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Article
Maternal &umbilical cord plasma homocysteine concentrations in pre-eclamptic pregnancy

Author: Miami A. Ali
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2014 Volume: 13 Issue: 1 Pages: 8-13
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Back ground: Serum concentrations of homocysteine decrease during normotensive pregnancy, but increases in pre-eclampsia like some other pregnancy complications. Hyperhomocysteinemia has been hypothesized to be associated with placental micro vascularization disease. Objectives: To evaluate the concentration of maternal &umbilical homocysteine in pre-eclamptic women in comparison with that of normotensive pregnant women. Study design: A case control study. Setting: Department of Gynecology and Obstetrics at Al-Yarmouk Teaching Hospital for a period of one year from April 2010 to April 2011. Patients & methods: Hundred singleton pregnant women with gestational age between 37 to 40 weeks were divided into two groups: (Study group): 50 pregnant patients with pre-eclampsia , 30 of them presented with severe pre-eclampsia and 20 presented with mild pre-eclampsia were compared to ( control group ) which include 50 normotensive pregnant patients. Bloods was collected from women in both groups, serum homocysteine and cord blood homocysteine were measured in patient with pre-eclampsia and were compared with that of normotensive patient. Results:Mean maternal serum homocysteine level in comparison between the study & the control groups was highly significant as the P value was (0.0001).Mean umbilical homocysteine level in comparison between the study & the control groups was highly significant as P value was (0.0001).Maternal homocysteine levels were found to have a significant strong direct correlation with the umbilical homocysteine in the severe pre-eclampsia since the r value was (0.808) while in the mild and the control groups, they were moderately correlated as the r value was (0.536,0.526) respectively. Conclusion :This study has shown a significant increase in homocystein concentration in maternal and umbilical cord blood of the fetuses in pre- eclamptic women compared with the values obtained from women of normal pregnancy.


Article
Homocysteine Changes in Preeclampsia
التغيرات في تركيز مادة الهوموسستائين في الدم في حالة مقدمة الارتعاج

Authors: Maha Al-Bayati مها البياتي --- Ali Taki Al-baldawi علي تقي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2007 Volume: 20 Issue: 3 Pages: 426-431
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractObjective: To determine whether homocysteine, a relatively new risk factor for possible endothelial cell dysfunction and premature vascular disease, is elevated in pregnant women with preeclampsia.Methods: A case-control study design conducted at Al-kadimiya teaching hospital for the period from September 2000 through April 2001. The study sample consisted of 100 pregnant women in labour subdivided into three groups (40 pregnant women with severe preeclampsia, 30 pregnant women with mild preeclampsia and 30 normotensive pregnant women as a control). Plasma homocysteine concentration measurement and observation of the maternal and fetal outcome was done for all groups.Results: The incidence of hyperhomocysteinemia was significantly higher among patients with severe preeclampsia (80%) compared to those with mild preeclampsia (67%) and the normotensive group (7%) and the incidence of adverse maternal and neonatal outcome is significantly higher among patients with severe preeclampsia compared to the others.Conclusion: Plasma total homocysteine concentration is elevated in pregnant women with preeclampsia during labour being significantly higher in cases with severe preeclampsia so hyperhomocysteinemia is considered a risk factor for adverse maternal and neonatal outcome.

