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Article
The Role of Some Inflammatory Markers (IL-6 and CRP)in the Pathogenesis of Acute Coronary Syndrome in IraqiCCU for Heart Diseases

Authors: Amal N. Almarayati --- Mohamed A. Taher محمد عباس طاهر --- Nadia GH. AbdulKarim
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 1 Pages: 43-49
Publisher: Baghdad University جامعة بغداد

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Abstract

In this work an enzyme linked immunosorbent assay (ELISA) technique has been used for detection of some inflammatory markers in serum of acute coronary syndrome (ACS)-Patients Admitted to the cardiac care unit (CCU) o f Iraqi Centre For Heart Diseases and Ibn AlNafees Teaching Hospital. The present method includes quantitative measurement of interleukine-6 (IL-6) and Creactive protein (CRP), as their increase during symptoms may be responsible for identifying the mechanism of myocardial damag, in addition to their best performance than other quantitative tests perhaps due to their association with atherosclerotic process that belongs to the endothelial dysfunction. Aim of this study is to estimate the prevalence and correlation of IL-6 with CRP in ACSpatients presented with unstable angina/ non-ST elevation myocardial infarction (UA/NSTEMI) symptoms to be as new diagnostic parameters in Iraqi CCU. Seventy (70) ACS- patients with mean age(58.55 year ± 9.98), from Jun.2009 to Feb. 2010 with diagnosis of UA/NSTEMI were included in this study. Proper history, physical examination, electrocardiograph (ECG), and Echocardiography (ECHO) were performed for all patients in addition to the routine laboratory works including fasting blood glucose, lipid profile, assay of transaminases activity (Aspartate and Alanine transaminase),and biomarkers analysis as cardiac troponin I and T, creatine kinase (CK and CK-MB) and myoglobin. Blood sample was collected from all patients for quantitative assay of IL-6 and CRP. All patients underwent diagnostic coronary angiography, were 66 of them with abnormal coronary outcome and four patients have normal coronary arteries, study include 39- male and 31 female. Seventeen of 67 patients (25.4%) had elevated serum level of IL-6 and fifty four of 62 patients (87.1%) had elevated serum level of CRP. Statistically found strong and significant (SS) correlation between IL-6 and CRP (assessed by Spearman's rho correlation coefficient, P<0.01). The significant proportion of UA/NSTEMI patients that had elevated serum levels of IL-6 and/or CRP, in addition to the strong correlation with coronary angiographic findings make tbrhese inflammatory markers to be considered as risk stratification factors and good predictors for coronary artery disease independent of other traditional risk factors for cardiovascular disease (CVD).

