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Article
Human Cytomegalovirus Up-regulates Nuclear Factor-κB in Women with Spontaneous Abortion

Author: Asmaa’ Baqer Al-Obaidi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 484-487
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Human cytomegalovirus (HCMV) infection during pregnancy causing serious problems through induction of viral genes that enhance the expression of different cellular factors ending in failure of pregnancy.Patients and Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein, and in situ hybridization technique to detect nuclear factor-κB (NF- κB) mRNA.Results: Only nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of NF-κB in HCMV positive cases as compared with HCMV negative and the control group (p = 0.001).Conclusion: This study strengthen the possibility that HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the expression of the transcriptional factor; NF-κB.

Keywords

HCMV --- NF-κB --- abortion


Article
Screening of Human Cytomegalovirus (CMV) in Diabetic Patients in Najaf Governorate

Authors: Zainab Hemeed Al-Heidery --- Heider H. Abbas --- Saif Jabbar Yasir
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 1 Pages: 236-244
Publisher: Babylon University جامعة بابل

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Abstract

The aim of current study was to study the relationship between the virus and diabetes mellitus through detection of human cytomegalovirus (HCMV) infection in diabetic patients in Najaf governorate by screening of anti-human cytomegalovirus IgM antibodies in the serum of diabetic patients by using of ELISA technique and detection of human cytomegalovirus DNA in blood samples by using of PCR technique. Blood samples collected from 140 diabetic patients randomly. ELISA technique was used to know the activity of humeral immunity among patients through detection of anti-HCMV IgM antibodies, where the result showed that IgM profile was positive in 49 patients(35 %). Regarding PCR technique, the study showed that among 140 diabetic patients gave positive results in 27 patients(19.2%); In contrast, the results of control group were negative for anti-HCMV IgM antibodies in both ELISA and PCR technique. This study concluded that the higher prevalence of seropositivity for human CMV in diabetic patients comparing with normal individuals which means that cytomegalovirus patients with diabetic were at high risk for CMV infections. A higher prevalence of CMV antibodies was observed in diabetic patients of all age-groups as compared with control group.

لقد كان هدف الدراسة معرفة العلاقة بين فايــــــروس (سي أم في) و مرضى السكري(مجموعة الدراسة) من خــلال التحــــري عن وجود الاصابة بالفايــــــــروس في مرضى السكري في محافظة النجــــــف بواســـــطة اجراء مســح لوجود الاجسام المضادة نوع( آي جي أم) في مصول مرضـــــــى السكري باستخدام تقنيــــــــــة (الاليزا), وكذلك من خــلال اجراء مسـح لوجود الحامض النــــووي(دي أن أي) لفايروس (سي أم في) في عينات دم نفس المــرضى باستخدام تقنية (بي سي آر) . تم خلال الدراسة جمع 140عينة دم بصورة عشوائية من مرضى السكري في مدينة الصدر الطبية في النجـــف. لقد استخدمت تقنية (الالـــــيزا) لمعرفة فعالية المناعة الخلطية بين المرضى من خلال كشـف وجود الاجسام المضـادة نوع (آي جي أم) والتي كانت نتيجته وجود 49 حالة موجبة (35 %) بينما اظهرت نتائج الدراســــة باســتخدام تقنيــة (بي سي آر) وجود 27 حالة موجبة (19.2 %) بينما أظهرت نتائـــج الدراســـــــة عدم وجود أي حالة موجبـــة في مجموعة السيطرة باستخدام كلا التقنيتين. لقد اظهرت الدراسة أن انتشـــــــار فايروس (سي أم في) في مجموعة الدراسة (مرضى السكري) كان أعلى بالمقارنة بمجموعة السيطرة مما يعني أن مرضى السكري أكثر خطورة للإصابة بفايروس (سي أم في) كما لوحظ أن وجود الاجســام المضادة لفايروس في دم مرضى السكري( مجموعة الدراسة) كان أكثر انتشارا في جميع الفئات العمرية مقارنة بمجموعة السيطرة

Keywords

HCMV --- Diabetic --- ELISA --- PCR.


