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Article
Molecular Analysis of Class II HLA-DRB Polymorphism

Author: Haider Hashim Zalzala
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: supplement Pages: 760-764
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Major Histocompatibility Complex (MHC) system is a polymorphic system and the extensive polymorphism of MHC gene in human and the allelic distribution in different ethnic population become a key component in investigating the genetic relations between populations. Geographical variety is one of the factors that affect HLA polymorphism.OBJECTIVE:This study is designed to study class II HLA-DRB polymorphism in Iraqi populations by molecular method.METHODS:Seventy four healthy Arab Iraqi populations were enrolled in this studyduring the period between November 2012 till April 2013. Direct interview was done with the populations and HLA typing was done by molecular method using Sequence Specific Primer (PCR-SSP) method using One Lambda Kit-USA. RESULTS:The most frequent alleles are DRB1*03,*11,*07 with a frequency of (0.47, 0.41, and 0.26) respectively. There are no significant difference between male and female regarding non-DRB1 alleles.CONCLUSION:1-The most frequent alleles in Arabic Iraqis populations are DRB1*03,*11, and *07.2-Gender is not a significant factors affecting the frequencies and hetro- or homozygosity for the nonDRB1 alleles in adults.KEY WORDS: HLA-DRB1, HLA polymorphism .


Article
HLA-DQA1 and HLA-DQB1 genotyping among lichen planus patients in Basrah‏ ‏province ‎
دراسة نظائر مستضدات ‏HLA-DQA1‎‏ و ‏‎–DQB1‎‏ ‏HLA‏ في المرضى المصابين بمرض الحزاز في محافظة ‏البصرة

Author: Nibras S. Al-Ammar‏ ‏‎ ‎
Journal: The Medical Journal of Basrah University المجلة الطبية لجامعة البصرة ISSN: 02530759 Year: 2014 Volume: 32 Issue: 1 Pages: 43-53
Publisher: Basrah University جامعة البصرة

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Abstract

Background: Lichen planus is an inflammatory, pruritic disease of the skin and mucus membranes, which can be ‎either generalized or localized. Many studies indicated that human leukocyte antigens might have a role in lichen ‎planus (LP). As far as my knowledge, no previous study had done in Iraq about HLA-DQA1 and -DQB1 alleles ‎frequencies in patients with lichen planus. ‎Aim: The aim of the present study is to investigate the additional genetic contribution to lichen planus susceptibility ‎lying on the HLA region, by focusing on the possible differential contribution of the different DQA1 and DQB1 carrying ‎haplotypes.‎Method: The present study was carried out in College of Medicine during the period between (2012-2014). 50 patients ‎with lichen planus attending Basrah General Hospital and private clinic, and 50 healthy controls‏ ‏were included in the ‎study, with age group from (13-67) years. 100 DNA samples were purified from the blood samples of patients and ‎controls, and then followed by PCR amplification of HLA-DQA1 and DQB1 genes in Cell Research Unit, Biology ‎Department, College of Science, University of Basrah. The sequencing-PCR was done in Korea, Bioneer sequencing ‎laboratories. ‎Results & Conclusions: Results indicated statistically significant decreased frequencies of HLA-DQA1*010201 ‎‎(P<0.005), DQA1*0201 (P < 0.05), and -DQB1*030201 (P < 0.005) alleles in lichen planus patients, which indicated ‎that these alleles might be a protective factors. Results also indicated statistically significant increased frequencies of ‎DQA1*010401 (P<0.005), DQA1*040101 (P<0.005) DQA1*050101 (P<0.005), DQB1*030101 (P<0.005) and ‎DQB1*050101 (P<0.005) alleles in lichen planus patients, which indicated that these alleles might be risk factors and ‎increase the ability of infection. The present study indicates that genetic constitution through HLA-DQ locus determines ‎the mechanism of disease as well as clinical and pathologic outcomes. More studies are necessary to test genetic ‎dependencies on the basis of larger samples which would increase statistical power. An accurate definition of disease ‎susceptible alleles will improve our understanding of antigen presentation mechanisms prevailing in the etiology of the ‎disease. This knowledge is necessary for the design of improved immune intervention strategies to halt lichen planus ‎progression in patients at risk of developing the disease or those who are already suffering from it.‎

