research centers


Search results: Found 36

Listing 1 - 10 of 36 << page
of 4
>>
Sort by

Article
Serum Zinc in Iraqi Acute Leukemic Patients

Author: Shatha Salah Asa,d شذى صلاح اسعد
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2009 Volume: 5 Issue: 1 Pages: 5-7
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Leukemia is a group of malignant disorders associated with increased numbers of blood white blood cells. Acute leukemia occurs at all ages. Because zinc influences many body systems and functions, zinc is an essential nutrient for tissue growth, cellular division, protein synthesis DNA and RNA replication it also ought to play a critical role in the growth of tumor. In this study, serum zinc was estimated in leukemic patients and compared with healthy subjects.Methods: The subjects in the present study were; fourty-four depressed patients aged (14-48 year), thirty-one apparently healthy subjects were selected as control group. Their sex and age were comparable to that of patients. Determination of serum zinc was carried out using flame atomic absorption spectrophotometer.Results: The results showed a significant decrease in serum zinc at (p<0.05) in leukemic patients as compared with healthy control.Conclusion: The decrease in serum concentration of zinc in leukemia can be explained by means of the changes in immunity system and the need for zinc to synthesize nucleic acid and tumor cell division in this disorder in addition to other possible mechanisms.

Keywords

leukemia --- zinc --- inflammation


Article
Dose-dependent Anti-inflammatory Effect of Silymarin in Experimental Animal Model of Acute Inflammation

Loading...
Loading...
Abstract

Silymarin, a flavolignans from seeds of ‘milk thistle’ “Silybum marianum” has been widely used from ancient times because of its excellent hepatoprotective action. It has been used clinically to treat liver disorders including acute and chronic viral hepatitis, toxin/drug-induced hepatitis and cirrhosis and alcoholic liver disease. The efficacy and dose-response effect of silymarin (125, 250 and 500 mg/kg) were assessed using egg albumin-induced paw edema in rats as a model of acute inflammation. In this model, 56 rats were used and allocated into 7 subgroups each containing 8 rats. All treatments were given intraperitonealy 30 minutes before induction of inflammation by egg albumin and then the increase in paw edema was measured 1h, 2h and 3h after induction of inflammation by using the vernier caliper. The results indicated that silymarin, at doses range used, significantly lowered paw edema (P<0.05) an effect comparable to that produced by the reference drugs, acetyl salicylic acid, meloxicam and dexamethazone. Paw edema suppressive effect of silymarin 250 and 500 mg/kg was comparable and both of them were significantly different from that of silymarin 125 mg/kg (P<0.05). Therefore, silymarin exert an important anti-inflammatory activity in animal model of acute inflammation, which was significantly increased as the dose increased up to 250 mg/kg.

لقد استخدم الأنسان ومنذ القدم مادة السليمارين المستخلصة من بذور نبات الكعوب بسبب تأثيرها في حماية الكبد. ولقد استخدمت سريريا في الوقت الحاضر لمعالجة أمراض الكبد الحادة والمزمنة والناشئة عن الفيروسات أو التعرض للسموم والكحول. تم في هذه الدراسة تقييم التأثير المضاد للألتهاب لجرع مختلفة من مادة السليمارين (١٢٥، ٢٥٠، ٥٠٠ ملغم/كغم) في نموذج الألتهاب الحاد المستحدث بواسطة الألبومين في قدم الجرذان. تم استخدام ٥٦ جرذا أبيض قسمت الى ٧مجموعات كل مجموعة ضمت ٨جرذان. تم علاج الجرذان بجرع مختلفة من السليمارين عن طريق الزرق بالبريتون قبل ۳٠ دقيقة من استحداث الألتهاب بزرق زلال البيض في قدم الجرذان، وتم قياس مستوى تكوين الوذمة بعد ساعة واحدة، ساعتين وثلاث ساعات بعد استحداث الوذمة باستخدام الفيرنية. أظهرت النتائج بأن للسليمارين فعالية مضادة للألتهاب تعتمد على الجرعة مقارنة بالمركبات القياسية المستخدمة للمقارنة (حامض أسيتيل ساليسيليك، ديكساميثازون والميلوكسيكام). ومن خلال النتائج التي تم التوصل أليها يمكن الأستنتاج بأن للسليمارين تأثير مضاد للألتهاب في النماذج المختبرية للألتهابات الحادة والذي يزداد بزيادة الجرعة حتى ٢٥٠ ملغم/كغم


