research centers


Search results: Found 30

Listing 1 - 10 of 30 << page
of 3
>>
Sort by

Article
Hepatitis C Virus Infection Assessment Among Chronic Hemodialysis Patients in AL-Kadhmiya Teaching Hospital

Authors: Jawad K. Mnuti --- Fadhil A. AL- Abbudi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 460-464
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Hepatitis C virus (HCV) has been recognized as an emerging problem in dialysis patients, and viral hepatitis remains a major hazard for both patients and medical staff of hemodialysis (HD) units.The reported yearly incidence of anti-HCV antibody worldwide between HD patients ranges from 10.5% to 24%, while the prevalence of anti-HCV antibody among dialysis patients varies in different countries (5-85%) worldwide, and may exceed 95% in the Middle EastOBJECTIVE:To asses the prevalence of anti-hepatitis C virus (HCV) among the hemodialysis unit in AL-Kadhmiya Teaching Hospital and to identify the risk factors of infection in relation to age, sex, blood transfusions and duration of dialysisPATIENTS AND METHODS:Across-sectional study was conducted in AL-Nahrain College of Medicine in AL-Kadhmiya Teaching Hospital in dialysis unit during the period from April 2008 to December 2010. 100 patients(58 male and 42 female their ages ranged from (15—75). are known cases of end stage renal failure on regular haemodialysis. All patients underwent a history and physical examination at baseline and investigations include blood urea nitrogen, creatinine, serum calcium, phosphorus, liver function test and screen for hepatitis C virus antibodies were tested by using Murex anti-HCV ELISA , Positive cases were confirmed by polymerase chain reactionRESULTS:The prevalence of HCV infection in patients in the dialysis unit was 41%. This study showed that there was an association between the history of blood transfusions, duration of the dialysis and kidney transplantation and the prevalence of HCV infection,( P.value <0.001.)Although the levels of AST and ALT were higher in the positive HCV marker group, there was no statistically significant difference between them.CONCLUSION:HCV infection is high in hemodialysis unit in alkadhmiya teaching hospital, HCV-related liver disease in patients on long-term dialysis often appears clinically mild, with only modest elevations in AST and ALT levels but most of them asymptomatic. Observation of appropriate preventive measures in the hemodialysis center is highly recommended


Article
Hepatitis C Virus Infection Assessment Among Chronic Hemodialysis Patients in AL-Kadhmiya Teaching Hospital

Authors: Jawad K. mnuti --- Fadhil A. AL- Abbudi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 460-464
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Hepatitis C virus (HCV) has been recognized as an emerging problem in dialysis patients, and viralhepatitis remains a major hazard for both patients and medical staff of hemodialysis (HD) units.The reported yearly incidence of anti-HCV antibody worldwide between HD patients ranges from10.5% to 24%, while the prevalence of anti-HCV antibody among dialysis patients varies indifferent countries (5-85%) worldwide, and may exceed 95% in the Middle EastOBJECTIVE:To asses the prevalence of anti-hepatitis C virus (HCV) among the hemodialysis unit in ALKadhmiyaTeaching Hospital and to identify the risk factors of infection in relation to age, sex, bloodtransfusions and duration of dialysisPATIENTS AND METHODS:Across-sectional study was conducted in AL-Nahrain College of Medicine in AL-KadhmiyaTeaching Hospital in dialysis unit during the period from April 2008 to December 2010. 100patients(58 male and 42 female their ages ranged from (15—75). are known cases of end stage renalfailure on regular haemodialysis. All patients underwent a history and physical examination atbaseline and investigations include blood urea nitrogen, creatinine, serum calcium, phosphorus, liverfunction test and screen for hepatitis C virus antibodies were tested by using Murex anti-HCVELISA , Positive cases were confirmed by polymerase chain reactionRESULTS:The prevalence of HCV infection in patients in the dialysis unit was 41%. This study showed thatthere was an association between the history of blood transfusions, duration of the dialysis andkidney transplantation and the prevalence of HCV infection,( P.value <0.001.)Although the levels of AST and ALT were higher in the positive HCV marker group, there was nostatistically significant difference between them.CONCLUSION:HCV infection is high in hemodialysis unit in alkadhmiya teaching hospital, HCV-related liverdisease in patients on long-term dialysis often appears clinically mild, with only modest elevations inAST and ALT levels but most of them asymptomatic. Observation of appropriate preventivemeasures in the hemodialysis center is highly recommended.