Article
The Reactivity of Anti-HCMV IgM to Various Specific HCMV Antigens Among Pregnant Women in Kirkuk.
فاعلية الأجسام المضادة نوع (ام) للفيروس المضخم للخلايا البشرية لمختلف المستضدات الخاصة بالفيروس بين النساء الحوامل في كركوك.

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Abstract

Human Cytomegalovirus (HCMV) is a DNA virus of the Betaherpesvirinae subfamily and Herpesviridae family. HCMV is a leading cause of congenital infections throughout the world. This study was carried out in Kirkuk governorate from July 2017 to January 2018,aimed at studying there activity of anti-HCMV IgM to various specific HCMV antigens among 180 pregnant women attending hospitals, primary health care centers and some private medical laboratories. The pregnant women were examined for HCMV-IgM seroprevalence using Electro-chemo-luminescence(ECLIA) technique then examined their reactivity for specific HCMV antigens using line immune assay. The rates of HCMV-IgM seropositive were 22 (12.22 %). Regarding the reactivity of determined HCMV-IgM against various HCMV antigens, the rates 14 (63.63%), 13(59.09%), 21(95.45%), 15(68.18%), 21(95.45%) and 16(72.72%) were seropositive for HCMV IE1, CM2, p150, p65, gB1 and gB2 antigens, respectively. Concerning the band intensity of HCMV-IgM reactions with HCMV antigens, the rates of (+++) were higher than other band intensity for all antigens with highest rate for gB1 antigen (85.71%). So, the highest rate of HCMV-IgM reaction with the number of antigens was 40.90% for three antigens at the same time. In conclusion, the highest rate of HCMV-IgM in pregnant women was for gB1and p150 antigens; while the highest rate of intensity reaction was (+++)and the highest rate of HCMV-IgM ability for reaction was for three antigens at the same time.

الفيروس المضخم للخلايا البشرية هو من الفيروسات ذات الحمض النووي دي والتي هي من العائلة الفرعية بيتا التابعة لعائلة فايروسات الهيربس (الحلأ) وتسبب تشوهات خلقية ولادية في جميع أنحاء العالم. استهدفت الدراسة التي أجريت في محافظة كركوك في الفترة من تموز 2017 إلى كانون الثاني 2018 إلى معرفة مدى تفاعل الأجسام المضادة نوع (ام) مع مختلف مستضدات الفيروس المضخم للخلايا البشرية من بين 180 امرأة حامل راجعن مستشفيات ومراكز الرعاية الصحية الأولية وبعض المختبرات الأهلية في كركوك. حيث تم فحص مصل النساء الحوامل للتحري من الأجسام المضادة نوع (ام) مع مختلف مستضدات الفيروس المضخم للخلايا البشرية ومن ثم معرفة تفاعلاتهم مع مختلف مستضدات الفيروس المضخم للخلايا البشرية باستخدام اختبار المناعة الخطي. حيث كانت معدل الانتشار المصلي 22(12,22 ٪). فيما يتعلق تلك الأجسام المضادة المحددة ضد المستضدات المختلفة؛ حيث أظهرت أن 14(63,63٪)، 13(59,09٪)، 21(95,45٪)، 15(68,18٪)، 21(95,45٪) و 16(72,72٪) تفاعلت مع IE1 ، CM2 ، p150 ، p65 ، gB1 و gB2 على التوالي. أما بالنسبة إلى شدة نطاق التفاعلات مع المستضدات؛ حيث كانت معدل شدة التفاعل (+++) أعلى من شدة التفاعلات الأخرى لجميع المستضدات وبأعلى معدل لمستضد gB1 حيث كانت 85.71٪، وكذلك فإن أعلى معدلات التفاعل لتلك الأجسام المضادة مع عدد المستضدات حيث كانت 40,90 ٪ لثلاث مستضدات في نفس الوقت. واستنجت الدراسة أن أعلى نسبة من النساء الحوامل لديهن أجسام مضادة نوع (ام) للفيروس المضخم للخلايا البشرية لمستضدات gB1 و p150، في حين كان أعلى معدل كانت لشدة التفاعل (+++) وأعلى معدل من قابلية الأجسام المضادة للتفاعل مع ثلاث مستضدات في نفس الوقت.

