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Article
Non- Hodgkin's Lymphoma; Epidemiology and Presentation

Authors: Zead Ismael Ibrahim --- Allawi N. Hussein --- AbdulSattar I. AL-Kubaysi --- Tariq A. AL-Shujairi --- et al.
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2013 Volume: 2 Issue: 1 Pages: 1-6
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The non-Hodgkin lymphomas (NHL) of childhood are a diverse collection of diseasesoriginating in the cells and organs of immune system.Objectives: To determine epidemiology and clinicopathological presentations of children with NHLadmitted to Child's Central Teaching Hospital.Methods: A retrospective study was done from 1st of January 2004 to the 31st of December 2009; thepatients with newly diagnosed NHL, age less than 15 years, who were admitted to thepediatric oncology unit in the Child’s Central Teaching Hospital.Results: The total number of patients was 84; the mean age at diagnosis was 6.3years, with a male tofemale ratio of 2:1. Most of patients were presented in stage III&IV (88%).Most commonpresenting features were abdominal distension or a mass in 51%.Burkitt lymphoma andBurkitt like lymphoma were the most common histological subtype (58.33%).Conclusions: The majority of cases were between 5-9 year age group, and the mean age atpresentation was 6.3 years old, with a male to female ratio of 2:1. The most commonpresenting site was the abdomen. The majority of cases were fallen in advanced stages(III&IV). Histopathologically Burkitt's lymphoma was the commonest subtype.


Article
Clinicopathological, immunohistochemical charachtaristic and the outcome of Hodghkin lymphoma patients in Erbil city, Iraq

Authors: Lilan Bahzad Mohammedzaki --- Kawa Muhammedamin Hasan --- Ranan Kardagh Polus --- Ahmed Khudair Yassin
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2019 Volume: 8 Issue: 1 Pages: 14-20
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: Hodgkin lymphoma (HL) has unique epidemiological features with diversifiedpathologies and exhibits considerable clinicopathological variations in different parts of the world.OBJECTIVES: We aimed in this study to assess clinic-pathological features, immunohistochemistryand outcome of HL patients treated in Erbil, northren Iraq.PATIENTS AND METHODS: This was a retrospective study conducted in Nanakaly Hospital forblood diseases and oncology in Erbil, North Iraq; a total of 125 patients diagnosed between January2012 and December 2016 were involved; they were assessed for their clinical characteristics andhistopathology and immunophenotyping findings and their outcome was evaluated as well.RESULTS: The median age was 28 years (range: 18–71 years); 55% were male and 41% had StageII disease; common histological type is nodular sclerosis (51.2%) followed by mixed cellularity (43.2%);CD30 was positive in nearly all cases of classical HL, and CD15 was positive in 98.7% and CD20was positive in 75% in nodular lymphocyte predominant subtype. Most of the patients receivedadriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy, and the 5‑year overall survivalin our study is 70%. Advanced stage (IV), high lactate dehydrogenase level, low hemoglobin, andsplenomegaly are significant predictors for poor survival.CONCLUSION: Our patient exhibited outcomes that were lower to those reported in developedcountries.


Article
Immunohistochemical and clinicopathological study of non-Hodgkin's lymphoma in Erbil, Kurdistan
دراسة كيميائية مناعية ونباتية لأورام ليمفوما اللاهودجكين في أربيل، كوردستان