Article
Effect of sitagliptin on lipid profile, Inflammation and Oxidative Stress in high cholesterol –fed male rabbits

Author: Dr Abdul-Hussein A. Faraj MBChB,MSc,PhD
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2011 Volume: 14 Issue: 2 Pages: 187-194
Publisher: University of Kufa جامعة الكوفة

Loading...
Loading...
Abstract

Back ground: Atherosclerosis is the major world wide killing disease. The most common risk factors are hyperlipidemia, diabetes, and ather factors like chronic infection and inflammation.Objective: This study was undertaken to assess the effect of sitagliptin on atherosclerosis via interfering with lipid parameter, inflammatory and oxidative pathwaysMethod: 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups: Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed 1% cholesterol enriched diet. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol enriched diet and treated with Sitaglipin 125mg/kg/day orally for the next 6 weeks. Results: Treatment of rabbits with sitagliptin for 6 weeks results in a significant reduction (P<0.05) in serum level of TC, TG, hsCRP and TNFα and a significant increase (P<0.05) in serum HDL level. There was a significant reduction (P<0.05) in aortic MDA and intima-media thickness, in comparison to the rabbits in the induced untreated control group.sitagliptin treatment cause increment in aortic GSH in comparison to induced untreated group.

يعتبر تصلب الشرايين المرض القاتل الرئيس على مستوى العالم. إن من أهم عوامل الخطورة لهذا المرض هي ارتفاع مستوى الدهون بالدم ومرض السكري وعوامل اخرى مثل الالتهابات المزمنههدف الدراسة: لتقييم تأثير السيتاكلبتين على تقليل مستوى الدهون بالدم والالتهابات وعوامل التاكسد وثأثيرها على سُمْكِ الطبقة الوسطية والداخلية للشريان الأبهر. الطريقة: أدخلت في هذه الدراسة 18 أرنبا محليا تم توزيع هذه الأرانب بصورة عشوائية إلى أربعة مجاميع المجموعة الأولى هي مجموعة السيطرة الطبيعية والمجموعة الثانية أعطيت غذاء عالي الدسم يحتوي1% كولسترول. المجموعة الثالثة أعطيت غذاء عالي الدسم لمدة ستة أسابيع, بعد ذلك أعطيت عقار السيتاكلبتيين 125ملم/ كغم لكل يوم عن طريق الفم.النتائج: سبب تغذية الأرانب بالغذاء عالي الدسم الذي يحتوي1% كولسترول لمدة أثني عشر أسبوعاً في زيادة معنوية (P<0.05) في مستوى الكولسترول الكلي والكلسيريدات الثلاثية ومستوى البروتين المتفاعل نوع C وعامل الالتهاب α-TNF في الدم و ومقياس درجة التصلب وزياده في عامل التاكسد مالونيلداي الديهايد(MDA) وانخفاضا في عامل التاكسد كلوتاثاييون GSH)) في الانسجه. سبب معالجة الارانب بعقار السيتاكلبتيين لمدة ستة أسابيع انخفاضا معنويا (P<0.05) في الكولسترول الكلي ,الكلسيريدات الثلاثية,مستوى البروتين المتفاعل نوع C وعامل الالتهاب α-TNF في الدم ومقياس درجة التصلب. بينما سبب زيادة معنوية (P<0.05) في مستوى الكولسترول عالي الكثافة في الدم وانخفاض في عامل التاكسد (MDA) وزياده في عامل التاكسد GSH))و سبب انخفاضا معنويا (P<0.05) في سمك الطبقه الداخليه والوسطى للشريان الابهر.


