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Article
The Relationship Between Hyperglycemia and the Rheumatoid Factor in the Serum of Diabetic Patients
العلاقة بين ارتفاع السكر والعامل الرثوي في مصل مرضى السكري

Author: Ali M. Al-Gharawi علي محمد الغروي
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2009 Volume: 6 Issue: 1 Pages: 99-105
Publisher: Baghdad University جامعة بغداد

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Abstract

This study was conducted to determine the relationship between two most common diseases in Iraqis patients , which are Diabetic mellitus (DM) and Rheumatoid Arthritis (RA); seeking rheumatoid factor in hyperglycemic sera. The results revealed that ; 62.5% of hyperglycemic (HG) patients had positive rheumatoid factor (RF) . No difference in number between both gender of HG patients (20 males and 20 females ) , RF reaction was nearly similar in males and females of HG patients ( 12 &13 respectively ) . Only 40% out of patient controls had positive RF . None of the apparently healthy subjects had positive RF .

يعد مرض السكري من أمراض العصر المزمنة والمقيتة , ومن مسببات الالتهابات. لذا تمت دراسة علاقة هذا المرض بداء التهاب المفاصل الريثاني (Rheumatoid Arthritis RA) من خلال دراسة عامل الالتهاب (rheumatoid factor RF) في مصول مرتفعي السكر( hyperglycemia). تم انتقاء (40) مريضا"يعاني ارتفاع السكر على أساس الفحص السريري والمختبري وعشرة أشخاص يعانون أمراضا" مختلفة غير السكري كمجموعة سيطرة وعشرة متبرعين من السويين ظاهريا" ولأعمار مضاهية للمرضى . تم الفحص السريري في العيادة الخارجية لمدينة الطب / بغداد . اجري العمل في المختبرات التعليمية لمدينة الطب . ومن هذا العمل المحدود لوحظ ما يلي : اظهر 62.5% من المرضى مرتفعي السكر(hyperglycemic HG) قيمة موجبة للعامل (RF) بينما اظهرفقط 40% من مجموعة السيطرة القيمة الموجبة للعامل ولم تظهر في نفس الوقت أي قيمة موجبة للعامل (RF) لمجموعة المتبرعين من السويين ظاهريا". كان عدد الرجال والنساء من مرضى مرتفعي السكر متساويا" ( 20 : 20 ). وقد اظهر الجنسين تفاعلا" ايجابيا" +ve للعامل الرثوي (RF) متقاربا" ( 12 رجلا" : 13 أمرأة ) .


Article
Admission plasma glucose level among non-diabetic patients sustaining acute coronary syndrome

Author: Hussein S. Sakhi
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2011 Volume: 10 Issue: 1 Pages: 1-7
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background Stress hyperglycemia occurs in 5−30% of patients with apoplexy, myocardial infarction, sepsis, trauma and other critical illnesses, and it correlates with poor outcome. Aims: assessment of the prevalence of admission hyperglycemia among acute coronary syndrome patients and its impact on the outcome. Patients and methods Observational case control study had recruited 80 non-diabetic adults’ patients (43 males, 37 females) who were randomly selected after admission to the CCU/department of medicine/ Al-Yarmouk Teaching Hospital in the period from March to October 2009 because of acute coronary syndrome. Detailed history and physical examination were done, body mass index, waist-hip-ratio were recorded, venous blood sample were taken from patients to measure plasma glucose level and HbA1c; ECG and echocardiogram were done to all patients included in the study. Results 80 patients (43 males, 37 females) completed the study, their age groups ranging from 37-76 years, 3 patients were excluded from the study (2 male, 1 female) when they found to have high HbA1c ( ≥6.5%). 16 patients (20.6% of total no.) (7 male, 9 female) with a mean age of (62.19±7.17) were found to have casual admission (stress) hyperglycemic, a p value <0.05. Hyperglycemia is more likely associated with a female gender, advancing age, higher BMI, android pattern of body fat distribution, and higher killip classes (III, IV). Conclusions Casual admission (stress) hyperglycemia is not uncommon among non- diabetic adults admitted for acute coronary syndrome. Poorer outcome in patients with ACS is more likely among those with higher glycemic level, especially with advancing age, female gender and increased total body fat.