تم في هذا العمل استعمال اختبار الامتصاص المناعي الإنزيمي للكشف عن بعض المؤشرات الالتهابية في أمصال مرضىمتلازمة الشرايين الإكليلية الحاد الراقدين في وحدات العناية بالقلب. واشتملت الدراسة على الطرق الكمية لقياس الحريك الخلوي6(أوالبين ابيضاضي) وبروتين الطور الحاد (أو بروتين سي الفعال) ٬ حيث إن زيادتهم بالدم أثناء حدوث الأعراض محتمل أن يكونالمسؤول عن التعريف بالية الضرر بعضلة القلب ٬ هذا بالإضافة إلى أدائهم المفضل عن بقية الاختبارات الكمية وذلك لعلاقتهم بتصلبالشرايين الذي يعود الى الاختلال الوظيفي للبطانة. الهدف من الدراسة لتقدير انتشار وارتباط الحريك الخلوي6و بروتين سي الفعالST- في مرضى متلازمة الشرايين الإكليلية الحاد مع أعراض الذبحة الغير مستقرة واحتشاء العضلة القلبية الغير مصحوبة بارتفاعلتكون هذه الاختبارات كأدوات تشخيص جديدة في وحدات العناية بالقلب في العراق. شملت الدراسة سبعون مريضا" segment58.55 ) ابتداء" من حزيران 2009 ولغاية شباط 2010 . تم اخذ التاريخ المرضي وإجراء year ± بالمتلازمة معدل أعمارهم ( 9.98الاختبارات الفيزيائية ٬ تخطيط كهربائية القلب وتخطيط صدى القلب للمرضى. عينات الدم جمعت من كافة المرضى لقياس الحريكالخلوي6و بروتين سي الفعال. جميع المرضى خضعوا للقسطرة الإكليلية التشخيصية التي أظهرت نتائج غير طبيعية للشرايينالاكليلية ل( 66 ) مريض و أربعة مرضى لديهم شرايين إكليلية طبيعية. شملت الدراسة 31 ذكر و 39 أنثى. 17 مريض ( 25.4 %) مناصل 67 لديهم ارتفاع بمستوى الحريك الخلوي6(اعتبر التركيز 25 بيكوغرام/مل كنقطة قطع لارتفاع مستوى الحريك الخلوي6بالدم) و 54 مريض ( 87.1 %) من اصل 62 لديهم زيادة بمستوى بروتين سي الفعال (باعتبار التركيز 3.83 ملغم/لتر كنقطة قطع(P< لزيادة مستوى بروتين سي الفعال بالدم). احصائيا" وجد ارتباط معنوي قوي بين الحريك الخلوي6و بروتين سي الفعال ( 0.01لعموم مرضى المتلازمة وكذلك بين ال 66 مريض ذوي الإصابات الإكليلية. النسبة المعنوية من مرضى الذبحة الغير مستقرة واحتشاءالذين لديهم زيادة بمستويات الحريك الخلوي6و/ او بروتين سي الفعال ST-segment العضلة القلبية الغير مصحوبة بارتفاعوارتباطهم القوي بنتائج القسطرة الإكليلية يجعل هذه المؤشرات الالتهابية كعوامل خطورة وتوقع جيدة لأمراض الشرايين الإكليليةمستقلين عن عوامل الخطورة المتعارف عليها في أمراض القلب الوعائية.

Keywords

ACS. IL-6. CRP.


Article
Serum interleukin-6 level using ELISA in patients with bladder cancer and having urinary tract infection
المستوى المصلىللانترلوكين 6باستخدام تقنيةالاليزاغير المباشرلدى مرضى سرطان المثانه المترافق مع التهاب المجاري البولية

Authors: Nidhal Abdulmohymen د.نضال عبد المهيمن --- Zainab F Ashoor د.زينب فاضل عاشور --- Amera Khodher د.عامره خضير
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2010 Volume: 23 Issue: 4 Pages: 251-256
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Background: IL-6 blood levels are elevated in numerous infectious, inflammatory, and autoimmune diseases and in cancer in association with increased synthesis of other cytokines stimulated by infectionAim: This study carried out to shed light on possible role of IL-6 in bladder cancer and it's correlation with bacterial infection.Materials & Methods: Serum IL-6 levels were measured in 132 patients and 25 healthy subjects by using ELISA technique. The patients were divided into 3 groups :Group-1: Newly diagnosed bladder cancer patients, Group-2: Post-chemotherapy patients, and Group-3: Other bladder disorders rather than bladder cancer. Urinary tract infections were studied for all groups by culturing urine samples using selective culture media.Results: There was no significant elevation of mean serum IL-6 levels between different groups ,but there were higher levels in cancerous patients ,when compared with non-cancerous patients, and the mean serum IL-6 levels in bladder cancer patients in correlation to the tumor grade ,showed no significant difference, but there was significant difference of serum IL-6 levels with mean value of (5903.8765 pg/ml) in 34 Gram-negative bacterial infected patients with and without bladder cancer, and (8466.6667 pg/ml) in 3 Gram-positive bacterial infected patients with and without bladder cancer than those who were free of infection with P value< 0.001 .Conclusion: Bacterial infected patients with and without bladder cancer revealed a significant increase in the mean serum IL-6 levels by ELISA.Key words: IL-6 .serum IL-6.bladder cancer.UTI .ELISA.

