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Article
Association between Interleukin-5 & Body Mass Index among Iraqi Asthmatic Patients

Authors: Wala'a E. Jasim --- Batool A. Al-Haidary --- Yacoob Y. Al-Rubayei
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 116-120
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Asthma is an allergic hypersensitivity disease in which many mediators play a role in its pathogenecity. One of these etiological agents is the mediators such as Interleukin-5 (IL-5). The aim of this study to demonstrate the association between IL-5 and obesity in asthma development. Materials & Methods: One hundred and four sera samples for asthma cases have been studied in comparison with 41 non-asthmatic bronchitis as a patient controls beside 30 apparently healthy controls. Cytokine has been estimated using ELISA method in correlation with Body Mass Index (BMI). Results: This study revealed a significant correlation between IL-5 concentration and BMI (P<0.05), particularly among females. Conclusion: There is certain correlation between obesity and asthma accompanied by IL-5. Key

Keywords

Asthma --- IL-5 --- ELISA --- BMI.


Article
IL-5 As Indicator of Acute Toxoplasmosis

Authors: Suha A.AL-Fakhar --- Sami Y. Guirges
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 134-138
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Exposure to Toxoplasma gondii may result in either chronic infection or acute infection, the latter being asymptomatic or symptomatic. Toxoplasma infection stimulates humoral immune response ,in addition to cellular mediated immunity. Also cytokines have a role in resistance to T.gondii like IL-5 which has protective role during infection with the parasite.OBJECTIVE:This study aimed to assess the correlation between IgM and IgG Toxoplasma antibodies and IL-5 in the course of acute toxoplasmosis .PATIENTS AND METHODS :45women suspected of having toxoplasmosis were tested by ELISA IgM and IgG toxoplasma antibodies , and the level of serum IL-5 was tested using ELISA technique only on 32 women .RESULTS:The results showed that there are higher titer of IgM and IgG-Toxoplasma antibodies and higher levels of serum IL-5 in women with Toxoplasma infection .CONCLUSION:Serum IL-5 can be used as indicator to predict the presence of acute toxoplasmosis in pregnant women at high risk to toxoplasmosis.

Keywords

toxoplasmosis --- IgG --- IgM --- IL-5.


Article
“Interleukin-5 Level in the sera of Iraqi Asthma Patients”

Author: Yacoob Y. Al-Rubayei
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2006 Volume: 17 Issue: 3 Pages: 1-10
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Asthma is an anaphylactic hypersensitivity reaction. It wasdenoted that many factors play a role in its pathogenecity such ascytokines. One of these cytokines is IL-5.The level of IL-5 has been estimated by applying ELISA technique in thesera of 94 Iraqi patients with asthma in comparison with 41 acute nonasthmaticbronchitis cases as a patient controls beside 30 apparent healthycontrols.This study showed highly significant elevatation of IL-5concentration in the sera of asthmatic patients in comparison with controlgroups (P< 0.001). Furthermore IL-5 test proved to be a perfect test forasthma cases and distinguishing it from healthy controls with a highsensitivity (97.1%) and 100% specificity while it's accuracy was (98.4%)..

في "دوا ر تلعب عوامل عدة وهناك .التأقیة الحساسیة فرط تفاعلات من الربو إنمستوى قیاس تم . 5 - انترلوكین هو السایتوكینات هذه أحد .السایتوكینات مثل الربو أم ا رضیة"ع ا رقیا 94 مصول في المناعي الممتز المرتبط الأنظیم مقایسة باستخدام 5 - انترلوكینإلى إضافة مرضى كسیطرة اللاربوي القصبات بالتهاب مریضا 41 ب مقارنة بالربو مریضابین عالیة معنویة فروق وجود الد ا رسة هذه أظهرت . الأصحاء سیطرة یمثلون "فردا 30ع المرضى مصول في 5 - الانترلوكین تركیز

