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Article
Correlation between vitamin D receptor gene polymorphisms and levels of some hormones in Iraqi infertile women with polycystic ovary syndrome

Author: Sanaa Jasim Kadhim , Ismail A. Abdul-hassan
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 4 Pages: 104-113
Publisher: Baghdad University جامعة بغداد

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Abstract

The polycystic ovary syndrome (PCOS) is a disorder that characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features. As defined by the diagnostic criteria of the National Institutes of Health (i.e., hyperandrogenism plus ovulatory dysfunction). The purpose of this study was to investigate the correlation between VDR gene polymorphisms and level of LH, FSH, TSH and Prolactin hormones .This study was carried out in the Institute of Genetic Engineering and Biotechnology for Postgraduate Studies - University of Baghdad through the period from November 2016 - August 2017, The PCOS patients were taken from the Kamal Al-Samarraee Infertility Treatment Hospital in Baghdad.Women with PCOS (n=50) and apparently healthy control group (n=50) , were enrolled . Genotyping of VDR gene (rs2228570) (rs7975232) , as well as (rs731236) SNPS between groups were determined by using Taqman genotyping assay . Hormonal analysis for LH, FSH, TSH and Prolactin was performed by using Automated Immune Assay (AIA). the results of the present study indicate that serum LH , FSH and TSH concentrations were unaffected by the studied SNPs of VDR gene within carriers of genotypes of rs2228570 , rs7975232 and rs731236 SNPs in VDR gene, while serum prolactin levels were significantly (p<0.05) higher in PCOS patients versus controls.

Keywords

PCOS --- VDR --- Polymorphism --- Infertile.


Article
Detection of Human Cytomegalovirus (HCMV) among Infertile Male in AL-Najaf governorate

Authors: Saif Jabbar Yasir --- Kareem Thamir Mashkoor --- Ghanim Aboud Al-Mola
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2012 Volume: 2 Issue: 3 Pages: 123-128
Publisher: University of Kufa جامعة الكوفة

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Abstract

The current study aimed to detect human cytomegalovirus among infertile individual. Bloodand seminal fluid collected from 300 infertile male randomly , ELISA technique was used to know theactivity of humoral immunity among them through measuring anti-HCMV IgM and IgG antibodies ,the result revealed that 31 (11%) were positive for IgM result and 234 (78%) were positive for IgG.The PCR technique showed that out of 300 samples only 22 (7.4%) gave positive results,In case of control group, results were negative for anti- HCMV IgM antibodies in ELISA testand PCR technique. While IgG gave a weak positive results.Aim of the study:The present study was to study the relationship between the virus and infertility throughdetection of human cytomegalovirus (HCMV) infection in infertile male in AL-Najaf governorate byscreening of anti-human cytomegalovirus IgM and IgG in the serum and detection of humancytomegalovirus DNA in seminal fluid, using PCR technique.

هدفت هذه الدراسة إلى التحري عن الفيروس المضخم للخلايا البشرية بين الذكور الذين يعانون من العقم. تم جمع عينات الدم و السائل المنوي بصورة عشوائية من ثلاثمائة مريض، لمعرفة نمط العدوى فيما بينها. تم استخدام تقنية ELISA لمعرفة نشاط المناعة الخلطية للازواج من خلال قياس الاجسام المضادة للفايروس البشري المضخم للخلايا ال IgM و IgG، أظهرت أن 31 (11 %) كانت النتيجة موجبة لأضداد الـ IgM و 234 (78 % (كانت موجبة لأضداد الـ IgG . أظهرت تقنية PCR أن من أصل 300 عينة 22 فقط (% 7.4) اعطت نتيجة ايجابية.اما في حالة مجموعة السيطرة، كانت النتائج سالبة بالنسبة للاجسام المضادة للفايروس المضخم للخلايا البشري باستخدام اختبار ELISA، وتقنية, PCR. في حين اعطت الاجسام المضادة IgG نتائج موجبة ضعيفة.