الملخص:خلفية الدراسه: ان مستوى الانترلوكين-6 في الدم يزداد في حالات مرضية مختلفة ,كالعديد من الامراض المعدية وامراض المناعة الذاتية اضافة الى الاصابة بالسرطان ,وزيادة انتاجه تتحفز بوجود اصابة جرثومية .هدف الدراسه:اجريت هذه الدراسة لتسليط الضوء على احتمالية دور IL-6في سرطان المثانة وعلاقة ذلك بوجود الاصابة البكتيرية .المواد وطرائق العمل : لقد تم قياس مستوى 6 IL-في مصل 132 مريض و25 شخص سليم باستخدام تقنية ELISA.حيث تم تقسيم المرضى الى ثلاث مجاميع : المجموعة الاولى :مرضى سرطان المثانة المشخصون حديثا ,المجموعة الثانية :مرضى سرطان المثانة المشخصون مسبقا والمعالجون بالعلاج الكيمياوي , والمجموعة الثالثة : حالات مرضية اخرى للمثانة عدى السرطان .كما تم دراسة خمج المجاري البولية لكل المجاميع بواسطة زرع عينات البول لكل المجاميع باستخدام اوساط زرعية خاصة لهذا الغرض .النتائج: لم يكن هناك إرتفاع نوعي في معدل هذا العامل بين المجاميع المختلفة ، لكن هناك نسب أعلى بين مرضى السرطان مقارنةً بالمرضى غير المصابين بسرطان المثانة . كما انه لم يكن هناك فرق نوعي في معدل IL-6 المصلي عند مرضى سرطان المثانة مع درجة تطور الورم لكن هنالك ارتفاع نوعى فى مستواه و بمعدل (5903,8765بيكوغرام /مل ) فى 34 مريض مصاب بخمج جراثيم سالبه لصبغة كرام من كل المجاميع المرضيه, و بمعدل (8466,6667بيكوغرام/مل )فى ثلاثة مرضى مصابين بخمج جراثيم موجبه لصبفة كرام من كل المجاميع المرضيه. الاستنتاجات: ان الاصابه بخمج المجارى البوليه تترافق مع زيادة المستوى المصلى للانترلوكين 6-سواء كان المريض مصاب بسرطان المثانه ام لم يكن.


Article
The role of serum IL-6 changes in evaluation of endometriosis
دور مصل IL-6 في تشخيص ومتابعة مرض بطانة الرحم المهاجره

Author: Tharwa H. Hassan AL-Tai ثروه هادي حسن
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2013 Volume: 55 Issue: 2 Pages: 158-161
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:- Endometriosis is a common chronic gynecological disorder characterized by the presence and proliferation of functional endometrial gland and stroma outside the uterine cavity, affecting approximately 10% of reproductive age women. Il-6 level increased in the patient with endometriosis.Objective:- Evaluate the correlation of IL-6 levels with the degree of severity of endometriosis Patients and methods:- In this study, 84 samples 51women with endometriosis (20 newly diagnosed and 31 treated cases) and 33 of healthy control group, were collected starting from November 2011 to end of January 2012, to investigate the IL-6 serum level by using ELISA kit. Results :- Endometriosis patients mainly presented at the age between (28-37). IL-6 serum levels were significantly decrease in those with stage IV endometriosis. Also appear to be significantly affected by the use of danazol or zoladex treatment of endometriosis and remain low even in treated patients. Serum IL-6 test was highly specific but with low sensitivity.Conclusion:-Serum IL-6 concentration seem to be the highly specific test that can be used as an early detection marker for endometriosis.Keywords: Endometriosis, IL-6

