research centers


Search results: Found 4

Listing 1 - 4 of 4
Sort by

Article
Some Parameters of Inflammation & Oxidative Stress in Relation to the Risk of Type 2 Diabetes Mellitus

Author: Abdul Kareem H. Issa
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2010 Volume: 9 Issue: 1 Pages: 25-30
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Background Many clinical trials have indicated that lifestyle modification can delay or prevent the progression to type 2 diabetes in people with impaired glucose tolerance test (IGT). Detection of IGT requires a test which is inconvenient to screen for this condition in clinical practice or in the general population. Therefore, there is a need to search for additional significant risk factors for type 2 diabetes. Patients &methods Seventy two adults ≥ 40 years old (36 males and 36 females) were evaluated in this study. They were subjects who performed a brief 75-grams oral glucose tolerance test and were classified as having normal glucose tolerance (NGT group; 24 subjects), impaired glucose tolerance (IGT group; 24 subjects), or diabetes mellitus (DM group; 24 patients).In addition to hematocrit (PCV) and erythrocyte sedimentation rate (ESR), serum level of highly sensitive C-reactive protein (hsCRP) was measured. Also the serum levels of thiobarbituric acid-reactive substances (TBARS), iron, copper and ferric reducing ability of plasma (FRAP) were estimated in addition to erythrocyte glutathione (Ery-GSH) level. Results Both IGT group and DM group have a significantly high hsCRP mean level (2.59 ± 1.03 and 2.89 ± 0.90 respectively vs. 1.57 ± 1.40 mg /L in NGT group, P< 0.001), and a significantly decreased FRAP level (939.2 ± 157.4 and 961.5 ± 125.1 respectively vs. 1063 ± 104.5 µmole/L in NGT group, p< 0.01 ) as well as a significantly high TBARS and a significantly low Ery-GSH level in comparison with NGT group. The positive correlation between hsCRP and TBARS, although was statistically not significant, showed a step-wise increment from NGT, to IGT and to DM group (r = 0.01, 0.14 and 0.23 respectively). Conclusions IGT is associated with a state of low-grade inflammation and oxidative stress. Serum levels of hsCRP as a marker of inflammation and TBARS as a marker of oxidative stress may serve for identifying people at high risk for developing type 2 diabetes. Such people will be important targets for programs that are designed to prevent diabetes.


Article
The role of glucose tolerance test in Diwaniya population in relation to(who) criteria

Author: Fadhl Alzamili فاضل الزاملي
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2012 Volume: 8 Issue: 13 Pages: 95-101
Publisher: Al-Qadisiyah University جامعة القادسية

Loading...
Loading...
Abstract

Recent researches into diabetes and impaired glucose metabolism has created a new array terminologyAnd definitions relating to glucose metabolism in clinical practice.To study the role Glucose Tolerance Test (OGTT) in diagnosis of different hyperglycemic classess.in diwaniya.Four hundred patients were studied for the existance of diabetic state using the Oral Glucose Tolerance Test.Only (37.5%) patients had frank diabetic state after 2h OGTT. (50%) patients ranging between Impaired Fasting Glucose ( IFG), and Impaired Glucose Tolerance Test. (12.5%), patients had no diabetes.Overlap between results makes these readings not applicable for all population,therfore using 2H OGTT..is warranted.

تشير البحوث الحديثة حول مرض السكري واعاقة ايض الكلوكوز الى وجود اتجاهات جديدة في تعريف المرض من الناحية السريرية.يهدف البحث لدراسة دور اختبار التحمل للكلوكوز(OGTT) في تشخيص الاصناف المختلفة لارتفاع السكر في الدم في مدينة الديوانية .تمت درست 400 حالة مرضية للكشف عن وجود حالة السكري باستخدام اختبار التحمل للكلوكوز .كانت نتائج الدراسة انه 37.5% من المصابين كانوا ايجابيين للاختبار بعد ساعتين و 50% منهم كانت نتائجهم بين اختبار اعاقة الكلوكوز للصائم(IFG) و اختبار التحمل للكلوكوز (OGTT) فيما كان 12.5% سالبين للاختبار .وقد استنتج ان هناك تداخل بين نتائج الاختبار لكل المصابين وعليه ان استخدام اختبار التحمل للسكر بعد ساعتين هو الافضل للقياس.