هدف الدراسة : بيان ومعرفة هل ان تركيز مادة الهوموسستائين في الدم والذي يعتبر نسبيا كعامل خطر جديد لاحتمال الاختلال الوظيفي في الخلايا البطانية والإصابة المبكرة بأمراض الأوعية الدموية يزداد لدى الحوامل في حالة مقدمة الارتعاج. أجريت هذه الدراسة في مستشفى الكاظمية التعليمي/ قسم النسائية والتوليد على مائة سيدة في حالة ولادة وقد قسمت السيدات الى ثلاثة مجاميع :1- المجموعة ا: تتالف من 40 سيدة تعاني من مقدمة الارتعاج الشديدة .2- المجموعة ب: تتالف من 30 سيدة تعاني من مقدمة الارتعاج البسيطة. 3- المجموعة ج: تتالف من 30 سيدة حامل تتمتع بصحة جيدة (كمجموعة ضبط ).شملت الدراسة قياس تركيز مادة الهوموسستائين في الدم ومتابعة صحة الأم والطفل بعد الولادة لكل المجاميع.تمخض تحليل النتائج إحصائيا عن مايلي : 1- وجدت علاقة وثيقة بين تركيز مادة الهومو سستائين في الدم وشدة مقدمة الارتعاج حيث ان تركيزه أعلى لدى السيدات الحوامل في المجموعة ا (80%) عنه في المجموعة ب (67%) و المجموعة ج (7%). 2- الزيادة في تركيز مادة الهوموسستائين في الدم مصحوبة بارتفاع نسبة المضاعفات لدى الام والطفل .الاستنتاج:تركيز مادة الهوموسستائين في الدم أعلى لدى السيدات الحوامل المصابات بمقدمة الارتعاج الشديد أثناء الولادة عنه لدى المصابات بمقدمة الارتعاج البسيط ومجموعة الضبط وزيادة تركيز مادة الهوموسستائين في الدم قد تسبب ارتفاع في نسبة المضاعفات لدى الأم والطفل.


Article
Estimation of the level of homocysteine and vitamin B12 in serum of patients with hypothyroidism
تقدير مستوى الهوموسستين وفيتامين B12 في مصل دم المرضى المصابين بقصور الغدة الدرقية

Authors: Asala Adnan Otla اصالة عدنان عطلة --- Nadia Ahmed Saleh نادية احمد صالح
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2019 Volume: 24 Issue: 1 Pages: 70-73
Publisher: Tikrit University جامعة تكريت

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Abstract

In this study, homocysteine and vitamin B12 levels were measured in patients with hypothyroidism in Salahdin Governorate. The study was conducted at the Tigris Educational Hospital in Tikrit. Blood samples were taken from patients with hypothyroidism (40 cases) with thyroid deficiency and 30 healthy (non-infected) subjects. Their ages ranged between 25-35 years. The study found that there was a significant increase p<0.05 in the homocysteine level compared to the healthy Individuals as control group. The study also showed a significant decrease in the level of vitamin B12 for patients p <0.05 compared to healthy individuals .

تم في هذه الدراسة قياس تركيز الهوموسستين وقياس فيتامينB12 لدى المرضى المصابين بقصور الغدة الدرقية في محافظة صلاح الدين. حيث اجريت الدراسة في مستشفى دجلة التعليمي في تكريت, وقد قسمت عينات الدراسة الى40 حالة مرضية مصابين بقصور في الغدة الدرقية و 30 عينة من الاصحاء (الاشخاص الغير مصابين) وتركزت اعمارهم بين (25-35) سنة. وقد توصلت الدراسة الى ان هناك ارتفاع معنوي عند مستوى احتمالية p<0.05 في مستوى الهوموسستين مقارنة بالأصحاء كما اظهرت الدراسة ان هناك انخفاض معنوي في مستوى B12 للمرضى عند مستوى احتمالية p<0.05مقارنة بالأصحاء

Keywords

Homocysteine --- vitamin B12


Article
Homocysteine and Thyroid Hormones in Patients with Familial Dilated Cardiomyopathy

