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Article
Effect of Metronidazole drug in the Levels of some Pregnancy Hormones during Blastocyst Implantation in Rat Uterus
تاثير عقار الميترونيدازول في مستويات في بعض هرمونات الحمل خلال غرس الكيسة الاريمية في رحم الجرذ

Authors: Kadhim M. Haddao --- Akram Y. Yasear --- Hussain A. Abdullatif
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2014 Volume: 12 Issue: 3 Pages: 9-15
Publisher: Kerbala University جامعة كربلاء

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This study aimed to determine the effect of metronidazole (MTZ) drug on the levels of progesterone and estrogen hormones during blastocyst implantation in the pregnant rat uterus during the implantation period. Understanding the roles of the variety of pregnancy hormones in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals. Forty eight female rats of confirmed pregnancy have been used ,divided into two treated groups received oral dosage commercial drug, 9 mg / 200 gm of life body weight as treatment dose of drug, 18 mg as double the treatment dose and 27 mg as the triple treatment dose. The results of this study revealed that taking treatment dose and double dose of the drug for 7 dpc group of pregnant rats cause decrease the level value of estrogen hormone in blood serum but this decrease didn’t reach significant level p>0.05. It was significant p<0.05 at the triple dose, and it is significant p<0.05 inversely for 9 dpc period, It means that the estrogen hormone level was decreased when the drug dose was increased were there were significant decrease p<0.05 in the value of progesterone level of blood serum at treatment dose, double and triple dose of the drg. There was significant affect p<0.05 for the mean of progesterone level in blood serum of the treated animal.

هدفت الدراسة الحالية إلى تبيان اثر عقار الميترونيدازول التجاري على معدلات قيم مستويات هرموني البروجيستيرون والاستروجين خلال غرس الأجنة في رحم الجرذ في اليومين السابع والتاسع من الحمل، حيث ان تقبل الرحم لانغراس الكيسة الاريمية في هذين اليومين يعتمد على هذين الهرمونين وفهم ادوارهما وغيرهما في تقبل الرحم لانغراس الكيسة الاريمية ضروري إلى تَحسين صحة الحوامل والخصوبة في البشر والحيوانات الأليفة. تم استخدام 48 جرذاً أنثى جرعت فمويا 9 ملغم من العقار / 200 غم من وزن الحيوان الحي و 18 ملغم و 27 ملغم يوميا ولمدة سبعة أيام وتسعة أيام ومن اليوم الأول من تأكيد الحمل. اجريت الدراسة في 2012 بوحدة ابحاث الرزازة وغربي الفرات - جامعة كربلاء. أظهرت النتائج الاحصائية أن تجريع عقار الميترونيدازول بجرعة علاجية وضعفها أدى إلى انخفاض في مستوى هرمون الاستروجين في مصل دم الجرذان الحوامل الا انه لم يصل إلى مستوى المعنوية p>0.05 في حين أن تجريعها بثلاثة أضعاف الجرعة قد أدى إلى انخفاض معنوي p<0.05 في مستوى الهرمون. وعلاقة الارتباط r غير معنوية p>0.05 عكسية لفترة 7 أيام ومعنوية p<0.05 عكسية لفترة 9 أيام. وهذا يعني ان مستوى الاستروجين قد انخفض عند زيادة جرعة الميترونيدازول الى ثلاثة اضعاف الجرعة العلاجية . وان تجريع العقار بجرعة علاجية وضعفها وثلاثة اضعافها قد أدى إلى انخفاض معنويp<0.05 في قيمة مستوى هرمون البروجيستيرون بمصل الدم وان علاقة الارتباط معنوية p<0.05 عكسية


Article
Characteristics of p-n Junction Silicon Carbide LED

Author: S.I. Valskina
Journal: Iraqi Journal of Applied Physics المجلة العراقية للفيزياء التطبيقية ISSN: 18132065 23091673 Year: 2006 Volume: 2 Issue: 1-2 Pages: 17-21
Publisher: iraqi society for alternative and renewable energy sources and techniques الجمعية العراقية لمصادر وتقنيات الطاقة البديلة والمستجدة