Article
Prevalence of Hepatitis C Virus Antigen Among Patients with Lichen Planus in Alkhalis City

Authors: Hayder Mahdi Idan --- Mohammed Ahmed Mahdi
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 6 Issue: 1 Pages: 60-65
Publisher: Diyala University جامعة ديالى

Loading...
Loading...
Abstract

Background: Lichen planus is an idiopathic inflammatory disease with characteristic clinical and pathologic features affecting the skin, mucous membranes, nails, and hair. It is likely that both endogenous (genetic) and exogenous (environmental) factors such as some drugs or some infection(s) may interact to elicit the disease.Objectives: To determine the prevalence of hepatitis C virus antigen among the patients with lichen planus and comparison with healthy control group. Materials and methods: Twenty patients with lichen planus were included in this study (12 males and 8 females) and (40) healthy control (28 males and 12 females), their ages ranged from (15-60) years, obtained from Alkhalis hospital during the period from 1st February to 30th September 2013, using enzyme linked immunosorbent assay (ELISA) technique to detect anti HCV antibody in patients serum and control group. Results: Two (10 %) had positive results for hepatitis C virus antigen (2) out of (20) patients suffering from lichen planus, while none of the within healthy control group had positive result. Statistically significant relationship was observed between both of them.Conclusion: The frequent study showed a difference in prevalence of hepatitis C virus in patients with lichen planus and healthy control.


Article
Prevalence of anti-hepatitis C virus antibodies among blood donors and risky groups in Diyala

Author: Abdul-Razak S. Hassan
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 467-470
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Objective: To determine the prevalence of hepatitis C virus (HCV) infection among blood donors and risky population in Diyala province.
Materials and methods: In this retrospective study, the records of HCV screening and confirmatory tests were reviewed for the period 1996-2001.Third generation Enzyme-linked immunosorbant assay (ELISA) and Enzyme immunoblot assay were used as screening and confirmatory tests respectively.
Results: The prevalence of HCV infection among blood donors was 0.15%, with the highest in 1997. The highest prevalence rates were found among multiple blood recipient; hemophilia, thalassemia and hemodialysis patients (27.3%, 16.9% & 14.3%) respectively. Whereas, the patients with chronic hepatitis B infection and those with acute icteric hepatitis showed slightly elevated prevalence (2.9% & 2.1%) respectively. The overall prevalence in the province was 9.9/105 population. The mean age of infected patients was 29.7 years and the male: female ratio was 3:1.
Conclusion: The prevalence of HCV infection in Diyala population is relatively low. However, the HCV infection is concentrated in certain risky groups, particularly multiple blood recipients.


Article
Screening of Hepatitis B- and C- Viral Markers in Iraqi Patients with Proteinuria

Author: Abdul Hadi K . Hussain
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 4 Pages: 362-368
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Viral hepatitis may lead to nephropathy as one of its multiple extra hepatic manifestations. Symptomatic proteinuria as detected by dipstick, and qualitative urine collection are simple tests in practice as well as useful cardinal test of underlying renal abnormalities. The aim of this study was to elucidate the impact of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections on the occurrence of symptomatic proteinuria amongst adults and pediatrics.PATIENTS & METHODS :A prospective study included (143) adult and pediatric Iraqi patients presented with symptomatic proteinuria, and 108 (age- and sex-matched) apparently healthy individuals (as control group) who were serologically screened for HBV & HCV markers using third generation Enzyme linked immunosorbent assay (ELISA) techniques, screening for HIV by ELISA and other related immunological and biochemical profile.RESULTS :It was found that the prevalence of hepatitis B surface antigen (HBsAg), anti hepatitis B core antibody (anti-HBc-IgM), anti hepatitis B surface antibody (anti-HBs) and anti hepatitis C antibody (anti-HCV) in the proteinuria group as compared to control group, were (7.0% vs. 0.9%, P<0.05) for HBsAg, (2.8% vs. 0% ,P>0.05) for anti-HBc-IgM, (20.3% vs. 23.1%, P>0.05) for anti-HBs antibody, and (6.3% vs. 0%, P<0.01) for anti-HCV.CONCLUSION :Our study demonstrated a significant association between proteinuria and HCV, and HBV infection in the adult and pediatric population. The interpretation of serological patterns of viral hepatitis markers in patients with newly diagnosed proteinuria are important, it might suggest that detailed urinalysis and qualitative urine protein assessment is mandatory when managing patients with HCV or with HBV infections.


