research centers


Search results: Found 7

Listing 1 - 7 of 7
Sort by

Article
Efficacy of simvastatin compared with atorvastatin in patients with hyperlipidaemia in Kurdistan
فعالية سيمفاستاتين مقارنة مع أتورفاستاتين في مرضى فرط شحميات الدم في كردستان

Authors: Ari Aziz Salih --- Wishyar Abbas Hamad --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 2 Pages: 90-97
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Lowering the blood cholesterol and low density lipoprotein levels may reduce the risk of coronary heart disease. This study was designed to evaluate the effect of lipid-lowering therapy by simvastatin 20 mg versus atorvastatin 20mg on patients suffering from hyperlipidemia.Method: This study is 16-weeks duration included 75 patients with hyperlipidemia. Patients were assigned randomly to receive either simvastatin 20 mg/day group (1), or atorvastatin 20 mg/day group (2). After 12 hours fasting, lipid profile, atherogenic index and alanine aminotransferase were assessed for the patients at baseline, 8-weeks and at the end of 16-weeks of treatment.Results: After therapy for both groups of patients, as compared to the levels at the baseline, the serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were significantly reduced while high density lipoprotein cholesterol (HDL-C) was significantly increased. Serum alanine aminotransferase (ALT) increased by both groups of treatment with no significant differences between the two modes of treatment.Conclusion: After treatment with simvastatin 20 mg and atorvastatin 20 mg, there were a reduction in total cholesterol, triglyceride, LDL-C, and VLDL-C, and an increase in HDL-C in both groups. Comparing the two types of treatment, atorvastatin 20 mg was more effective in lowering triglyceride and VLDL-C than simvastatin 20 mg while Simvastatin led to greater reduction in LDL-C. Both modes of treatment were well tolerated by the patients.


Article
Effects of simvastatin on lipid profile, atherogenic index and serum transaminases in hyperlipidemic patients
آثار سيمفاستاتين على البروتين الدهني ومؤشر تصلب الشرايين و مصل transaminases في مرضى شحميات الدم

Authors: Ari Aziz Salih --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2011 Volume: 15 Issue: 2 Pages: 29-33
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Hyperlipidemia is characterized by increased concentrations of lipids including triglycerides, total cholesterol, low density lipoproteins, very low density lipoproteins in the blood and some times decreased high density lipoproteins .Many drugs have been used for treatment of this disorder. The present study was designed to estimate the effects of simvastatin on lipid profile, atherogenic index, transaminases, creatinine, uric acid and alkaline phosphatase.Methods: This study covered 70 subjects, they were divided into two groups, the first group included 45 hyperlipidaemic patients which were treated with 20mg simvastatin and second group included 25 normal subjects. After 12 hours fasting, serum lipid profile, transaminases; alkaline phosphatase, uric acid and creatinine were measured for the patients in 3 intervals before treatment, after 8 weeks and 16 weeks of treatment, and one time for normal subjects.Results: : After therapy, simvastatin showed a significant reduction in serum (TC, TG, LDL, VLDL and atherogenic index) and also, significant rise in HDL noticed, by performing a comparison between the group before treatment, and groups after treatment.Serum ALT, AST and ALP were significantly increased but were still within normal levels.Insignificant effect was observed from serum creatinine, uric acid and also body mass index by performing a comparison between group before treatment and groups after treatment.Conclusions:Simvastatin was effective in controlling lipid profile and atherogenic index, with no significant abnormality in liver functions.


Article
Effect of atorvastatin, with or without ezetimibe, on serum lipid profile and ALT in hyperlipidemic patients
تأثير أتورفاستاتين ، مع أو بدون ezetimibe ، على الملف الدهني للدهون و ALT في مرضى شحميات الدم

Authors: Wishyar Abbas Hamad --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2011 Volume: 15 Issue: 1 Pages: 13-19
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Hyperlipidaemia is raised serum levels of one or more of total cholesterol, low-density lipoprotein and triglycerides. Many drugs have been used for the treatment of this disorder. This work compares the effects of atorvastatin with or without ezetimibe on lipid profile, atherogenic index and serum alanine aminotransferase.Methods: This study covers 90 subjects, 60 untreated hyperlipidemic patients, and 30 healthy subjects. Patients were divided into 2 groups, the first group included 30 patients treated with atorvastatin 20 mg/day alone, the second group included 30 patients treated with a combination of 2 drugs (atorvastatin 10 mg plus ezetimibe 10 mg) taken daily at night. Serum lipid profile, atherogenic index and serum alanine amniotransferase were measured after 12 hours fasting for the patients in 3 intervals: before, and after 8 weeks and 16 weeks of treatment.Results: After therapy for both groups of patients, as compared to the levels before treatment, has shown that serum total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein cholesterol were significantly reduced while high density lipoprotein cholesterol was significantly increased. Serum alanine aminotransferase increased by both groups of treatment with no significant difference between the two modes of treatment which has the same findings in comparison to the control group.Conclusion: Combination of atorvastatin 10 mg and ezetimibe 10 mg daily, is more effective than atorvastatin 20 mg taken alone.