الخلفية: مرض الحزاز يسبب التهاب الجلد والأغشية المخاطية، والذي يكون إما عام أو موضعي. بينت العديد من الدراسات إن مستضدات ‏الخلايا البيضاء لها دور مهم في مرض الحزاز. حسب معرفتي ليس هناك دراسة في العراق عن ترددات اليلات ‏HLA-DQA1‎‏ و ‏‎-‎DQB1‎‏ في المرضى المصابين بالحزاز.‏الهدف: الهدف من الدراسة الحالية هو التحقق من علاقة جينية إضافية لقابلية الإصابة بمرض الحزاز والتي تكون موجودة في منطقة ‏HLA، مع ‏التركيز على علاقات لأنماط أخرى من ‏DQA1‎‏ و ‏DQB1‎‏.‏الطريقة: أجريت هذه الدراسة في‎ ‎كلية الطب، جامعة البصرة‎ ‎خلال الفترة مابين ‏‎ ‎‏(2012-2014). 50 مريض من المراجعين لمستشفى البصرة ‏العام والعيادة الخاصة، و 50 من الأصحاء تم شمولهم في هذه الدراسة، من الفئة العمرية مابين ( 13-67) سنة. 100 نموذج ‏DNA‏ تم عزلها ‏من نماذج دم المرضى والأصحاء، بعد ذلك تم تضخيم جينات ‏HLA-DQA1‎‏ و ‏DQB1‎‏-‏HLA‏ باستعمال ‏PCR‏ في وحدة أبحاث ‏الخلية، فرع علوم الحياة، كلية العلوم، جامعة البصرة. تمت دراسة تتابع نظائر الجينات في مختبرات ‏Bioneer‏ في كوريا. ‏النتائج والإستنتاجات: وضحت النتائج وجود نسبة تكرار واطئة ذات مغزى ايجابي لنظائر الجينات ‏‎ HLA-DQA1*010201‎‏ ‏‎(P<0.005)‎، ‏HLA-DQA1*0201‎‏ ‏‎(P<0.05)‎، ‏HLA-DQB1*030201‎‏ ‏‎(P<0.005)‎‏ في المرضى المصابين بمرض ‏الحزاز، مما يبين إن هذه النظائر قد تكون عوامل حماية من المرض. بينت النتائج نسبة تكرار عالية ذات مغزى ايجابي لنظائر الجينات ‏‎(P<0.005) HLA-DQA1*010401‎، ‏‎(P<0.005) -DQA1*040101‎، ‏DQA1*050101‎‏ ‏‎(P<0.005)‎، ‏DQB1*030101‎‏ ‏‎(P<0.005)‎‏ و ‏‎-DQB1*050101‎‏ ‏‎ (P < 0.005)‎‏ في المرضى المصابين بمرض‎ ‎الحزاز مما يبين إن هذه النظائر ‏قد تكون عوامل خطورة تزيد من قابلية الإصابة. وضحت الدراسة الحالية إن الدور الوراثي من خلال ‏HLA-DQ locus‏ يحدد آلية المرض ‏إضافة إلى النتائج السريرية والمرضية. المزيد من الدراسات ضرورية لاختبار التبعات الوراثية على أساس نماذج أكبر والتي قد تدعم النتائج إحصائيا. ‏إن التعريف الدقيق للاليلات ذات الصلة بالمرض سيحسن فهمنا لآليات تمثيل المستضدات المسببة للمرض. هذه المعرفة ضرورية لتصميم ‏استراتيجيات مثبتة للتدخل المناعي الذي يعمل على إيقاف تقدم مرض الحزاز في المرضى المعرضين لخطر تطور المرض أو أولئك الذين يعانون ‏بالفعل منه‎.‎