Article
Evaluation of T-lymphocytes in Peripheral Blood of Diabetic Patients
تقدير الخلايا اللمفاوية التائية في الدم المحيطي لمرضى داء السكر

Authors: Rojan G. AL-Allaff1 روجان غانم محمد العلاف1 --- Mohamed A. Al-Shahery2 محمد نجيب الشاهري2
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2017 Volume: 22 Issue: 9 Pages: 30-33
Publisher: Tikrit University جامعة تكريت

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Abstract

Our study includes the estimation of absolute number of T-lymphocytes by using (E-rosette) test in diabetic patients with hyperglycemia. The study included the collection of (20 )blood samples from individuals Type I ,II diabetes mellitus, ten of them were of type one I others of type II, with age range between (8-55)years and of both sexes. Blood samples from healthy individuals as control samples were used as well. The study showed a significant decrease in absolute numbers of T-lymphocytes in diabetic patients when compared with control and also a significant reduction in the absolute number in type I and type II diabetic patients compared with control, our result suggest that there is a defect in T-lymphocytes numbers in diabetic patients with hyperglycemia.

تضمنت دراستنا الحالية تقدير الاعداد المطلقة للخلايا اللمفاوية التائية بأستخدام تقنية (E-rossate) لمرضى داء السكر والذين يعانون من الارتفاع المزمن لمستويات السكر في الدم (hyperglycemia)، تضمنت الدراسة اختبار (20) عينة دم لمرضى داء السكر، (10) لمرضى النمط الاول والباقي لمرضى النمط الثاني وبعمر تراوح بين (8-55) سنة ومن كلا الجنسين واستخدمت عينات دم لاشخاص معافيين كعينة سيطرة .اظهرت النتائج وجود انخفاض معنوي في الاعداد المطلقة للخلايا اللمفاوية التائية لمرضى داء السكر بشكل عام مقارنة بعينة السيطرة ،كما اظهرت النتائج وجود انخفاض معنوي في اعداد الخلايا اللمفاوية التائية لمرضى النمط الاول والثاني مقارنة بعينة السيطرة لذلك اقترحت دراستنا وجود خلل في اعداد الخلايا اللمفاوية التائية لمرضى داء السكر والذين يعانون من حالة (hyperglycemia).

Keywords

Hyperglycemia --- Diabetes --- E-rosette


Article
Isolation, Purification and Identification of Active Chemical Compound Lup-20(29)-ene-3, 28-diol (Betulin) from Tetradium daniellii Leaves and Study the hypoglycemic Effect on Rabbits
عزل , تنقية وتشخيص المركب الكيميائي الفعال Lup-20(29)-ene-3, 28-diol من أوراق نبات Tetradium daniellii ودراسة تأثيره المخفض لسكر الدم في الأرانب المختبرية

Author: Jamal Harbi Hussien Alsaadi جمال حربي حسين السعدي
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2016 Volume: 6 Issue: 1 Pages: 54-61
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Diabetes mellitus is a syndrome and serious complex chronic condition leading to higher blood glucose levels that is a major source of health disorder worldwide, about 171 million or more diabetes mellitus cases worldwide in patients ages 20 years or more. The active chemicals compounds that isolated from medicinal plants were used succifully to treat this disease .the current study was extracted and isolated the bioactive compound (Lup-20(29)-ene-3, 28- diol ) from (Tetradium daniellii ) leaves. Were isolated, separated, purified and identified by thin layer chromatography, column chromatography, gas chromatography, IR-spectroscopy, 1H-NMR,C13-NMR,dept-NMR, Gas chromatography – mass spectroscopy. Also study of hypoglycemic action in blood glucose levels in normalglycemic and alloxan induced diabetic rabbits of Lup-20(29)-ene-3, 28-diol compound, a significant decreasing (P<0.01) at fourth and sixth hrs , and high significant decreasing (P<0.001) at twenty forth hrs. in hyperglycemic rabbits ,while in no rmalglycaemic rabbits, a significant decline (P<0.05) was at sixth , and a high significant decreasing ( P<0.01) was recorded at twenty forth hrs.