Article
coronary artery lesions in patients with acute coronary syndrome . the role of the traditional risk factors

Author: Hassan Yousif Al-Najjar حسن يوسف النجار
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 2 Pages: 143-148
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract


Article
Study of Lipids Disorder in sera of Patients with Type II Diabetes Mellitus in Diyala
دراسة اضطراب الدهون في مصول دم المرضى المصابين بداء السكري(النوع الثاني) في محافظه ديالى

Authors: Zuhair Maroof Hussien زهير معروف حسين --- Yasmine Sami Nassir ياسمين سامي ناصر --- Dawood Salman Al-Azzawi داود سلمان العزاوي
Journal: JOURNAL OF MADENAT ALELEM COLLEGE مجلة كلية مدينة العلم الجامعة ISSN: 2073,2295 Year: 2013 Volume: 5 Issue: 2 Pages: 73-80
Publisher: City College of Science University كلية مدينة العلم الجامعة

Loading...
Loading...
Abstract

Diabetes mellitus has been known to associate with lipid disorders and cardiovascular complication. This study was carried out to determine the changes in serum lipid profile in type 2 diabetic patients. Lipid profile was measured in sera of thirty males and females type-2 diabetic patients who attend Baqubah Educational Hospital in Diayla province and compared with thirty healthy of matched age and sex, as control group. The result indicate the presence of significant increase in serum TG (p < 0.0001), TC (p < 0.0001), LDL-C (p <0.0001), and VLDL-C (P <0.0001). Serum HDL-C levels were significantly decreased (p < 0.0001) in type 2 diabetic patients. In conclusion several lipid abnormalities were found in type 2 diabetes mellitus.

من المعروف ان مرض السكري يقترن مع عدم انتظام الدهون ومشاكل امراض القلب. تم في الدراسة الحالية تعيين التغيرات في مستوى الدهون في مصول المرضى المصابين بمرض السكري الذين تتراوح اعمارهم من (45-65) سنة . وقد تم قياس مستوى الدهون في مصل 30 مريض بداء السكري(النوع الثاني) من كلا الجنسين في مستشفى بعقوبة التعليمي في محافظة ديالى وتم مقارنتها مع 30 من عينات السيطرة الاصحاء من كلا الجنسين وباعمار مقاربة. اشارت النتائج الى وجود زيادة معنوية في مستوى الكولسترول , الدهون الثلاثية , البروتين (P<0.0001)VLDL والبروتين الدهني منخفض الكثافة جدا LDLالدهني منخفض الكثافة (P<0.0001)HDL في حين ان هناك انخفاض معنوي في مستوى البروتين الدهني عالي الكثافةفي مصل الدم للمرضى المصابين بداء السكري(النوع الثاني ).


Article
The Effect of Aqueous Extract of Capparis spinosa Flowers on the Level of Serum Lipids in Rabbits
تأثير المستخلصات المائية لأزهار نبات الكبرCapparisspinosaفي مستوى دهون مصل الدم في الأرانب

Author: Wajeeh Y. AL-Ani وجيه يونس العاني
Journal: Al- Anbar Medical Journal مجلة الأنبار الطبية ISSN: PISSN: 27066207 / EISSN: 26643154 Year: 2012 Volume: Vol.10 Issue: 2 Pages: 86-91
Publisher: University of Anbar جامعة الانبار