Author: Basil O.M. Saleh
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 2 Pages: 88-91
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Familial linkage of primary dilated cardiomyopathy (DCM) occurs more commonly than often is appreciated. In 10-20 percent of patients, a first degree relative also shows evidence of primary DCM suggesting that familial transmission is relatively frequent.METHODS:this study included 7 patients aged 40-70 years (2 females and 5 males) with familial dilated cardiomyopathy (FDCM) and 17 healthy subjects aged 29-60 years (6 females and 11 males). Plasma fasting total homocysteine tHCY, serum folic acid (FA), vitamin B6, total triiodothyronine (T3), and total thyroxine (T4) were measured in these two groups.RESULTS:The mean value of plasma tHCY was significantly higher in patients with FDCM than in control (P<0.001). The mean (±SD) values of serum folic acid and vitamin B6 were significantly decreased in FDCM patients when compared with those of control group (P<0.05, P<0.01, respectively).A significant inverse relationship between plasma tHCY concentration and the values of serum FA was shown in the FDCM patients (r=-0.78, P<0.05). The mean values of serum T3 and T4 were insignificantly decreased in patients with FDCM than in controls.CONCLUSION:The level of plasma tHCY is significantly higher in FDCM patients than in healthy control. This severe hyperhomocyteinemia of FDCM patients may be related to evolution and development of myopathic state in such patients.


Article
Evaluation of Amino acid Homocysteine in Hypertensive Patients

Author: Ali Taqi. Al-Baldawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 2 Pages: 151-154
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT :BACKGROUND :Hypertension is a world wide disease and in 90% of cases the cause is unknown . Its early detectionand treatment can prevent serious complications such as ischemic heart disease (IHD) . Furthermorethe association of lipids with IHD is a well-known fact . However abnormally high levels ofhomocysteine were found to be strongly linked to an increase risk of coronary artery disease .OBJECTIVES:To evaluate the total plasma homocysteine concentration in hypertensive patients.METHODS :Total plasma homocystein concentrations were measured using High Performance LiquidChromatography(HPLC) with Ultraviolet( UV) detector in 60 hypertensive patients (27 male and 33female) aged 35 years and more . Cholesterol , triglyceride , HDL-cholesterol , LDL-cholesterol ,VLDL-cholesterol were determined .The prevalence of high total homocysteine values were determinedby comparison with normal reference population.RESULTS :Total plasma homocysteine levels were significantly higher in patients than in normal population. Totalserum cholesterol and triglyceride concentrations were also significantly higher in patients than innormal population with no association to the level of homocysteine which is regarded as a specialindependent vascular risk factor.CONCLUSION :The study involves the evaluation of homocysteine in hypertensive patients plasma homocysteinelevels were significantly higher in patients than in control groups. There were no significant differencesbetween male and female patients.


Article
The Effect of Chronic liver diseases on homocysteine and vitamin B12 in patients serum

Author: Essam F. Al-Jumaily * BSc, PhD د. عصام الجميلي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 4 Pages: 399-402
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Homocysteine (Hcy) is a sulfur containing amino acid that is formed as an intermediary in methionine metabolism. Raised plasma homocysteine levels, which may contribute to the increased risk of chronic liver disease. Patients and Methods: Sixty two patients with chronic liver disease and 26 healthy individuals were included as normal controls for the study. The HPLC system was used for the determination of Hcy and vitamin B12. Results: A highly significant Hcy concentrations were noted in all patients with cirrhosis, chronic hepatitis or liver mass. There was a trendency towards higher Hcy concentrations in more advanced stages of liver disease. The study showed that the concentrations of total Hcy were significantly higher in the patients than in the normal control group, irrespective of the age or gender. Mean serum concentration of vitamin B12 were significantly increased in cirrhotic patients and those with liver cancer compared to the control subjects and chronic hepatitis symptomatic patients. Conclusion: The serum levels of both homocystein (Hcy) and vit. B12 were significantly increased in cirrhotic patients and those with liver cancer compared to chronic hepatitis symptomatic patients.Key words: chronic liver disease, homocysteine, vitamin B12.


