these congenital anormalities and neonatal complications.Methods: This prospective study was performed in the Neonatal Intensive Care Unit in 3 teaching hospitals in Baghdad, from 1st day of January to day 31 of December 2015, and 306 live birth neonates were delivered by ART, and evaluated by the researcher and his residence pediatricians' doctors, and other congenital anomalies were assessed by ultrasonography, x-ray and echocardiography. Information about each neonate were taken from the records and families which includes: gestational age (term ≥ 37 week and preterm < 37 week) no post-term case were reported, body-weight (≥ 2.5 kg and < 2.5 kg), sex, system affected, age of the parents, consanguinity, residence, job of the parents, level of education, health condition of the parents, causes of infertility, any family history of congenital anomalies, death in the family. Exclusion criteria included mothers’ age above 40, any maternal chronic diseases and chronic drugs taken. Congenital anomalies were classified into systems according to WHO recommendation. Results: Three hundred and six neonates were delivered, from which, 30 (10%) had congenital anomalies with male to female ratio (1.2:1), (20 (67%) twins and 10 (33%) were singletons), a significant association between congenital anomalies in ART products and male sex, consanguinity, and gestational age, as the p-value is significant (< 0.05), and the most common system affected was the gastro-intestinal tract (3%), but there was no significant association with body-weight.Conclusion: The ART born neonates are more prone for congenital anomalies. Gastrointestinal anomalies, especially esophageal atresia, are the commonest type of congenital anomalies followed by neurological anomalies. Male sex, consanguinity, and gestational age are significant risk factors for congenital anomalies. While body weight had no significant association with congenital anomalies.Keywords: Assisted reproductive technique (ART), intensive care unit, gastro-intestinal tract.Citation:Deia K. Khalaf. The risk factors and frequency of congenital anomalies in neonates born after assisted reproductive technique in Baghdad. Iraqi JMS. 2017; Vol. 15(4): 339-344. doi: 10.22578/IJMS.15.4.3


Article
Correlation Between Helicobacter Pylori Infection and Severity of Asthma
العلاقة بین الإصابة بالملویات البوابیة وشدة الربو القصبي

Authors: Sadiq J. Ali Almuhana --- Ammar Jabbar Majeed --- Abdul-Razzaq Hassan Alkaaby --- Sabah Ali Jaber Alhelu
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2015 Volume: 5 Issue: 2 Pages: 130-137
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: Microbial exposures have been suggested to confer protection from allergic disorders, and reduced exposures to gastrointestinal microbes have been proposed as an explanation for the increase in asthma severity and prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus may be inversely related to the severity of asthma. Objective: The aim of this study is to find whether infection with H.pylori reduces the probability of development of severe asthma in patients with persistent asthma.Patients and methods: In this study fifty patients with persistent asthma includes 19 males and 31 females their ages range from (17 – 66) years For all those patients, full history and complete physical examination have been done, then after, the patients subjected to pulmonary function test. After that, two milliliters sample of venous blood have been drawn, then, the sample centrifuged and sent to assess for H.pylori infection serology. Data was analyzed by using SPSS.Results: There is significant association between severity of asthma and result of H.pylori so with increase severity of asthma there is decrease in percentage of positive H.pylori serology. And there is no statistical significant are noted between patients sex or age and results of H.pylori infection test. Conclusion: There is significant inverse association between severity of asthma and result of H.pylori infection serology. This association not affected by ages and sex of patients.Recommendations: Since the exact mechanism by which H.pylori affect asthma is not clear, there is need for further studies to explore it.

خلفية الدراسة: طالما كان يعتقد إن الإصابات الجرثومية توفر حماية من إمراض الحساسية,وقلة التعرض للجراثيم المعوية أعطت تفسير لزيادة انتشار الربو وزيادة شدته,ولذلك بما إن الانتشار العام للإصابة بالملويات البوابية بدأ بالانحسار, لذلك وجدنا أن نتيجة الفحص المناعي للإصابة بالملويات البوابية تتناسب عكسيا مع شدة الإصابة بالربو المزمن.الهدف :الهدف من هذه الدراسة هو تحديد هل أن الإصابة السابقة بالملويات البوابية تقلل من احتمالية حدوث حالة الربو الشديد عند مرضى الربو المزمن.المنهجية : شارك في هذه الدراسة خمسون مريض مصابون بالربو المزمن , يتكونون من 19 ذكر و31 أنثى تتراوح أعمارهم بين 17 و 66 سنة , من كل هؤلاء المرضى تم اخذ تاريخ مرضي شامل وخضعوا لفحص سريري كامل, بعد ذلك اجري لهم فحص وظائف الرئة , من ثم سحب من كل مريض عينة بمقدار 2 مليليتر من الدم الوريدي,من ثم تم إجراء الطرد المركزي للعينة وأرسلت لغرض إجراء فحص الملويات البوابية المناعي.النتائج: تم إيجاد علاقة إحصائية معتبرة بين شدة الربو والنتائج الموجبة لفحص الملويات البوابية المناعي ,حيث كلما زادت شدة الربو كلما قلت نسبة النتائج الموجبة للفحص المناعي,كذلك تم إثبات عدم وجود علاقة إحصائية معتبرة تربط أعمار المرضى أو أجناسهم بنتائج الفحص المناعي.الاستنتاج : هناك علاقة عكسية بين شدة الربو القصبي ونتائج فحص الملويات البوابية المناعي.التوصيات: نظرا لعدم وضوح العلاقة المباشرة بين الملويات البوابية والربو القصبي نوصي بالمزيد من الدراسات لاكتشاف تلك العلاقة .

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