Keywords

HCMV --- ECLIA --- CM2 --- p150 --- gB. --- HCMV --- ECLIA --- CM2 --- p150 --- gB


Article
The Reactivity of Anti-HCMV IgM to Various Specific HCMV Antigens Among Pregnant Women in Kirkuk.
فاعلية الأجسام المضادة نوع (ام) للفيروس المضخم للخلايا البشرية لمختلف المستضدات الخاصة بالفيروس بين النساء الحوامل في كركوك.

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Abstract

Human Cytomegalovirus (HCMV) is a DNA virus of the Betaherpesvirinae subfamily and Herpesviridae family. HCMV is a leading cause of congenital infections throughout the world. This study was carried out in Kirkuk governorate from July 2017 to January 2018,aimed at studying there activity of anti-HCMV IgM to various specific HCMV antigens among 180 pregnant women attending hospitals, primary health care centers and some private medical laboratories. The pregnant women were examined for HCMV-IgM seroprevalence using Electro-chemo-luminescence(ECLIA) technique then examined their reactivity for specific HCMV antigens using line immune assay. The rates of HCMV-IgM seropositive were 22 (12.22 %). Regarding the reactivity of determined HCMV-IgM against various HCMV antigens, the rates 14 (63.63%), 13(59.09%), 21(95.45%), 15(68.18%), 21(95.45%) and 16(72.72%) were seropositive for HCMV IE1, CM2, p150, p65, gB1 and gB2 antigens, respectively. Concerning the band intensity of HCMV-IgM reactions with HCMV antigens, the rates of (+++) were higher than other band intensity for all antigens with highest rate for gB1 antigen (85.71%). So, the highest rate of HCMV-IgM reaction with the number of antigens was 40.90% for three antigens at the same time. In conclusion, the highest rate of HCMV-IgM in pregnant women was for gB1and p150 antigens; while the highest rate of intensity reaction was (+++)and the highest rate of HCMV-IgM ability for reaction was for three antigens at the same time.

الفيروس المضخم للخلايا البشرية هو من الفيروسات ذات الحمض النووي دي والتي هي من العائلة الفرعية بيتا التابعة لعائلة فايروسات الهيربس (الحلأ) وتسبب تشوهات خلقية ولادية في جميع أنحاء العالم. استهدفت الدراسة التي أجريت في محافظة كركوك في الفترة من تموز 2017 إلى كانون الثاني 2018 إلى معرفة مدى تفاعل الأجسام المضادة نوع (ام) مع مختلف مستضدات الفيروس المضخم للخلايا البشرية من بين 180 امرأة حامل راجعن مستشفيات ومراكز الرعاية الصحية الأولية وبعض المختبرات الأهلية في كركوك. حيث تم فحص مصل النساء الحوامل للتحري من الأجسام المضادة نوع (ام) مع مختلف مستضدات الفيروس المضخم للخلايا البشرية ومن ثم معرفة تفاعلاتهم مع مختلف مستضدات الفيروس المضخم للخلايا البشرية باستخدام اختبار المناعة الخطي. حيث كانت معدل الانتشار المصلي 22(12,22 ٪). فيما يتعلق تلك الأجسام المضادة المحددة ضد المستضدات المختلفة؛ حيث أظهرت أن 14(63,63٪)، 13(59,09٪)، 21(95,45٪)، 15(68,18٪)، 21(95,45٪) و 16(72,72٪) تفاعلت مع IE1 ، CM2 ، p150 ، p65 ، gB1 و gB2 على التوالي. أما بالنسبة إلى شدة نطاق التفاعلات مع المستضدات؛ حيث كانت معدل شدة التفاعل (+++) أعلى من شدة التفاعلات الأخرى لجميع المستضدات وبأعلى معدل لمستضد gB1 حيث كانت 85.71٪، وكذلك فإن أعلى معدلات التفاعل لتلك الأجسام المضادة مع عدد المستضدات حيث كانت 40,90 ٪ لثلاث مستضدات في نفس الوقت. واستنجت الدراسة أن أعلى نسبة من النساء الحوامل لديهن أجسام مضادة نوع (ام) للفيروس المضخم للخلايا البشرية لمستضدات gB1 و p150، في حين كان أعلى معدل كانت لشدة التفاعل (+++) وأعلى معدل من قابلية الأجسام المضادة للتفاعل مع ثلاث مستضدات في نفس الوقت.