Article
Urinary level of Matrix Metalloproteinase (MMP-9) as a biomarker in cystitis and schistosomal chronic cystitis patients

Author: Huda Sadoon Jassim AL-Biaty
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2016 Volume: 15 Issue: 2 Pages: 52-55
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Cystitis means inflammation of the bladder, specifically inflammation of bladder wall. Evaluating the level of urinary MMP-9 as a prognostic biomarker in cystitis (schistosomal and non schistosomal) was the aim of the study. Urine samples and bladder biopsies were collected from 50 cystitis patients who were included schistosomal chronic cystitis and non schistosomal cystitis and also from 38 healthy individuals as control. Urinary concentration of MMP-9 was measured by ELISA technique. Specificity and sensitivity of marker were also calculated. The results showed that MMP-9 urinary level was significantly increased in cystitis patients (3842.90pg/ml) compared to healthy (634.80pg/ml), there was a significant differences in the mean levels of urine MMP-9 for different age groups of patients, but non-significant between females and males. MMP-9 was elevated in both schistosomal chronic cystitis and non-schistosomal cystitis patients and this elevation of marker was higher in schistosomal chronic cystitis but with non-significant, also urine MMP-9 showed significant increase in males than females schistosomal cystitis, and statistical differences between age groups. Matrix Metalloproteinase was specific (87.47%) and was more sensitive (93.22 %) in cystitis patients. We concluded that MMP-9 has a role in inflammation processes of cystitis.

Keywords

MMP-9 --- Cystitis --- Schistosoma --- Inflammation --- Urine --- Biopsy


Article
Effect of immune modulation on brain ischemia reperfusion injury

Authors: Hashim T. Raheem --- Najah R. Hadi --- Karrar J. Kareem --- Kahlaa A. Kadhim
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2015 Volume: 6 Issue: 1 Pages: 166-175
Publisher: University of Kufa جامعة الكوفة

Loading...
Loading...
Abstract

Cerebral ischemia–reperfusion injury is a complex process resulting in cellular damage and death. Ischemia and reperfusion in the brain induces an inflammatory response which may exacerbate initial levels of tissue injury. In this study, we investigated the possible immune modulation of rosuvastatin in brain ischemia reperfusion injury via interfering with inflammation. Twenty four adult albino rats were randomized into four groups (each of 6) as follow: Group (1) sham group: the rats were subjected to the same surgical procedures as other groups but the common carotid arteries were not occluded; Group (2) control (ischemic-reperfused) group: the rats were subjected to the same surgical procedures as other groups with bilateral common carotid arteries occlusion (BCCAO) for 30 min. followed by reperfusion for 1 hr but without drug; Group (3) control vehicle group: three days before surgery, rats received daily the vehicle of rosuvastatin drug, normal saline (0.9% Nacl) (1 ml/kg/day) intraperitoneally, then anesthesia and surgery with BCCAO for 30 min. followed by reperfusion for 1 hr were done and Group(4) rosuvastatin treated group: rats received daily rosuvastatin intraperitoneally. The dose of rosuvastatin was (10 mg/kg /day) for three days before the surgery, then anesthesia and surgery with BCCAO for 30 min. followed by reperfusion for 1 hr. At the end of the experiment, the levels of cerebral IL-6 significantly (p < 0.05) increased in control group as compared with the sham group. Histopothological analysis showed that rats in control group showed significant cerebral injury. Treatment with rosuvastatin significantly counteracted the increase in the cerebral levels of IL-6. Histopathological analysis revealed that rosuvastatin significantly reduced the severity of cerebral injury in the rats underwent BCCAO. We concluded that inflammatory cytokines are involved in global cerebral ischemia induced by bilateral common carotid arteries occlusion. Cerebral ischemia reperfusion injury can be modified by rosuvastatin via its anti-inflammatory effect. The aim of the study is to investigate the possible immune modulation of rosuvastatin in brain ischemia reperfusion injury.


Article
C-Reactive Protein as a Marker in the Iraq Patients with Poisoning Thyroid Gland Disease

Authors: Maryam D. Kamel --- Abbas A. Mohammed --- Ali A. Ibrahim
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2018 Volume: 36 Issue: 1 Part (B) Scientific Pages: 44-47
Publisher: University of Technology الجامعة التكنولوجية

Loading...
Loading...
Abstract

The present study aimed to investigate the possibility of using Creactiveprotein (CRP) and the level of CRP in serum sample as a markerfor patients with poisoning thyroid gland disease. In addition, therelationship between inflammation and poisoning thyroid gland. About 21of serum samples were examined from patients with poisoning thyroid gland(aged between 14 and 60 years old). Qualitative test was done to detect thepresence of CRP in the patient’s serum. The qualitative test showed that21(100%) patients with poisoning thyroid gland give positive result to CRP.The HPLC analysis done to determine the concentration of CRP in patient'sserum. The HPLC analysis showed that the level of concentration for CRPin serum between (6.4-9.49mg/l). According to the results of the present,the significant changes in the levels of CRP for the patients with thyroiddisorders observed in current study confirm that inflammation has animportant role on pathogenesis of thyroid dysfunctions regardless of theirthyroid dysfunction type. As well as the present study shown that, the CRPis a useful marker for patients with poisoning thyroid gland.