Keywords

Asthma --- IL-5 --- ELISA --- ROC


Article
Possible Role for Interleukin-5 in Asthma

Authors: Wala'a E. Jasim --- Batool A. Al-Haidary --- Yacoob Y. Al-Rubaeyi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 4 Pages: 425-430
Publisher: Baghdad University جامعة بغداد

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Abstract


Background: Asthma is an allergic disease characterized by airway obstruction as a result of cellular accumulation due to the liberation of certain mediators. Among those mediators are the cytokines such as IL-5.
Patients & Methods: Interleukin-5 concentration has been estimated in 94 sera samples of Asthmatic patients in comparison with 41 non-asthmatic bronchitis as patient controls in addition to 30 apparent healthy control group using ELISA method.
Results & Conclusions: There is highly significant elevation of IL-5 in the asthmatic cases in comparison with healthy controls (P< 0.001). We conclude that this cytokine may play the major role in asthmatic attack & it may be a good marker for the disease.

Keywords

Asthma --- IL-5 --- bronchitis --- Eosinophilia --- IgE


Article
A Study Effects of Licorice Plant and Prednisolone on Some Physiological and Immunological Parameters in Experimental Model

Authors: Zaid Al-Nuaimi --- Nasser Almukhtar --- Safaa Alturaihy
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 113 -125
Publisher: Babylon University جامعة بابل

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Abstract

The present study conducted thirty of adult male white rabbits to uncover the impact of Licorice in minimize the signs associate degreed symptoms after induction of allergic bronchial asthma in rabbits and elucidate what extent it will show an beneficial effects herbs therapy, in state use corticosteroids medical care. The rabbits haphazardly divided into 5 groups and albumen sensitizer was used to stimulate allergic reaction beside to use sensitization boost challenge dose that emphasize by the presence of the clinical symptoms of innate reflex, wheezing, chest tightness and shortness of breath. As well as, to changes within the level of total white blood corpuscle count, Eosinophils measurements, Interleukin-5 estimation and body temperature measurements. Meanwhile, eight days after induction allergic reaction. Extraction of Licorice was given in a variety dose of (160 and 80) mg/kg orally was administrated for eight days. Blood collected samples were done on the day sixteen and thirty, for investigate the above previous parameters through collected blood serum samples. statically analysis fore results were showed that the albumen action considerably (p≤ 0.05) induce allergic response in those of experimental rabbits associate degreed show an elevation with total white blood corpuscle, Eosinophils and Interleukin-5 levels. Whereas orally treating rabbits with root extract observe a big decrease (p≤ 0.05) within the total white blood corpuscle, Eosinophils and with the degree of Interleukin-5. As these effects of (the plant extract) wherever analyzed in comparison with recorded noticeable effects in those of glucocorticoid treated group and those healthy management teams severally.


Article
Assessment the Level of Interleukine-5 and Eosinophils Count in Allergic Rhinitis and Asthma Patients

Authors: Salwa Ahmed Alkarady --- Ferial Gemeel Abed --- Raad Fanokh Al-Jobory
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2016 Volume: 24 Issue: 5 Pages: 1221-1226
Publisher: Babylon University جامعة بابل