Article
Frequency of HLA Antigens in a Sample of Iraqi Brucellosis Patients
تكرار مستضدات خلايا الدم البيض البشرية لعينة عراقية من مرضى داء البروسيلا

Authors: Ammna N. Jasim آمنة نصيف جاسم --- Aaiad H. A. Al-Rikaby أعياد حميد عاجل الركابي --- Ali H. Ad'hiah علي حسين أدحية
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2012 Volume: 9 Issue: 1 Pages: 86-92
Publisher: Baghdad University جامعة بغداد

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Abstract

Fifty one patients with serologically confirmed brucellosis and 70 healthy controls were phenotyped for HLA-A, -B, -DR and -DQ antigens by using standard microlympho-cytotoxicity method, and lymphocytes defined by their CD markers (CD3, CD4, CD8 and CD19). The results revealed a significant (Pc = 0.001) increased frequency of HLA-DR8 (41.18 vs. 10.0%) in the patients . A significant increased percentage of CD8+ lymphocytes was also increased in the patients (25.15 vs. 22.0%; P = 0.006), while CD3+ lymphocytes were significantly decreased (75.1 vs. 79.4%; P = 0.02).

نمط مظهريا احدى وخمسون مريضا من مرضى داء البروسيلا المشخصين مصليا وسبعين من الأصحاء لمستضدات خلايا الدم البيض البشرية A و B و DR و DQ باستخدام الطريقة القياسيةMicrolymphocytotoxicity test ، وفضلا عن توصيف الخلايا اللمفية في ضوء بعض الواسمات (CD3 و CD4 و CD8 و CD19). أوضحت النتائج زيادة معنوية(الاحتمالية المصححة = 0.001) بتكرار المستضد HLA-DR8 (41.18 مقابل 10.0%) في المرضى. كما ارتفعت في المرضى ايضا وبفرق معنوي النسبة المئوية للخلايا اللمفية الحاملة للواسم CD8 (25.15 مقابل 22.0%؛ الاحتمالية = 0.006)، في حين انخفضت معنويا الخلايا الحاملة للواسم CD3 (75.1 مقابل 79.4%؛ الاحتمالية = 0.02).

Keywords

Brucellosis --- HLA --- CD markers


Article
Analysis of Human Leukocyte Antigen Classes in Patients with Prostate Cancer and Benign Prostate Hyperplasia

Authors: Abdul Karrim S. AL-Khafaji --- Nidhal Abdul AL Mohymen --- Amer AL Najjaar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 98-101
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Certain HLA alleles are occurring in a higher frequency in individuals with particular diseases than in the general population. METHODS: HLA-typing for class I and class II antigens expressed by cells of 40 patients with prostatic adenocarcinima (CAP) and 48 patients with benign prostatic hyperplasia (BPH), ranged in age between 48-80 years were detected by lymphocytotoxicity test using 16A, 39B, 7CW, 14DR and 4DQ antisera. RESULTS: Patients with BPH showed an increased frequency in HLA DR53, while CAP patients showed an increased frequency in HLA-A33 and HLA DR53 antigens compared to 100 healthy Kidney donor individual as a control. The increase in HLA- antigens frequency was proved by statistical analysis, relative risk (RR) and etiological function (EF) values estimation. CONCLUSION: Possibility in the future, for novel selective immunomodulatory therapeutic strategies which stimulate a clinically significant re-expression of class I protein and associated with CTL responses

Keywords

HLA --- Prostate cancer


Article
HLA Profile in Iraqi Rheumatic Valvulitis Patients

Author: Ahmed A.A. Al-Hassan*MSc د. احمد الحسين
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 2 Pages: 238-244
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region influence susceptibility to certain disease.Objectives: This study was established to shed light on the possible association of HLA class I and II antigens with RV patients.Patients and Methods: Lymphocytotoxicity assay for HLA for class I and II typing had been done for (100) Iraqi patients suffering from rheumatic valvulitis (RV), the control groups consisting of (75 healthy individuals and 35 non rheumatic heart disease (NRHD) patients ). Results: The results showed a significant association of A33-Ags with these patients as compared with healthy and cardiac controls (P=0.005), (P=0.033) respectively. Another interesting finding was the low frequency of A1 in RV patients when compared with healthy control (p=0.002), suggesting that A1 allele may confer protective effect against this disease. In addition significant association between blood group B and RV was evident (p=0.04). An interesting observation was a strong association of blood group B and A33 among those patients (P<0.001).Conclusion: The present results are consistent with hypothesis that susceptibility to RV is genetically linked and in turn may be associated mainly with A33 in Iraqi patients. Key words: HLA, rheumatic valvulitis