Keywords

poisoning thyroid gland --- APR --- CRP --- Inflammation --- HPLC


Article
Assessment of Dental Calculus, Plaque and Gingival Inflammation in Patients with Urinary Stone

Authors: Maher Balash Mohammed --- Maha Sh. Mahmood
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2019 Volume: 31 Issue: 1 Pages: 14-18
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Dental calculus is mineralized dental plaque formed on teeth and dental prosthesis surfaces in the oral cavity. Urinary stone is a crystal aggregation formed in urinary system due to minerals saturation present in urine. The structure of dental calculus is similar to that of urinary stone.Objective: To assess oral hygiene and gingival status in patients with urinary stone. And compared with healthy subjects.Patients and Methods: Sixty participants, 25-40 years, were involved in this study who were divided into study and control group. The study group involved patients with urinary stone while the control group involved healthy subjects. Clinical parameters including plaque, calculus and gingival indices were recorded for all participants. The correlation between the recorded clinical parameters was estimated.Results: The study group mean (±SD) plaque (1.435±0.499), gingival (0.995±0.288) and calculus (1.28 ±0.66) indices were found to be significantly high compared with control group(0.868±0.265), (0.602±0.265) (0.501±0.457 ) respectively. The formed calculus was positively associated with accumulated plaque (r: 0.608, p < 0.05) and gingival inflammation(r: 0.612, p < 0.05).Conclusion: Urinary stone patients were associated with more plaque and calculus accumulation, and had worse gingival inflammation compared to healthy participants. Thus, they need to be more aware of their gingival health status and improved preventive care of oral health.


Article
Evaluation of Serum Interleukin-6 Levels inCorrelation to the Severity of Acute Appendicitis

Loading...
Loading...
Abstract

Background: Acute appendicitis is a common surgical problem that is associated with an acute-phase reaction. Previous studies have shown that cytokines and acute-phase proteins are activated and may serve as indicators for appendicitis.Objective: The aim of this study was to evaluate of serum levels of interleukin-6 (IL-6) in correlation to the severity to acute appendicitis.Methods: This is a prospective study from December 2008 to March 2009 of patients who had appendectomy in Department of Surgery, Al-Kindy Teaching Hospital - Baghdad/Iraq. Serum for estimating levels of interleukin-6 (IL-6) was taken pre-operatively. Depending on the macroscopic evidence during the operation and the histopathological examination of the specimens, the patients were separated into 3 groups, group one with negative appendectomy (normal appendix), group two with non-complicated acute appendicitis (catarrhal, suppurative), and group three with complicated acute appendicitis (perforated, gangrenous). The histopathological results were correlated with IL-6 values statistically.Results: A total number of 50 patients were included in this study, 28 male (56%) and 22 female (44%). The mean age was 23 year (ranged from 7 to 50). On histological examination, there were 7 patients (14%) in group one, 29 patients (58%) in group two, and 14 patients (28%) in group three. Serum IL-6 values gave true negative results in 6%, true positive results in 82%, false negative results in 4%, and false positive results in 8%. We determined, therefore, in the present study the sensitivity, specificity, and accuracy of serum IL-6 were calculated as 95.34%, 42.85%, and 88% respectively.Conclusion: Laboratory results should be considered to be integrated within the clinical assessment. If used critically, IL-6 can provide surgeons with complementary information in discerning the necessity for urgent operation.