داء السكر هو أضطرب في عملية أيض سكر الكلوكوز في الجسم يؤدي إلى ارتفاع مستوىات هذا السكر في الدم بصورة غير طبيعية لأسباب مختلفة , مما يسبب ضرر كبير في مختلف أنظمة جسم الإنسان لذلك استعملت الكثير من الأدوية والعقاقير الطبية ومنها المركبات الكيميائية الفعالة المعزولة من الأعشاب والنباتات الطبية بنجاح لعلاج هذا المرض , في الدراسة الحالية تم استخلاص وعزل المركبTetradium daniellii من أوراق نبات Lup-20(29)-ene-3, 28-diol الكيميائي حيث تم عزل , تنقية وتشخيص المركب الكيميائي الفعال بوساطة تقانات كروموتوغرافيا الطبقة الرقيقة , كروموتوغرافيا العمود كروماتوغرافيا الغاز , مطيافية تحت الحمراء و مطيافية الكتلة ,مطيافية الرنين النووي المغناطيسي ,كما تم دراسة التأثير المخفض لسكر الكلكوز في الأرانب المختبرية للمركب الكيميائي المعزول Lup-20(29)-ene-3, 28-diol لوحظ فعالية قوية في تخفيض مستويات كلكوز الدم , حيث أظهرت النتائج انخفاضا معنويا عند مستوى معنوية (P˂0.01 ) عند الساعة الرابعة والسادسة وانخفاضا معنويا عاليا (P˂0.001 ) عند الساعة الرابعة والعشرين في الأرانب المصابة بفرط السكر المحدث بالالوكسان , بينما في الأرانب السليمة وجد انخفاضا معنويا (P˂0.05 )عند السادسة وارتفاعا معنويا عاليا (P˂0.01 ) عند الساعة الرابعة والعشرين .


Article
The Importance of Uric Acid and Catalase as antioxidants in Diabetic Subjects

Author: NAMEER A. ALI
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2006 Volume: 6 Issue: 1 Pages: 58-64
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

This study was designed to show the hazards of hyperglycemia on antioxidants level in diabetic subjects (type 2) and put lights on the importance of uric acid as scavenging compound in diabetic subjects. The study was conducted at the Department of Physiology, College of Medicine in Al Mustansyria University. A total of 30 healthy individuals were enrolled as a control group in this study with 33 diabetic subjects of type 2 DM.Uric acid and catalase enzymes were measured in both groups. The level of catalase was significantly lower in diabetic subjects than in control p < 0.01. Also the uric acid was significantly lower in diabetic subjects than the controls P < 0.05.It has been regarded that hyperglycemia is the principle factor in reducing the level of uric acid and catalase enzyme in the plasma of our diabetic subjects which both are regarded as part of defense mechanism against the increase in oxidative stress associated with hyperglycemia


Article
Hyperglycemic side effect of L Asparaginase in the treatment of childhood acute lymphocytic leukemia
ارتفاع سكر الدم كعرض جانبي بالعلاج بعقار الاسبارجنيز لدى الأطفال المصابين بابيضاض الدم اللمفاوي الحاد

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Abstract

Background: Hyperglycemia or diabetic ketoacidosis is one of many side effects known for Lasparagenas drug which is use in the induction therapy of acute lymphoblastic leukemia in children.Objective: To detect hyperglycemia as side effect of L Asparaginase therapy.Methods: From Jan2004through May2004 25children who was diagnosed as acute lymphocytic leukemia(ALL) and was treated in the oncology unit at central teaching hospital for children,15 children were newly diagnosed and the 10 were in relapsed state ,all those were treated with the drug L asparaginase as part of the of protocol for induction of remission of ALL .Blood glucose level were taken before starting therapy as base line and after the 3rd dose and after the 6th dose by glucometer , urine was examined for any sugar or ketone concamitly ,age ,sex ,body weight ,complete blood picture , and family history of diabetes mellitus of each were taken.Result: There were an increase in blood glucose level in(10%) of the children, that had risk factors for hyperglycemia as age more than ten years, positive family history of diabetes mellitus(DM), only one child who is newly diagnosed leukemia had hypoglycemia.Conclusion: ASP may cause increase or decrease in blood glucose level that needs regular measurement of blood glucose during induction and urine exam for glucoseuria. Key words: hyperglycemia, L ASP, ALL childhood.

الملخص:هذه الدراسة شملت (25)طفلا خلال شهر كانون الثاني 2004الىشهر أيار وكان الأطفال مشخصون بمرض ابيضاض الدم اللمفاوي الحاد في ردهة أمراض الدم في مستشفى الطفل المركزي التعليمي في بغداد وكان منهم15 مريض حديثي التشخيص و10 مرضى سابقين يعانون من انتكاسة المرض وقد أعيد علاجهم.استعمل عقار ل اسبارجنيز كجزء من بروتوكول علاج المرض.اخذ قياس نسبة السكر في الدم وكذالك السكر والكيتون في البول لكل طفل قبل بدا العلاج وبعد الجرعة الثلاثة وبعد الجرعة السادسة بعد ساعتين لكل اختبار(بوست برا نديل تيست).لقد تبين ان هنالك حالات ارتفاع في سكر الدم بنسبة 10% لدى الأطفال الذين لديهم عامل خطورة لارتفاع السكر مثل العمر أكثر من عشر سنوات أو وجود داء السكري في العائلة علما ان هناك حالة واحدة فقط عند حديثي التشخيص كانت نسبة السكر فيها منخفضة.وعليه فان عقار الاسبارجنيز من الممكن ان يسبب زيادة أونقصان في نسبة السكر في الدم كتائثير جانبي وعليه يجب قياس نسبة السكر في الدم بشكل دوري خلال العلاج.