Loading...
Loading...
Abstract

Background: The aqueous and alcoholic extract of Capparis spinosa Possessed many different pharmacological activity such as anti-hyperlipidemic Properties. The aim: The present study aims at investigating the influence of the aqueous extract of Capparis spinosa flowers on the levels of serum lipids profile for normal and hyperlipidemic rabbits. Material and method: Twenty male white rabbits of (2-2.5)Kg. in weight and of age six months hyperlipoproteinaemia was induced experimentally by feeding the first ten with a were used, The high cholesterol diet ( 2gm/kg/day animal fat with adding 2 gm / Kg / day cholesterol powder.) For six weeks then they divided into two subgroups: (A) as a positive control and ( B ) . The other ten rabbits were given ordinary diet and served as controls ,then divided into two subgroups ( C ) as negative control and ( D ). Subgroups (B) and (D) were treated daily for 30 days with an aqueous extract of Capparis spinosa flowers with concentration of 100 mg / ml and an oral dose of 5 ml/ Kg / day, that was given orally by intragastric tubation.After 12- 14 hours of fasting, 5 ml of venous blood was drawn, then centrifuged for 10 min. at 3000 rpm for serum separation. Serum lipids were determined by the enzymatic method and Statistical analysis was performed.Results :The results showed that the treatment of rabbits with an aqueous extract of Capparis spinosa flowers in concentration of 100 mg / ml and therapeutic dose of 5 ml/ kg / day via oral administration and for thirty days , reduced significantly (P < 0.05) the total serum cholesterol ( TC) level , triglycerides ( TG ) , low- density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) in hyperlipidemic rabbits ( group B ) and had no effect on the level of high-density lipoprotein cholesterol (HDL-C) . Also the aqueous extract reduced significantly (P < 0.05) the level of ( TG) and ( VLDL-C ) in normal rabbits (group D) ,while no significant reduction was seen in the level of TC., LDL-C and HDL-C . Conclusion: The experimental results showed a therapeutic importance of Capparis spinosa flowers in lowering the levels of serum lipids and decreasing the infection risk of acute coronary syndrome.

خلفية البحث : تمتلك المستخلصات المائية والكحولية لنبات الكبر Capparisspinosa فعاليات بايولوجية ودوائية مختلفة واهمها الفعالية المضادة لفرط دهون مصل الدم .الهدف : اختبار تأثير المستخلص المائي لأزهار نبات الكبر Capparisspinosaعلى مستويات دهون مصل الدم في الارانب .طرق البحث: أستخدم في هذه الدراسة عشرون ذكرا من الارانب البيضاء تراوحت اوزانها 1.5) – 2) كغم وبعمر حوالي ستة أشهر وتم احداث مرض فرط الدهون تجريبيا في الارانب العشرة الاولى وذلك بإطعامها غذاء غنيا بالدهون يتكون من 2 غم/كغم يوميا دهنا حيوانيا مضاف اليه 2 غم/كغم من الكوليسترول ولمدة ستة اسابيع قسمت بعدها الى مجموعتين A) ) كمجموعة سيطرة موجبة و B)) كمجموعة معاملة اما الارانب العشرة الثانية فقد اطعمت طعاما عاديا وقسمت ايضا الى مجموعتين هما C كمجموعة سيطرة سالبة و D)) كمجموعة معاملة بعدها عوملت مجموعتي المعاملة B)) و D)) فمويا بالمستخلص المائي لازهار الكبر بتركيز 100ملغم/مل وبجرعة تجريبية 5 مل/كغم/يوم عن طريق التجريع الفموي ولمدة ثلاثين يوما. أستحصلت نماذج الدم من الوريد الحافي الاذني للأرانب واستخدمت الطرق الانزيمية لتقدير دهون مصل الدم كما أخضعت نتائج البحث الى التحليل الاحصائي . النتائج : اظهرت نتائج البحث ان معاملة الارانب بالمستخلص المائي لأزهار نبات الكبر بتركيز 100ملغم/مل وبجرعة تجريبية 5 مل/كغم/يوم عن طريق التجريع الفموي لمدة ثلاثين يوما خفض معنويا0.05) >P ) من مستوى الكوليسترول الكلي ( TC) والكليسريدات الثلاثية TG )) وكليسترول البروتينات الدهنية واطئة الكثافة( LDL-C) وكذلك كليسترول البروتينات الدهنية واطئة الكثافة جدا( VLDL-C) في الارانب التي أحدث بها مرض فرط الدهون تجريبيا ( مجموعة B ) ولم يؤثر معنويا على مستوى كوليسترول البروتينات الدهنية عالية الكثافة( HDL-C). كما لوحظ ان المستخلص المائي لازهار الكبر قد خفض وبشكل ملموس احصائيا من مستوى الكليسريدات الثلاثية TG )) وكليسترول البروتينات الدهنية واطئة الكثافة جدا( VLDL-C) في الارانب السليمة والمعالجة بالمستخلص المائي لأزهار نبات الكبر ( مجموعة D ) ولم يؤثر معنويا على مستوى الكوليسترول الكلي ( TC) و مستوى كوليسترول البروتينات الدهنية واطئة الكثافة( LDL-C) أو مستوى كوليسترول البروتينات الدهنية عالية الكثافة( HDL-C) .الاستنتاجات : ان نتائج البحث التجريبية بينت الاهمية العلاجية لأزهار نبات الكبر وتاثيرها في خفض مستويات دهون مصل الدم والتقليل من خطورة الاصابة بأمراض الشرايين التاجية الحاد


