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Article
Trace elements and oxidative stress markers in saliva of subjects with amalgam fillings

Authors: Huda Sh. Ahmed هدى احمد --- Taghreed F. Zaidan تغريد زيدان --- Ali Yakub علي يعقوب
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 3 Pages: 63-66
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Amalgam is the most frequently used restorative material for dental treatment. It is mainly used inposterior teeth, usually on occlusal surfaces as an economical, long lasting and durable filling material and representthe main source of exposure to mercury and other toxic metals (copper, tin, silver, etc.).This study designed to measure oxidative stress marker malondialdehyde (MDA) and anti-oxidants (uric acid andglutathione) concentrations in saliva of subjects with amalgam fillings. And measure trace elements (copper, zinc)concentrations in saliva of subjects with amalgam fillings.Subjects,materials and methods: Fifty subjects were participated in this study, they were between the age of (20-50)years with amalgam fillings (cases group) and fifty one subjects with no amalgam fillings (control group), they weregender and age matched to that of subjects with amalgam fillings. Informed consent and ethical approval wasobtained. Each subject fill a case sheet questionnaire then examined by using sterile dental mirror and sterile dentalprobe to determine any oral manifestations and to calculate the number of amalgam filled teeth and the number offilled surfaces.Results: The results obtained from this study showed that Oxidative stress marker (MDA) were increased whileantioxidants (glutathione, uric acid) were decreased in saliva of subjects with amalgam fillings. Trace elements(copper, zinc) were higher in saliva of subjects with amalgam fillings; salivary copper was significantly higher insubjects with > 10 amalgam filled teeth. Salivary total glutathione was significantly correlated (negative correlation)with the number of filled teeth. Salivary copper was significantly correlated (positive correlation) with the number offilled teeth and filled surfaces.Conclusion: This study revealed that amalgam fillings associated with increase in oxidative stress marker(MDA) anddecrease in antioxidants (glutathione, uric acid).Trace elements (copper, zinc) increased in saliva of subjects withamalgam fillings.


Article
Study of some Antioxidants in plasma of patients with bladder cancer
دراسة بعض مضادات الاكسدة في بلازما مرضى سرطان المثانة

Authors: Abdul-Nasser M. Abdula --- Mhammed AL-Dori --- Israa G. Zainal
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2009 Volume: 27 Issue: 4 Pages: 751-758
Publisher: University of Technology الجامعة التكنولوجية

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Abstract

The objective of this study was to determine the catalase activity (CAT),ceruloplasmin activity (CP), glutathione level (GSH) in the plasma of (44) normaldonars (22 male, 22 female,) and (66) patients with bladder cancer (22 smoker male, 22non smoker male, 22 female). Data analysis showed a significant decrease in the meanvalues of CAT (89.577 ± 17.140 of a smoker male, 92.102 ± 18.898 of non-smokermale, 90.225± 12.997 of a female) as compared to normal individuals (155.541 U/mgHb of a male, 150.797 U/mg Hb of a female) respectively, and GSH (0.109 ± 0.056 of asmoker male, 0.110 ± 0.051 of non-smoker male, 0.084 ± 0.028 of a female) ascompared to normal individuals (0.838 μmol/L of a male, 0.809 μmol/L of a female)respectively. A significant increase in the mean value of CP in plasma of patients withbladder cancer (56.477 ± 2.671 of a smoker male,55.602 ± 3.042 of non-smoker, 52.101± 3.212 of a female) was recorded as compared to normal individuals (43.908 IU of amale, 41.110 IU of a female) respectively, There is also a negative relationship betweenCAT & Cp and GSH & Cp levels (r = - 0.089, and r = - 0.104) respectively, while thereis a positive relationship between CAT and GSH (r = 0.081) in-patients with bladdercancer.