Keywords

HCMV --- ECLIA --- CM2 --- p150 --- gB. --- : HCMV --- ECLIA --- CM2 --- p150 --- gB


Article
Detection of Human Cytomegalovirus (HCMV) among Infertile Male in AL-Najaf governorate

Authors: Saif Jabbar Yasir --- Kareem Thamir Mashkoor --- Ghanim Aboud Al-Mola
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2012 Volume: 2 Issue: 3 Pages: 123-128
Publisher: University of Kufa جامعة الكوفة

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Abstract

The current study aimed to detect human cytomegalovirus among infertile individual. Bloodand seminal fluid collected from 300 infertile male randomly , ELISA technique was used to know theactivity of humoral immunity among them through measuring anti-HCMV IgM and IgG antibodies ,the result revealed that 31 (11%) were positive for IgM result and 234 (78%) were positive for IgG.The PCR technique showed that out of 300 samples only 22 (7.4%) gave positive results,In case of control group, results were negative for anti- HCMV IgM antibodies in ELISA testand PCR technique. While IgG gave a weak positive results.Aim of the study:The present study was to study the relationship between the virus and infertility throughdetection of human cytomegalovirus (HCMV) infection in infertile male in AL-Najaf governorate byscreening of anti-human cytomegalovirus IgM and IgG in the serum and detection of humancytomegalovirus DNA in seminal fluid, using PCR technique.

هدفت هذه الدراسة إلى التحري عن الفيروس المضخم للخلايا البشرية بين الذكور الذين يعانون من العقم. تم جمع عينات الدم و السائل المنوي بصورة عشوائية من ثلاثمائة مريض، لمعرفة نمط العدوى فيما بينها. تم استخدام تقنية ELISA لمعرفة نشاط المناعة الخلطية للازواج من خلال قياس الاجسام المضادة للفايروس البشري المضخم للخلايا ال IgM و IgG، أظهرت أن 31 (11 %) كانت النتيجة موجبة لأضداد الـ IgM و 234 (78 % (كانت موجبة لأضداد الـ IgG . أظهرت تقنية PCR أن من أصل 300 عينة 22 فقط (% 7.4) اعطت نتيجة ايجابية.اما في حالة مجموعة السيطرة، كانت النتائج سالبة بالنسبة للاجسام المضادة للفايروس المضخم للخلايا البشري باستخدام اختبار ELISA، وتقنية, PCR. في حين اعطت الاجسام المضادة IgG نتائج موجبة ضعيفة.

Keywords

HCMV --- Infertile males --- ELISA --- PCR


Article
Detection of Human Cytomegalovirus in Colorectal Adenocarcinoma by In Situ Hybridization Technique

Author: Faiza Abdulla Mukhlis
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 52-56
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Human Cytomegalovirus (HCMV) infects a wide range of human cells, including colonic epithelial cells that give rise to adenomas and adenocarcinomas. Persistent productive infection of tumor cells is essential for oncomodulation by HCMV.This study aimed to detect HCMV matrix protein using in situ hybridization technique (ISH) in colorectal adenocarcinoma compared to normal colon tissues, and to the presence of cytomegalovirus inclusion bodies in infected colorectal carcinomas.Patients and methods: Twenty six of colorectal adenocarcinomas were obtained in paraffin-blocks compared to 10 normal colon specimens which were age and sex matched as control group. Detection of HCMV was obtained by in situ hybridization technique.Results:The biotinylated probe specific for DNA encoded HCMV-matrix protein showed hybridization with nucleic acid in 20 cases out of (26) of colorectal adenocarcinomas representing (76.9%) compared to normal colon tissue which revealed no hybridization signals. Moderate to high scoring signals were detected in moderate to poorly differentiated groups. Inclusion bodies were detected in 11 (42.3%) cases with positive hybridization signals.Conclusion: HCMV may play a role in the colorectal adenocarcinoma pathogenesis. In situ hybridization test are considered the most sensitive and specific tools for detection of HCMV DNA in tissues. Epidemiological, histopathological identification of cytomegalic inclusion bodies and molecular studies are necessary to confirm the association of HCMV and colorectal tumorogenesis in Iraqi population.