Authors: Maysoon Alhaideri --- Rafal Abdul Razaq Al-rawi --- Tara Sirwan Kamil
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 2 Pages: 756-762
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Non-Hodgkin lymphoma is a cancer of the lymphatic system. Types of non-Hodgkin lymphoma vary significantly in their severity from indolent to very aggressive. The aim of this study was to investigate the incidence, immunohistochemical expression, clinical and histopathological prognostic factors of patients with non-Hodgkin lymphoma.Methods: A total of 59 patients with non-Hodgkin lymphoma cases were reviewed and investigated at Razgary Teaching Hospital in Erbil city during the period from January, 2011 to January, 2013. Data of patients were tabulated and distributed according to their age, sex, site, immunohistochemical expression and WHO classification.Results: Age of non-Hodgkin lymphoma patients ranged from 2 to 88 years with a mean of 45 year. Around 49% of the patients were of age group over 50 years and 54.2% of pa-tients were male. Immunohistochemical investigation indicated that 71.2% of non-Hodgkin lymphomas were of B cell type, the highest percentage (33.3%) of them was of diffuse large cell type. While the T cell type was found in 20.3%, the highest percentage (33.3%) of them was of Anaplastic lymphoma. CD20 and CD3 showed more consistent and strong expression for B and T cells non-Hodgkin lymphoma, respectively. Results showed high BCL2 expression. Nodal non-Hodgkin lymphoma account for 50.8% of the total cases.Conclusion: Most non-Hodgkin lymphomas were of B cell type and highest percentage is of diffuse large cell type. CD20 and CD3 were more reliable as an indicator of B and T cell lineage, respectively. Most non-Hodgkin lymphomas were of intermediate-high grade. Nodal site represent highest rate for primary non-Hodgkin lymphoma.


Article
Prognostic Significance of Immunohistochemical Overexpression of P53 And Bcl-2 Proteins in Patients with Non-Hodgkin’sLymphoma

Authors: Farah Amer Albejow --- Hadeel Abdul-Elah Kerbal --- Najlaa Bader Alawadi --- Ahmed Raji Kharulla
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 721-729
Publisher: Babylon University جامعة بابل

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Abstract

Non-Hodgkin's lymphomas are the hematologic malignancy with the most prevalence worldwide, they are generally classified as B-cell or T-cell lymphoma .Theincidence rate of NHL for the total population is 5.16 % according to Iraqi cancer registry (ICR) in 2010.This study was designed to asses’bcl-2 and p53 overexpression in Iraqi patients with NHL and correlation with different prognostic indices (age, sex, stage, grade, and International prognostic index).Samples included in this study represented as 50 formalin-fixed paraffin embedded lymph node blocks of patients with NHL,during the period from September 2013 till November 2014,and these blocks collected from the histopathology laboratories of Al-Hilla Teaching Hospital as well as many private histopathology laboratories in Hilla city, These blocks stained Immunohistochemically for bcl-2 and p53 protein expression by using L-SAB+ staining methods.Results revealed Significant correlation between bcl-2, p53overexpression and different grades of NHL (p-value < 0.05), while there are no significant relationship between bcl-2, p53 and age, sex, stage, and IPI score (p-value > 0.05).In conclusion there are up regulation of P53 protein associated with down regulation of bcl2 protein in patients with high, intermediate to low grades of NHL while no significant association with IPI score& factors.

Keywords

Non-Hodgkin lymphoma --- P53 --- Bcl-2


Article
Salivary Immunoglobulin A Assessment in Lymphoma Patients before and after Chemotherapy

Authors: Mohammed H. Abdulshaheed محمد عبد الشهيد --- Fawaz D. Al-Aswad فواز الاسود --- Haider N. Salh حيدر صالح
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 3 Pages: 65-68
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Lymphomas are group of diseases caused by malignant lymphocytes that accumulate in lymph nodesand caused the characteristics lymphadenopathy. Occasionally, they may spill over into blood or infiltrate organsoutside the lymphoid tissue. The major subdivision of lymphomas is into Hodgkin lymphoma and non–Hodgkinlymphoma and this is based on the histologic presence of Reed-Sternberg cells in Hodgkin lymphoma. Salivaryimmunoglobulin A is the prominent immunoglobulin and is considered to be the main specific defense mechanism inoral cavity. The aim of this study was to determine the level of salivary immunoglobulin A in lymphoma patientsbefore and after chemotherapy treatment.Subjects, materials and methods: The study included 25 patients (15 male and 10 female) with non–Hodgkinlymphoma(B-cell type) , 25 patients( 16 male and 9 female ) with Hodgkin lymphoma and 25 (15 male and 10female) healthy control group. Whole un-stimulated saliva was collected to determine the level of salivaryimmunoglobulin A, which measured by Enzyme Link Immunosorbent Assay.Results: The level of salivary immunoglobulin A was significantly higher in pre-treatment patients in comparison withcontrol group, and there was a significant decrease after chemotherapy treatment when compared to their baseline levels in both study groups.Conclusion: The salivary immunoglobulin A was higher in lymphoma patients than control, then its level showedobvious decrease after chemotherapy treatment.