الخلفيه:- بطانة الرحم المهاجرة هو خلل مزمن يصيب الجهاز التناسلي للمرأة ويتصف بوجود وأنتشار غدة وسدى خارج تجويف الرحم حيث يصيب 10% من النساء اللاتي في سن الإنجاب، ويعد هذا المرض أحد أكثر الأمراض تعقيداً وإرباكاً ومن أعراضه المرهقة الم دوري في الحوض مما يجعل حياة المريضة لا تطاق إن تركت الحالة بدون علاج. ويزداد مستوى IL-6 لدى مريضات بطانه الرحم المهاجره.الطريقه:- اجريت هذه الدراسه في مستشفى كمال السامرائي حيث تم جمع اربع وثمانون عينه من الدم (51 أمراة ممن أصببن بمرض بطانة الرحم المهاجرة (20 حالة حديثة و31 حالة تمت معالجتها) وثلاثه وثلاثون أمراة سليمة.اجري هذا البحث للفتره من اواخر تشرين الثاني 2011 ولغايه كانون الثاني 2012.خضع جميع الافراد الى أختبار أخذ عينات الدم بهدف قياس مصل IL-6 وذلك بأستخدام تقنية ELISA.الهدف:- تقييم العلاقه بين مستويات IL-6 مع درجه شدة بطانة الرحم المهاجرة . النتائج:- خلصت دراستنا إلى إن مريضات بطانة الرحم المهاجرة يعانين بشكل كبير في عمر يتراوح بين 28-37سنه (54%)،وان مستوى مصل IL-6 فقد انخفض بنحوِ كبير لدى المصابات اللاتي في المرحلة الرابعة، واستمر بالانخفاض لدى من عولجن بماده الزولدكس او الادانازول. كما اظهر مصل IL-6 كان 100% نوعية. الاستنتاج:- تركيز مصل IL-6 أكثر نوعيه واقل حساسيه والذي يعد علامة مبكرة للكشف عن مرض بطانة الرحم المهاجر. الكلمات المفتاحية:- بطانة الرحم المهاجرة، IL-6


Article
The association between leptin and some immunological factor with infertility in male and female in Diyala province
دراسة العلاقة بین مستوى ھرمون اللبتین وبعض العوامل المناعیة مع حالات العقم لدى الرجال والنساء في محافظة دیالى

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Abstract

This study has been done in Diyala province from 20/ Nov./2011 to 10/ Oct. / 2012 in general laboratory in Baguba hospital . The main goal of the study is to limit the role of leptin hormone and some immunological factors such as IL – 6 and CRP in infertility in male and female .The study showed that the level of leptin hormone for the infertile male and female ( 18.22 ± 1.26 ) which is higher than the fertile male and female ( 2.53 ± 0.04 ) with statistical difference ( p<0.05 ) , This study showed that the reduction in the level of IL – 6 in infertile male and female ( 34.69 ± 187 ) Comparing with fertile male and female ( 37.28 ± 2.26 ) without statistical difference .mean while the of positive infertile male in the test of CRP ( 35.45 % ) higher than the level of positive fertile male in the test of CRP ( 0.91 % ) and the level of positive infertile female in the test CRP ( 59.09 % ) is higher than the level of positive fertile female in the test CRP ( 4.55 % ) with statistical difference ( p<0.01 )..

اجريت هذه الدراسة في محافظة ديالى للفترة من 20 / تشرين الثاني / 2011 م ولغاية 10 / تشرين الثاني / 2012 م في مختبر الصحة العام في بعقوبة ، كان الهدف من الدراسة هو تحديد دور هرمون اللبتين وبعض العوامل المناعية والتي هي IL – 6 و CRP في العقم لدى الرجال والنساء ، بينت هذه الدراسةان مستوى هرمون اللبتيـــن لدى الرجـال العقيـمين والنســــــــــاء العقيـمـات ( 18,22 ± 1,26) اعلى من مستواه لدى الرجال الخصبين والنساء الخصبــات ( 2,53 ± 0,04 ) بفرق احصائي ذو دلالة معنوية ( p<0,05 ) ، فيما لوحظ في هذه الدراسة ايضا ان هناك انخفاضا في مستوى IL – 6 لدى الرجــال العقيمين والنسـاء العقيمـــات ( 34,69 ± 1,87 ) مقارنة بالرجال الخصبين والنساء الخصبات ( 37,28 ± 2,26 ) بفرق احصائي ذو دلالة غير معنوية ، فيما كانت نسبة الرجال العقيمين الايجابين في فحص CRP ( 35,45 % ) اعلى من نسبة الرجال الخصبين الايجابين في فحــص CRP ( 0,91 % ) ، وان نسبة النساء العقيمات الايجابيات في فحص CRP ( 59,09 %) اعلى من نسبة النساء الخصبات الايجابيـات في فحص CRP ( 4,55 % ) بفرق احصائي ذو دلالة معنوية (p<0,01 ).


