research centers


Search results: Found 3

Listing 1 - 3 of 3
Sort by

Article
The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers

Loading...
Loading...
Abstract

Herpes labialis is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums, or the skin around the mouth. Although there is no successful treatment available, the local use of compounds with effective anti-inflammatory and cytoprotective effects may be of value in this respect. This project was designed to evaluate clinically the local use of silymarin, a group of flavonoids with powerful antioxidant, anti-inflammatory and cytoprotective activity, in the treatment of herpes simplex ulcer. Fifty three patients with herpes labialis ulcers (HLU) were enrolled in this randomized, single blinded, placebo controlled clinical study, and they were allocated into 4 groups, treated with 1%, 3% and 5% silymarin paste and placebo formula respectively. Patient's responses to treatment were followed by clinical evaluation of healing time, size of the ulcers and pain sensation, in addition to evaluating biochemical and immunological markers of the oxidative stress and inflammatory response. HLU patients showed dose dependent improvement in the healing time, pain score and size of ulcer as a result of treatment with various concentrations (1%, 3% and 5%) of silymarin paste, associated with improvement in the oxidative stress state and immunological parameters. In conclusion, silymarin can be used locally as paste formula for the treatment of HLU, an effect which may be attributed to its antioxidant, anti-inflammatory and cytoprotective properties.

Keywords

Herpes labialis --- ulcers --- silymarin


Article
The clinical effectiveness of topical propo-lis in comparison with Acyclovir in pa-tients with recurrent herpes labialis

Authors: Abbas F Al-Taee --- Wasan M Al-Omary --- Jawnaa K Mamdoh
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2012 Volume: 12 Issue: 2 Pages: 236-241
Publisher: Mosul University جامعة الموصل

Loading...
Loading...
Abstract

To evaluate the clinical effectiveness of ethanolic extract of propolis (viscous solution12.5%) compared with the effect of Acyclovir (ACV) cream 5% in patients with recurrent herpes labialis (RHL). Materials and Methods: Thirty patients with active lesions (intact vesicle and rupture lesions) were included in this clinical trial. Fifteen patients were treated with viscous solution of ethanolic propolis extract while the other fifteen patients were treated with Acyclovir cream 5%. Results: Com-plete resolution of prodromal symptoms ( itching, tingling or burning) and erythema were noticed in propolis group after two days of treatment compared with none in ACV group. Statistically very high-ly significant difference in RHL lesion size in ACV group was observed (P<0.000), compared with highly significant difference in propolis group (P < 0.001). Conclusions: ACV cream 5% appeared to be more effective topically in healing time than ethanolic extract of 12.5 % viscous solution of propo-lis.Topical propolis would alleviate symptoms and erythema of RHL completely after two days whe-reas this action was not seen in topical ACV cream 5%.


Article
Effectiveness Of Low Level Diode Laser (1064) And Acyclovir in Treatment Of Recurrent Herpes Labialis. (Comparative Clinical Study)

Authors: Gassan Y Hamed --- Ahmed S Khudhur --- Zaid A Alshamaa
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2017 Volume: 17 Issue: 1 Pages: 23-31
Publisher: Mosul University جامعة الموصل

Loading...
Loading...
Abstract

Aims: To evaluate the clinical effectiveness of low level diode laser (1064) compared with the effect of Acyclovir (ACV) cream 5% in patients with recurrent herpes labialis (RHL). Materials and Methods: Thirty patients with active lesions (intact vesicle and rupture lesions) were included in this clinical trial. Fifteen patients were treated with low level diode laser (1064) while the other fifteen patients were treated with Acyclovir cream 5%. Results: Complete disappearance of prodromal symptoms ( itching, tingling or burning) and erythema were noticed in low level diode laser (1064) group after three days of treatment compared with ACV group. Conclusions: low level laser (1064) appeared to be more effective in healing time and pain relief than ACV cream 5%. Key words: Dental crowding; ClassII malocclusion; Dentoskeletal morphology.

Listing 1 - 3 of 3
Sort by
Narrow your search

Resource type

article (3)


Language

English (3)


Year
From To Submit

2017 (1)

2012 (1)

2007 (1)