Keywords

HCMV --- Infertile males --- ELISA --- PCR


Article
EVALUATION OF EPIDIDYMAL AND TESTICULAR SPERM ASPIRATION IN AZOOSPERMIC INFERTILE MALES IN BASRAH

Authors: Murtadha MS Majeed Al-Musafer --- Safaa T Al-Maatooq
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2014 Volume: 20 Issue: 2 Pages: 81-88
Publisher: Basrah University جامعة البصرة

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Abstract

This study aimed to evaluate the safety and efficacy of percutaneous epididymal and testicular sperm aspiration as a diagnostic technique to confirm sperm production and as a therapeutic technique to harvest sperms for use in the intracytoplasmic sperm injection and the indications for performing testicular biopsy in azoospermic infertile males. Thirty married patients were included in this prospective study from February 2011 to December 2012 seen in Basrah General Hospital. Their age ranged from 20 to 40 years. All patients underwent full medical examination with laboratory tests which included seminal fluid analysis, serum leutinising hormone (LH), follicular stimulating hormone (FSH), testosterone, and prolactin in addition to color Doppler ultrasonography of the scrotum. Patients with history of undescended testes, varicocele, & testicular pathology were excluded from this study. All patients showed normal physical examination with normal secondary sexual characters. The external genitalia were normal with normal sizes of their testes. The percutaneous epididymal and testicular sperm aspirations were positive in 12 out of 30 patients (40%). The rest had negative aspirations (60%). The testicular biopsy which performed in the patients with negative aspiration showed normal germinal epithelium with mature spermatozoa in only 5 patients out of 18 (28%) while the rest 13 patients had spermatogenic arrest (72%). In conclusion, percutaneous epididymal and testicular sperm aspiration has been found helpful as a diagnostic technique for patients with non-reconstructable azoospermia. It is a minimally invasive sperm retrieval technique and appears to be an effective alternative to microsurgical epididymal sperm aspiration, which is more invasive and costly. It is less invasive than testicular biopsy and preferably performed as a first step procedure in an attempt to obtain sperms for both diagnostic and therapeutic purposes.


Article
The Impact of Obesity on Some Reproductive Hormones in Infertile Men

Authors: Mahdi Abdulwahed Mahdi --- Ruwaidah Fawziy Khaleel --- Mutaz Sabah Ahmeid
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2017 Volume: 7 Issue: 1 Pages: 44-51
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Obesity, defined by the World Health Organization (WHO) as “abnormal or excessive fat accumulation that may impair health .The effects of obesity on male reproduction have been less well studied than those on female reproduction, but there is a growing body of evidence suggesting that obesity has an adverse effect on male reproduction However, a little is known about the effect of obesity on male reproductive system and infertility. Infertility is defined as inability to achieve conception within one year. It has not yet been clearly established how excess adiposity relates to the biological changes that underlie male infertility, although there are several theories worth exploring. The endocrine abnormalities associated with obesity in women are well known with an increase in androgen metabolism and changing in reproductive hormones in over weight and obese men.


Article
EFFECT OF AQUEOUS EXTRACT OF TURMERIC ON PATHOGENIC BACTERIA ISOLATED FROM SEMEN IN A SAMPLE OF IRAQI INFERTILE MEN

Author: Rehab Sh Al-Maliki رحاب شفيق المالكي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2012 Volume: 10 Issue: 2 Pages: 105-110
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Contamination of semen with sexually and none sexually transmitted bacteria plays an important role in male infertility, contaminating bacteria should be eradicated by antibiotics, but most of bacteria become resistant to available antibiotics. Therefore most researchers search to find other antibacterial agents.Objective: To evaluate the frequency of bacteria in semen of infertile men and investigate the antibacterial activity of aqueous extract of turmeric (AET) on certain isolated bacteria from semen of infertile men compared with that of doxycycline as a standard antibiotic.Methods: Forty two semen samples obtained from infertile men attending The Higher Institute of Infertility Treatment and Assisted Reproductive Technology were evaluated bacteriologically using standard bacterial culture. Then investigated the antibacterial activity of AET on certain isolated bacteria from semen of infertile men compared with doxycycline using disc diffusion method.Results: Out of 42 semen samples of infertile men, 35(83.03%) were infected with different bacterial species (spp.) accompained with highest incidence rate. The overall frequency of N.gonorrhea and S.epidermides was 8(19%) and for remaining bacterial isolated from semen (S.aureus, G.vaginalis and E.coli) were 6(14.28%). Comparable antibacterial activity of ATE and doxycycline was found to be evident against most isolated bacteria (P<0.001) in mean inhibition zones of AET between Gram’s positive and Gram’s negative bacteria (23.35±0.68 and 8.35±1.52, respectively).Conclusion: Most of isolated bacteria from semen of infertile males had high frequency, which were generally accepted as pathogenic bacteria. Antibacterial activity of AET was comparable with doxycycline against most isolated bacteria and it was found more effective on Gram’s positive than Gram’s negative bacteria.Keywords: Turmeric, pathogenic bacteria, semen, infertile men


Article
Comparison of letrozole with gonadotropins and letrozole_gonadotropin combination for ovulation induction in PCOS women after clomiphene citrate failure

