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Article
HISTOLOGICAL AND STRUCTURAL STUDY OF PROLAPSED INTERVERTEBRAL DISC

Authors: Khalida K Jbara --- Thamer A Hamdan
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2006 Volume: 12 Issue: 1 Pages: 2
Publisher: Basrah University جامعة البصرة

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Abstract

The research of the etiology of low back pain and right leg pain has been focused on the study of histological degenerative changes of human intervertebral disc prolapse. In patients with low back pain & right leg pain and disc prolapsed according to magnetic resonance imaging (MRI), histological and histochemical studies have demonstrated several histological degenerative changes in the structure of the prolapsed intervertebral disc. Surgically excised intervertebral disc from 105 patients with lumber disc prolapsed were studied by histomorphology aided with histochemistry this include patients with prolapsed disc due to several causes. 5 control intervertebral discs were studied for comparison. Our result indicated that their was a degenerative structural changes of the intervertebral disc prolapse. Chondrocytes cloning, invasion of blood vessels into the disc matrix, disorganisation and disorientation of collagen fibers, matrix depletion and many other changes were observed.

Keywords

HISTOLOGICAL --- PROLAPSED --- INTERVERTEBRAL --- DISC


Article
A study of 22 Cases of Dorsal Inter-Vertebral Disc Prolapse treated by Thoracic Laminectomy

Author: Ali K. AL-Shalchy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 414-415
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: dorsal spine intervertebral disc prolapse (IVDP) not a very common entity compared with cervical & lumbar region usually treated surgically.
Patients & method: 22 patients studied in the specialized surgical hospital neurosurgical department from Jan 2002 till Jan. 2006. the study included age, gender, cases. clinical features, diagnoses & surgical management.
Results: 22 patients were studied 76% of the patients are at the age of 30-60 with slight male predominance, all diagnosed by MRI & or CT scan, all managed surgically by laminectomy the results are compared with other studies.
Conclusion: posterior thoracic laminectomy at the dorsal region is a safe, simple procedure with good results if done early & meticolous.


Article
Y Risk Factors of Recurrent Lumbar Disk Herniation

Author: Isam Ali Alsudany
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 1168 -1172
Publisher: Babylon University جامعة بابل

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Abstract

Recurrent intervertebral disc prolapsed (RDP) is a major cause of poor result after lumbar discectomy surgery. The aim of current study is to assess risk factors of recurrent disc prolapse in Iraqian population in Hilla teaching hospital from 2002-2013. The study reviewed 40 patients with recurrent disc prolapsed and 100 patients without recurrence retrospectively. To evaluate possible risk factors for herniation recurrence A clinically significant recurrent herniation was defined as a disc herniation causing lower limb pain (sciatica) and (MRI) evidence of disc material at the same level of the previous surgery. Other 100 patients without recurrence were used just for compares to identify possible risk factors for recurrent RDP. There was important variation between groups with and without RDP in sex, smoking, height, weight and occupational characteristic. By putting these differences in logistic regression analysis, it showed that gender (male), height, heavy workers and heavy smoker could expected in lumbar disc prolapsed recurrence(RDP). Taking into consideration sex, heavy smoking and heavy workers as predictors of recurrent RPD, surgeons should advice their patients to limit hard work and put away smoking especially in tall and male ones to prevent RDP recurrence.


Article
PENETRATION OF CEFOTAXIME INTO INTERVERTEBRAL DISCS REMOVED FROM PATIENTS UNDERGOING DISCECTOMY

Authors: Thamer A Hamdan --- Mohammed S Hashim --- Nazar S Haddad --- Abdullah M Jawad
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2019 Volume: 25 Issue: 1 Pages: 3-9
Publisher: Basrah University جامعة البصرة

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Abstract

Abstract The intervertebral disc is an avascular tissue, and penetration of antibiotics occurs by passive diffusion. Cefotaxime penetration has not been well studied. The aim is to investigate the penetration of cefotaxime into the intervertebral disc removed from patients undergoing discectomy. Twenty-six patients undergoing discectomy were recruited for this study. They were given one gram of cefotaxime intravenously as a prophylactic antibiotic. Cefotaxime was extracted from nucleus pulposus and serum and analyzed using an HPLC method with cefuroxime axetil as internal standard. Cefotaxime penetrated into all the 26 samples of nucleus pulposus resulting in a mean concentration of 0.66±0.13 µg/gm. The mean serum concentration at time of disc removal was 13.61±3.54 µg/ml. The concentration in 16 samples were below the minimum inhibitory concentration against Staph. aureus with an average of 0.27±0.03 µg/g. There is a statistically significant correlation between time after intravenous cefotaxime administration and its concentration in the nucleus pulposus. The greater increase is in the third hour after administration. Factors like age, body weight, gender, number of associated diseases and surgical history did not seem to affect nucleus pulposus cefotaxime concentration. In conclusion, cefotaxime can penetrate into the nucleus pulposus but its concentration is relatively low. This concentration has a strong positive correlation with time after cefotaxime intravenous administration. Cefotaxime, therefore, needs to be given at least two hours before disc removal, with re-dosing immediately before operation to maintain high serum concentration. Keywords: Surgery, cefotaxime concentration, intervertebral disc, nucleus pulposus, discectomy


Article
The impact of height, weight and body mass Index on the occurrence of herniated intervertebral lumbar disc.
تأثير الوزن والطول ومؤشر كتلة الجسم على حدوث انزلاق غضروفي قطني الفقرية

Author: Jawad Alashaw
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2011 Volume: 1 Issue: 171 Pages: 133-137
Publisher: Tikrit University جامعة تكريت

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Abstract

To assess the impact of body height, weight and/or body mass index (BMI), in the occurrence of lumber disc herniation. A Prospective, case control study. Sixty two patients as a study group 39% are women with the age below 50 yrs (mean of the age 36.161  8.46) with a controlled group 74 persons below 50 yrs, 42% females (mean of the age 35.635  8.431).The studied groups were subjected to measurement of height and weight to derive body mass index (BMI). Supine straight leg raising (SLR) test is performed with the patients. The taller patients are found to be more liable to have lumber disc herniation.
Conclusion: I suppose those patients with high height and weight (more BMI) are more prone to develop lumber disc herniation

لتقييم تأثير ارتفاع الجسم، الوزن و / أو مؤشر كتلة الجسم (BMI)، في حدوث فتق القرص الخشب. والاستشراف، ودراسة مراقبة حالة. اثنان وستون المرضى كمجموعة الدراسة 39٪ من النساء مع سن أقل من 50 عاما (متوسط ​​عمر 08:46 36  161) مع مجموعة التحكم من 74 شخصا أقل من 50 عاما، إناث 42٪ (متوسط ​​عمر 8431  635 35). و وتعرض المجموعات المدروسة لقياس الطول والوزن لاشتقاق ومؤشر كتلة الجسم (BMI). مستلق رفع الساق المستقيمة (SLR) يتم إجراء اختبار مع المرضى. تم العثور على أطول المرضى على أن تكون أكثر عرضة لديهم الخشب فتق القرص.والخلاصة: أنا افترض أولئك المرضى الذين يعانون من ارتفاع عال والوزن (مؤشر كتلة الجسم أكثر) هي أكثر عرضة لتطوير الخشب فتق القرص

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