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Abstract

Silicon carbide has been widely used as material for manufacturing yellow, red, green LED and optoelecronics devices (indicators, screens). The silicon carbide LED technology has been investigated for improvement of their operational characteristics. This includes the influences of the surface processing (etching, annealing), the formation method for the p-n junctions and the contacts on the LED properties. Light-emitting devices used as light sources for optical-fiber communication lines. LED fabricated by Al+ ion-implanted in 6H-SiC and investigated their characteristics for an effective green LED. The brightness of the ion-implanted p-n junction was found to be two orders higher than that of diffusion p-n junction, and the best value was 2000-10000 cd/m2 with passing current about 0.5mA through area 50x50μm and applied voltage about 2.6±0.2V. The ion-implanted structures showed a high stability of light in the temperature range of 77-600K.


Article
women age and embryo implantation following intracytoplasmic sperminjection and embryo transfer in infertile patients

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Article
THE IMPACT OF NURSING INTERVENTION ON THE PHYSICAL AND PSYCHOLOGICAL STATUS IN PATIENTS UNDERGOING PACEMAKER IMPLANTATION: AN INTERVENTIONAL STUDY

Authors: Hakemia Shaker Hasian --- Khalida A.M.AL-Gersha --- Amar .T.Al Hamdi
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2009 Volume: 22 Issue: 4 Pages: 55-66
Publisher: Foundation of technical education هيئة التعليم التقني

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Abstract

Objective : to evaluate the effectiveness of nursing intervention on the physical and psychological status of patients undergoing pacemaker implantation.Methodology:The population of the study consisted of (59) patients admitted to Al- Kadumia teaching hospital from 15 th of April 2004 to 15 th of March 2005.The sample is divided into the study group (30) patients who received pre-post operative special nursing care by the investigator and the other control group (29) patients received a routine care from the hospital .Results: The results show that there is statistically highly significant difference between the study and the control groups in sitting and standing from a chair for two minutes two weeks post pacing.The results also revealed that there is a marked improvement in the psychological status of study group as compared to control group.Recommendation: The investigator recommends, that patients undergone pacemaker implantation must be involved in pre and post implantation teaching program to improve physical and psychological status.

الهدف: تقويم اثر التداخل التمريضي للمرضى المغروز لهم ناظم القلب الاصطناعي على الحالة الجسمية والنفسيةالمنهجية: تكون مجتمع البحث من (59) مريضا من مرضى ناظم القلب الاصطناعي من مستشفى الكاظمية التعليمي للفترة من الخامس عشر من شهر نبسان 2004إلىالخامس عشر من شهر ايار2005 قسمت عينة البحث إلى مجموعة الدراسة وتضمنت ( 30) مريضا خضع أفرادها للعناية التمريضية المقدمة لهم من قبل الباحثة وتم إعطائهم التعليمات قبل وبعد العملية والمجموعة الأخرى ,المجموعة الضابطة وتضمنت (29) مريضا خضع أفرادها للعناية التمريضية الروتينية المقدمة لهم من قبل المستشفى النتائج :أشارت نتائج الدراسة الى وجود علاقة ذات دلالة إحصائية عالية بين مجموعة الدراسة والمجموعة الضابطة في الجلوس والوقوف من الكرسي لمدة دقيقتين بعد أسبوعين من عملية الغرز وأشارت نتائج الدراسة الى تحسن واضح في الحالة النفسية لمجموعة الدراسة مقارنة بالمجموعة الضابطة. التوصيات :وبناء على هذه النتائج يوصى الباحث بان المرضى الذين يخضعون لعملية غرز ناظم القلب الاصطناعي يجب إن يزجوا في برنامج تعليمي قبل وبعد غرز الناظم لتحسين حالاتهم النفسية والبد نية


Article
Histological Study on the Effect of Metronidazole (Flagyl®) on the Distribution of Collagen Fibers in the Uterus of the Pregnant
Rattusnorvegicus Raton Days 7 and 9 of Pregnancy (* )دراسة نسجية لأثر عقار(Flagyl®) Metronidazole على توزيع الياف الكولاجين في رحم اناث الجرذ النرويجي Rattusnorvegicus في الايام السابع والتاسع من الحمل(*)