Article
Measuring of C-reactive protein titer in patients with acute hepatitis-C Virus infection

Authors: Rana S. Naseer --- Salah M. Hasan --- Donia A. Razzaq Mahmod
Journal: nursing national Iraqi specility المجلة العراقية الوطنية للعلوم التمريضية ISSN: 18122388 Year: 2011 Volume: 24 Issue: 2 Pages: 64-70
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Objective(s): To measure serum C-reactive protein (CRP) titer as a predictive diagnosis of acute hepatitis C virus (HCV) infection. Methodology: Two hundred and ten patients with acute HCV infection and 234 apparently healthy individuals as control group were enrolled in this study in Baghdad medical city (Teaching Laboratories). The patents include 74(35.2%) females and 136 (64.8%) males with mean age (27±16.5) years. The control group includes 114 (48.7%) females and 120 (51.3%) males with mean age (26±5.8) years. Blood samples were collected from out patients from Alfadul in Baghdad city. Sera were separated and stored at 20 0C. The diagnosis of acute HCV infection was based on detection of HC Ag and anti- HCV IgM and standard liver function tests. Determination of CRP titer was assessed by semi-quantitative tube agglutination test. All data were statistically analyzed. Results: Based on 95% percentile, the baseline CRP titer in healthy individuals was 1:8 (16mg/l) and for patients 1:512 (1024mg/l). There was a statistically significant increase in the mean CRP titer in patients with acute HCV infection compared to healthy individuals (P< 0.001) .The validly of CRP titer 1: 64 as a cut –off value to predict HCV infection provide a sensitivity and specificity of 100 % and 96% respectively. Furthermore, there was a significant correlation between CRP titer and liver function test values. Recommendation:Therefore, in further studies, we recommends the evaluation of C- reactive protein titer in patients with acute hepatitis B Virus infection and patients with non–infectious diseases such as cardiovascular disease, diabetes mellitus and hyperlipidemia infection, and compare between them.

الهـدف: قياس عيارية بروتين (C) المنشط في التشخيص التنبؤي لالتهاب الكبد الفيروسي نمط (C) الحاد.المنهجيـة: شملت الدراسة 210 من المرضى المصابين بإلتهاب الكبد الفيروسي نمط (C)الحادّ و234 شخصاً من الأصحاء ظاهرياً كمجموعة ضابطة. تضمنت مجموعة المرضى 74 (35,2%( أناث و136) 64,8%( ذكور وبمعدل عمر (16,5±27) سنة. المجموعة الضابطة تألفت من 114 (48,7% ( أناث و120 (51,3%) ذكور وبمعدل عمر( 5,8± 26) سنة. جُمِعَت نماذج الدم وتمّ فصل الأمصال وتجزنتها في أنابيب صغيرة وحفظت في درجة حرارة – 20 م . تشخيص حالات إلتهاب الكبد الفيروسي نمط (C) الحادّ اعتمد على وجود المستضد السطحي (HC Ag) والضدات النوعية lgM (Anti-HC –lgM) إجراء فحوص وظائف الكبد تحديد عيارية بروتين المنشط أجري بطريقة التلازن شبه الكمية جميع البيانات حللت إحصائياً.النتائـج: اعتماداً على نسبة 95% فإنّ المستوى الأساس العيارية بروتين(C) المنشط بين الأشخاص الأصحاء كان 1: 8 (16 ملغرام/لتر) وبين المرضى 1:512 (1024 ملغرام/لتر). أظهرت النتائج الوسيط الحسابي العيارية بروتين (C) المنشط كان أعلى بشكل معنوي اححائيا مقارنة بالاشخاص الاصحاء (P<0.001) ان صلاحية عيارية بروتين(C) المنشط عند القيمة الفاصلة 1: 64 للتنبؤ بإلتهاب الكبد الفيروسي نمط (C)الحاد اعطت حساسية خصوصية 100% و 96% على التوالي , وان نسبة الصواب كانت 98%. فضلاً عن ذلك، أظهرت النتائج وجود ترابط معنوي إحصائياً بين عيارية بروتين (C) المنشط يمكن ان يكون ذا قيمة في التشخيص التنبؤي لااتهاب الكبد الفيروسي نمط (C) الحادّ عندما يشكل التشخيص السريري 50%.