Keywords

HLA --- rheumatic valvulitis


Article
HLA ANTIGENS OF ARAB CHRISTIANS IN IRAQ

Author: Batool M. Mahdi* د. بتول مطر مهدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 2 Pages: 145-155
Publisher: Baghdad University جامعة بغداد

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Abstract

SummaryBACKGROUND: Iraq had more than twenty-four millions inhabitants of populations. This nation is one of the most populated countries in the world. It is difficult to define Iraqi populations genetically (HLA polymorphism) because they are structured of a mixture of many groups. HLA phenotype frequencies that encoded by many closely linked genes that are responsible for a variety of cell surface alloantigen proteins that are responsible for differences in different ethnic groups. Arab Christians in Iraq, accounting for more than three millions inhabitant mostly the northwest and other parts of Iraq. This raised the need for a preliminary study of the HLA trend in this population. Aim of study:1-Estimating the gene frequency of HLA class I (A, B, Cw) and class II (DR and DQ) alleles in Iraqi Arab Christians.2-Assessing the genetic relationship between Iraqi Arab Christians and other Arabian, Asian and European populations.Materials and Methods: A total of unrelated 568 Iraqi Arab Christians (AC) healthy volunteers and individuals referred to Immunology and Tissue Typing Center in Al- Karamah Teaching Hospital for organ transplantation and Forensic medicine) were examined for HLA polymorphism using complement dependent cytotoxicity test from June-2003 to April-2004.Results and conclusions: The phenotypes of all loci of (AC) were in agreement with Hardy-Weinberg equilibrium. In case of HLA-A locus, three variants dominate this locus Al(0.123), A2 (0.149) and A3(0.134) which showed some similarities with Arabian , Asian and European people in the world. A3 had been found to be associated with Hereditary Hemochromatosis (HH) but the risk increased when there is a linkage disequilibrium between A3/B14. Fortunately, BI4 allele had a low frequency in this group and common allele was B35(0.154) and 851(0.128) which had an association with Behqet 's syndrom. So one can predict high incidence of this disease in this group of population. Last locus was studied in class I was Cw4 that had a higher rate (0.173) in HLA -Cw loci.In case of class II, it was done on small number of persons and the common allele was DR2(53.84%) which is protective from insulin dependent diabetes mellitus disease while DQ1 is common allele in HLA-DQ loci.HLA typing of (AC) had some similarity with Arabian people because of their same ancestry and also had some similarity with Caucasoid Europeans because of outbreading and intermixing with those populations due to migration.Key wards: HLA, Christian, Arab, Iraq.

Keywords

HLA --- Christian --- Arab --- Iraq.


Article
HLA Typing in Iraqi Patients with Obesity and Primary Osteoarthritis.

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Abstract

Background: Osteoarthritis (OA) is a degenerative joint disease. It is one of the major causes of disability in developed and developing countries. Human leukocyte antigen (HLA) as part of immune system has a role in the disease process.Objectives: To investigate whether there is an association between HLA class II-DRB and OA.Methods: A case control study with 26 patients with osteoarthritis and 22 apparently healthy obese control persons matching in ethnicity were enrolled in this study during the period between October 2012 till March 2013. Direct interview was done with each patient and HLA typing was done by molecular method using Sequence Specific Primer (PCR-SSP) method using One Lambda Kit-USA. Results: The results showed that females were more affected than males with disease when compared with control. Odds ratio were used to test level of significance. This study showed that HLA DR4 (DRB1*04), DR2 (DRB1*15 and DRB1*16), DR9 (DRB1*09), DR10 (DRB1*10, DRB5*, DRB4* and DRB3*) (odds ratio: 14.26, 9, 9, 9, 14.26, 9.5 and 4.5) respectively are associated with OA.Conclusions: OA is highly associated with HLA class II DR4 (DRB1*04), DR2 (DRB1*15, DRB1*16), DR9 (DRB1*09), and DR10 (DRB1*10).DR5 (DRB1*05) is not associated with OA.