Article
3.PEDIATRIC HODGKIN LYMPHOMA IN IRAQ-KRG-SULAIMANI

Authors: Basil K. Abdallah باسل عبدالله --- Nawshirwan G. Rashid نيشروان رشيد --- Shwan A. Tawfiq
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 1 Pages: 12-17
Publisher: Al-Nahrain University جامعة النهرين

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Background: Hodgkin lymphoma (HL) is a highly curable malignancy. It is a unique neoplasm, in which the malignant cell is the Reed-Stenberg cell (RSC); it constitutes approximately 40% of all lymphomas that present during childhood.Objective: To obtain local data on the pattern of childhood and adolescent HL in our community at presentation and then compare it with the international figure.Methods: Eighty-five patients with newly diagnosed pediatric HL were admitted to Hiwa Hematology/Oncology Hospital in Sulaimaniya province of Iraqi Kurdistan were included in this study, they were studied prospectively from March 2006 to March 2014. The patients staged by Ann Arbor Staging system and categories into three risk group depending on the Stage and Number of Nodal Sites and the presence of Bulky Disease. Data analyzed using SPSS software; version 13 and P-value obtained by Chi-square test.Results: The median age at diagnosis was about 13.7 years with peak age of incidence was between 15-18 year and with male predominance. Most common site of the primary tumor was cervical lymph nodes; nodular sclerosis was the most common histopathological subtype and the majorities were presented in stage IIA. Conclusion: The stage in this study was age dependent but neither there was relation between the site of the primary tumor and the risk categories nor relation between risk categories and sex.Keywords: Hodgkin lymphoma, stage, sex distribution, risk categoryCitation: Abdallah BK, Rashid NG, Tawfiq SA. Pediatric Hodgkin lymphoma in Iraq-KRG-Sulaimani. Iraqi JMS. 2019; 17(1): 12-17. doi: 10.22578/IJMS.17.1.3.


Article
Immunophenotypic study of non-Hodgkin lymphomas in adult and elderly patients at National Center of Hematology-Baghdad.

Authors: Abdusalam Hatim Mohammed --- Sajid Saad Mohammed --- Jawad. k. Mashaali
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 2 Pages: 127-131
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Background: Non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferativemalignancies with different patterns of behavior and responses to treatment. The understanding andhistopathological diagnosis of NHL has improved with the use of advanced technology. Theimmunophenotyping of tumors of hematopoietic origin serves in the first place to distinguish theseneoplasms from others, and to distinguish neoplasms from reactive processes.Objectives: The aim of this study was to determine the percent of each category of NHLPatients and Methods: Sixty eight patients who were diagnosed to have stage 4 non-Hodgkin lymphomaby histopathological examination of bone marrow aspirate and biopsy at National Center ofHematology/Baghdad were subjected to immunohistochemistry examination, two cases diagnosed ashairy cell leukemia by histopathological examination but not by immunohistochemistry as there were noCD markers available at the time of study so they were discarded from this study. Immunohistochemistrywas done either in hospital or in private laboratory for proper subtyping of the disease and yet to receivecorrect therapy and better response.Results: Cases were diagnosed as fallowsB-cell lymphoma constitute 57 cases 86.36%T-cell non-hodgkin lymphoma 6 cases 9.09%Splenic lymphoma 1 case 1.5%Mantle cell lymphoma 2 cases 3.03%Conclusion: Immunohistochemical study is a specific method to aid histopathology in proper diagnosisand subtyping of non-Hodgkin lymphoma