Article
The Impact Of Severity Of Ischaemia In Acute Coronary Syndrome On The Extent Of Coronary Artery Disease At Angiography The Role Of Past Ischaemia

Author: Hassan Yousif Al-Najjar حسن يوسف النجار
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 3 Pages: 236-241
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Clinical classification of patients with acute coronary syndrome is essential step in identifying severe cases before referring them, fairly quickly, for the ultimate investigation of coronary angiography .Hence it is important to find out the extent at which the severity of the disease, based on clinical classification, agrees with its severity at angiography and to see whether traditional Risk factors or pas ischaemia played a role.
Patients and Methods : The angiographer data of 178 consecutive pts with Acute Coronary Syndrome (ACS) were retrospectively analyzed. The pts consisted of 114 with Unstable Angina (UA) and 64 pts with Non-ST-Segment Elevation Myocardial Infarction (NSTEMI). Patients were classified depending upon the predominating clinical assessment during hospitalization into four groups of progressively worsening ischaemia. They were; group 1; New onset Angina; 27 pts, group 2; Deteriorating Chronic Angina, 33 pts, group 3; Rest Angina 54 pts, and, group 4; Non-ST-Elevation Myocardial Infarction (NSTEMI), 64 pts.
Results : Coronary Angiography revealed that the frequency of multi-vessel coronary Disease (MVD) in group 1, 2, 3, and 4 were 48%, 73%, 72%, and 56% respectively which meant that worsening of ischaemia was not accompanied by commiserate increase of the frequency of MVD in Rest angina
and NSTEMI. To explain that we calculated the average number of Five traditional Risk Factors; Hyperlipidaemia (HL), Diabetes Mellitus (DM), Hypertension (HTN), Smoking (SM), and Positive Received March 2006 Family History (PFH) in the four groups ofACS (R.F. score) and they were 1.72, 1.87, 2.13, 2.51 in Accepted May 2006groups 1,2,3, and 4 respectively. Then we studied the relation of having one, two, three, and four orfive Risk Factors and the frequencies of Multi-vessel disease and they were; 43%, 67%, 76%, and 84% respectively which meant that the frequency of MVD ought to increase from group 1 to group 4 supporting the clinical classification. This prompted us to look into the individual Risk factors. The clinical data showed that the incidence of HL had risen significantly in Ch. D. angina and Rest Angina (P: 0.03) and that the incidence of SM had risen significantly in NSTEMI (P.• 0.001). Since the angiographic data had demonstrated a significant association of HL with MVD and SM with SVD we may understand why the rate of MVD was not higher in NSTEMI than UA. To explain why the frequency of MVD in Rest Angina (g. 1) was not higher than Ch. D. Angina (g. 2) despite having worse ischaemia and higher R.F. Score we scrutinized the data and noticed that the main difference between group 1 and group 2 that chronic stable angina had preceded the onset of UA in Group 2 while it did not do in group 1. On the other hand Rest Angina and NSTEMI pis were a mixture of those with and without prior ischaemia. To follow this point further we divided both groups into two subgroups: one with history of prior ischaemia and one without it. The frequency of MVD in Rest Angina and NSTEMI with prior ischaemia were 83%% and 81 %% compared to 54% and 39% respectively in pts without it.Conclusion this study has shown that clinical classification in Acute Coronary Syndrome may predict severity of the underlying CAD to some extent however considering the no. Of risk factors and which Risk factor and whether there was antecedent ischaemia would improve the prediction a great deal.

Listing 1 - 7 of 7
Sort by
Narrow your search

Resource type

article (7)


Language

English (6)


Year
From To Submit

2013 (1)

2012 (2)

2011 (2)

2006 (2)