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Article
INTRAUTERINE INSEMINATION TREATMENT IN SUB FERTILITY: ANALYSIS OF FACTORS AFFECTING OUTCOME
التلقيح الاصطناعي كعلاج لنقص الخصوبة: تحليل العوامل التي تؤثر على النتائج

Authors: BARAA L. MOHAMMED برا محمد --- MAIDA Y. SHAMDEEN مائده شمدين
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2010 Volume: 4 Issue: 1 Pages: 16-27
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background Intra uterine insemination is an assisted reproductive technique using husbandor donor sperm, at the time of ovulation in natural or stimulated cycle put in the uterine cavityor in the cervical canal.Objective To identify factors that can predict successful outcome in intrauterineinsemination.Methods a prospective study, 193 cycles of intrauterine insemination were analyzed toidentify prognostic factors regarding treatment outcome. The variables selected for analysiswere: female age, infertility duration and etiology, types of infertility, sperm parameters afterpreparation (count and progressive motility), number of preovulatory follicles, thickness ofendometrium and type of ovarian stimulation. The data were analyzed with chi square test.Results The overall pregnancy rate was 7.8%; the miscarriage rate was 60%, and no ectopicpregnancy or multiple pregnancies were encountered. Five significant variables wereidentified for successful outcome: endometrial thickness (P=0.001), number of treatmentcycles (P=0.002), number of preovulatory follicles (P=0.038), progressive motility of spermafter preparation (P=0.05), and female age (P=0.05).Conclusion intrauterine insemination should be considered prior to more invasive andexpensive other assisted reproductive techniques as in vitro fertilization and gamete intraFallopian transfer. Careful couple's selection is a crucial factor in enhancing conception withthis method.

الخمفبة: الخمل صٍ الاصظىبع ه اضدى ظرق خلى بٍح الخصوتج تبسخعهبل السبئل الهىو هو الزور او هو هخترغ, تعد اسراء تعض الهعبهلاح عم هٍ وضلو السبئل داخل الرضن او عىق الرضن ف فخرث الاتبطج.الهدف: ا سٍبد العواهل الهسبعدث لاىسبش الىخبئز ف ضبلاح الخمل صٍ الاصظىبع داخل الرضن.الطرق: دراسج هسخلتم جٍ ل 391 دورث خملتص داخم ,ض دٍ خن خضم مٍهب لا سٍبد الظرق الافطل لخضس وٍ الىخبئز. العواهل الخ اخذح تىعر العختبر كبىح: عهر الزوسج, هدث وستة العلن, ىوغ العلن, وهواصفبح السبئل الهىو تعد الخضط رٍ,Chi-( عدد التو طٍبح الىبطسج, ذخو تظبىج الرضن وىوغ الادو جٍ الهىشظج الهسخعهمج. خن خضم لٍ الىخبئز تبسخخدان .)square test النتبئح: كبو هعدل ضدود الضهل 7.77 %, ىستج الاسهبض عىد الضواهل كبو 06 % , لن خضدد ضبلج ضهل خبرر (P= الرضن ولا ضبلج ضهل هخعدد. لوضع وسود خهسج هوذراح هف دٍث عمي الىخبئز وكبىح: ذخو تظبىج الرضن ( 0.001 ىشبظ الض بٍهو تعد ,(P= عدد التو طٍبح الىبطسج كتل الخمل صٍ ( 0.038 ,(P= ,عدد الدوراح الخ خن الخمل صٍ فتهب ( 0.002 .(P= واخ رٍا عهر الزوسج ( 0.05 (P= عهم جٍ الخىش ظٍ ( 0.05 الاستنتبج: الاسخعبىج تبلخمل صٍ الاصظىبع ف ضبلاح العلن كتل المسوء الي العهم بٍح الاخرى لخلى بٍح الخصوتج هذل عهم جٍ اظفبل الاىبت ةٍ. وىستج الىسبش خعخهد عمي الاخخ بٍر الاهذل لمزوس وٍ.