Article
Prevalence of Epstein - Barr virus types in subtypes of Hodgkin lymphoma in Kerbela city, Iraq
انتشار انواع فيروس الابسن بار في الانواع الفرعية للاورام اللمفاوية الهودجكن في مدينة كربلاء ، العراق

Authors: Hussein Abd Ali Mohamed Sadeq Al Her --- M ohanad Mohsen Ahmed --- Haider Jebur Kehiosh
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2019 Issue: 16 Pages: 77-90
Publisher: Kerbala University جامعة كربلاء

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Background: Epstein-Barr virus (EBV) is a ubiquitous virus associated with lymphomas. However, in Karbala as other parts of Iraq, EBV detection is not a part of the workup for lymphoma diagnosis. The aim of this study: to study the prevalence of EBV types in the subtype of Hodgkin lymphoma among patients from Kerbala province, Iraq. Methods: Archival formalin-fixed paraffin embedded blocks from 31 patients with mean age 32.56±15.685 (range from 5 to 70years) diagnosed Hodgkin lymphoma during the period from 2010 to 2018 in Karbala city included in this study. Histological diagnosis was reviewed. Around 25mg of archival tissue were used to extract DNA. DNA extracts were used Polymerase Chain Reaction (PCR) targeting the EBNA3C region of the viral genome. This PCR system offered detection and typing of the EBV. T-test and chi-square were used to evaluate the association between age with the subtype of Hodgkin lymphoma, gender and EBV state. Results: The majority of the Hodgkin lymphomas belonged Mixed Cellularity HL (MCHL) [n=18, 58%] where Nodular Sclerosis HL (NSHL) was seen in 42 % (n=13). The other subtypes of HL were not reported in this study. Male more affected with HL than female (16 vs.15) and the peak age range of HL 31to 40 years. EBV was detected in 18(58%) out of all cases. EBV type 1 was more common in MCHL were types 2 was the most common among NSHL cases. To our knowledge, this is the first time such data has been generated in Iraq. Conclusion: most of the HL cases in Kerbela are associated with EBV. there is a difference in the distribution of the EBV types according to the subtypes of lymphoma.

الخلفية: فيروس الابسن بار هو فيروس شائع الانتشار ويكون عادة مرتبط بالأورام اللمفاوية. ومع ذلك ، في كربلاء وفي مدن العراق الاخرى ، لا يعتبر كشف الفايروس جزءًا من عملية تشخيص الإصابة بالورم اللمفاوي. الهدف من هذه الدراسة: دراسة مدى انتشار أنواع الفايروس في الانوع الفرعية من الاورام اللمفاوية الهودجكين بين المرضى من محافظة كربلاء ، العراق.االطريقة: من الشرائح النسيجية المثبتة بالفومالين والمغمورة بالشمع لــ 31 مريض بمتوسط العمر 32.56 ± 15.685 ( من 5 إلى 70سنة ) المشخصين بورم الغدد اللمفاوية هودجكين خلال الفترة من 2010 إلى 2018 في مدينة كربلاء تم دراستها. تم مراجعة التشخيص النسيجي . استخدم حوالي 25 ملغم من المقاطع النسيجية المخزونه لاستخلاص الحمض النووي. تم استخدام مستخلصات الحمض النووي في تفاعلات الكوثرة باستهداف منطقة الجين EBNA3C في الجينوم الفيروسي. استخدم التفاعل لتشخيص الفايروس و تميز انواع فايروس الابسن بار .تم استخدام اختبار تي و مربع كاي لتقييم الارتباط بين العمر بالانواع الفرعية من سرطان الغدد اللمفاوية هودجكين والجنس و مقارنتها مع نتائج تشخيص الفايروس .النتائج: كانت غالبية الأورام اللمفاوية هودجكين تنتمي إلى النوع الفرعي MCHL حيث كانت 18 (58%)حالة من 31 ثم النوع الفرعي NSHLفي 13(42%) حالة. و لم تسجل حالات من الأنواع الفرعية الأخرى من الاورام الهوجكن في هذه الدراسة. الذكوراكثر اصابة من الإناث بالاورام اللمفاوية الهوجكن (16 مقابل 15) . كانت الفئة العمرية من 31 إلى 40 عاما الاكثر اصابة بالاورام اللمفاوية الهوجكن . تم الكشف عن الفايروس في 18 حالة من جميع الحالات (58 ٪). كان EBV1 أكثر شيوعًا في النوع الفرعيMCHL . كان EBV2 الأكثر شيوعًا بين حالات NSHL . على حد علمنا هذه هي المرة الأولى التي يتم فيها تسجيل مثل هذه البيانات في العراق.الاستنتاج: ارتبطت معظم حالات الاصابات بالاورام اللمفاوية الهوجكن مع فايرس الابسن بار .هناك اختلاف في توزيع أنواع الفيروس وفقا لأنواع سرطان الغدد اللمفاوية.


