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Article
Evaluation of Hematocrit Level, Red Blood Cells and White Blood Cells Counts in Blood from Patients with Different Severities of Periodontal Diseases

Authors: Maha Abdul Aziz Ahmed --- Chinar Jabbar Ali
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 3 Pages: 1-6
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Anemia of chronic disease (ACD) occurs in the presence of chronic infection, inflammatory conditionsor neoplastic conditions despite of adequate iron and vitamins storage. Gingivitis is the inflammation of the gingiva,periodontitis is the inflammation in the periodontium that extend deeper with loss of connective tissue attachmentand supporting bone. The main pathogenesis of periodontal diseases and ACD is immune activation.Aims of study: Determine and compare the clinical periodontal parameters (plaque index (PLI), gingival index (GI),bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL)). Evaluate thehematocrit (Hct) level, red blood cells (RBCs) count and white blood cells (WBCs) count. Assess the correlationsbetween the clinical periodontal parameters and hematological parameters at patients had gingivitis, chronicperiodontitis (CP) with different severities (mild, moderate and severe) with healthy periodontium subjects.Materials and Methods: 35-50 years old, 150 male subjects were included in this study. They were divided into threestudy groups: group of 30 patients with gingivitis, group of 90 patients with CP which subdivided into (Mild CP=30patients, Moderate CP =30 patients, Severe CP =30 patients) and control group 30 subjects with clinically healthyperiodontium. Blood samples were collected then by automated blood analyzer the Hct, RBCs and WBCs wereevaluated.Results: Comparisons among groups and subgroups revealed significant differences in Hct and WBCs, while RBCswas non-significant. Means values of RBCs count showed reduction in mild and severe CP subgroups. while, the Hctand WBCs mean values increased in patients with periodontal disease. The correlations between the clinicalperiodontal parameters with WBCs and RBCs were almost non-significant but, with Hct was mostly significantnegative correlations.Conclusion: Inflammatory and immune responses in periodontal diseases caused change in different hematologicparameters which could contribute to the development of anemia of chronic disease.


Article
Determination of Serum Trace Elements and Hematological Parameters in Lymphoma Patients Receiving Chemotherapy

Authors: Zainab Hadi Kamil --- Mufeed Jalil Ewadh --- Abdulsamie Hassan Alta'ee
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2016 Volume: 24 Issue: 9 Pages: 2498-2509
Publisher: Babylon University جامعة بابل

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Abstract

BackgroundTrace elements are essential components of biological structures, some of them play an important role as anticancer and others can be toxic at concentrations beyond those necessary for their biological functions.AimThe objective is to examine changes in serum concentration of trace elements (Cobalt (Co), Germanium (Ge), Molybdenum (Mo), Nickel (Ni) and Vanadium (V)), Mg and hematological changes in Hodgkin and Non-Hodgkin lymphoma patients receiving therapy.Materials and methodsThe study was included 25 patients with Non-Hodgkin lymphoma (NHL) and 25 patients with Hodgkin lymphoma (HL) as compared with 50 healthy subjects. Serum concentration of trace elements are measured by flame atomic absorption spectrophotometer. The total leukocyte count (TLC), hemoglobin concentration (Hb) and packed cell volume or hematocrit (Hct) are determined.Results Statistical analysis of data demonstrated significant decrease (p<0.001) in Mg and Co concentration and (p<0.01) in Ge concentration in patients with lymphomas receiving therapy as compared with healthy adults.V and Ni concentrations are significantly increased (p<0.001) in patients with lymphomas receiving therapy as compared with healthy adults. The study shows significant decrease (p<0.05) in Hb concentration and Hct percentage in patients with lymphomas receiving chemotherapy as compared with healthy subjects. It revealed significant decrease (p<0.005) in female patients with lymphoma who receive chemotherapy. Significant decrease (p<0.001) in TLC in patients with lymphomas receiving therapy as compared with healthy adults are observed. ConclusionLymphoma patients receiving therapy are often low in Mg, Ge and Co levels while Ni and V levels are high in patients with Hodgkin and Non-Hodgkin lymphoma.There is a significant decreased in TLC in patients with Hodgkin and Non-Hodgkin lymphoma whose are receiving chemotherapy..Anemia occurred in patient with lymphomas as a side effect of chemotherapy.

تعتبر العناصر النزرة مركبات أساسية في البناء الحيوي والبعض منها يلعب دوراَ مهماً كمضادات سرطانية والبعض الآخر يمكن ان يكون له تأثير سمي بالرغم من أهميته في الفعاليات الحيوية.الهدف من الدراسة معرفة التغيرات في تراكيز العناصر النزرة (الكوبالت (Co) ، الجرمانيوم (Ge) ، الموليبدينوم (Mo) ، والنيكل (Ni) و الفاناديوم (V) ) والمغنيسيوم (Mg) وكذلك التغيرات الدموية لدى مرضى سرطان الغدد اللمفاوية الهودجكني واللاهودجكني والمتلقين للعلاج الكيمياوي.شملت الدراسة 25 مريضاً بسرطان الغدد اللمفاوية الهودجكني و25 مريضاً بسرطان الغدد اللمفاوية اللاهودجكني مقارنة مع الاصحاء (50 شخصاً). تم قياس تراكيز العناصر النزرة في مصل الدم بجهاز المطياف (flame atomic absorption spectrophotometer) كما تم قياس تركيز الهيموكلوبين (Hb) ونسبة مكداس الدم (Hct) والعدد الكلي لخلايا الدم البيض (TLC).بين التحليل الاحصائي للعينات انخفاضاً معنوياً (p<0.001) في تركيز كل من Mg و Co وانخفاضاً معنوياً (p<0.01) في تركيز Ge لمرضى سرطان الغدد اللمفاوية لكلا النوعين والمتلقين للعلاج الكيمياوي مقارنة مع الاصحاء. كما ارتفع تركيز كل من Ni و V (p<0.001) لدى المرضى في هذه الدراسة.اظهرت الدراسة انخفاضاً معنوياً (p<0.05) في تركيز الهيموكلوبين ونسبة مكداس الدم وانخفاضاً معنوياً (p<0.001) في العد الكلي لخلايا الدم البيض لدى مرضى سرطان الغدد المفاوية والمتلقين للعلاج الكيمياوي مقارنةً مع الاصحاء.الاستنتاج: غالباً ما يكون تركيز كل من العناصر Mg و Ge و Co منخفضاً في مصل دم المرضى المصابين بسرطان الغدد اللمفاوية والمتلقين للعلاج الكيمياوي بينما يرتفع تركيز كل من Ni و V في مصلهم.حصول انخفاض معنوي في العدد الكلي خلايا الدم البيض لمرضى سرطان الغدد اللمفاوية والمتلقين للعلاج الكيمياوي كما يظهر لديهم فقر دم كعارض جانبي نتيجة للغلاج الكيمياوي.

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