Article
Comparison between Recombinant Immunoblot assay 3rd generation and enzyme linked immunosorbent assay for detection hepatitis C virus .
المقارنة بين التهجين المناعي البقعي الجيل الثالث و مقايسة الأنزيم المرتبط الممتز المناعي في التحري عن التهاب الكبد الفيروسي سي.

Loading...
Loading...
Abstract

This study was carried out to compare between recombinant immunoblot assay 3rd generation and enzyme linked immunosorbent assay for identify hepatitis C virus. Seventy six Iraqi patients undergo hepatitis C were involved in this study. The study was carried out from July 2010 to April 2011 were followed up in public health center- Baghdad. These patients included 54 males and 22 females as well as their ages ranged between (8-68) year with a mean age of 47.1±13.79, besides, the majority of patients are at the age between 31-60 year (54 %), while children elicit less frequency of infection (2 %). Additionally the ratio between male to female was 2.45:1. There are two methods which are used for HCV diagnosis. The first method by using ELISA technique for detection of anti HCV antibody. 61 out of 76 sera samples of hepatitis patients (i.e. 80.2%) were found to be positive for this test. Another advanced method such as recombinant immunoblot assay 3rd generation (RIBA) has been applied, all these specimens gave positive results (100 %) with significant difference was noticed between them (P<0.05), therefore the current results confirm that a RIBA 3rd generation is more sensitive manner to detect hepatitis C virus than ELISA.

أجريت هذه الدراسة للمقارنة بين التهجين المناعي البقعي الجيل الثالث و مقايسة الأنزيم المرتبط الممتز المناعي في التحري عن التهاب الكبد الفيروسي سي. أجريت الدراسة في مختبر الصحة المركزي- بغداد للفترة من حزيران 2010 ولغاية آب 2011. تضمنت الدراسة 76 مريض عراقي مصاب بالتهاب الكبد الفايروسي سي و مؤلفين من 54 ذكر و 22 أنثى و بعمر يتراوح من 8-68 سنة وبمعدل عمري قدره 47.1±13.79 وكذلك أوضحت الدراسة بان أكثر من نصف المرضى يقعون ضمن الفترة العمرية الممتدة من 31-60 سنة ( 54 % ) وبينما سجل الأطفال اقل إصابة وبنسبة (2%). وبالإضافة إلى ذلك كانت نسبة الذكور أعلى من الإناث 2.45:1. تم استخدام طريقتين لتشخيص التهاب الكبد الفايروسي سي ، الطريقة الأولى باستخدام مقايسة الأنزيم المرتبط الممتز المناعي في التحري عن التهاب الكبد الفيروسي سي ، حيث أوضحت النتائج بان 61 من مجموع 76 نموذج مصلي لمرضى التهاب الكبد الفيروسي اعطو نتيجة موجبة باستخدام هذه الطريقة وبنسبة (82%) وبينما أعطت جميع النماذج المصلية نتيجة موجبة باستخدام طريقة التهجين المناعي البقعي الجيل الثالث وبنسبة (100%) لذلك فان نتائج الدراسة اثبت بان طريقة التهجين المناعي البقعي الجيل الثالث أكثر حساسية من طريقة مقايسة الأنزيم المرتبط الممتز المناعي في التحري عن التهاب الكبد الفيروسي سي.