Keywords

IUI --- Infertility --- ART


Article
Comparison Between Two Methods of Ovulation Induction: Clomiphene Alone and Clomiphene +Tamoxifen in PCOS Patients

Author: Ali Hassan Mohammed علي حسن محمود
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2012 Volume: 2 Issue: 1 Pages: 101-105
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Infertility affects about 10-15% of reproductive-age couples. About half the causes of infertility are female related and approximately 40% of the cases are caused by anovulation, mostly in PCO women.Objective: This study was conducted to determine and compare the effects of two drug treatment regimens: higher dose of clomiphene and a combination of lower dose of clomiphene and tamoxifen in treating infertile women with PCO. Materials and Methods: The study was a randomized clinical trial conducted on 100 infertile patients who referred to Albatool Infertility Clinic between the years (Jan. 2009-Dec.2009). The patients were selected who had received at least 3 periods of clomiphene, but no pregnancy had occurred. They were randomly divided into two groups. In the first group, clomiphene was increased to 100 mg and the second group 20 mg of tamoxifen was added to 50 mg of clomiphene from day 5-9 of menstruation cycle. Infertility duration, duration of medicine used, endometrial thickness, ovulation, and pregnancy rate were studied in both groups. Results: Ovulation rate in clomiphene group was 54.9%; Tamoxifen + clomiphene group was 73.5% without significant differences in both groups. (PV = 0.053). Positive pregnancy rate in clomiphene group was 39.2%; clomiphene + tamoxifen group was 61.2% (P value < 0.05).Conclusion: pregnancy rate was higher in clomiphene/tamoxifen group than in the clomiphene group. The presence of a dominant follicle in the two treatment groups in women between 18-24 was not significant, but in women between 25-39 years was significant (PV= 0.049). The recommendation is to add Tamoxifen to Clomiphene in 35-39 women with 20≤ BMI ≤26.99 before the use of gonadotropins treatment in PCOS with or without IUI(intra uterine insemination), because these options have higher risk of multiple pregnancy and ovarian hyperstimulation syndrome.


Article
Relationship between antiMüllerian ovarian hormone, activin-A, and follistatin hormones levels with pregnancy rate following intrauterine insemination

Authors: Nidhal Salim Alwan --- Saad S. Al-Dujaily سعد صالح الدجيلي
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2013 Volume: 3 Issue: 6 Pages: 6-10
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Recently the reproductive hormones, Anti-Mullerian hormone (AMH), activin A, and follistatin (FS) have been found to play an important role in folliculogenesis, oocyte maturation and corpus luteum function by changing the pattern of granulosa cell expression which in turn affects the success of fertilization potential.Objectives:To examine the relation of in vivo concentrations of AMH, activin A, and FS hormones on the ovaries status in the phases of menstrual cycle and to elucidate the relationship of these hormones with pregnancy rate following intrauterine insemination(IUI).Materials and methods:Seventy seven infertile couples were recruited from infertility clinic population at the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies through the period from September 2011 to May 2012. Those infertile couples were divided to 3 groups according to the infertility cause (male factors causes, anovulatory causes and unexplained causes of infertility). Measurements of AMH, activin A, and FS hormones levels were done at cycle day (CD25-). Then measurements of activin A, and FS hormones levels were done only at preovulatory cycle(CD1214-) when the size of the Graffianfolliclerangebetween1824-mm and at least one follicle was present and before hCG injection and at day 28 of the cycle(CD28) . IUI was performed 3640- hours after hCG injection then measurement of the three hormones was performed after successful IUI. The result of successful pregnancy was recorded and statistical relation with AMH, activin A and FS hormones was assessed.Results:There was a positive significantcorrelationbetweenendometrialthickness(ET)andpregnancyrate and the best ET to predict pregnancy is more than 7mm. There was no significantrelation(P>0.05) between AMH level and pregnancy rate. A significantcorrelationwasfoundbetweenfollistatin levels in preovulatory (CD 1214-) with a cutoff value 0.20ng/ml to predict pregnancy. There was a significantrelationbetweenactivin-Alevelandpregnancyratewithapredictivecutoff value 397.5 ng/ml on (CD 28) only.Conclusions:Activin-A can be regarded as a biomarker candidate for diagnosing very early pregnancy at luteal phase following IUI. Follistatin preovulatory (average CD13) has the most predictive value for pregnancy following IUI.