Authors: Kadhem M. Haddao --- Akram Y. Yasear --- Hussain A. Abdullatif
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2012 Volume: 1 Issue: المؤتمر العلمي الاول للتربية للعلوم الصرفة Pages: 25-36
Publisher: Kerbala University جامعة كربلاء

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To determine the effect of Metronidazole (Flagyl®) on distribution of collagen fibers in the pregnant rat uterus during the implantation period on days 7 and 9 day post coitum (dpc), sixty-four female rats of confirmed pregnancy have been used ,divided into two treated groups (48 rats) received oral dosage commercial Metronidazole (Flagyl®( and one control group (16 rats) received distilled water via the same route. Histological technique was applied for sections taken from implantation sites at days 7 and 9 dpc. The sections were stained in Hematoxylin and Eosin and Gomori's one step-trichrome stains. The results indicates that blastocysts were able to implant successfully and have initiated the implantation reaction and decidualization in the uteri of all rats used. As a normal reaction on day 7 dpc collagen fibers was found to be virtually absent in the decidual tissue of primary decidual zone (PDZ) and secondary decidual zone (SDZ) in contrast to undifferentiated zone (UDZ) in which the fibers was widely distributed. On day 9 dpc collagen fibers were abundant in the mesometrialdecidual zone (MDZ). Collagen fibers were an important support to the blood vessels in this area which represents a prime route for establishment of nutrient supply through maternal blood vessels supplying the chorioallantoic placenta of rat. The results have revealed that oral intake of Metronidazole did not interfere with the normal process of implantation of rat blastocyst.

لمعرفة تأثير عقار الميترونيدازول (فلاجيل®) Metronidazole (Flagyl®) التجاري على انتشار الكولاجين في رحم الجرذ الحامل خلال فترة الغرس فى اليوم السابع والتاسع من بدء الحمل استعمل 64 أنثى جرذ تأكد حملهن في مجموعتين الاولى علاجية ضمت (48) جرذ تم تقسيمها إلى مجموعتين 24 لكل واحدة تم تجريعها العقار فمويا والثانية مجموعة سيطرة (16) جرذ انثى تم تجريعها ماء مقطر بنفس الطريقة. تم تطبيق التقنية النسيجية على مقاطع الرحم من أماكن الغرس في اليومين السابع والتاسع من الحمل ، حيث صبغت العينات بـصبغة هيماتوكسيلينوايوسين وصبغة كوموري Gomori’s one step trichrome stains. اظهرت نتائج البحثتمكن الأكياس الأُريميةBlastocystsمن الانغراس وتكوين النسيج الساقط Decidualizationفى أرحام كل الجرذان. وكنتيجة طبيعية في اليوم السابع من الحمل day 7 dpc)) فان ألياف الكولاجين لم تكن موجودة فى كل من مناطق الغشاء الساقط الأولى Primary Decidual Zone (PDZ)والثانويSecondary Decidual Zone (SDZ) بينما كانت واسعة الانتشار في المنطقة غير المتميزة Undifferentiated Zone (UDZ. في اليوم التاسع day 9 dpc)) كثر تواجد الألياف الكولاجينية في منطقة الغشاء الساقط المسراق- رحميةMesometrialDecidual Zone (MDZ). الألياف الكولاجينية كانت داعماً مهماً للأوعية الدموية في هذه المساحة التي تغذى اللقانقيالمشيمى لسخد الجرذ the chorioallantoic placenta. بينت هذه الدراسة أن تجريع عقار الميترونيدازولFlagyl® (Metronidazole) لم يتعارض مع العملية الطبيعية لغرس الكيسة الأريميةBlastocyst في الجرذان.