Article
SEROCONVERSION RATE OF HEPATITIS C VIRUS INFECTION AMONG HAEMODIALYSIS PATIENTS IN AL-KADHIMIYA TEACHING HOSPITAL (DIALYSIS UNIT)

Authors: Arif S Malik عارف سامي مالك --- Hasanain MH AL-Rubaie حسنين الربيعي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 4 Pages: 343-349
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

BackgroundHepatitis C virus (HCV) infection is a serious public health problem throughout the world. Chronic haemodialysis patients are at higher risk for acquiring hepatitis C virus (HCV) infection.ObjectiveTo assess the rate of seroconversion of hepatitis C virus (HCV) infection every month for one year duration, to evaluate the possible associated risk factors and the relationship of hepatitis C virus infection with blood transfusion and duration of hemodialysis.MethodsFifty seven patients, 37 males (65%) and 20 females (35%), who were on regular haemodialysis in Al-Kadhimiya Teaching Hospital was studied during the period between January 2009 and December 2009. Patients were analyzed monthly with anti –HCV antibodies using a commercial enzyme-linked immuno-sorbant assay BioKit (bioelisa HCV 4.0) and serum Alanin aminotransferase measurements.ResultsTwenty three patients (40.3%) were HCV positive of whom, 13 were males (56.5%) and 10 were females (43.5%). History of blood transfusion, number of blood transfusion and duration of haemodialysis, had significant correlation in acquiring HCV infection.ConclusionSeroconversion of HCV infection was of high rate incidence (40.3%). Duration of HD, history of blood transfusion and number of blood transfusion(s) are factors affect the rate of seroconversion of HCV infection in patients on regular HD. The higher rate of seroconversion of HCV infection needs further research to identify the causes and to establish a well organized prophylactic program by using more sophisticated and accurate investigation.Key wordsHepatitis C virus infection, Hemodialysis, Chronic renal failure


Article
Using Anti-Nuclear Antibody and Rheumatoid Factor to Evaluation of Immune- Pathogenic Link of Rheumatoid Arthritis and Hepatitis C Virus in Iraqi Patients

Author: Mohammed A. Saleh
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2012 Volume: 15 Issue: 2 Pages: 126-131
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

This study was aimed to assess immune- pathogenic association of HCV infection among RA patients. A cross sectional study was conducted on the following groups: patient group includes forty patients with RA. Their age range was between (20-70) years with (7) (17.5%) males and (33) (82.5%) females. Healthy Group: thirteen serum samples were collected from apparently healthy individuals they served as a control group.Their age range was between (23-59) years. Results of this study reveals that the majority of RA patients are females (82,5 %) with females to males ratio of 4.7: 1. Moreover, the mean of age for RA and control groups are (46.83 ± 12.06) and (45.23 ± 12.58), respectively. The prevalence of RA among RA females was (82.5%) and (17.5%) for male and the frequency of rheumatoid Factor positivity among RA patients was (70%) in comparison with (0.0%) for apparently healthy control group with significant differences (P ≤ 0.001). Also, ANA positivity was higher (27,5%) than that for healthy control group (0.0%) with significant differences (P≤ 0.005). Results showed that, the frequency of positivity anti-HCV Ab was (5%) among RA patients in comparison with apparently healthy control group (0 %). Our results sustain the possible contribution of HCV infection in the pathogenesis of RA.

هدفت هذه الدراسة إلى أثبات العلاقة مابين التهاب الكبد الفيروسي نمط (ج) ومرض الحمى الرثوانية وذلك من خلال قياس العلاقة المناعية-الأمراضية مابين التهاب الكبد الفيروسي نمط (ج) والحمى الرثوانية.تم أجراء هذه الدراسة على المجموعات التالية: مجموعة المرضى والتي تضمنت أربعين مريض مصابين بمرض الحمى الرثوانية وكان مدى أعمار المرضى مابين (20-70) سنة وعدد الذكور (7) (17.5 %) والإناث (33) (82.5%). مجموعة الأصحاء: جمعت ثلاثة عشر عينة مصل من أفراد أصحاء ظاهريا وكان مدى أعمار لأصحاء مابين (23-59) سنة. أظهرت نتائج الدراسة بان أغلبية المرضى من الإناث (82.5 %) ونسبة الذكور إلى الإناث 4.7:1، علاوة على ذلك كان متوسط العمر لمجموعتين المرضى والسيطرة ( 46.38 ± 12.06)،(45.23 ± 12.58) على التوالي. أكدت الدراسة بان نسبة انتشار مرض الحمى الرثوانية في الإناث (82.5%) وفي الذكور (17.5%) وبينما معدل موجبيه العامل الرثواني في مرضى الحمى الرثواني كان (70%) بالمقارنة مع مجموعة السيطرة (0.0%) مع وجود فرق معنوي ، من ناحية أخرى أوضحت الدراسة بان نسبة موجبيه الأجسام المضادة ضد النووية عالية (27%) بالمقارنة مع مجموعة السيطرة (0.0%) مع وجود فرق معنوي ، فضلا على ذلك أكدت الدراسة بان نسبة الايجابية للإصابة بفيروس التهاب الكبد الفيروسي نمط (ج) في مرضى الحمى الرثوانية كانت (5%) بالمقارنة مع مجموعة السيطرة. نتائج الدراسة أثبتت احتمالية مساهمة فيروس التهاب الكبد نمط (ج) في أمراضية الحمى الرثوانية.