Article
Evaluation of Some Genetic Factors in Rheumatoid Arthritis patients in Iraq
تقييم بعض العوامل الوراثية في مرضى التهاب المفاصل الرثوي في العراق

Author: Israa K. Al –Yasiri Jaafar K. Al-Mousawi Ali M.Al- Mohana
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2014 Volume: 13 Issue: 2-2 Pages: 66-74
Publisher: Baghdad University جامعة بغداد

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Abstract

Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disease affecting the joints. With more sophisticated and effective therapies becoming available and with the understanding that early intervention is crucial in preventing irreversible joint damage. The main purpose of this observational study was to evaluate and detects a good genetic factors may be used in early detection of RA. A total of 40 patients with RA who were fulfilled four or more of the 1987 American College of Rheumatology (ACR), 20 patients with joints problems (JP), 20 RA patient relatives (PR) and 10 apparently healthy control individuals were included in this study. Human leukocyte antigen (HLA) genotyping was performed using Mr. Spot SSO system. The distribution of HLA class II genotypes in 20 RA patients and 30 control groups were studied. HLA-DRB1*04 was significantly most common genotypes in the RA patients (70%) compared to control groups (23.3%). While, the frequency of HLA-DRB1*11 was very high among controls (53.3%) compared to RA patients (25.0%), but the difference was not statistically significant. RA susceptibility in most Iraqi patients was associated with the HLA-DRB1*04 genotype. The HLA-DRB1*04 allele contributed significantly to the development of RA .HLA- Therefore, HLA-DRB1*04 allele appears to play an important pathogenic role in all subsets of RA.

التهاب المفاصل الرثوي هو من أمراض المناعة الذاتية المزمنة والمدمرة التي تؤثر على المفاصل بالعلاجِ المتطوّرِ والأكثرِ فعّالية الذي أصبح متوفرا وبالفَهْم بأنّ التدخّلِ المبكّرِ حاسمُ في مَنْع الضررِ المشتركِ الغير قابل للعكس فان من المهم والمهم جدا تشخيص التهاب المفاصل الرثوي في مرحلة مبكرة جدا ولتسهيل التشخيص في المراحل المبكرة من المرض، في كثير من الأحيان عندما لم يكن كل الأعراض السريرية واضحة للعيان، إن الغرض الرئيسي لهذه الدراسةِ هذه هو الكشف عن اختبار للعوامل الوراثية يمكن استخدامه في الكشف المبكر عن التهاب المفاصل الرثوي . شملت هذه الدراسة أربعين مريض يعانون من التهاب المفاصل الرثوي لديهم أربعة أو أكثر من العلامات المحددة من قبل الجمعية الأمريكية للروماتزم, 20 مريض يعانون من مشاكل في المفاصل، 20 شخص من أقارب المرضى الذين يعانون من التهاب المفاصل الرثوي و 10 أشخاص أصحاء كمجموعة سيطرة. كما تم استخدم تقنية مستر سبوت نظام SSO (التسلسل المتخصص أحادي النيوكليوتيدات) من أجل الكشف الوراثي عن مستضد كريات الدم البيض البشرية (HLA). تم دراسة التوزيع الوراثي لمستضد كريات الدم البيض البشرية (HLA) الصنف الثاني لعشرين من مرضى التهاب المفاصل الرثوي وثلاثين من مجاميع السيطرة، أثبتت هذه الدراسة أن HLA-DRB1 * 04 كان معنويا وأكثر شيوعا (70٪) بين المرضى بالمقارنة مع مجموعات السيطرة (23.3٪). في حين HLA-DRB1 * 11 كان موجودا في عدد صغير نسبيا من مرضى التهاب المفاصل الرثوي (25٪) بالمقارنة مع مجموعات السيطرة (53.3٪). ومع ذلك، لا توجد هنالك فروق معنوية. وجد ان الحساسية للإصابة بمرض التهاب المفاصل الرثوي في المرضى العراقيين مرتبط بوجود العامل الوراثي HLA-DRB1 04 * و أن أليل 04 * HLA-DRB1 ساهم بشكل كبير في تطوير التهاب المفاصل الرثوي، ولذلك، يبدو أن HLA-DRB1 * 04 أليل تلعب دورا هاما في التهاب المفاصل الرثوي.