Article
Correlation between intra uterine insemination outcome and Kruger strict criteria using two staining methods to detect the sperm morphology of infertile men
العلاقة بين نتائج التلقيح الاصطناعي والمعايير المحددة لطريقة كروكر باستخدام نوعين من الصبغات لتحديد شكلياء النطف في الرجال العقيمين

Author: saad s. aldujaily سعد صالح الدجيلي
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2011 Volume: 1 Issue: 1 Pages: 12-20
Publisher: Al-Nahrain University جامعة النهرين

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BackgroundSince 1999 , the World Health Organization (WHO) recommended the assessment of sperm morphology by Kruger strict criteria(KSC), The manual of WHO contains the cut off values of sperm morphology measured by KSC for normal subject and patients treated by in vitro fertilization (IVF) and intra- I cytoplasmic sperm injection(ICSI) without any information regarding intrauterine insemination( IUI). ObjectivesThe objective of this study is to achieve two major goals that are :1-Assessment of sperm morphology by applying KSC , using two different biological stains, named commercially Testsimplets {TS)pre-stained slides and Sperm-O-Scan (SOS)stain 2-To have a cut off value for morphologically normal sperm that resulting into a successful IUI outcome.Materials and Methods;Fifty five unselected couples attending the Institute of Embryo Researches and Infertility Treatment were included in this prospective study from December 2007 til) August 2008 ,The mean age of male partner was 31,7±1-87years with an average duration of 6<25±1.65years of infertility. The women were prepared for IUI. All the males were subjected to semen analysis with in vitro sperm I activation using layering swim-up technique. Assessments of the morphologically normal sperm(MNS) of the samples were performed by using both, High power field and KSC by using TS and SOS stains before and after the activation. Correlation of the positive IUI results and MNS by KSC waw recorded denoting the cut off value for successful results.ResultsThe mean of morphologically normal sperm applying KSC with the use of SOS Stain before in vitro sperm activation was 16.10% and after activation was 37.85% and by using TS stain before in vitro sperm activation was 15.14% and after activation was 37.09% No significant (P>0.05) differences was detected between the results of MNS of the two stains. The result of IUI was 11 positive pregnancies out of the 55 cases. The mean of MNS using KSC for these positive cases was 11.58% and 12.84% for SOS and TS stains, respectively.ConclusionsThe cut off value of MNS by applying KSC and using two different I biological stains for a successful IUI program was 11.58% by SOS stain and 12.84% by TS pre-stained slides. Although the study found no statistical differences between the two stains, TS found to be easier, I simpler and less time consuming technically than SOS stain.


Article
Measurement of serum Inhibin B as a predictive evaluation of ovarian response following ovulation induction program in intrauterin insemination
قياس هورمون الانهيبين (ب) في مصل الدم كمقياس تقييمي لتخمين استجابة المبايض في برامج تحفيز الاباضة المستخدمة في التقنيات المساعدة على الانجاب

Authors: ليلى خضر غالب --- نوال خيري
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 34-39
Publisher: Al-Nahrain University جامعة النهرين

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Background:The evaluation of ovarian reserve has been, and still, the focus of substantial clinical research. The assessment of ovarian reserve is valuable for determining stimulation protocols, and because of limited predictive value of age alone, or other passive hormonal analysis in estimating response to the exogenous stimulation, Dynamic research was done on serum inhibin B.Objective:Measurement of serum inhibin B as a predictive evaluation of early ovarian response following ovulation induction program in intrauterine insemination(IUI).Materials and Methods:Thirty couples were involved in IUI program. They divided into two groups: group (1) 15 women were treated by Gonadotropin(Gn) recombinant follicle -stimulating hormone (rFSH). While group (2), 15 women were treated by Clomiphene citrate (CC). Treatment started at day 3 of the menstrual cycle. Serial hormonal profile tests namely; inhibin B, Estadiol (E2), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH) were done at days 3, 7 of the menstrual cycle and the day of human chorionic gonadotropin hormone (hCG) injection with recurrent ultrasonograghy (U/S) to confirm the number and development of the follicles.Results:There was a significant difference in the level of inhibin B (P< 0.05) between day3 and 7 of the cycle with the mean of the follicle number 1.67± 0.18 in group(1), while in group (2) there was a non significant difference (P>0.05) in the level of inhibin B between day 3 and 7 of the cycle with the mean of the follicle number 2.14 ±0.17. Percentage of pregnancy rate in IUI in this study was 19.23Z.Percentage of pregnancy rate in group (1) was 25% .while in group (2) was 14.28% ,but there is a significant difference (P<0.05) in the pregnancy rate between the two groups.Conclusion:It was concluded that serum irihibin B obtained at day 7(day 5 of (Gn) therapy) offers an early and accurate prediction of ovarian response to (Gn) stimulation while there was no significant change in the level of inhibin B between day 3 and 7 of the cycle in patients treated by CC .