ومستوى (CP) وفعالية السيرلوبلازمين (CAT) تهدف هذه الدراسة إلى تحديد فعالية الكاتليز في بلازم ا ( 44 ) من عينات السيطرة، ( 22 ذكور و 22 إناث ) و( 66 ) مرضى بسرطان (GSH) الكلوتاثيون المثانة ( 22 ذكو ر مد ّ خنين و 22 ذكور غير مد ّ خنين و 22 إناث ). أظهرت النتائج بأن هناك نقص واضح في 92.102 للذكور غير المد ّ خنين ± 89.577 للذكور المد ّ خنين و 18.898 ± 17.140 ) (CAT) معدل قيم 155.541 للذكور و 150.7971 U/mg Hb) 90.225 للإناث) بالمقارنة مع القيم الطبيعية ± و 12.997 0.110 للذكور ± 0.109 للذكور المد ّ خنين، 0.051 ± 0.056 ) GSH للإناث) على التوالي، و U/mg Hb 0.838 للذكور، 0.809 μmol/L) 0.084 للإناث) بالمقارنة مع القيم الطبيعية ± غير المد ّ خنين، 0.028 في بلازم ا (CP) للإناث ) على التوالي . هناك زيادة واضحة في معدل قيمة السيرلوبلازمين μmol/L 55.602 للذكور غير ± 56.477 للذكور المد ّ خنين، 3.042 ± المرضى المصابين بسرطان المثانة ( 2.67141.110 للإناث ) IU ، 43.908 للذكور IU) 52.101 للإناث) مقارنة بالقيم الطبيعية ± المد ّ خنين، 3.212 ( r = - GSH & Cp وكذلك بين GSH و CAT على التوالي ,تبين أيضا إن هنالك علاقة سالبة بين (r = و ( 0.081 CAT 0.089 على التوالي، بينما هنالك علاقة موجبة بين , and r = - 0.104) في مرضى سرطان المثانة. GSH


Article
The Role of Garlic Extract on the Effect of Organic Pesticides on Murine Liver Cells

Author: Khalid Hamdan Gathwn
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 344-350
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND:Organic phosphorus pesticides are most widely preferred pesticides, and know to have detrimental effect on various living organisms.METHODS:Twenty four male Balb/c mice were used. These were divided into four group (1,2,3,4) . Chlorpyriphos was given orally on alternate days by garage (20mg/kg body weight), aqueous garlic alone was given orally daily by garage (200mg/kg body weight, while garlic extract followed by chlorphriphos was also given.RESULTS:Lipid peroxidation (LPO) was measured in liver homogenate . The extent of LPO was significantly increased in animals treated with pesticide while non-significant result were obtained with garlic extract alone . Pretreatment with garlic followed by pesticide showed similar values. The levels of glutathione and total thiol was significantly decreased in animals treated with pesticide and non- significant with garlic . pretreatment with garlic followed by pesticide showed similar value. The free radical scavenging enzyme like SOD , as well as GSH- dependent enzyme (GPx, GST and GR) show significant decrease in animals treated with pesticide and non-significant with garlic. Pretreatment with garlic followed by pesticide showed similar to that of control.CONCLUSION:Pesticide exposure could be prevented by Co-administration of garlic extract.


Article
Effect of Some Environmental Conditions on the Oxidative Stress and Transition Metals Status in Iraqi Subjects

Authors: Muhanad Mohammed Nori --- Saad Abdul-Rehman Hussain --- Nada Khadum Al- Tae'e --- Hameed Mahmood Majeed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 2 Pages: 147-151
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: It has long been recognized that exposure to various metals is highly toxic, producing a wide variety of illnesses, including cancer. The role of these metals in free radical formation and initiation of lipid peroxidation was extensively studied; where the free form of iron or copper can effectively be involved in a free radical generation. OBJECTIVES: To evaluate the effects of the some environmental conditions on the levels of the oxidative stress markers, malondialdehyde (MDA) and glutathione (GSH), and some of the transition metals, iron, copper and zinc, in he serum of Iraqi subjects who exposed to different environmental conditions. METHODS: Blood samples were taken from 137 healthy male adults who work in different types of jobs (25 farmers, 25 workers in gasoline, 25 workers in liquid propane gas, 25 workers in casting, 25 workers in paints and 12 workers in plastic and rubber materials). The serum levels of MDA, GSH, iron copper and zinc were estimated and compared in different groups. RESULTS: The result showed that exposure of healthy subjects to different occupational hazards produces significantly different changes in the oxidative stress markers as revealed by excessive production of the lipid peroxidation end product (MDA) and depletion of the soluble antioxidant (GSH); and impairment of the trace element status (copper and zinc). CONCLUSION: The extracellular defense mechanisms were severely affected by the insults of oxidative stress processes due to environmental pollution in some work places in Iraq.