Article
THE FREQUENCY OF 2 HOURS POST GLUCOSE LOAD HYPERGLYCEMIA IN SUBJECTS WITH NORMAL FASTING GLUCOSE
فرط سكر الدم بعد ساعتين من اختبار تحمل السكر عند الاشخاص الذين لديهم مستوى السكر بعد الصيام ضمن الحد الطبيعي

Authors: ANNE K. AL-UBAIDY عاني العبيدي --- DHIA J. Al-TIMIMI ضياء التميمي
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2007 Volume: 1 Issue: 1 Pages: 105-111
Publisher: University of Dohuk جامعة دهوك

Loading...
Loading...
Abstract

Background The prevalence of impaired glucose tolerance (IGT) and previously undiagnosed diabetes mellitus(PU-DM) in variety of ethnic group has been well documented. Limited information, however, is available about the presence in Iraqi population. Objective The aim of this study is to investigate the prevalence of the glucose intolerance and undiagnosed diabetes among healthy adult population. Materials and methods A total of 918 members of the general population of Baghdad city were studied. They presented different age groups (ranging from 20 to 60 years).All subjects were in good health, and had normal fasting serum glucose levels (<6.1 mmol/L).For assessment of hyperglycemia, all subjects underwent an oral glucose tolerance test. Results Among 918 subjects (401 males and 517 females), 19.0% males and 16.8% females had IGT. The prevalence of PU-DM was 1.2% for males and 5.6% for females. The prevalence increased with age in both genders. IGT and PU-DM were more commonly seen in obese subjects than in normal weight subjects (IGT: 24.5% vs 11.9%) and (PU-DM: 6.3% vs 1.9%). Conclusions This report on the IGT and PU-DM from Baghdad population showed a high prevalence of these disorders.

و اختلال تحمل الغلوكوز (PU-DM) خلفية الموضوع: بينت الوثائق الى انتشار الداء السكري الغير المشخصفي مختلف المجاميع الاثنية. بالنسبة للعراق، يبدو أن المعلومات في هذه الظاهرة محدودة. (IGT) الهدف: التحري عن انتشار السكري الغير المشخص و أختلال تحمل الغلوكوز عند العراقيين البالغين.المواد و الطرق: تم تقييم حالة السكر عند 918 شخصًا بعد اجراء فحص تحمل السكر. جميع الاشخاص بصحة جيدة 60 سنة. – و كان مستوى السكر عندهم بعد الصيام ضمن المستوى الطبيعي و تراوحت أعمارهم بين 20النتائج: أظهرت النتائج أن 19 % من الذكور و 16.8 % من الاناث يعانون من أختلال تحمل الغلوكوز. كذلك وجود %1.2 من الذكور و 5.6 % من الاناث يعانون من السكري الغير المشخص. أن زيادة انتشار هذه الظاهرة يتناسب مع تقدم العمر و بدانة الجسم.الاستنتاج: تؤكد النتائج المستخلصة من هذا البحث انتشار ظاهرة الداء السكري الغير المشخص و أختلال تحملالغلوكوز عند سكان مدينة بغداد.


Article
Glucose Tolerance Test in Beta-Thalassemia Major in Al-Sader City

Authors: Qais Abdullah Ali Al-Salahe --- Mohammed Shaker Al-Awady --- Abas Abdalsaheb Al-Gharbawy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 4 Pages: 550-559
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:β-thalassemia are inherited defects in the synthesis of B-globin portion of hemoglobin. The combination of transfusion and chelating therapy has dramatically extended the life expectancy of thalassemic patients.OBJECTIVE: This study is to determine the prevalence of diabetes mellitus and association of some factors with impaired glucose tolerance test in transfusion dependent β- thalassemia major.PATIENTS AND METHODS: A case-control study done on patients attending blood disease center in Ibn-Al-Balady hospital from 1st of July to 31st of October 2011. Data collected from 287 thalassemic patients (being attended the hospital for regular follow up and blood transfusion) and their relatives which included age, sex, height, weight, history of splenectomy, family history of DM, hepatitis B or C infection, serum ferritin level and an oral glucose tolerance test.RESULTS: It was found that 9.7% of β- thalassemic patients had impaired glucose tolerance test and 1.1% were diagnosed with diabetes, 32.7% were splenectomized, 38.3% had viral hepatitis infection, mean serum ferritin in those older than 20 years was 5923±1033µg/l and 16.8% had family history of diabetes. CONCLUSION: Increased serum ferritin concentration, splenectomy and viral hepatitis infection are associated with abnormal glucose tolerance in patients with blood transfused b-thalassemia. Aggressive iron-chelating therapy and prevention and treatment of viral hepatitis infection were warranted.

Listing 1 - 4 of 4
Sort by
Narrow your search

Resource type

article (4)


Language

English (4)


Year
From To Submit

2014 (1)

2012 (1)

2010 (1)

2007 (1)