Author: Bushra M. Majeed
Journal: Tikret Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية ISSN: 18172716 Year: 2013 Volume: 9 Issue: 1 Pages: 54-60
Publisher: Tikrit University جامعة تكريت

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Abstract

The aim of this study is to compare the efficacy of letrozole with gonadotropin and letrozole plus gonadotropin for ovulation induction in PCOS women after clomiphene citrate failure, Seventy eight women with PCO failed to conceive with clomiphene citrate divided in to three groups A,B,C treated with letrozole tablet, , letrozole plus follicular stimulating hormone and follicular stimulating hormone injection alone respectively for ovulation induction..Results: ovulation rate was (65.4%),(76.9%) and(76.9%) in group A,B &C respectively, pregnancy rate in study groups were (50%),(69.2%)and(65.4%) in A,B,&C respectivelyConclusion: Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and significant higher pregnancy rate was observed in letrozole co treatment with gonadotropins as compared to other two protocoles


Article
Vitamin E and C Status In The Sera and Cervical Mucus Secretion of Infertile Female With Unexplained Infertility

Authors: Naseer J.H. Al.Mukhtar --- Sahib Y.H.Al.Morshidy --- Ban J.Edan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 3 Pages: 675-691
Publisher: Babylon University جامعة بابل

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Abstract

Back ground : Infertility is one of the most important and under appreciated reproductive health problems in developing countries. The causes of infertility can be found in about 90% of cases, while about 10% of patients don’t know why they can not conceive .The causes of this case (unexplained infertility) seems to be heterogeneous, with suggested potential causes ranging from disturbances in endocrinological, immunological , genetic and reproductive physiological factors.One of the main causes of unexplained infertility is the reactive oxygen species (ROS). Therefore this study is aimed to estimate and calculate the vitamin E and C level. To carry out this aim, the vitamin E and C level had been estimated in both sera and cervical mucus secretions among healthy fertile women (control) and patients with unexplained infertility.Patients and method: The study groups were attended to Babylon Maternity and Pediatric Hospital and privet clinics. All studied patients are suffering from primary or secondary unexplained infertility types and are diagnosed by gynecologist. The study is carried out on (30) apparently healthy fertile women as a control group, their mean age (30.133±8.011years) and (60) infertile women as patient group , their mean age (29.866 ±7.195 years). Results: Vitamin C levels decrease insignificantly(p>0.05) in serum and cervical mucus secretion(9.944 ± 1.549mg/l and14.233 ±3.458mg/l) in patient group comparing with(10.383±3.655mg/l and(16.447± 4.042mg/l) in control group.Vitamin E levels decrease significantly (p<0.05) in serum and cervical mucus secretion(5.272 ± 1.228mg/l and 4.644 ± 1.343 mg/l) in patient groups comparing with (7.337±3.535 mg/l and 7.023± 0.754 mg/l) in control groups. Conclusion: The present study shows that the vitamins level plays an important role in human fertility. Vitamin E levels is significantly decreased in sera and cervical mucus secretion in patients with unexplained infertility.

يعتبر العقم من أهم المشاكل الصحية في الدول النامية.و يمكن تحديد أسباب العقم في 90% من الحالات بينما يبقى السبب في 10 % من الحالات غير معروف.وهذا العقم غير المفسر ربما تكمن أسبابه في الاضطرابات الفسلجية :هرمونية أو مناعية أو وراثية. ويبدو في الوقت الحاضر إن أنواع الأوكسجين الفعالة واحدة من الأسباب الرئيسية للعقم الغير مفسر.لذلك صممت هذه الدراسة لتحديد وقياس أنواع الأوكسجين الفعالة والتي تسمى بالجذور الحرة وكذلك قياس مضادات الأكسدة في مصل الدم و الإفرازات المخاطية لعنق الرحم لمعرفة مدى علاقتها بالعقم غير المفسر.المرضى وطرق العمل : شملت الدراسة (60) امرأة مصابة بالعقم غير المفسر متوسط أعمارهن (7.195±29.866) عاما واللاتي شخصن سرريا و مختبريا . تم فحص النساء من قبل أخصائية نسائية في مستشفى بابل للولادة والأطفال وفي العيادات الخاصة في بابل و للفترة من أيلول 2008 ولغاية أيار 2009. كما تضمنت الدراسة (30) عينة قياسية من النساء المنجبات متوسط أعمارهن(8.011±30.133) عاما ، حيث تم دراسة نسبة فيتامين أي (E) و نسبة فيتامين سي(C) في مصل الدم وفي الإفرازات المخاطية لعنق الرحم و لكلا المجموعتين. النتائج : بينت النتائج إن نسبة فيتامين إي قد انخفض انخفاض معنوي في مصل الدم و الإفرازات المخاطية لعنق الرحم 1.228 ±5.272 )و 1.343 ±4.644ملغم /لتر) للنساء العقيمات عند مقارنتهم بالنساء المنجبات(7.337 ±3.535 و 0.754 ± 7.023 ملغم /لتر. إما نسبة فيتامين سي فقد وجد انخفاض غير معنوي في مصل الدم و الإفرازات المخاطية لعنق الرحم 1.549±9.944)و 3.458 ±14.233 ملغم /لتر) للنساء العقيمات عند مقارنتهم بالنساء المنجبات(10.383±3.655 و 16.447 ± 4.042 ملغم /لتر). الاستنتاج: ان نسبة فيتامين اي له علاقة وثيقة بالعقم وان نسبته منخفضة في حالات العقم غير المفسر.