Article
Determination of Toxoplasmosis Disease Activity by Estimation of IL-6 Cytokine
تحديد نشاط داء المقوسات الكوندية بواسطه تقدير مستوى الانترلوكين 6

Authors: Lina K. Al-Zohairy لينا قاسم الزهيري --- Ban N. AL-Qadhi بان نوري القاضي
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 2C Pages: 1600-1611
Publisher: Baghdad University جامعة بغداد

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Abstract

Toxoplasma gondii (Nicolle and Manceaux ) infects all warm-blooded animals, including humans. Early diagnosis and determining the infective stage are critical for treating immunosuppressed individuals and pregnant women with toxoplasmosis. This parasite modulates pro- and anti-inflammatory responses to regulate parasite multiplication and host survival. The aim of this study was to investigate the probability of using IL-6 as a marker of toxoplasmosis disease activity (acute and chronic) in different groups of women (miscarriage, pregnant and single) and estimate the relationship between infection and gestational age and history of abortion in miscarriage and pregnant women. The most abortion were occurred at the first trimester in chronic infected miscarriage women also, the most abortion were occurred at the first trimester in acute infected pregnant women. The result showed that acute infected miscarriage women with previously abortion scored high significant percentage of infection in comparison to non- abortifacient, chronic infected one and pregnant women. IL-6 was significantly higher in acute infected miscarriage women in comparison to single and pregnant acute one but chronic infected pregnant women characterized by the lowest level of this cytokine in comparison to all studied groups.

طفيلي Toxoplasmaتصيب كل الحيوانات ذوات الدم الحار من ضمنها الانسان. التشخيص المبكر وتحديد الطور المعدي يكون ذو اهميه بالغه في علاج افراد الاشخاص ذوي المناعه المنخفضه والحوامل المصابات بداء المقوسات الكوندية. هذا الطفيلي يتوسط الاستجابه البادئه والمضادة للالتهابات لتنظيم تكاثر الطفيلي وبقاء المضيف. الهدف من هذه الدراسه هو للكشف من امكانيه استخدام انترلوكين 6 كدلاله لنشاط داء المقوسات الكونديه ( الحاد والمزمن ) في مجاميع مختلفه من النساء ( مجهضات ، حوامل وغير متزوجات) وتقدير العلاقة بين الاصابه ومدة الحمل و تاريخ الاجهاض في النساء المجهضات والحوامل. اغلب الاجهاضات حصلت في الاشهر الاولى من الحمل في النساء المجهضات ذوات الاصابه المزمنه ، كذلك اغلب الاجهاضات حصلت في الاشهر الاولى من الحمل في النساء الحوامل ذوات الاصابه الحادة. اظهرت النتائج انه النساء المجهضات ذوات الاصابه الحادة والمجهضة سابقا سجلت اعلى نسبه اصابه للمرض مقارنة بالنساء المجهضات ذوات الاصابه المزمنه غير المجهضات سابقا والنساء الحوامل. وبينت النتائج ان مستوى انترلوكين 6 كان عاليا معنويا في النساء المجهضات ذوات الاصابه الحادة مقارنة مع الغير متزوجات والحوامل ذوات الاصابه الحادة لكن النساء الحوامل ذوات الاصابه المزمنه تميزت بمستوى اقل من هذه ا مقارنة مع كل المجاميع المدروسه.

Keywords

toxoplasmosis --- IL-6 --- miscarriage --- pregnant.


Article
SERUM LEVELS OF INTERLEUKIN-1 ALPHA AND INTERLEUKIN-6 IN ACUTE CORONARY SYNDROME PATIENTS

Authors: Kismat M Turki قسمة محمد تركي --- Mohammed O Hamzah محمد عمران حمزة
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 3 Pages: 281-284
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

BackgroundCytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of acute coronary syndrome patients (ACS).ObjectiveThis study aims to investigate the serum levels of IL-1α and IL-6 in ACS patients.MethodsThe study covered 140 subjects. It comprised a total of 101 patients with ACS patients [62 with acute myocardial infarction (AMI) and 39 with unstable angina (UA)], compared with 39 healthy individuals with no history of cardiac disease. Serum IL-1α and IL-6 analysis was performed by ELISA.ResultsThe present results revealed that there were significant elevation in mean serum levels of IL-1α and IL-6 in patients with ACS ( AMI and UA) as compared to healthy control (P<0.001). Moreover, the levels of these cytokines were significantly higher in AMI patients when compared to UA patients (P<0.001).ConclusionThese finding suggest that IL-1α and IL-6 play an important role in pathogenesis of ACS.KeywordsAcute coronary syndrome, IL-1α and IL-6.