Article
Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon
دراسة مستوى تعبير جين beta 2 microglobulin في مرضى التهاب الكبد الفيروسي سي قبل وبعد العلاج بالانترفيرون

Author: Mohammed A. Saleh محمد عبد الدايم صالح*
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2012 Volume: 9 Issue: 3 Pages: 504-510
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

This study has been carried out to evaluate the expression level of beta 2 microglobulin gene on patients infected by hepatitis C virus before and after treatment with interferon. The study included 117 hepatitis C patients comprising as 63 pre-treated patients, the range of age was between 20-65 year with a mean age of 48.12 ± 16.1 and 54 post-treated patients with age range was between 23-63 year with the mean of 46.1 ± 18.1. Also it was found that more than half of patients were located within third and fourth decade i.e. 30-49 year, with a percentage of 52.4% and 55.6 % for pre-treatment and post-treatment patients respectively. Moreover , regarding both groups, males are more than females with the ratio of ( 3.2:1) among pre-treatment group and 2:1 among post-treatment group. Further , It has been found that the concentration of β2 microglobulin was (3.425±0.943mg/L) among pre-treatment group and (1.860±0.723 mg/L) among post-treatment group with significant correlation (P=0.05). Besides that , in the present study ,It has been found the concentration of β2 microglobulin was decrease after treatment from (3.425±0.943 mg/L) to (1.860±0.723mg/L) which was statistically significant (P=0.05) , Thus β2 microglobulin can be used as a supporting marker of responsiveness to treatment with interferon in hepatitis C patients as well as indicator for monitoring the disease progression.

أجريت هذه الدراسة لتقييم مستوى تعبير جين beta2 microglobulin في مرضى التهاب الكبد الفايروسي سي قبل وبعد العلاج بعقار الانترفيرون .شملت الدراسة 117 مريض مصاب بالتهاب الكبد الفايروسي سي مؤلفين من 63 مريض غير معالج وبعمر يتراوح من 20-65 سنة وبمعدل عمري قدره 48.12±16.1 و54 مريض معالج وبعمر يتراوح من 23-63 سنة وبمعدل عمري قدره 46,1±18,1 وكذلك أوضحت الدراسة بان أكثر من نصف المرضى يقعون ضمن العقد الثالث والرابع من العمر (30-49 سنة) وبنسبة 52,4% للمجموعة غير المعالجة و55,6% للمجموعة المعالجة ومن جهة أخرى كانت نسبة الذكور أعلى من الإناث ولكلا المجموعتين 3.2:1 للمجموعة غير المعالجة و2:1 للمجموعة المعالجة ومن ناحية أخرى كان تركيز beta2 microglobulin بالنسبة للمجموعة غير المعالجة (3.425±0.943mg/L) و(1.860±0.723mg/L) بالنسبة للمجموعة المعالجة مع وجود فرق معنوي (P=0.05) وبالإضافة إلى ذلك بان نتائج الدراسة أوضحت بان تركيز beta2 microglobulin انخفض بعد العلاج من (3.425±0.943 mg/L) إلى (1.860±0.723mg/L) مع وجود فرق معنوي (P=0.05) وكنتيجة لذلك يمكن استخدام beta2 microglobulin كواسمة داعمة لمعرفة الاستجابة العلاجية لعقار الانترفيرون في مرضى التهاب الكبد الفايروسي سي وكمؤشر لمراقبة تتطور المرض

Listing 1 - 10 of 30 << page
of 3
>>
Sort by
Narrow your search

Resource type

article (30)


Language

English (23)

Arabic and English (4)


Year
From To Submit

2019 (2)

2017 (2)

2016 (3)

2015 (2)

2014 (1)

More...