Article
Factors Affecting Pregnancy Outcome in Subfertile Couples Subjected toIntracytoplasmic Sperm Injection
بعض العوامل المؤثرة على نجاح عملية الحقن المجهري للنطف عند الازواج العقيمين

Authors: Amal M. Mubark --- AseelJassim Al- Bderi --- Basima Sh. Al-Ghazali
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2014 Volume: 4 Issue: 3 Pages: 36-40
Publisher: University of Kufa جامعة الكوفة

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Abstract

Purpose: Studying some Factors Affecting pregnancy outcome in subfertile couples subjected tointracytoplasmic sperm injection.Method: study performed in fertility center in Al-Sadder teaching hospital in Al-Najaf city during the period between October 2012 and April 2013 , the study include 140 subfertile couples that subjected to intracytoplasmic sperm injection(ICSI).Results: the results show some factors that affect pregnancy outcome like women age, cause and type of infertility .The results revealed that the age of women was significantly affect the pregnancy outcome, also the results show that sperm quality more important than sperm count .Recommendations: studying other hormones releated to fertility like leptinConclusions: Multiple factors affecting ICSI outcome, the most important one is female age The cause of infertility and its type also affect the outcome, also the results show that sperm quality more important than sperm count .

الهدف :دراسة لبعض العوامل المؤثرة على نجاح عملية الحقن المجهري للحيمن عند الازواج العقيمينالمنهجية: دراسة اجريت في مركز الخصوبة في النجف للفترة من ايلول 2012 والى نيسان2013 شملت140زوج عقيم اخضع للحقن ألمجهري للحيمن النتائج: .الدراسة بينت بعض العوامل المؤثرة على نتائج الحمل مثل عمر المرأة, سبب العقم ونوعه, نشاط ونوعية الحيامن المنوية. الدراسةاظهرت تاثيرا معنويا لعمر المريضة و تاثيرا معنويا لنوعية الحيمن و ليس لعدد الحيامن.الاستنتاجات:عدة عوامل تؤثر في نجاح عملية الحقن المجهري للحيمن .اكثرها اهمية هو عمر المراة و نوع العقم و لنوعية الحيمن و ليس لعدد الحيامن. التوصيات: نوصي بدراسة هرمونات اخرى مرتبطة بالعقم مثل اللبتين .


Article
Intrauterine insemination outcome with and without ovulation induction treatment

Author: Adeela h H. Hussein *, Inas T. Ahmed **, Abeer A. Mahmood
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2015 Volume: 11 Issue: 2 Pages: 76-81
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:: Infertility is a very common condition affecting approximately 13-14% of couples in the reproductive age. In general population; about 85% of couples have achieved conception within a year. Intrauterine insemination is one of the procedure which have a role in the treatment of infertile couple.Objectives:is to confirm that the use of ovulation induction in the course of intrauterine insemination elevates the pregnancy success rate.Method:This study had been conducted between December 2013 till December 2014 in AL-Elwiyah maternity hospital and AL-Samaraii hospital / Baghdad.On history and clinical examination; the chosen couple had the following criteria; primary infertility for more than one year, no previous IUI trials, husbands with normal seminal fluid analysis, wives in reproductive age group; with regular cycles of 24 – 35 days, body mass index (18-26)kg/m2, normal body contour, no galactorrhea nor hirsutism, normal uterine cavity and patent fallopian tubes by hysterosalpingography. Total number of cases is 76; had been divided into two groups who underwent IUI schedule, 38 cases preceded by ovulation induction and the other 38 cases had spontaneous ovulation by showing a single dominant Graffian follicle size of 18 mm measured by daily vaginal ultrasound.Results:During the study period; the total number of married women participated in the study were 76; divided into two groups. The first group contains 38 women who had the inclusion criteria of our research, underwent IUI after follow up and confirmed spontaneous ovulation, the second group included 38 women who also had the same inclusion criteria and underwent IUI after effective ovulation induction. 5 cases became pregnant while 33 cases didn’t conceive, while in the second group with ovulation induction; 12 cases became pregnant while the remaining 26 cases failed to conceive;Theoverall pregnancy rate was highest(31%) in the group treated with ovulation induction and intrauterine insemination in comparison with the other group which revealed a pregnancy rat.e of only (13%).Conclusion:For fertile couple in which no recognized cause for her infertility ;as for history;clinical examination and investigation are concerned, then combination of ovulation induction with intrauterine inseminationis an effective means for achieivingpregnancyrate by 31%compared with only 13%pregnancy rate in naturally ovulation cycle.