Article
Studying the risk factors for ectopic pregnancy among spontaneous and assisted conception
دراسة عن عوامل الخطورة للحمل خارج الرحم الناتج عن الحمل الطبيعي والحمل المساعد

Authors: فاخر سلمان العاني --- هدى مالك محمد
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2013 Volume: 3 Issue: 5 Pages: 38-43
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

ackground:An ectopic pregnancy, or eccyesis, is a complication of pregnancy in which the pregnancy implants outside the uterine cavity. Theoretically, differences between conception via ART and natural conception may affect the risk of ectopic pregnancy. Data on the risk factors for developing ectopic pregnancy after IVF are still inconsistent. There is controversy whether ART increase or decrease the ectopic pregnancy.Objectives:To describe the occurrence or risk factors of ectopic pregnancy following IUI, IVF and spontaneous pregnancyPutlcnts and Methods:The recorded cases of ectopic pregnancy in the period between January 2010 to January 2011 in four teaching hospitals and two private hospitals were surveyed. New cases in the period between July 2011 to July 2012 in two teaching hospitals were also included in this study. The data was collected from medical records and interview.Results:A total of 86676 pregnancies were recorded during the period of the study with, the number of ectopic pregnancy out of total pregnancies in Baghdad was 408 during the period of this study. It was found that the type of conception was significantly associated with infertility (P < 0.001), ovulation induction (P<0.001), dilatation and curettage (P = 0.016), and history of contraception (P =0.002).Conclusion:Although several risk factors for ectopic pregnancy are known, the causes of increasing incidence of ectopic pregnancy remain unknown. The risk factors of ectopic pregnancy following IUI, IVF and spontaneous pregnancy included history of infertility, medication used for ovulation induction, history of contraception, and dilatation curettage as these factors are tightly linked with the types of conception. Increasing knowledge of risk factors for ectopic pregnancy may improve understanding of the causes of infertility.


Article
Correlation between in vitro sperm preparation techniques, endometrial thickness, hormonal profile and successful pregnancy rate following IUI: retrospective and prospective study
العلاقة بين تقنيات تنشيط النطف ,عدد الجريبات وحجمها, سمك بطانة الرحم , قياس الهرمونات وبرنامج تحفيز المبايض المستخدم في عملية التنمية داخل الرحم مع معدلات الحمل :دراسة استرجاعية ومستقبلية

Authors: مي عبد الكريم ابو رغيف --- saad s.aldujaily سعد صالح الدجيلي
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2012 Volume: 2 Issue: 4 Pages: 9-14
Publisher: Al-Nahrain University جامعة النهرين

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Background:The intra uterine insemination (IUI) still an easy, simple and effective method to overcome the infertility that resulted from different causes. Although the equipments and methods of assisted reproductive technologies (ART) were highly developed, the percentage of successful IUI live-birth not exceed 20- 30%.Objective;The present study was aimed to elucidated the cut off values of in vitro sperm preparation technique, follicular number and size, endometrial thickness and hormonal profile that lead to successful pregnancy rate (PR)following IUI.Materials and Methods:In retrospective study, one hundred cases of infertile couples were in who were became pregnant following IUI at the Institute of Infertility Diagnosis and Assisted Reproductive Technologies, through the period from January 2007 to January 2010. Depending on the results of retrospective study, IUI was achieved for 100 infertile patients between August 2010and June 2011. The mean of significant prognostic variables were measured in both studies namely: age, type of infertility, type of sperm activation techniques, the protocol of ovulation induction medicine, the mean of hormonal status of Luteinizing Hormone (LH), Estradiol(E2), and number with diameter of follicles, endometrial thickness a cycle day before hCG injectionResults:The protocol of ovulation induction in IUI cycles by using clomiphene citrate(CC) and recombinant gonadotropin (rFSH) was significantly(p<0.05) improve the IUI results compared to CC alone or CC with Pergonal®. The mean values obtained by ultrasonography namely; two follicles, and dominant follicle of 19.5mm in size with endometrium thickness of >9.5mm were gave significantly successful IUI outcome compared to other values. In prospective study similar results were obtained .therefore the overall pregnancy rate was 37% per cycle. Conclusion:The calculated data of successful IUI outcomefrom retrospective study gave a best pregnancy rate in prospective study which was 37%.Consequently, these results can be considered as guideline for physician who interest in assisted reproduction to have a success in IUI.