Article
ANTIHYPERGLYCEMIC EFFECTS OF THYMOQUINONE IN DIABETIC RATS

Author: Jabbar A.A. Al-Sa'aidi; 1 , Hashim M.A. Kareem 2 ; , Wijdan T.M. Al-Tameemi 2
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: 18138497 Year: 2014 Volume: 13 Issue: 2 Pages: 180-192
Publisher: Basrah University جامعة البصرة

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Abstract

To investigate the antihyperglycemic potent of thymoquinone (TQ), this study has been conducted in streptozotocin-induced diabetic male rats.Diabetes was induced by single injection with streptozotocin (60 mg/kg b.w., i.p.). Rat ≥ 200 mg/dl of blood glucose was used as diabetic.Sixty five adult male rats (aged 56 days and weighted 138±8.8g) were divided into fivegroups, non-diabetic control (were drenched with drinking water) and four diabetic groups(DM, TQ50,TQ100, and DMI) were drenched with drinking water,TQ (50 mg/kg, bw), TQ (100 mg/kg, bw), and injected with insulin (4 IU/animal), respectively, for 42 days. During the experiment,body weight gains were recorded and blood samples were obtained weekly for assessment of plasma glucose and insulin concentrations. TQ treated male rats showed normal activity and body health throughout the experiment. Significant decrease of body weight gain has been recorded in untreated diabetic (DM) and insulin treated diabetic (DMI) groups as compared with that of intact control (C) and TQ treated diabetic (TQ50 and TQ100) groups, started from the fourth day of experiment, while DM group registered the lowest body weight gain among the experimental groups. Results of blood glucose concentrations referred to significant elevation in diabetic groups as compared with intact control. While in comparison between the diabetic groups, blood glucose concentration decreased significantly TQ50, TQ100, and DMI groups compared with DMI group. It has been found that insulin treated (DMI) and TQ treated (TQ50 and TQ100) male rats recorded no significant difference in serum insulin concentration when compared with each other but they were significantly lower than that of intact control male rats (C), but the average means of these four groups were significantly higher than that of non-treated diabetic male rats (DM).These changes were time dependent during the studied experimental period. It can be concluded that drenching of 100 mg/kg of TQ has potent hypoglycemic effect in experimentally-induced diabetic male rats.


Article
The incidence of stress hyperglycemia in acute ischemic stroke patients (in Al-Yarmouk teaching hospital)

Authors: Abdul- Hameed Al-Kassir --- Zaid Tarik زيد طارق
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 46-51
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Aims: Stress hyperglycemia represents a transient increase in blood glucose in reaction to acute illness. Cases with stress hyperglycemia have higher mortality rates and worse functional outcomes than the ones with known diabetes or normoglycemia. This study evaluated the incidence of stress hyperglycemia in acute ischemic stroke patients and its relationship with stroke risk factors. Patients and Methods: WHO criteria is used to confirm hyperglycemia and HbA1c test to detect stress hyperglycemia in a sample of 220 patients with acute ischemic stroke who were admitted to Al-Yarmouk teaching hospital in Baghdad from 1 April to 31 December 2010. Results: thirty nine patients with acute ischemic stroke had stress hyperglycemia. There is significant effect of gender, hypertension, atrial fibrillation and dyslipidemia on patients with stress hyperglycemia while this is not found with obesity and smoking.Conclusions: stress hyperglycemia is a common phenomenon in patients who develop acute ischemic stroke.


Article
The effect of experimentally induced hyperglycemia by alloxan on some hematological parameters in rabbits
تأثير ارتفاع سكر الدم المستحث تجريبيا بواسطة ألألوكزان على بعض معايير الدم في الأرانب

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Abstract

The study was designed to investigate the effects of hyperglycemia on some hematological and serum lipid parameters in rabbits during a period of seventy days. This study was achieved in the university of Al-Qadisyiah / college of veterinary medicine college department of pathology from 31/10/2008 till 10/02/2009. The parameters evaluated include serum lipids, red and white blood cell indices. The results show that the hyperglycemia significantly reduced (P<0.05) packed cell volume and red blood cell count when compared with control groups. Also, the hyperglycemia significantly reduced (P<0.05) white blood cell count when compared with control.