Article
Detection of human cytomegalovirus genome in malignant gliomas by in situ hybridization technique

Authors: Ban A. Abdul majeed** PhD --- Faiza A. Mukhlis* PhD --- Shatha F. Abdullah* FICM
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 2 Pages: 178-183
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Human Cytomegalovirus ( HCMV ), lies dormant in the glial cells , and can be reactivated under conditions of inflammation and immunosuppression. In vitro, the virus can transform cells and dysregulate many cellular pathways involved in oncogenesis. This study was conducted to detect HCMV matrix-protein mRNA using In Situ Hybridization technique in glial brain tumor tissues compared to normal brain tissues and the presence of cytomegalic inclusion bodies in brain tumor tissues.Patients and Method: Thirty eight of glial tumor specimens were obtained in paraffin blocks compared to eight normal brain autopsy specimens which were age and sex matched with the study group as a control group. ISH was conducted tissue sections using a biotinylated Long DNA Probe for CMV Matrix Protein together with in-situ hybridization (ISH) detection kit.Results: The biotinylated probe specific for mRNA encoded HCMV – Matrix Protein showed hybridization with viral nucleic acids in 34 cases(out of 38)of malignant glial tumor specimens representing (73.9% ) of the total study groups . All cases with high grades astrocytoma revealed a positive hybridization in a percentage of 32.6% from 15 cases with grade III, and 10 ( 21.7% ) cases with grade IV astrocytoma. Nine out of 38 cases with grade III astrocytoma representing (23.7%), 7 (18.4 %) cases with glioblastoma multiforme and 2 oligodendroglioma cases(5.3 %), revealed inclusion bodies on histological examination. Conclusions: HCMV may play a role in the glioma pathogenesis. In Situ Hybridization test proved to be a very sensitive and specific technique for the detection of HCMV mRNA in tissues. Epidemiological, histopathological identification of cytomegalic inclusion bodies , and molecular studies are necessary to confirm the association of HCMV related human cancers in general Iraqi population.


Article
HUMAN CYTOMEGALOVIRUS INFECTION AMONG NEONATES WITH SYMPTOMATIC CONGENITAL INFECTIONS AND BIRTH DEFECTS

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Abstract

Background:Human cytomegalovirus (HCMV) is the major viral etiology of congenital infection and birth defects, during current maternal infection the fetal transmission is high (30-40%) and the symptomatic neonates have diseases involving the neurologic, hematopoietic, respiratory and other organ systems, causing high mortality and long-term sequelae.Objective:To measure the frequency of congenital and perinatal HCMV infection among symptomatic neonates and its possible burden of disease among them.Methods:A total of one hundred ninety-eight symptomatic neonates with clinical manifestations of overt congenital infection enrolled in this study from September 2014 to March 2015. Serum samples were obtained from each subject targeted in this study. HCMV infection was defined as HCMV-IgM antibody positive by Electrochemiluminescence Immunoassay (ECLIA) techniques. Results:The prevalence of HCMV infection among symptomatic neonates with congenital infection was 25 (12.6%). The average age of HCMV detection was 9.96 (SD 6.73) days with a median of 7 days, a minimum of 3 days and a maximum of 28 days. Jaundice was the most predominant clinical finding 14 (56%), followed in order of frequency by hepatomegaly 9 (36%) and pneumonitis 7 (28%).Conclusion:The high prevalence of neonatal HCMV infection among neonates with symptomatic congenital infections could indicate a high rate of maternal HCMV primary or current infection among our population.Keywords: HCMV, congenital infection, neonates, clinical finding.