Article
Detection of Epstein - Barr virus Type1 and Type2 in Subtypes of Non- Hodgkin Lymphoma in Kerbela Province by Using Polymerase Chain Reaction
التحري عن فيروس الابسن بار النممط الاول النمط الثاني في الانواع الفرعية للاورام اللمفاوية اللاهودجكن في مدينة كربلاء بواسطة تفاعل الكوثرة .

Authors: Hussein Abd Ali Mohamed Sadeq Al Her --- M ohanad Mohsen Ahmed
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2019 Volume: 17 Issue: 2 Pages: 15-27
Publisher: Kerbala University جامعة كربلاء

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Abstract

Epstein-Barr virus (EBV) is a ubiquitous virus associated with lymphomas. However, in Kerbala as other parts of Iraq, EBV detection is not a part of the workup for lymphoma diagnosis. . Archival formalin-fixed paraffin- embedded blocks from 44 patients with mean age 45.9±22.8 (range from 4 to 86years) diagnosed as Non Hodgkin lymphoma during the period from 2010 to 2018 in Kerbala city included in this study. Histological diagnosis was reviewed. Around 25mg of archival tissue were used to extract DNA. DNA extracts were used Polymerase Chain Reaction (PCR) targeting the EBNA3C region of the viral genome. This PCR system offered detection and typing of the EBV. T-test and chi-square were used to evaluate the association between age with the subtype of Non Hodgkin lymphoma, gender and EBV state. The majority of the Non Hodgkin lymphomas(NHL) belonged diffuse large B cell (DLBC) [n=28, 63.6%], T-cell rich Diffuse large B-cell [n=9, 20.5%], high grade B cell Burkitt- like (BL) [n=3, 6.8%], small Blymphocytic [n=2,4.5%],high grade B cell(CD20-ve,CD30-ve[n=1,2.3%] and peripheral T-cell [n=1,2.3%]. The other subtypes of NHL were not reported in this study. Male and female were equal affected with NHL (22 for each) and the peak age range of NHL over 60 years. EBV was detected in 21(47%) out of all cases. EBV type 1 was more common to EBV2in all subtype of NHL. To our knowledge, this is the first- time such data has been generated in Iraq. In this study present evidence that Non- Hodgkin lymphoma cases in Kerbela are associated with EBV1 and EBV2 types. There is a difference in the distribution of the EBV types according to the subtypes of lymphoma. The aim of this study: to detect types of EBV in the subtype of Non- Hodgkin lymphoma (NHL) among patients from Kerbala province, Iraq