Article
Determination of the Concentration Level of Homocystiene in The Serum of Patients With Myocardial and Type II Diabetes in Salahaddin Province
تقدير تركيز الهوموسستين في مصل الدم للمرضى المصابين بالجلطة القلبية ومرض السكري النوع الثاني في محافظة صلاح الدين

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Abstract

Clinical studies predict an increase in the mortality rate among patients with heart disease and diabetes in the world by 2020 because of the symptoms of high blood pressure that leads to aggravation of the cardiovascular disease. Any rise in the level of amino acid in the blood directly contributes to high blood pressure and symptoms of diabetes that are considered a significant exacerbation of the causes of cardiovascular disease. Controversy still holds about the direct and indirect relationship between amino acids and cardiovascular disease (heart attack) and type II diabetes. Therefore, our study included verification of the relationship between amino acid concentration and the symptoms of heart attacks and diabetes type II. Our research was based on a study of 50 cases of patients of both sexes who suffer from heart disease and Type II diabetes, in addition to 25 healthy persons of 25-45 years of age as a group control. Cases were randomly adopted from outpatient clinics in Tikrit Teaching Hospital. Reliable measurements of amino acid levels in the blood serum of people with stroke, heart attack and diabetes were done by using Eliza technique. They were compared with the approved standard controls. A sharp increase in the concentrations of homocysteine, triglycerides and cholesterol has been observed at the level of statistical significance (p ˂ 0.01) in patients who suffer from stroke, heart disease and diabetes type II compared with the healthy group. Whereas, a different relationship has been observed with folic acid and vitamin B12. The concentration of folic acid at the level of statistical significance (p ˂ 0.01) and the concentration of vitamin B12 at the level of statistical significance (p ˂ 0.05) have decreased in patients with stroke, heart disease, diabetes type II compared with the healthy group.

تتوقع الدراسات السريرية ازدياداً في نسبة الوفيات لدى مرضى القلب والسكري في العالم بحلول عام 2020 بسبب ارتفاع مرض ضغط الدم المؤدي إلى تفاقم أمراض القلب والأوعية الدموية. إن أي ارتفاع في مستوى الحامض الأميني في الدم يسهم بشكل مباشر في ارتفاع ضغط الدم وأعراض مرض السكري التي قد تكون أحد الأسباب الهامة لاستفحال الأمراض القلبية الوعائية. لا يزال الجدل حاصل حول العلاقة المباشرة وغير المباشرة بين الحامض الأميني والأمراض القلبية الوعائية (الجلطة القلبية) ومرض السكري النوع الثاني. لذلك شملت دراستنا على التحقق من علاقة تراكيز الحامض الأميني مع أمراض الجلطة القلبية والسكري النوع الثاني.استند بحثنا على دراسة 50 حالة من المرضى الذين يعانون الأمراض القلبية والسكري النوع الثاني، إضافة الى 25 من الأصحاء الذين لا يعانون كمجموعة سيطرة تتراوح اعمارهم بين 25-45 سنه. تم تبني الحالات بشكل عشوائي ومن كلا الجنسين من العيادات الخارجية لمستشفى تكريت التعليمي. واعتماد مستوى الحامض الأميني المُقاس في مصل الدم بواسطة تقنية Eliza للمصابين بالجلطة القلبية ومرض السكري ومقارنتها مع الضوابط المعتمدة. فقد لوحظ هناك ارتفاع حاد في تراكيز الهوموسستين وثلاثي الكليسريدات والكولسترول عند مستوى دلالة (p ˂ 0.01) لدى المرضى الذين يعانون من جلطة القلب والسكري النوع الثاني مقارنة مع مجموعة الأصحاء. وكما لوحظ انخفاض تركيز حامض الفوليك عند مستوى دلالة إحصائية (p ˂ 0.01) وانخفاض فيتامين B12 عند مستوى دلالة (p ˂ 0.05) لدى مرضى جلطة القلب والسكري النوع الثاني مقارنة مع مجموعة الاصحاء.


