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Article
Some Immunological Evaluations of Propolis in Albino Male Mice

Author: Ali H. Ad'hiah
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 121-125
Publisher: Baghdad University جامعة بغداد

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Abstract

Propolis is a complex resinous bee product that has a wide range of biological activities. In thepresent investigation, two oral doses (10 and 20 mg/kg/day) of propolis (ethanol extract) wereevaluated immunologically in albino male mice (80 animals) through three types of experiments. Inthe first, the propolis was tested alone, while in the second and third experiments, propolis was givenbefore and after the immune suppressive drug MMC (pre- and posttreatments, respectively). The three experiments were paralleled with three negative controls, inwhich the propolis was replaced with distilled water. In the first experiment, the dose 10 mg/kg ofpropolis enhanced the parameters investigated, and a significant increase was observed in the totalcount of leucocytes (10.7 vs. 7.8 x 103 cells/cu.mm.blood), lymphocytes (7.0 vs. 5.3 x 103cells/cu.mm.blood), neutrophils (2.9 vs. 2.1 x 103 cells/cu.mm.blood), monocytes(0.5 vs. 0.3 x 103 cells/cu.mm.blood) and eosinophils (0.3 vs. 0.1 x 103 cells/cu.mm. blood), PI (15.2vs. 10.8%), PFC (72 vs. 38%), AR (0.84 vs. 0.57 mm) and DTH (0.68 vs. 0.40) as compared tonegative controls. Much more enhancements were observed in the dose 20 mg/kg. In the second andthird experiments, a similar picture was drawn in the interaction of propolis (pre- and posttreatments)with MMC, in which the propolis extract was able to modulate the immune suppressiveeffect of MMC, and this was dependent on the type of treatment and dose, and again, the dose 20mg/kg was more effective in this respect.Key words and Abbreviations: Arthus reaction (AR), Delayed type hypersensitivity reaction (DTH),Mitomycin C (MMC), Phagocytic index (PI),Plaque forming cells (PFC), Propolis and Sheep red blood cells (SRBC).


Article
Acetaminophen Mimics the Action of Salbutamol in Relaxing Gravid Human Uterus - In - Vitro

Author: Mahdi I. Hilmy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 126-129
Publisher: Baghdad University جامعة بغداد

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Abstract

Management of preterp'labour generally treated by salbutamol even with some expected disturbing -maternal pulmonary oedema , respiratory distress and cardiovascular side effects and neonatal low-sized and cellularity of thymus and lymph nodes . This demands finding a substitute free of these side effects . Initially, acetaminophen was tested on rats uterine horns and on pregnant rats and reported an effective relaxation of the uterine horns and profound delay in parturition . These results jestified an in-vitro study on strips of gravid human uterus ruptured during difficult labour. Acetaminophen (50 mg) reduced tension by 50% which was comparable decrease in tension when 5 gg of salbutamol was added. Profound drop in tension when adjunct use of both drugs, while repeated three doses of 50 mg acetoaminophen were added separately resulted in corresponding drops in tesion down to below resting level . These findings encouraged future clinical trials on threatened women with abortion since the use of acetaminophen in the usual dosage is effective tocolytic agent without any maternal side effect but with mild possible neonatal lung congestion as a result of transient narrowing of ductus arteriosis especially in advanced gestation age.

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