Article
Does dexamethasone interfere with process of blastocyst implantation in the pregnant rat uterus?
هل يتعارض الدكساميثازون مع عملية انغراس الكيس الارومي في رحم الجرذان الحوامل؟

Authors: Alaa Hussein AL-Safy1 --- Akram Yousif Yasear
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2018 Volume: 16 Issue: 1 Pages: 271-278
Publisher: Kerbala University جامعة كربلاء

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Abstract

Results has been revealed that the blastocysts from both the control and treated groups were successfully implanted. The decidual tissue as one of the indicators of success of implantation was formed .Implantation of blastocysts started in the antimesometrial side of uterus at day 7 of pregnancy , then the position of the embryos were shifted to mesometrial side of the uterus. Conclusion of this study have shown that dexamethasone is safe during implantation period, but probable side effects might occur during subsequent stages of pregnancy

أظهرت النتائج ان الاكياس الارومية تمكنت من الانغراس بنجاح وتم تكوين النسيج الساقطي في ارحام الجرذان من كلا مجموعتي السيطرة والعلاج. اعطت نتائج اليوم السابع من الحمل لمجموعتي السيطرة والمعالجة نفس النتائج من خلال حصول الانغراس وتكوين النسيج الساقطي في بطانة الرحم اولا في المنطقة المضادة للمساريق الرحمي والذي يعتبر مؤشر لنجاح الانغراس. اما اليوم العاشر كانت مواقع الانغراس واضحة جدا وان الجنين في هذه المرحلة قد تحول من المنطقة المضادة للمساريق الرحمي الى منطقة المساريق الرحمي واما النسيج الساقطي فكان باعلى درجة من النمو والتطور . نستنتج من هذه الدراسة ان استعمال الديكساميثازون يعد آمنا اثناء فترة الانغراس. ولكن قد تكون له آثار سلبية والتي من المتوقع أن تحصل في فترات لاحقة من الحمل .


Article
Role of leukemia inhibitory factor(LIF) gene variation on implantation rate following IVF program in PCOS and non PCOS women

Author: Zena F. Hussein1̽ , Bushra J. Al- Musawi 2 , Ismail H. Aziz3 , Saad S. Al-Dujaily 4
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 2 Pages: 57-67
Publisher: Baghdad University جامعة بغداد

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Abstract

Implantation of the blastocysts into the maternal uterus is a crucial step in mammalian reproduction, which is controlled by a number of complex molecules like hormones, cytokines, and growth factors and their cross talk. A network of these molecules plays a crucial role in preparing receptive endometrial and blastocysts. This study aimed to found out the role of Leukemia inhibitory factor (LIF) , gene expression, concentration and genetic polymorphisms in the endometrial that may interfere with implantation process of polycystic ovary syndrome(PCOS) and non-PCOS women. A convenient blood (6ml)sample of 80 infertile women undergoing in vitro fertilization (IVF) program were intentionally divided according to the cause of infertility into 40 healthy women their husbands complaining from male infertility factors, and 40 infertile women with polycystic ovary syndrome. Leukemia inhibitory factor( LIFs) were measured on ovulatory and luteal phase of cycle (CD14-CD16,17) at the day of ovarian pickup and embryo transfer by using quantitive polymerase chain reaction(qPCR ), Elisa technique ,polymerase chain reaction(PCR) and sequencing to determine any genetics polymorphisms in LIFgene study. Results of the present study indicate that no mutation was detected in LIF gene in the healthy and PCOS women. The LIF gene expression in addition to levels of serum leukemia inhibitory factors are more valuable in predicting the pregnancy out come in infertile PCOS women than in non-PCOS women .This result can be utilized to be used as predictors of implantation window for successful implantation and pregnancy.


Article
Progesterone Therapy Administered 24 hours Before Embryo Transfer in ICSI Cycle Improves Embryo Implantation and Pregnancy in Women With Luteal Phase Defect.

Authors: Saeeda A. AL-Anssari --- Mundhir T. Ridhaa --- Zuher Kanan --- Ahmed K. Allow --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 101-106
Publisher: Baghdad University جامعة بغداد