Article
The Benefit of Semen Cryostorage on Certain Sperm Function Parameters Following in Vitro Activation

Author: Khalid S. Al –Azzawi خالد سهيل العزاوي
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 4 Issue: 1 Pages: 15-19
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Under different circumstances, adequate production of the semen specimen followed by preparation for intrauterine insemination (IUI) is of utmost importance at many centers. Cryostorage for 24 - 48 hours, could solve the problem of semen to the performance of IUI. It is also advantageous if the male partner has difficulty in producing a semen sample or not available at the time of IUI and reducing psychological pressure on the day of his partner's aiming for repeating insemination after 24 hr.Aim: The objective of this study was to investigate the beneficial effect of semen cryostored at 5 degrees centigrade (5°C) for 24 hr by modifying Tris Solution (MTS) mixed with 30% egg yolk (EY) on maintaining the functional and fecundity sperm parameters of patient`s semen. Materials & Methods: Thirty eight infertile patient`s semen samples (who was visiting the High Institute of Infertility Diagnosis & Assisted Reproductive Technology (ART) for three weeks) were involved in this study. Semen analysis was done for all samples as recommended by (WHO Laboratory Manual for the examination of human semen and sperm–cervical mucus interaction 1999). The patient`s semen samples were divided into two groups; both groups were activated in vitro with FertiCultTM medium using the simple layer method (SLM) for 30 min; a second group treated with (MTS) mixed with 30% (EY) and cryostorage for 24 hr after activation.Results: The results showed a highly significant (P<0.001) improved of all the certain sperm function parameters of group 2 (cryostorage group) compared with group 1. It showed also improvement of all parameters of infertile men semen. There was a highly significant (P<0.001) increase in the percentage of grade A and grade B active sperm motility in group 2 compared with group 1.Conclusions: It is concluded that the use of (MTS) with 30% (EY) maintains adequate sperm viability and fecundity after 24 hr of cryostorage, and it was extremely recommended for patients requiring intrauterine insemination (IUI) in different circumstances.

الخلفية العلمية: في مختلف الظروف يكون حجم عينة السائل المنوي الماخوذة من المرضى كافية لغرض اجراء عملية التلقيح الاصطناعي هو العامل الاهم في جميع مراكز التلقيح الاصطناعي. خزن السائل المنوي بالتبريد لمدة 24-48 ساعة ممكن ان يساعد ويحسن من عملية التلقيح الاصطناعي ايضا له فائدة بالنسبة للازواج الذين يواجهون صعوبات في اعطاء عينة السائل المنوي او يكونون غير متواجدين وقت اجراء عملية التلقيح الاصطناعي كما انه يخفف من الضغظ النفسي للازواج الذين يحاولون اعادة عملية التلقيح الاصطناعي بعد مرور 24 ساعة على العملية الاولى.الهدف: تهدف هذه الدراسة الى التعرف على التاثير النافع والمفيد لوسط ترس المحور المضاف له مح البيض بنسبة (30%) على معالم النطف الوظيفية بعد خزن السائل المنوي قبل التنشيط وبعد اجراء عملية التنشيط عليه باستخدام المحلول اعلاه بدرجة حرارة 5°C لمدة 24 ساعة ومقارنة هذا التاثير المفيد لهذا المحلول على السائل المنوي قبل التنشيط وبعد التنشيط.المواد وطرق العمل: تم دراسة ثمانية وثلاثون من عينات المرضى الذين يعانون من حالة العقم. تم اجراء تحليل للسائل المنوي استنادا الى منظمة الصحة العالمية .(WHO 1999) تم معاملة عينات المرضى قبل التنشيط وبعد التنشيط بوسط ترس المحور المضاف له مح البيض بنسبة (30%) وتم خزن العينات بدرجة حرارة 5°C لمدة 24 ساعة بالتبريد. النتائج: اظهرت النتائج فرق معنوي (P<0.001) عالي في تحسن معالم النطف الوظيفية في عينات السائل المنوي قبل التنشيط وبعد التنشيط بعد خزنها باستخدام محلول الترس المضاف له مح البيض في التبريد لمدة 24 ساعة كما اظهرت النتائج ايضا وجود فرق معنوي عالي(P<0.001) عند مقارنة النتائج باستخدام وسط ترس مع مح البيض ونتائج التنشيط باستخدام وسط FertiCultTM . الاستنتاج: يستنتج من هذه الدراسة ان محلول الترس المضاف له مح البيض بنسبة (30%) اظهر تحس واضح في معالم النطف الوظيفية بعد خزن السائل المنوي بالتبريد لمدة 24 ساعة لذلك توصي هذه الدراسة باستخدام عينات السائل المنوي المحضرة بهذه الطريقة في عمليات التلقيح الاصطناعي.