Article
The Impact of Resistin and IL-6 On Type I Diabetes Mellitus (T1DM) and Its Duration in Children

Authors: Mahjob AL-Nedawy --- Ban A. Majaad --- Hadef D. El-Yassin --- Manal k. Resheed AL-Ani
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 181-188
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Type I diabetes mellitus is characterized autoimmune destruction of β- cells . IL-6 is a cytokine (one of a class of immune system regulators ) it plays a role, in acute phase inflammatory response to cellular injury.Human Resistin gene is expressed in pancreatic islets , pre- adipocytes and bone marrow and is of relevance for inflammation processes.OBJECTIVE:To investigate serum concentration of resistin and pro inflammatory IL-6 in T1DMchildren and to study the impact of the duration of disease on these parameter. In order to shed some light on the mechanism of initiation and propagation of β-cell damage in those patients.SUBJECTS AND METHODS:Sixty diabetes children ( 33 males and 27 females), aged (1.3-13) years (mean± SD) (5.6±2.8) years , consecutively admitted to the AL-Mansour Teaching Hospital for children , were enrolled in this study. All had T1DM . Duration of disease varied from ( 0.13- 84) months . Age matching group of thirty healthy volunteer children , (18 females ,12 males) was included as a control without any family history of diabetes. Resistin and IL-6 were measured ( by enzyme linked immunosorbant assay , ELISA) .RESULTS :Fasting serum Resistin levels were lower in patients compared to controls although the correlation was not significant .However serum resistin levels were higher in females compared to males in both groups ( patients and controls) with a significant correlation between the groups of the same gender .Duration of the disease had no impact on either gender.On the other hand IL-6 showed a significantly higher serum level in patients than control.Un like Resistin , the duration of disease had a great impact on IL-6 serum levels as shown in text.CONCLUSION : Resistin levels in patients with (T I DM) non significantly lower than in control individuals , that’s meaning T I DM), as disease did effect the levels of serum Resistin sub clinically by the treatment with insulin leading to hyper insulinemia .Resistin antagonizes insulin action, leading to decrease in patients more than controls . Resistin levels tended to have higher in females than male ,however this trend did not reach statistical significant in total population due to sex hormone . The highly significant positive correlation between the levels of IL-6 and duration is due to persistente production and elevation for long time of patients with T1DM indicating of ongoing β- cell destruction .But Resistin was non dependent on the duration of the disease because human resistin gene is expressed in pancreatic islets cell.


Article
The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 536-541
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Insulin is a hormone produced by the beta cells of the pancreas. Insulin is necessary for the uptake of glucose into all cells in the body other than the Brain. C reactive protein (CRP) is a main inflammatory factor that is produced by the liver during acute infection or inflammation and its concentration in plasma can increase as much as 1000-fold during injury and infection. Interleukin-6 (IL-6), a major regulatory proinflammatory cytokine, is produced by a variety of cells, including leukocytes, adipocytes, and endothelial cells, and acts on the liver to stimulate the production of a number of acute-phase proteins.OBJECTIVE:The present study was designed to examine the relationship between fasting plasma IL-6 and CRP concentrations and insulin action in acute myocardial infarction patients.SUBJECTS AND METHODS:The study included 50 patients with acute Myocardial infarction (AMI) and forty healthy subjects as control group. Levels of insulin, CRP and IL-6 were measured.RESULTS:The levels of insulin, IL-6 and CRP were significantly elevated in AMI patients with (p<0.001). There was positive correlation between insulin with CRP and IL-6 in acute myocardial infarction patients.CONCLUSION:The significant increase in insulin in AMI may be related to inflammation. Insulin positively correlated with inflammatory markers (CRP and IL-6)


Article
Evaluation of serum anti-Cardiolipin antibody, hs-CRP and IL-6 levels in chronic periodontitis as possible risk factors for cardiovascular diseases

