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Article
Association of HLA (Class I & II) and Susceptibility to

Author: Ikbal Kh. Al-Joofy Ph.D* د. اقبال الجوفي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 2 Pages: 265-266
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Hydatid cyst disease is a parasitic zoonotic disease caused by genus Echinococcus. This disease believed to has genetic background in it's aetiopathogenesis course . The aim of this study is to shed light on the possible correlation between HLA-class I (A,B,C) & HLA-class II (DR & DQ) antigens and the susceptibility to this disease. Patients & Methods: Fifty patient with hydatid cyst disease before undergoing surgical operation were investigated for HLA. Class I and class II by using microlymphocytotoxicity test. The results were compared with 115 healthy control. Results: Significant increased trend of HLA-A28 and A-11, -B18 and B-35, -DR3 and DR-11 (P<0.001, P<0.01) in patients with this disease as compared with healthy control. On the other hand, increased trend of HLA-28 (P<0.01) in patients with hydatid disease especially in those with a cyst location in liver. Conclusions: High frequency of HLA-A11 and –A28, B18 and –B35, -DR3 and –DR11 antigens may play major role in susceptibility to hydatid disease. HLA-A28 could be the most related antigen to this disease and acting as genetic marker that could in one way or another play crucial role in susceptibility especially in cases of hydatid disease in liver. Keywords: Hydatid cyst disease, HLA-typing


Article
Association of HLA – I and HLA – II molecules with Mycobacterium Tuberculosis Infection.
علاقة مستضدات التوافق النسيجي صنف I و II مع الاصابة بجراثيم السل الرئوي

Authors: Farook K. Hassan فاروق خالد حسن --- Haitham Khasim وهيثم قاسم --- Nidhal A. Al-mohymen نضال عبد المهيمن
Journal: Al- Anbar Medical Journal مجلة الأنبار الطبية ISSN: PISSN: 27066207 / EISSN: 26643154 Year: 2005 Volume: 5 Issue: 1 Pages: 5-9
Publisher: University of Anbar جامعة الانبار

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Abstract

Aim: To study the association of HLA-I and HLA-II molecules in lymphocytes suspension obtained from tuberculosis patients .Material and Methods : Patients : 105 positively diagnosed patients as having tuberculosis and 40 healthy control subjects. Blood from all subjects tested were exposed to micro assay and a panel of monoclonal antibodies (McAbs) to HLA-I and HLA-II antigens .Results : Lymphocytes suspension showed that there is an association between HLA-A30(19), DQ6, DR1, B18, whereas negative association recorded when HLA-B13, DR8, DQ4, is seen .

الهدف : دراسة العلاقة بين الاصابة بالتدرن الرئوي ومستضدات معقدات التوافق النسيجي المواد وطرائق العمل : خضع (105) مريض ثبت تشخيصهم بالتدرن الرئوي بالإضافة الى ومجموعة microtoxcicity شخص معافى ظاهرياً الى تقنية القتل الخلوي الدقيق (40) من الاضداد وحيدة النسيلة خاصة بالمعقدات التابعة للصنف I و II النتائج : بين عالق الخلايا اللمفية علاقة مجموعة من الاضداد التابعة للصنف I و II كالاتي علاقة موجبة HLA-A30(19), DQ6, DR1,B18,DQ4 بينما لا توجد علاقة مع HLA-B13, DR8, DQ4


Article
HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

Authors: Dr. BATOOL M. MAHDI ‘M.B.Ch.B., M.Sc. SALAWA M. SHAREEF “(B.S.) د. بتول مطر مهدي --- salalwa M.Shareef
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 2 Pages: 140-144
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia . We also demonstrate the presence of antibodies in serum of acute lymphoblastic leukemic patients against HLA class I.DESIGN: Prospective study.SETTING: Tissue typing and histocompatibility center at Al- Karamah Teaching Hospital. PATIENTS AND METHOD: 70 acute lymphoblastic leukemia patients from pediatric hospitals. HLA ( human leukocyte antigens) typing done for them by serological method and cross matching and blood grouping were also done for them.RESULTS: there was significant difference between patients and control groups regarding HLA -C6.DR1, DR4, DR7, DQ1.DQ2 ,DQ3, DQ4. There was 14.2 % (10/70) of patients had antibodies against HLA class I. There was no significant association between blood group and acute lymphoblastic leukemia .CONCLUSION: Genetic factor increased susceptibility with acute lymphoblastic leukemia ( HLA- DR1 DQ1, HLA - DR4 DQ4, HLA- DR4 DQ3, HLA- DR7 DQ2. This HLA typing increased susceptibility to be affected with leukemia after infection.RECOMMEND A TION: HLA typing was done to acute lymphoblastic leukemic patients by molecular -DNA based method (PCR-SSP, RSCA) in addition to serological method.KEY WARD : ALL, HLA typing, antibodies, blood group.

Keywords

ALL --- HLA typing --- antibodies --- blood group.


Article
activation of complements pathways in patients with bachcet's disease

Authors: Ikbal Kh. AL-Joofy اقبال الجوفي --- khalida Al- Mousawy --- raad .K.Muslih --- jassim.Al-Khafaji --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 2 Pages: 190-193
Publisher: Baghdad University جامعة بغداد

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Abstract


Article
HLA-DR and DQ Antigens in Iraqi Patients with Behget's Disease

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Abstract

Summary:Background: Behqet's disease (BD) is a multisystemic in inflammatoty disorder, disease onset is believed to be triggered by many factors with a particular genetic background. The aim of this study is to investigate the possible correlation between HLA-DR & DQ antigens and onset of this mysterious disease.Method: By using microlymphocytoxicity test, the frequencies of 18 HLA-DR & DQ antigens were calculated in 65 patient with BD compared with 32 patients control with recurrent oral ulcers (ROU) & 115 healthy control.Results: Significant increased trend of HLA-DR52, DR53 and DQ3 antigens (P<0.001), and significant reduced frequencies of DQ4 antigen (P<0.01) in patient with BD as compared to H.C. group, on the other hand significant decreased DR1 antigen in patient with BD (P<0.005) as compared with patients with ROU.Conclusion: Higher frequency of DR52, DR53 & DQ3, these alleles could in one way or another play a crucial role in susceptibility to BD. Whereas DR1 DQ4 phenotypes decrease the risk to develop, this disease.Key words: Behget's disease, HLA- typing HLA-DR and DQ.

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