يعتبر فيروس الابسن بار فيروس شائع الانتشار ويكون عادة مرتبط بالأورام اللمفاوية. ومع ذلك ، في كربلاء وفي مدن العراق الاخرى ، لا يعتبر كشف الفايروس جزءًا من عملية تشخيص الإصابة بالورم اللمفاوي. تهدف هذه الدراسة التحري عن مدى انتشار أنماط الفايروس في الانواع الفرعية من الاورام اللمفاوية اللاهودجكين بين المرضى من محافظة كربلاء ، العراق.استخدمت الشرائح النسيجية المثبتة بالفومالين والمغمورة بالشمع لــ 44 مريض بمتوسط العمر 45.9± 22.8 (تتراوح اعمارهم من 4 إلى 86سنة ) المشخصين بورم الغدد اللمفاوية الاهودجكين خلال الفترة من 2010 إلى 2018 في مدينة كربلاء تم دراستها. تم مراجعة التشخيص النسيجي من قبل مختص الانسجة . استخدم حوالي 25 ملغم من المقاطع النسيجية المخزونه لاستخلاص الحمض النووي. تم استخدام مستخلصات الحمض النووي في تفاعلات الكوثرة باستهداف منطقة الجين EBNA3C في الجينوم الفيروسي. استخدم التفاعل لتشخيص الفايروس و تميز انواع فايروس الابسن بار .تم استخدام اختبار تي و مربع كاي لتقييم الارتباط بين العمر بالانواع الفرعية من سرطان الغدد اللمفاوية اللاهودجكين والجنس و مقارنتها مع نتائج تشخيص الفايروس ..اظهرت النتائج ان غالبية الأورام اللمفاوية اللاهودجكين بانها تنتمي إلى النوع الفرعي DLBC حيث كانت 28 (63.6%)حالة ثم النوع الفرعي المختلط صغير وكبير T-cell rich Diffuse large B-cell في 9(20.5%) حالة , و البركت لمفوماBL 3(6.8%) و واحد حالة لكل من HGBC و PTC. و لم تسجل حالات من الأنواع الفرعية الأخرى من الاورام الهوجكن في هذه الدراسة. الذكور , الإناث نفس عدد الاصابات بالاورام اللمفاوية اللاهوجكن (22) . كانت الفئة العمرية اكثر من 60 عاما الاكثر اصابة بالاورام اللمفاوية اللاهوجكن . تم الكشف عن الفايروس في 21 (47%) حالة من جميع الحالات. كان EBV1 أكثر شيوعًا في جميع الانواع الفرعية من النوع. EBV2. على حد علمنا هذه هي المرة الأولى التي يتم فيها تسجيل مثل هذه البيانات في العراق. كانت اهم الاستنتاجات ان كثير من حالات الاصابات بالاورام اللمفاوية اللاهوجكن مرتبطة مع فايرس الابسن بار .هناك اختلاف في توزيع أنواع الفيروس وفقا لأنواع سرطان الغدد اللمفاوية


Article
Determination of Serum Trace Elements and Hematological Parameters in Lymphoma Patients Receiving Chemotherapy

Authors: Zainab Hadi Kamil --- Mufeed Jalil Ewadh --- Abdulsamie Hassan Alta'ee
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2016 Volume: 24 Issue: 9 Pages: 2498-2509
Publisher: Babylon University جامعة بابل