Keywords

Rheumatoid arthritis --- HLA.


Article
Association of HLA Class II Alleles (DRB1 and DQB1) in Iraqi Women with Endometriosis

Author: Amna M. Ali1, Mohammed I. Nader2,Batool H. AL-Ghurabi3, Ahmed K. Mohammed4
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2016 Volume: 15 Issue: 2 Pages: 42-50
Publisher: Baghdad University جامعة بغداد

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Abstract

Endometriosis is a chronic gynecological disease manifested by the occurrence of ectopic foci of endometrial tissue in the pelvic cavity and/or ovary. Etiopathogenesis of the disease is still poorly understood but there is a growing bulk of evidence that genetic factors and immunological abnormalities play a role in this disease. This study was performed to investigate the association of human leukocyte antigens class II genotypes (HLA-DR and DQ) with the susceptibility to endometriosis. Fifty female patients with endometriosis their age range (19 – 46) years and 30 femalesas control their ages were matched with the patients were enrolled in this study. Blood was collected from patients and controls, DNA was extracted from blood samples, and then HLA-genotyping was performed by polymerase chain reaction-sequence specificoligonucleotide probes (PCR-SSO).The present findings showed that DRB1*0307, DRB1*0701 and DQB1*0301 alleles were found with highly significant frequencies among patients (22 %; 34% and 24 %), in comparison with healthy control (0.0%) for three alleles, (P <0.001). On the other hand, it was observed that HLA-DRB1*0323 in high frequency among healthy individuals (23.3%) rather than in the patients (0.0%); with (P <0.001).This study demonstrates that HLA- DRB1*0307, DRB1*0701 and DQB1*0301 alleles may contribute to the increased susceptibility to endometriosis, whereas HLA-DRB1*0323 allele may confer protective effects against it, suggesting HLA-based different etiopathogenesis.

Keywords

: Endometriosis --- HLA --- Genotyping.


Article
Association of HLA class I -A and B alleles with hydatidosis In Iraqi patients

Author: Samir Sabaa1,Lazim Hammed2,Batool Al-Ghurabi3
Journal: Almuthanna Journal of Pure Science (MJPS) مجلة المثنى للعلوم الصرفة ISSN: 22263284 Year: 2014 Volume: 2 Issue: 1
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

Hydatidosis is a parasitic disease caused by infectionwith larval stage of cestode worm Echinococcusgranulosus ,it is a worle_wide disease results in serioushealth and financial loss. Iraq considered as an endemicregion for this disease. the association of HLA –allelesfrequency with the occurrence of various diseases werestudied . and significant associations were found, nosufficient studies on hydatidosis and possible role of HLAtyping and the immune status of the patients andassociation of them with cyst characteristics ,andcytokines profile and their effect on production ofimmunoglobulin . blood samples were collected forextraction of DNA and amplification by (PCR-SSO) andHLA typing by Automatic Line Probe Assay (Auto-Lipa) forHLA typing of both patients and healthy control groups, tostudy the association of certain HLA alleles. Withoccurrence of Hydatid disease. The present studyreported increase in frequency of HLA-A*0273 in hydatidpatients compare to healthy control .

Keywords

HLA --- alleles --- Hydatidosis --- PCR

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