Article
Determination of glutathione peroxidase (GSH-Pex) activity in sera & RBCs of Iraqi Women With Breast Tumors
تقدير فعالية الكلوتاثايون بيروكسيديز في امصال وكريات الدم الحمراء لنساء عراقيات مصابات باورام الثدي

Authors: Zayzafoon N. N. Al-Azawi زيزفون العزاوي --- Fatin F. Al-Kazzaz فاتن فاضل القزاز --- Peri H.Saifullah بري حبيب سيف الله
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2009 Volume: 6 Issue: 4 Pages: 723-730
Publisher: Baghdad University جامعة بغداد

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Abstract

Breast tumor patients generally have more oxidative stress than normal females. This was clear from non significant decrease in RBCs and serum of GSH-Pex activity in all groups of patients. The study had found that free radicals in malignant breast tumors were higher than benign tumors; therefore the GSH- Pex might be used as markers for prognosis of the disease.

تكون النساء المصابات بسرطان الثدي عموما اكثر عرضة للاجهاد التاكسدي مقارنة بالنساء غير المصابات. ولكن لم يكن هناك انخفاض معنوي في فعالية ال (GSH-Pex) في الامصال وكريات الدم الحمراء في جميع مجاميع المرضى. وقد اظهرت الدراسة ارتفاع نسبة الجذور الحرة في الاورام الخبيثة مقارنة بالحميدة، ولهذا يمكن استخدام اﻠ (GSH-Pex) كدالة لتقدم المرض.


Article
Effect of Cement Pollution on some Biochemical Parameters in the Blood Serum of Hamam AL-Alil Cement Factory Workers
تأثير ملوثات الأسمنت على بعض المتغيرات الكيموحيوية في دم عمال معمل سمنت حمام العليل

Author: Haitham L. Al-Hayali هيثم لقمان الحيالي
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2009 Volume: 20 Issue: 2 E Pages: 19-28
Publisher: Mosul University جامعة الموصل

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Abstract

Long time exposure to cement industry pollution leads to several health problems. This study was designed to investigate the effects on 55 workers which were divided into groups according to the departments of Hamam AL-Alil Cement Factory-Iraq. The biochemical parameters included in the study are: calcium, zinc, lactate dehydrogenase, alkaline phosphatase, acid phosphatase, glutathione and malonaldehyde. The results showed that there was a significant increase in calcium, lactate dehydrogenase, alkaline phosphatase, acid phosphatase and malonaldehyde in workers serum which increased with increasing exposure time. The results also showed a significant decrease in glutathione and zinc in workers serum which increased with increasing exposure time in all factory department.

إن التعرض المستمر لملوثات صناعة الاسمنت يؤدي إلى العديد من المشاكل الصحية. لذلك صممت الدراسة للبحث في تأثير هذه الملوثات على 55 عامل والذين تم توزيعهم إلى مجاميع حسب مواقع عملهم في معمل سمنت حمام العليل- العراق. تناولت الدراسة قياس عدد من المتغيرات الكيموحيوية مثل الكالسيوم، الزنك، اللاكتيت ديهايدروجينيز الفوسفاتيز القاعدي، الفوسفاتيز الحامضي، الكلوتاثيون والمالونالديهايد.أظهرت النتائج بأن هنالك زيادة معنوية في كل من مستوى ايونات الكالسيوم وأنزيمات اللاكتيت ديهايدروجينيز والفوسفاتيز القاعدي والفوسفاتيز الحامضي والمالونالديهايد مع انخفاض معنوي في مستوى الكلوتاثيون وايونات الزنك في مصل دم العاملين مع ازدياد فترة التعرض.


Article
The Effect of magnetic field strength as a free radical on diabetic subjects

Authors: Ghalib A. Al-Sharefi --- Nameer A. Ali
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2006 Volume: 6 Issue: 2 Pages: 1-9
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The study was designed to found out the effect of magnetic field strength on the level of free radicals in the blood of diabetic subjects. It was done in the department of physiology, the medical college of Al-Mustansiriyah University and the research lab of the medical physics section. The study was Design as a prospective, randomized, case-control study. Out came measures: magnetic field (MF) was designed to build field strength of 10, 20 & 30 millteslar. The estimation of oxidative stress and antioxidant was done by measurement of malondialdenyde MDA and Glutathione (GSH) level. This study showed that the level of enythrocyte glutatione was significantly lower in diabetic subjects (P < 0.0.) while plasma MDA was significantly higher in diabetes subject than in the control group. All the measured parameters showed no significant changes when exposed to MF up to 30mTS. We concluded that a magnetic field of up to 30MTS has no harmful effect on the biological system activity in normal and D.M.


