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4-Hydroxy-2-Nonenal, Indused Nitric Oxide Synthase Statues in Hypertension Patients

Authors: Ali D. Hammed --- Alaa H. Jawad --- Perry H. Saifullah
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2017 Volume: 20 Issue: 3 Pages: 6-11
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The oxidative stress is one of the main cause for cardiovascular diseases (like Hypertension) also one of the results of these diseases. This study involved 56 subjects matched ages and sex divided into two groups; 28 hypertensive subject and 28 healthy subject as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin. The results show that there is a significant increase in (4HNE) between patients group and control group. INOS was significantly higher in patients compared to controls while there were no significant difference found in albumin between patient and control group. The increase in 4HNE which is a product of lipid peroxidation is attributed to destruction in body cell caused by due to the increase in stress events. And the increase in iNOS because iNOS produces large amounts of NO as a defense mechanism in response to cytokines and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth. It has been concluded that is important nappy on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. There is a positive relationship between oxidation results from hypertension and their developments. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases


Article
8.4-Hydroxy-2-nonenal, Induced Nitric Oxide Synthase Status in Hypertension with Kidney Disease Patients

Authors: Ali D. Hammed علي ظافر حميد --- Alaa H. Jawad علاء حسين جواد --- Noor M. Ali نور مصطفى علي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 2 Pages: 146-152
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:The oxidative stress is one of the main reasons for cardiovascular diseases and also one of results of these diseases, its development (like kidney disease).Objective:To identify the effect of oxidative stress nitric oxide and reactive oxygen species on cardiovascular diseases.Methods:The study involved 56 subjects comparable in age and sex divided into two groups; 28 hypertensives subjects with kidney disease and 28 apparently healthy subjects as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin.Results:There was a significant increase in (4HNE) between patients' group and control group. iNOS was significantly higher in patients as compared to controls while there were no significant differences found in albumin between patient and control group. There is a positive relationship between oxidation results from hypertension and their developments. There is a positive correlation between BMI and disease.Conclusion:Based on this study is important on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. In addition, the effect of oxidative stress, which leads to high blood pressure and thus chronic kidney disease.Keywords;Chronic kidney disease, hypertension, 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS), albumin, creatinine, reactive oxygen speciesCitation:Hammed AD, Jawad AH, Ali NM. 4-Hydroxy-2-nonenal, induced nitric oxide synthase status in hypertension with kidney disease patients. Iraqi JMS. 2019; 17(2): 146-152. doi: 10.22578/IJMS.17.2.8

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