Author: Batool H. Al-Ghurabei بتول الغرابي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 161-165
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: It has long been established that there is an association between cardiovascular disease andperiodontitis. Evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents viainduced systemic inflammatory mediators’ production and increase in serum levels of autoantibodies such as anticardiolipinantibody. The aim of the present study was to determine the presence of anti-cardiolipin antibody(ACLA)-IgG and -IgM, and to investigate the systemic levels of inflammatory markers of cardiovascular diseases likehigh sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with chronic periodontitisin (CP) as wellas to examine the relationships between these mediators and clinical periodontal parameters.Subjects and Methods: Blood samples were collected from 45 patients with CP (20 with sever periodontitis and 25with moderate periodontitis) and from 30 healthy age matched individuals served as controls. Clinical periodontalparameters used in this study were plaque index, gingival index, probing pocket depth, clinical attachment leveland bleeding on probing. The levels of serum ACLA-IgG, ACLA-IgM, hs-CRP and IL-6 were determined using enzymelinkedimmunosorbent assays.Results: The current results revealed that serum levels of ACLA-IgG, hs-CRP and IL-6 were significantly higher inpatients group as compared to healthy control group (p<0.05, p<0.001), whereas the serum level ACLA-IgM was notobserved any significant differences between two groups (p>0.05). Concerning the comparison between twopatient groups, sever CP group showed significant elevation in serum levels of ACLA-IgG, hs-CRP and IL-6 (p<0.05,p<0.001), while there is no differences in serum level of ACLA-IgM when compared to moderate CP patients group(p>0.05). Furthermore, in regards to the correlation between serum ACLA-IgG, ACLA-IgM, hs-CRP and IL-6, andclinical periodontal parameters, IL-6 level was showed significant positive correlation with clinical attachment level,whereas hs-CRP was showed significant positive correlation with each of probing pocket depth, clinical attachmentlevel and bleeding on probing. Moreover; linear positive correlation was noticed between ACLA-IgG and clinicalattachment level. Conversely, ACLA-IgM level did not show any correlation with clinical parameters of periodontitis(p>0.05).Conclusion: Elevation in prothrombotic autoantibodies, ACLA-IgG and inflammatory mediators (hs-CRP and IL-6)factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk forcardiovascular events


Article
Expression of Serum Cytokines (IL-6 & IL-8) and Oxidative Stress Marker (MDA) in Patients with Knee Osteoarthritis

Authors: Munaf S. Daoud --- Israa A.Abdul Kareem --- Mohammed I. Hamzah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 187-194
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Osteoarthritis is a degenerative joint disease, occurring primarily in older persons. Although many factors initiate this disease, progress to overt OA needs many biological substances like IL-6 and IL-8 that reduce cartilage repair ability or like reactive species that induce cartilage destruction through direct degradation of matrix components. OBJECTIVE: To shed the light on the expression of serum IL-6 and IL-8 levels, and production of serum malondialdehyde level (marker of oxidative stress), then estimation of the correlation among serum IL-6, IL-8 and MDA levels in patients with knee osteoarthritis.PATIENTS AND METHODS: This study was conducted in AL-Kadhemiya Teaching Hospital during the period from April 2011 to December 2011. The study included two groups: knee osteoarthritis( KOA) group of patients and the control group. Each group was further sub-divided into: obese & non-obese according to their BMIs. Sixty osteoarthritic patients aged 40-70 years were chosen depending on medical history, clinical examination, and radiographic observations. 10 ml of blood needed for assessment of the above makers. Thirty healthy control (age and sex-matched) were enrolled in this study. RESULTS: Mean serum IL-6 and IL-8 levels were significantly higher in KOA patients compared to control group for both (P<0.001), with the highest levels seen in the obese KOA group. Mean serum MDA level was significantly higher in patients with KOA compared with that in control (P<0.001). Significant negative correlation was observed between serum IL-6 and IL-8 levels. CONCLUSION: IL-6, IL-8 & MDA have important role in the pathogenesis of KOA. Receptors of IL-6 and IL-8 on chondrocytes could be considered as target for future therapy of any arthritic inflammation and also to consider MDA reduction in patients with knee osteoarthritis, as part of treatment of osteoarthritis.

Keywords

KEYWORDS: IL-6 --- IL-8 --- MDA

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