Article
Genetic polymorphisms of GSTM1 and GSTT1 Genes and Endometrial Cancer in Basrah, south of Iraq
التعدد الوراثي للجينين GSTM1 و GSTT1 وعلاقتهما بخطورة الاصابة بسرطان بطانة الرحم في البصرة جنوب العراق

Author: Adnan Issa Al-Badran عدنان عيسى البدران
Journal: Journal of Basrah Researches (Sciences) مجلة ابحاث البصرة ( العلميات) ISSN: 18172695 Year: 2011 Volume: 37 Issue: 5A Pages: 54-59
Publisher: Basrah University جامعة البصرة

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Abstract

The genes glutathione S- transferase M1 (GSTM1) and GSTT1 involved in phase II metabolism catalyse glutathione – mediated reduction of exogenous and endogenous electrophiles. A case control study was designed to identify the association between polymorphisms at GSTM1 and GSTT1 genes and endometrial cancer risk. While there was a lack of association between GSTM1 null genotype with the risk of endometrial cancer, the null genotype of GSTT1 had a 5.7 fold increased risk toward endometrial cancer (OR=5.76; 95% CI = 2.07-15.97). Both GSTM1, GSTT1 null genotype increased risk to about 3 fold. When stratified according to different grades of endometrial cancer the GSTM1 was more representative in grade III (OR=2.6), the association becomes stronger when the GSTT1 gene was also null (OR= 4.6).

الجينين GSTM1 و GSTT1 من ضمن جينات الطور الثاني التي تعمل على ايض المواد المسرطنة الداخلية والخارجية.صممت هذه الدراسة للتعرف على العلاقة بين التعدد الوراثي في الجينين GSTM1 و GSTT1 وزيادة الخطورة بالاصابة بسرطان بطانة الرحم في النساء . وجدت الدراسة انه لاتوجد علاقة احصائية واضحة بين فقدان الجين GSTM1 وخطورة الاصابة بسرطان بطانة الرحم بينما ازدادت هذه الخطورة بمقدار اكثر من خمس مرات عند فقدان الجين . GSTT1 وعند توزيع عينات المرضى استنادا الى درجة المرض فقد وجد ان فقدان الجين GSTM1 قد تمثل بشكل كبير في الدرجةالثالثة Grade IIIمن المرض (OR= 2.7) . هذا الارتباط كان اكبر عندما كان الجين GSTT1 مفقودا ايضا(OR= 4.6).


Article
Measurement ofmalondialdehyde and glutathione concentration in plasma of male rats that drenched with acrylamide and omega3
قياس تركيز المالونديالديهايد الكلي و الكلوتاثايون في مصل الدملذكور الجرذان المجرعة بالاكرالامايد و الاوميغا3

Author: Shatha hussien kadhum
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2013 Issue: 4 Pages: 85-90
Publisher: Kerbala University جامعة كربلاء

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Abstract

Acrylamide has toxic effects on most ofliving body systems ,so in this article we studied the effect of acrylamide on malondialdehyde (MAD) and glutathione (GSH) of male rats that drenched omega3 fatty acids. the results showed that there isasignificant increase p˂0.003 in plasma MDA in fourth group as compared with other groups while this value decreased in second group as compared with the others and this study showed that there isasignificant increased p˂0.0001 in plasma GSH in fourth group as compared with other groups while this value decreased in second group as compared with the others.

يعد الاكرالامايد مادة ذات تاثير سمي في معظم اجهزة الجسم ،درست تاثير هذه المادة على المالونديالديهايد والكلوتاثايون لذكور الجرذان المجرعة للاوميغا3 .لقد وجدتزيادة معنوية في تركيز المالونديالديهايد تحت مستوى احتمالية0.003˂ᵖ في المجموعة4 مقارنة مع بقية المجاميع بينما انخفضت هذه القيمة في المجموعة2 مقارنة مع بقية المجاميع ،بينما كانت هناك زيادة معنوية في تركيز الكليوتاثايون تحت مستوى احتمالية0.0001˂ ᵖ في المجموعة4 مقارنة مع بقية المجاميع وانخفضت هذه القيمةفيالمجموعة2 مقارنة مع بقية المجاميع.