هدف هذه الدراسة هو فحص وتقييم تأثير ارتفاع نسبة سكر الدم على بعض معا يير الدم ونسب الدهون في الأرانب خلال سبعين يوما وهي الفترة التي استغرقتها التجربة.اجريت هذه الدراسة في قسم الامراضظ كلية الطب البيطري ظ جامعة القادسية من الفترة 31/10/2008 حتى 10/02/2009 وتشمل تقييم معايير مصل الدم والدهون وكريات الدم الحمراء و البيضاء. وتبين النتائج أن فرط سكر الدم أحدث انخفاضاً كبيراً (0.05P<)في حجم الخلايا المرصوصة وخلايا الدم الحمراء عند مقارنتها مع مجموعة السيطرة، و أيضاً أحدث فرط سكر الدم انخفاضاً كبيراً (P<0.05) في خلايا الدم البيضاء عند مقارنتها مع مجموعة السيطرة، وقد تسبب فرط سـكر الدم بزيادة مؤثرة بشـــــكل كبيــر ( P<0.05) في تركيز الكوليسترول في مصل الدم بينما كان تاثيرها أقل أهمية ( P<0.05) علىنسبة الدهون البروتينية الثقيلة الى كوليسترول مصل الدم عند مقارنتها مع مجموعة السيطرة ومع ذلك ، فإن فرط سكر الدم قد احدث زيادةً كبيرةً ( P<0.05)في تراكيز كوليسترول مصل الدم triacylglycerol)).


Article
The Value of Admission Glucose and Glycosylated Hemoglobin in Patients with acute Coronary Syndrome

Authors: Manal Khudhur Abdul Razzaq --- Jawad Ibrahim Rasheed --- Haider Shaheed Mohmmad
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 1 Pages: 75-84
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: In nondiabetic patients, elevated admission glucose level is a strong predictor of short-term adverse outcome in patients with acute coronary syndrome. Admission glucose may be affected by meals, the circadian cycle, and also the stress response. Glycated hemoglobin A1c is a convenient marker of long-term glucose regulation. However, the prognostic value of diabetic control assessed by HbA1c level in patients with acute coronary syndrome (ACS) is still undefined.OBJECTIVE: To determine the association between (admission glucose and HbA1c) and short term outcome in patients not known to be diabetics presented with ACS.PATIENTS AND METHODS: This observational study included 50 consecutive patients without known diabetes mellitus admitted to the coronary care unit with ACS. Patients were sub-divided into three groups: patients with unstable angina (UA, n = 10), those with ST segment elevation myocardial Infarction (STEMI, n = 18) and those with non ST segment elevation myocardial infarction (NSTEMI, n = 22). Patients were stratified according to their HbA1c into three groups: Group 1: <6.5 (12, 24%), group 2: 6.5- 8.5 (22, 44%) and group 3: > 8.5 (16, 32%). Both glucose and HbA1c were measured on admission. The diagnosis of ‘‘undiagnosed DM’’ was made if patients presented with fasting glucose >7.0 mmol/L or random glucose >11.1 mmol/L together with an admission HbA1c >6.5% according to the latest ADA recommendations. Main outcome measure was left ventricular (LV) systolic function which was assessed by ejection fraction (EF); and the set point was 50%. Data were analyzed separately using multiple regression analysis.RESULTS: The mean age of patients was 60.6 ± 6.33 years and 74% were males. Of total, 42% were smokers, 68% were hypertensive, 48% had hyperlipidemia and BMI ≥ 30 in 22%. Eighteen percent of patients were diagnosed as new cases of DM. Mean admission glucose was higher in patients with EF< 50% compared to those with EF> 50% with statistically significant difference (P< 0.05). There was a linear correlation between EF% and HbA1c in all types of presentation. 95.5% of patients in group 2 and 100% of patients in group 3 showed EF<50% with statistically significant difference (P< 0.05). CONCLUSION: HbA1c on admission is a powerful predictor of LV systolic dysfunction as a major adverse event of acute coronary syndrome in patients not known to be diabetics. Measurement of HbA1c levels may improve risk assessment in those patients when presenting with ACS

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