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Abstract

BackgroundTrace elements are essential components of biological structures, some of them play an important role as anticancer and others can be toxic at concentrations beyond those necessary for their biological functions.AimThe objective is to examine changes in serum concentration of trace elements (Cobalt (Co), Germanium (Ge), Molybdenum (Mo), Nickel (Ni) and Vanadium (V)), Mg and hematological changes in Hodgkin and Non-Hodgkin lymphoma patients receiving therapy.Materials and methodsThe study was included 25 patients with Non-Hodgkin lymphoma (NHL) and 25 patients with Hodgkin lymphoma (HL) as compared with 50 healthy subjects. Serum concentration of trace elements are measured by flame atomic absorption spectrophotometer. The total leukocyte count (TLC), hemoglobin concentration (Hb) and packed cell volume or hematocrit (Hct) are determined.Results Statistical analysis of data demonstrated significant decrease (p<0.001) in Mg and Co concentration and (p<0.01) in Ge concentration in patients with lymphomas receiving therapy as compared with healthy adults.V and Ni concentrations are significantly increased (p<0.001) in patients with lymphomas receiving therapy as compared with healthy adults. The study shows significant decrease (p<0.05) in Hb concentration and Hct percentage in patients with lymphomas receiving chemotherapy as compared with healthy subjects. It revealed significant decrease (p<0.005) in female patients with lymphoma who receive chemotherapy. Significant decrease (p<0.001) in TLC in patients with lymphomas receiving therapy as compared with healthy adults are observed. ConclusionLymphoma patients receiving therapy are often low in Mg, Ge and Co levels while Ni and V levels are high in patients with Hodgkin and Non-Hodgkin lymphoma.There is a significant decreased in TLC in patients with Hodgkin and Non-Hodgkin lymphoma whose are receiving chemotherapy..Anemia occurred in patient with lymphomas as a side effect of chemotherapy.

تعتبر العناصر النزرة مركبات أساسية في البناء الحيوي والبعض منها يلعب دوراَ مهماً كمضادات سرطانية والبعض الآخر يمكن ان يكون له تأثير سمي بالرغم من أهميته في الفعاليات الحيوية.الهدف من الدراسة معرفة التغيرات في تراكيز العناصر النزرة (الكوبالت (Co) ، الجرمانيوم (Ge) ، الموليبدينوم (Mo) ، والنيكل (Ni) و الفاناديوم (V) ) والمغنيسيوم (Mg) وكذلك التغيرات الدموية لدى مرضى سرطان الغدد اللمفاوية الهودجكني واللاهودجكني والمتلقين للعلاج الكيمياوي.شملت الدراسة 25 مريضاً بسرطان الغدد اللمفاوية الهودجكني و25 مريضاً بسرطان الغدد اللمفاوية اللاهودجكني مقارنة مع الاصحاء (50 شخصاً). تم قياس تراكيز العناصر النزرة في مصل الدم بجهاز المطياف (flame atomic absorption spectrophotometer) كما تم قياس تركيز الهيموكلوبين (Hb) ونسبة مكداس الدم (Hct) والعدد الكلي لخلايا الدم البيض (TLC).بين التحليل الاحصائي للعينات انخفاضاً معنوياً (p<0.001) في تركيز كل من Mg و Co وانخفاضاً معنوياً (p<0.01) في تركيز Ge لمرضى سرطان الغدد اللمفاوية لكلا النوعين والمتلقين للعلاج الكيمياوي مقارنة مع الاصحاء. كما ارتفع تركيز كل من Ni و V (p<0.001) لدى المرضى في هذه الدراسة.اظهرت الدراسة انخفاضاً معنوياً (p<0.05) في تركيز الهيموكلوبين ونسبة مكداس الدم وانخفاضاً معنوياً (p<0.001) في العد الكلي لخلايا الدم البيض لدى مرضى سرطان الغدد المفاوية والمتلقين للعلاج الكيمياوي مقارنةً مع الاصحاء.الاستنتاج: غالباً ما يكون تركيز كل من العناصر Mg و Ge و Co منخفضاً في مصل دم المرضى المصابين بسرطان الغدد اللمفاوية والمتلقين للعلاج الكيمياوي بينما يرتفع تركيز كل من Ni و V في مصلهم.حصول انخفاض معنوي في العدد الكلي خلايا الدم البيض لمرضى سرطان الغدد اللمفاوية والمتلقين للعلاج الكيمياوي كما يظهر لديهم فقر دم كعارض جانبي نتيجة للغلاج الكيمياوي.

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