Article
Antioxidants Use of Vitamin C and vitamin E in Patients with Vitiligo
استعمال مضادات الأكسدة ( فيتامين Cو E) في مرضى البهاق

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Abstract

Abstract:Background: The etiology of vitiligo is still unknown, but the autocytotoxic theory suggests that increased melanocytes activity leads to its own destruction. One of the proposed mechanisms by which autocytotoxicity may occur is that the destruction take place through reactive oxygen species.Objectives: The present work was arranged to evaluate the effect of antioxidants in the form of vitamin C and vitamin E in patients with vitiligo in the view of their effects on the alterations in oxidative stress as measured by plasma and red blood cells Malondialdehyde (MDA) and the changes in antioxidant mechanism as measured by plasma and red blood cells Glutathione (GSH)..Patients & Methods: Twenty-three patients with vitiligo were included in this study. The severity of the disease was graded according to the rule of nine into three grades (mild, moderate, and severe). The oxidative stress (plasma and red blood cells Malondialdehyde) and the antioxidants (plasma and red blood cells Glutathione) were measured in all patients. All patients included in this study received a combination of vitamin C and E (vitamin C 500 mg, vitamin E 100 mg twice a day) for 2 weeks and then the oxidative stress (plasma and red blood cells Malondialdehyde) and the antioxidants (plasma and red blood cells Glutathione) were measured again. Results: The results showed that only the mild group showed a statistically significant reduction in mean plasma MDA of 0.86 micro mole/L after two weeks of treatment P<0.02. The changes observed in mean plasma MDA in the remaining 2 groups and in the total cases were small and not statistically significant, while in erythrocytes MDA, the changes observed in mean erythrocytes MDA in the 3 severity groups of vitiligo and in the total cases were small in magnitude and not significant statistically. Also, the changes observed in mean Plasma GSH in the 3 severity groups of vitiligo and in the total cases were small in magnitude and not statistically significant. Conclusion: The results showed that the oxidative stress decreased significantly after treatment with antioxidant drugs in the mild group (i.e. early in the course of the disease when the disease is still active) and this may have a therapeutic applications suggesting that antioxidants may help to decrease the oxidative stress if it was given early in the course of the disease.Keywords: Vitiligo, Glutathione, Malondialdehyde, Antioxidants, Oxidative stress.

الملخص:مقدمة: داء البهاق من الأمراض الجلدية الشائعة غير المعروفة الأسباب. نظرية التدمير الذاتي هي إحدى النظريات المعروفة لتعليل المرض. تنص هذه النظرية على إن فاعلية الخلايا الصبغية ( الملانية) تؤدي إلى تحطم هذه الخلايا عن طريق الجذور الحرة.الأهداف: تقييم فاعلية مضادات الأكسدة (فيتامين C و فيتامين E في داء البهاق من خلال التأثير على جهد التأكسد المقاس من خلال المالوندهايد في البلازما و كريات الدم الحمر و كذلك التأثير على الميكانيكية المضادة للتأكسد المقاسة من خلال الكلوتاثايون في البلازما و كريات الدم الحمر .المرضى و طرق العمل: ثلاثة و عشرون مريضا مصابين بداء البهاق أدخلوا في هذه الدراسة في استشارية الأمراض الجلدية و التناسلية في مستشفى بغداد التعليمي للفترة من آذار 2001 إلى كانون الثاني 2002. تم تقسيم المرضى إلى ثلاثة أقسام حسب شدة المرض ( بسيط، متوسط و شديد). تم قياس جهد التأكسد من خلال قياس مستوى المالوندهايد في البلازما و كريات الدم الحمر و كذلك قياس الميكانيكية المضادة للتأكسد من خلال الكلوتاثايون في البلازما و كريات الدم الحمر قبل العلاج و بعده. تم علاج جميع المرضى بمزيج من فيتامين C 500 مغم و فيتامين E 100 مغم مرتين يوميا لمدة أسبوعين.النتائج: كان هناك انخفاض في جهد التأكسد في حالات البهاق البسيطة فقط فيما كان الفرق في بقية المجاميع غير مهم احصائيا.الاستنتاج: قد يقلل العلاج بمضادات الأكسدة جهد التأكسد في بعض حالات البهاق خصوصا في بداية المرض

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