Article
Some Parameters of Inflammation & Oxidative Stress in Relation to the Risk of Type 2 Diabetes Mellitus

Author: Abdul Kareem H. Issa
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2010 Volume: 9 Issue: 1 Pages: 25-30
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Background Many clinical trials have indicated that lifestyle modification can delay or prevent the progression to type 2 diabetes in people with impaired glucose tolerance test (IGT). Detection of IGT requires a test which is inconvenient to screen for this condition in clinical practice or in the general population. Therefore, there is a need to search for additional significant risk factors for type 2 diabetes. Patients &methods Seventy two adults ≥ 40 years old (36 males and 36 females) were evaluated in this study. They were subjects who performed a brief 75-grams oral glucose tolerance test and were classified as having normal glucose tolerance (NGT group; 24 subjects), impaired glucose tolerance (IGT group; 24 subjects), or diabetes mellitus (DM group; 24 patients).In addition to hematocrit (PCV) and erythrocyte sedimentation rate (ESR), serum level of highly sensitive C-reactive protein (hsCRP) was measured. Also the serum levels of thiobarbituric acid-reactive substances (TBARS), iron, copper and ferric reducing ability of plasma (FRAP) were estimated in addition to erythrocyte glutathione (Ery-GSH) level. Results Both IGT group and DM group have a significantly high hsCRP mean level (2.59 ± 1.03 and 2.89 ± 0.90 respectively vs. 1.57 ± 1.40 mg /L in NGT group, P< 0.001), and a significantly decreased FRAP level (939.2 ± 157.4 and 961.5 ± 125.1 respectively vs. 1063 ± 104.5 µmole/L in NGT group, p< 0.01 ) as well as a significantly high TBARS and a significantly low Ery-GSH level in comparison with NGT group. The positive correlation between hsCRP and TBARS, although was statistically not significant, showed a step-wise increment from NGT, to IGT and to DM group (r = 0.01, 0.14 and 0.23 respectively). Conclusions IGT is associated with a state of low-grade inflammation and oxidative stress. Serum levels of hsCRP as a marker of inflammation and TBARS as a marker of oxidative stress may serve for identifying people at high risk for developing type 2 diabetes. Such people will be important targets for programs that are designed to prevent diabetes.


Article
Relation of Immuno-Inflammatory Markers (IL-6, Crpand ESR Value) With Prediction of Ischemic Heart Disease

Authors: Mahdi Haider Al-Najy --- Ikbal Khider Al-Joofy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 4 Pages: 318-322
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT: BACK GROUND:Ischemic heart diseases (I.H.D) become more common during 21st century as the dominant chronic diseases in many parts of the world, and it is predicted to be become the main causes of disability and death world wide. Many factors play a role in pathogenesis of I.H.D among those could be immuno-inflammatory markers which may lead to development of this disease.OBJECTIVE:The present study was conducted to obtain more clarification about the impact of some immuno-inflammatory markers (IL-6, CRPand ESR value) on the clinical expression of heart disease among Iraqi patients.METHODS:Hundred Iraqi patients with I.H.D (80 male and 20 female) ages ranged from 20 to 80 year were involved in this study, including 4 subgroups: 17 with heart failure (H.F). ; 26 with myocardial infraction (M.I); 12 with stable angina (S.A) and 45 with unstable angina (U.A) who was attending the Iraqi center for heart disease and Baghdad hospital from December 2006 to march 2007. Using enzyme amplified sensitivity immuno assay (EASIA) technique to measure the level of IL-6, and enzyme linked immunosorbant assay (ELISA) technique to measure the levels of CRP, in addition to westergren method to determine ESR were done for both patients groups and healthy control group.RESULTS:Significant increased (p<0.05) in the serum level of IL-6 in all patients subgroups: MI, HF, UA, and SA. Respectively compared with control group, also all patients subgroups: SA, HF, MI, UA, consequently revealed significant increased (p<0.05) in the mean of CRP concentration compared with control group. Moreover, highly significant elevated (p<0.01) in the erythrocyte sedimentation rate (ESR) value in the patients subgroups: SA, UA, MI, HF respectively compared with control group.CONCLUSION:Elevated levels of inflammatory markers, particularly CRP and IL-6 are a relatively strongly predictor of I.H.D and in one way or another ESR value and CRP level reflect the degree of the inflammatory status of these diseases.

Keywords

ischemic heart diseases --- inflammation --- IL-6 --- CRP --- ESR.

Listing 1 - 10 of 36 << page
of 4
>>
Sort by
Narrow your search

Resource type

article (36)


Language

English (29)

Arabic (3)

Arabic and English (2)


Year
From To Submit

2019 (4)

2018 (4)

2017 (1)

2016 (4)

2015 (3)

More...