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Abstract

Fifty blood samples have been collected from patients attending the center of the allergy and asthma in the province of Babylon ( 25 before immunotherapy treatment and 25 after treatment ), in addition to 10 samples from non-allergic persons as a control . IL-5 concentrations have been measured by using ELISA, while the eosinophils have been measured by using complete blood count device. This results shows that there is an increase in the level of IL-5 and eosinophils count before allergen-specific immunotherapy treatment for allergic rhinitis patients which reached 53.1402 ± 3.67801pg/ml and 0.8249 ± 0.20108 cell/mm3 respectively and asthmatic patients 49.8922 ± 7.43190 pg/ml and 0.6523± 0.25712 cell/mm3 respectively in compared with their level after treatment for allergic rhinitis patients which reached 22.7315 ± 4.03680 pg/ml and 0.3642 ± 0.14734 cell/mm3 and asthma patients 22.7177 ± 4.13433 pg/ml and 0.3645± 0.15743 cell/mm3 respectively, and for control which reached 24.5404 ± 8.64920 pg/ml and 0.2252 ± 0.09139 cell/mm3 respectively. The results showed that there were an increase in the level of IL-5 for allergic rhinitis patients before and after treatment in compared with asthma patients , eosinophils increase in allergic rhinitis patients in compared with asthma patients before immunotherapy treatment, but the opposite is true for their count which increase in asthma patients in compared with allergic rhinitis patients after treatment. The level of IL-5 and eosinophils count decrease gradually by increasing the period of immunotherapy treatment which divided into three groups two months , six months and one year , the level of IL-5 for these groups 26.2821  3.81978 pg/ml , 21.3737  2.47124 pg/ml and 20.5029  4.67899 pg/ml respectively , while the count of eosinophils for these groups reached 0.4567  0.15057 cell/mm3 , 0.4282  0.15162 cell/mm3 and 0.26270.06517 cell/mm3 respectively.

تم جمع 50 عينة دم من المرضى المراجعين لمركزالحساسية والربو في محافظة بابل (25 قبل العلاج و 25 بعد العلاج ) , بالاضافة الى 10 عينات من اشخاص غير مصابين بالحساسية من النوع الاول اعتبرت كسيطرة, تم قياس تركيز IL-5 باستخدام تقنية ELISA , في حين تم قياس تعداد كريات الدم الحمضة باستخدام جهاز عد كريات الدم الكامل. اظهرت النتائج وجود ارتفاع في مستوى IL-5 كذلك الخلايا الحمضة قبل العلاج المناعي لكل من مرضى التهاب الانف التحسسي 53.1402 ± 3.67801pg/ml و 0.8249 ± 0.20108 خلية/ملم3 على التوالي و مرضى الربو , 49.8922 ± 7.43190 pg/ml و 0.6523± 0.25712 خلية/ملم3 على التوالي, مقارنة مع مجموعة بعد العلاج لمرضى التهاب الانف التحسسي 22.7315 ± 4.03680 pg/ml و 0.3642 ± 0.14734 خلية/ملم3 على التوالي ومرضى الربو 22.7177 ± 4.13433 pg/ml و 0.3645± 0.15743 خلية/ملم3 على التوالي, ومجموعة السيطرة التي بلغت 24.5404 ± 8.64920 pg/ml و0.2252 ± 0.09139 خلية؟ملم3 على التوالي. اظهرت النتائج كذلك ارتفاع مستوى IL-5 بالنسبة لمرضى التهاب الانف التحسسي مقارنة مع مستواه لمرضى الربو قبل وبعد العلاج المناعي, اما بالنسبة للخلايا الحمضة فقد وجد ارتفاع في تعداد هذه الخلايا عند مرضى التهاب الانف التحسسي مقارنة مع مرضى الربو لمجموعة قبل العلاج, لكن يصبح العكس هو الصحيح حيث يرتفع تعداد هذه الخلايا عند مرضى الربو مقارنة مع مرضى التهاب الانف التحسسي لمجموعة بعد العلاج. ينخفض تركيز IL-5, والخلايا الحمضة تدريجيا بزيادة مدة العلاج المناعي التي قسمت الى ثلاث مجاميع شهرين و ستة اشهر و سنة واحدة , بلغ تركيز IL-5 لهذه المجاميع 26.2821  3.81978 pg/ml , 21.3737  2.47124 pg/ml و 20.5029  4.67899 pg/ml على التوالي, في حين بلغ تعداد الخلايا الحمضة لنفس المجاميع كالتالي 0.4567  0.15057 خلية / ملم3 , 0.4282  0.15162 خلية / ملم3 و 0.2627  0.06517 خلية / ملم3.

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