Article
Fertilizing oocyte married women by ICSI by the sperm of the husband and legitimacy in Iraq
تخصيب بويضات المراة المتزوجة بواسطة الحقن المجهري عن طريق الحيوانات المنوية للزوج ومشروعيتها في العراق

Authors: Sarah Saad Abdullah سارة سعد عبدالله --- Ali Hassan Al-Hussainy علي حسن الحسيني --- Abass Fadhel Jawad عباس فاضل الدليمي
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2016 Volume: 12 Issue: 3 - part 1 Pages: 106-117
Publisher: Diyala University جامعة ديالى

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Abstract

The study included (40) pairs of which are suffering from the problem of not having children for various reasons, where the samples were diagnosed and conduct all tests have been identified ICSI for their condition process, where the process they underwent at the Higher Institute for infertility diagnosis and techniques of assisted reproduction / Al-Nahren University in Iraq was the number of oocyte withdrawn (306) and the number of oocyte was excluded (109). the number of oocyte fattened with the sperms of the husband (197) and the number of oocyte fertilized oocyte (158) and the number of oocyte non-fertilized (39), the results showed the study, said knowledge of uranium useful oocyte in predicting the quality of fertilization and in the classification of the embryos to the steps easy to choose embryos most efficient and transferred to the womb of the mother , the average of the infertile in the operation of ICSI in Iraq is 80% , which is a very similar average in the European institutions to treat infertility , but still variance occurred in the number of pregnant woman, The recommended idea regarding the legality of ICSI is the allowance (acceptance) but it is conditional and according to the question asked .

شملت الدراسة 40 زوجا من اللذين يعانون من مشكلة عدم الانجاب ولاسباب شتى ، حيث تم تشخيص العينات واجراء كافة التحاليل وتم تحديد عملية الحقن المجهري لحالاتهم ، حيث اجريت العملية عليهم في المعهد العالي لتشخيص العقم والتقنيات المساعدة على الانجاب/جامعة النهرين في العراق فكان عدد البويضات المسحوبة (306) بويضة وكان عدد البويضات المستبعدة (109) بويضة وكان عدد البويضات للزوجة المحقونة بحيامن الزوج (197) بويضة وان عدد البويضات المخصبة (158) بويضة وعدد البويضات الغير مخصبة (39) بويضة ، اظهرت نتائج الدراسة ان معرفة تخصيب البويضات مفيدة في التنبؤ بجودة الاخصاب وفي تصنيف الاجنة الى درجات يسهل من عملية اختيار الاجنة الاكثر كفاءة ونقلها الى رحم الام ، فكانت نسبة معدل الاخصاب البالغة (80 %) هي نسبة مقاربة جداً للمعدلات في المراكز الاوربية لعلاج العقم والتقنيات المساعدة على الانجاب، ولكن النسبة انخفضت عن نسبة معدل مثيلاتها في المراكز الاوربية لحالات الحمل كونة يعتمد على كل حالة بشكل منفصل عن الاخرى، والرأي الراجح في مشروعية عمليات الحقن المجهري في الشريعة الاسلامية هو الجواز بشروط وضعها الفقهاء وعلى وفق السؤال الموجه اليهم .

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