Article
Correlation between Homocysteine and Insulin Resistance in women with Polycystic Ovarian Syndrome Referring to AL-Yarmook Teaching Hospital

Authors: Dhilal Q. Mohammed --- Hawaa AL-Dhahir --- Sabah M. Husein
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2014 Volume: 4 Issue: 2 Pages: 32-39
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Polycystic ovarian syndrome (PCOS) is one of the most common endocrinedisorders among females in reproductive age. Women with PCOS have severalcardiovascular disease risk factors. Hyperinsulinemia and insulin resistance (IR)which is a known key factor in the development of type 2 diabetes (T2DM) mayassociate PCOS. Homocysteine, a sulfur-containing amino acid, is toxic to vascularendothelium, leads to early atherosclerosis. PCOS said to be associated with highplasma homocysteine.Objective:To determine the correlation between insulin resistance and homocysteine in PCOSpatients.Methods:Patients diagnosed as PCO according to Androgen Excess and PCOS Society/2009criteria were grouped into two groups: those with BMI less than 30kg/m2 and thosewith BMI 30kg/m2 and more. Blood was drawn for biochemical and hormonalassay. Information tabulated, means and percentages used, and the results wereanalyzed.Results: Homocysteine levels were significantly higher (P value < 0.05) in PCOSgroup (12.28±1.89 μmol/l) as compared to control (9.51±1.92 μmol/l).HOMA-IRwas significantly higher (P value < 0.05) in PCOS (4.15±2.54) as compared tocontrol (1.69±0.54) .There was no correlation between IR and homocysteine withinPCOS group.Conclusions:Polycystic ovarian patients have higher levels of homocysteine and IR compared tocontrol but there is no correlation between IR and homocysteine within PCOS group.


Article
The relationship between homocysteine , folate, B12 serum level and breast cancer in sample of women in Baghdad city –Iraq.
علاقة مستوى الهوموسستين ، الفوليت،B12 المصل وسرطان الثدي في عينة من النساء في مدينة بغداد – العراق

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Abstract

The study included eighty cases of women with breast cancer (as patients group) with age range from 30 to 8years, The control group included twenty healthy women. The level of Homocysteine, vitamin B12 and folate were estimated in the serum of patients group and compared with the control and it has been compared to some other aspects such as aBody mass index (BMI), type of feeding and Family history. The statistical analysis revealed a significant difference (p ≤ 0.05) between the mean of Homocysteine level (13.18 ± 0.61) µmol/l for patients group compared with mean (9.78 ± 0.60) µmol/l of control group . It was also found a significant difference (p≤ 0.05) between the mean of folate level for patients group and control group , (8.64 ± 0.40) ng/ml and (13.19 ± 1.19) ng/ml for both groups, respectively,.It was noticed that there was interaction between the mean of homocysteine, B12 and folate level in serum with age, marital status ,type of feeding and family history.

شملت الدراسه على عينة تكونت من 80 حاله من النساء المصابات بسرطان الثدي بأعمارتراوحت من (30 - 80) سنه بالأضافة الى عينة شملت على عشرين من النساء الصحيحات أستعملت كمجموعة سيطره.قدر مستوى الهوموسستين , فيتامين B12والفوليت في مصل الدم لكل من مجموعة المرضى والسيطره كذلك تم دراسة مؤشر كتلة الجسم ,نوع الرضاعه وتاريخ العائله الوراثي. اظهرت نتائج التحليل الاحصائي عند مستوى الأحتماليه (p≤0.05) فروقات معنويه بين متوسطي مستوى الهوموسستين للنساء المصابات ومجموعة السيطره, حيث بلغت قيمة المتوسطين 13.18 ± 0.61)µmol/l) وµmol/l (l9.78 ± 0.60) لكل منهما وعلى التوالي. كذلك لوحظ هنالك فرق معنوي بين مستويات الفوليت للنساء المصابات وبين مجموعة السيطره بمتوسط قدره ng/ml (8.64 ± 0.40) و ng/ml (13.19 ± 1.19) لكلا المجموعتين وعلى التوالي . ايضا تم ملاحظة وجود فرق معنوي عند مستوى الأحتماليه (p≤0.05) لكل من قيم الهوموسستين , B12 والفوليت مع تأثير عامل العمر, الحاله الزوجيه, نوع الرضاعه وتاريخ العائله بالأصابه بالمرض .