Article
The role of Human Cytomegalovirus infection in Iraqi brain tumor patients

Author: Elham Mudallal Amer, Ali. H .M.Ali Alkhfaji, Zuhar N .Hamad
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 4 Pages: 15-25
Publisher: Baghdad University جامعة بغداد

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Abstract

A total of (40) astrocytoma patients tissues were enrolled in the present study which include (20) normal surrounding areas from similar tissues used as a control group. The fourty cases represented by formalin fixed paraffin embedded brain tumor tissues blocks and these blocks were collected from the archives of histopathology laboratories at Neurosurgery Teaching Hospital in Baghdad. During the period 2014 to 2015. In our study, the astrocytoma patients were classified into four groups according to their grades (I, II, III, IV). A retrospective study of (40) paraffin embedded samples which were previously diagnosed as brain tumors along with normal unaffected tissues or tissue surrounding the tumors as control were selected from different Histopathology laboratories. All the slides of the paraffin-embedded samples were re-examined and specific sections were selected to be prepared for the techniques (CISH). The Paraffin-embedded samples were sectioned to several sections with (3-4 mm) thickens on charged slides Using Chromogenic insitu hybridization procedure (CISH technique) was used to detect the HCMV on the embedded tissues by light microscope. All grade have positive results for HCMV nucleic acids but the higher percentage (100%) was present in high grades astrocytoma grades (IV).

Keywords

Cytomegalovirus --- Brain tumor --- CISH --- HCMV --- PCR.


Article
Assessment of Co-Infection of Human Cytomegalovirus DNA and Epstein Barr-Virus (ZEBRA-Genes) in Tissues of Ovarian Tumors

Author: Ruqaya M. J. Awadh1 , Shakir H. Mohammed Al-Alwany2
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2019 Volume: 18 Issue: 2 Pages: 95-105
Publisher: Baghdad University جامعة بغداد

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Abstract

Infection by Epstein Barr-Virus (EBV) begins with a short replication phase. The virus remains in a latent phase, only entering the lytic phase in response to a cascade of transcriptional signals. These signals are triggered by the ZEBRA protein (BZFL1) along with Rta (BRLF1). Human cytomegalovirus (HCMV) is responsible for a lifelong persistent infection which ranged from 50% to 90% in adult population, and is related to either socioeconomic status or geographic location. HCMV infection might lead to buildup tumor cells via the protection of certain tumor cells from apoptosis and modulating angiogenesis. The study was designed to determine ZEBRA-EBV gene and DNA-HCMV infections in tissues from ovarian tumors. An 150 ovarian tissues were examined for ZEBRA-EBV gene with DNA-HCMV. Those samples belonged to (45) patients diagnosed with ovarian cancer ; (45) from benign ovarian tumors and (20) patients with borderline ovarian tumors as well as (20) apparently normal ovarian tissues. The detection of ZEBRA-EBV gene and DNA-HCMV were done by chromogenic In situ hybridization (CISH). The positive results of ZEBRA - EBV -CISH detection in malignant ovarian tumors, where 64.4% (29 out of 45 tissues) showed positive signals. While ,in the benign ovarian tumors group were 37.8 % (17 out of 45 tissues) ,followed by borderline ovarian tumors & the apparently healthy ovarian control tissues were 30% (6 out of 20 cases) and 7.5% (3 out of 40 cases), respectively. The present study shows the positive results of HCMV-CISH detection in malignant ovarian tumors, where 55.6% (25 out of 45 cases) showed positive signals, while, 44.4% negative signals which represented 20 out of 45 cases in this group. While, in the benign ovarian tumor group was 35.6% (16 out of 45 cases). Negative signals which in benign group represented 29 out of 45 cases constituted 64.4% .Whereas ,the positive results in borderline ovarian tumor group were 40% (8 out of 20 tissues), followed by the apparently healthy ovarian control tissues was 12.5% (5 out of 40 tissues). We concluded from this study, ZEBRA -EBV genes as well as HCMV-DNA positive signals in malignant, borderline and benign tumors tissues ,they suggest an important role for these viruses in the development of ovarian tumors in Iraqi patients.

Keywords

Ovarian Tumors --- ZEBRA –EBV --- HCMV --- CISH.

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