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Background: Ovulation induction by human menopausal gonadotrophin (HMG) results in temporal luteal phase defect. Luteal support therapies are required to support embryo implantation in stimulated cycle especially in luteal phase defect infertile women. Objective: The objective of the present study was to investigate the clinical significance of progesterone, aspirin and HCG on human embryo implantation in women with luteal phase defect following ICSI and embryo transfer (ET). Patients and Methods: The female patients were divided into six groups depending on the type of the luteal support protocols (LSP). Group 1 (No= 54), received 10 mg oral progesterone (P), group 2 (No= 35) received P plus HCG, group 3 (No= 59) received P plus HCG plus oral aspirin, group 4 (No= 47) received vaginal P administered 24 hours before embryo transfer plus oral aspirin, group 5 (No= 40) received vaginal P administered 12 hours after embryo transfer plus oral aspirin and group 6 (No= 46) received intramuscular P plus oral aspirin. The LSP were continued for at least 12 weeks, when the B-HCG test was positive, (tested two weeks after embryo transfer). Results: Statistical analysis of the clinical data showed no significant differences between the LSP in regard to patient's age, body mass index (B/M2), basal FSH/LH ratio and estradiol concentration at the day of HCG injection. The ICSI rate, percentages of embryos developed in vitro, and the numbers of the transferable quality embryos were similar in all groups (P>0.05). The pregnancy rate was significantly higher (P < 0.05), in group 4 compared to other groups (38.66% versus 24.51%(G 1), 22.53% (G 2), 28.66% (G 3), 25% (G 5), 21.60% (G 6). The percentages of viable fetal sac development per patient were 31.49 (17/54), in G 1, 42.86 (15/35), in G 2, 49.16 (29/59), in G 3, 59.58 (28/47), in G 4, 32.50 (13/40), in G 5, and 34.79 (16/46), G 6. The percent of viable gestation sac was significantly higher in group 4 compared to other groups (P < 0.05). Conclusions: The administration of 400 mg /day vaginal progesterone 24 hours before ET and 100 mg/day aspirin five days after ET results in significant improvements in pregnancy and embryo implantation rates and development of viable fetuses in luteal phase defect infertile women undergoing ICSI-ET.


Article
Embryo Implantation In Intracytoplasmic Sperm Injection-Stimulated Cycle Using Testicular And Epididymal And Ejaculated Sperm From Azoospermic, And Severely- Teratospermic Men.

Authors: Zuhair, A. Kanan, --- Saeeda, A. M. AI-Anssari, --- Mundhir T.Ridha-Barzanchi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 3 Pages: 313-318
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The infertility affects about 20% to 28% of Iraqi population and the primary and secondary infertility cover 80% and 20% of infertility cases respectively. It has been shown that the major male infertility factors include oligospermia, astheno-spermia, teratospermia and azoospermia.Objectives: The objective of this study was to compare the fertilizing capacity, in vitro embryonic developmental rate and embryo implantation following the use of epididymal, testicular, and ejaculated sperm in azoospermic and severely teratospermic men. Patients and Methods: The males in experiment one were divided into three groups, severely terato-spermic group (STSG, n=44), azoospermic-epididymal group (ASEG, n=35) and azoospermic-testicular group (ASTG, n=40). In experiment two the azoospermic patients were divided into two groups, obstructive (OASG, n=35) and non-obstructive (NASG, n=42). Both groups were underwent testicular extraction and intracytoplasmic sperm injection (TESE-ICSI) treatments.
Results: Concentration of FSH, LH, prolactin was significantly higher in non-obstructive group compared to obstructive group (P<0.001). The concentrations of testosterone and the volume of the testes were significantly higher in the obstructive group versus non-obstructive group (P <0.01). Percentages of the fertilizable oocytes and the number of the transferred embryos per patient in the ASTG group were significantly lower compared to STSG and ASEG groups. The pregnancy and implantation rates were not significantly different in the STSG, ASSEG, and ASTG groups. ICSI rate and embryo developmental rate and the number of the transferred embryos per patient were significantly lower in the non-obstructive group (NASG) compared to the obstructive group (OASG) Pregnancy and viable fetus percentages were similar between both groups (P>0.05).
Conclusions: Sources of sperm retrieval found to have no effect on embryo implantation and pregnancy rates when viable sperm are available for ICSI. Pregnancy and viable gestation sac percentages were not affected by the etiology of azoospermia in either obstructive, or non-obstructive with focal areas of spermatogenesis were present in testes of azoospermic men.


Article
the clinical significance of luteal therapy in the stimulate cycle following the transfer of superovulated embryos

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