Article
Improved endometrial thickness and vascularity following vitamins E and C administration in infertile women undergoing controlled ovarian stimulation
تحسين سماكة بطانة الرحم والأوعية الدموية بعد تناول الفيتامينات E و C في النساء المصابات بالعقم اللائي يخضعن لتحفيز المبيض المتحكم فيه

Author: Shaimaa Abdulamer Nasir شيماء عبد الامير ناصر
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2017 Volume: 13 Issue: 23 Pages: 174-179
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Background: The most frequently used treatment to induce ovulation is clomiphene citrate which, unfortunately has the disadvantage of causing impaired endometrial growth. For successful conception to be achieved, optimal endometrial conditions are mandatory. The idea of giving vitamin C and E to infertile women on clomiphene citrate has been raised in published literature; however the subject is still controversial.Aim of the study: To study the effect of adding vitamins C and E supplementation to infertile women undergoing controlled ovarian stimulation, on endometrial thickness and vascularity.Patients and methods: The present case control study included 80 infertile women visiting infertility unit at Maternity and children hospital / Al-Dewaniyha city/ Iraq. From June 2014 to June 2016. Their age range was 20 to 35 years. They were classified into two groups: the first one included 40 patients and were treated using combine therapy of clomiphine citrate and vitamin E and C and the second group included 40 infertile women treated with clomiphine citrate only.Results: Median endometrial thickness was significantly greater in group 1 than that of group 2, 4.5 mm versus 3.1 mm on day 2 and 8.3 m versus 5.9 mm on day 12, respectively (P<0.001). Median endometrial vascular resistance was not significantly different in day 2; however it was significantly lower in group 1 compared to that of group 2 when assessed in day 12, 0.4 versus 0.6, respectively (P<0.001).

الخلفية: العلاج الأكثر استخداما للحث على الإباضة هو عقار كلوميفين سترات والذي ، للأسف ، لديه عيب التسبب في ضعف نمو بطانة الرحم. لتحقيق المفهوم الناجح ، تكون ظروف بطانة الرحم المثلى إلزامية. إن فكرة إعطاء فيتامين C و E للنساء المصابات بالعقم على سترات عقار كلوميفين قد أثيرت في الأدبيات المنشورة ؛ لكن الموضوع لا يزال مثيرا للجدل.الهدف من الدراسة: دراسة تأثير إضافة مكملات الفيتامينات C و E إلى النساء المصابات بالعقم اللائي يخضعن لتحفيز المبيض المتحكم به ، على سماكة بطانة الرحم والأوعية الدموية.المرضى والطرق: شملت دراسة مراقبة الحالة الحالية 80 امرأة مصابة بالعقم تزور وحدة العقم في مستشفى الولادة والأطفال / مدينة الديوانية / العراق. من يونيو 2014 إلى يونيو 2016. كان متوسط ​​أعمارهم 20 إلى 35 سنة. تم تصنيفها في مجموعتين: الأولى شملت 40 مريضا وعولجوا باستخدام الجمع بين العلاج من عقار كلوميفين سترات وفيتامين E و C والمجموعة الثانية شملت 40 امرأة يعانون من العقم تعامل مع سترات كلوميفين فقط.النتائج: كان متوسط ​​سماكة بطانة الرحم أكبر بكثير في المجموعة 1 من المجموعة 2 ، 4.5 مم مقابل 3.1 مم في اليوم 2 و 8.3 م مقابل 5.9 مم في اليوم 12 ، على التوالي (P <0.001). لم يكن متوسط ​​مقاومة الأوعية الدموية بطانة الرحم مختلفة بشكل كبير في اليوم 2 ؛ ومع ذلك ، كان أقل بكثير في المجموعة 1 مقارنة مع المجموعة 2 عند تقييمها في اليوم 12 ، 0.4 مقابل 0.6 ، على التوالي (P <0.001).

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