Article
The Impact Of Smoking And Diabetes On Homocysteine Levels In Patients With Myocardial Infarction

Authors: Mohammed Ajah Aouda --- Adian Saad Hamza
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2017 Volume: 6 Issue: 2 Pages: 75-80
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

The iaim of this study is to measure the compound Hcy levels as a risk factor for patients with MI to the number of patients in the province of Thi-Qar. Increased levels of homocysteine in the blood is considered a risk factor for myocardial Infarction. Smoking and diabetes disease lead to increased concentrations of homocysteine and thus increase the risk of MI. Blood samples were obtained from (63) patients with myocardial infarction, as well as (48) healthy subjects as a control group. The results indicated to that proportion of patients male (57%) and females (43%), smokers (49%) and non- smokers (51%), most of them are females. The results also showed that (32%) live in cities, compared to (68%) live in rural areas, and patients who have a family history of (56%) compared to (44%) They do not have a family history and the results showed that diabetes disease is more associated with diseases of the disease infarction heart and by (86%), followed by hypertension (56%) disease. Serum homocysteine was significantly higher in MI patients compared to the control group.Homocysteine levels were higher in low educated, smokers and unemployed individuals, less family income individuals as well as in individuals with family history of MI or Coronary artery disease. High hypertensive, diabetic and obese individuals had also higher levels of homocysteine. Based on the results of this study suggested measuring the amino acid Homocysteine levels of security as one of the effective ways to diagnose patients with myocardial infarction in hospitals.

الهدف من هذه الدراسة هو قياس مستويات الهوموسيستين كعامل خطر للمرضى الذين يعانون من احتشاء عضلة القلب لعدد المرضى في محافظة ذي قار. تعتبر زيادة مستويات الهوموسيستين في الدم عامل خطر لاحتشاء عضلة القلب. يؤدي التدخين ومرض السكري إلى زيادة تراكيز الهوموسيستين وبالتالي زيادة خطر الإصابة بمرض أحتشاء العضلة القلبية. تم الحصول على عينات دم من (63) مريضا يعانون من احتشاء عضلة القلب، فضلا عن (48) عينة لأشخاص أصحاء كمجموعة تحكم. وأشارت النتائج إلى أن نسبة المرضى الذكور (57٪) والإناث (43٪) والمدخنين (49٪) وغير المدخنين (51٪)، ومعظمهم من الإناث. وأظهرت النتائج أيضا أن 32٪ يعيشون في المدن مقابل 68٪ يعيشون في المناطق الريفية والمرضى الذين لديهم تاريخ عائلي (56٪) مقابل (44٪) ليس لديهم تاريخ عائلي، وأظهرت النتائج أن مرض السكري هو أكثر ارتباطا بأمراض القلب احتشاء المرض وبنسبة (86٪)، تليها ارتفاع ضغط الدم (56٪) المرض. وكانت تراكيز الهوموسيستين في مصل الدم أعلى بكثير في مرضى أحتشاء العضلة القلبية بالمقارنة مع مجموعة التحكم. وكانت مستويات الهوموسيستين أعلى في الافراد المدخنين والعاطلين عن العمل، وكذلك الأفراد الذين لديهم تاريخ عائلي للأصابة بأحتشاء العضلة القلبية. وكان ارتفاع ضغط الدم، والسكري والسمنة المفرطة ترتبط أيضا مع مستويات أعلى من هوموسيستين. واستنادا إلى نتائج هذه الدراسة اقترح قياس مستويات الحمض الأميني الهوموسيستين باعتبارها واحدة من الطرق الفعالة لتشخيص المرضى الذين يعانون من احتشاء عضلة القلب في المستشفيات.

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