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Article
Patterns of Sensitization to Inhalant Allergens among Asthmatic Children in Karbala Province

Authors: Mohammad R. I. Ghazal --- Zuhair M. Al-Musawi --- Haidar A. N. Abood*,
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 2 Pages: 1630-1636
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: The patterns of sensitization to inhalant allergens among asthmaticchildren varies greatly in different countries. The detection of sensitization to inhalantallergens in asthmatic patients is used primarily to establish the diagnosis of allergicasthma. Also it is helpful in reducing asthma exacerbations through allergen exposureavoidance.Objectives: This study aims to determine the most common inhalant allergens associatedwith childhood asthma in Karbala province using allergen-specific IgE immunoassay.Patients and Methods: The present study was conducted in Karbala Teaching Hospital forChildren on 75 asthmatic children with elevated total serum IgE levels. All patients werescreened for the presence of specific IgE against inhalant allergens most frequently involvedin childhood asthma using EUROLINE Pediatric Inhalation IgE test kit that include 20inhalant allergens. The position of the band was used to determine the specific allergen whilethe color intensity of the band was used as predictive for the specific IgE concentration inserum samples.Results: Among 75 patients screened for specific IgE, 60 patients (80%) were sensitized to atleast one allergen and allergen-specific IgE was not detected in 15 (20%) patients. 30% ofsensitized patients, were sensitized to single allergen and 70% were sensitized to multipleallergens. Cat allergen was found in 60% of sensitized patients followed by European housedust mite allergen (55%). However, dog and aspergillus fumigatus allergens accounted for45% and 33.3% respectively. Most patients sensitized to cat and dog allergens (55.5% and52% respectively) showed clear bands signal intensity (moderate allergen-specific IgEconcentration). However the majority of patients sensitized to other inhalant allergensshowed weak bands signal intensity (low allergen-specific IgE concentration).Conclusions: Animal allergens (mostly cat) are the predominant inhalant allergens associatedwith childhood asthma in Karbala province with relatively higher allergen-specific IgEconcentrations than house dust mite and fungal allergens.


Article
Role of Inhalant allergens in asthma: Evaluation by Skin Test
دور من المواد المسببة للحساسية في المستنشق الربو: التقييم من قبل اختبار الجلد

Author: Moheeb A. Salih مهيب احمد صالح
Journal: The Medical Journal of Tikrit University المجلة الطبية لجامعة تكريت ISSN: 18131638 Year: 2010 Volume: 2 Issue: 162 Pages: 53-59
Publisher: Tikrit University جامعة تكريت

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Abstract

The skin test performed on 273 patients with allergic asthma to determine the most common sensitizing allergen in our locality . In 32.6% of patients ( 89 patients ) the test was positive to single allergen and in 67.4 % of patients it was positive to multiple allergens . Two allergens positive skin test forms 41% , while the test was positive for three or above allergens in 26.4% of patients . House dust mite was the predominant inhalant allergen that gave positive skin test in asthmatic . It was accounted for 26.9% followed by house dust allergen 18.2%

اختبار الجلد التي أجريت على 273 مريضا يعانون من الربو التحسسي لتحديد مسببات الحساسية الأكثر شيوعا في توعية المجتمع المحلي لدينا. في 32.6٪ من المرضى (89 مريضا) وكان الاختبار إيجابية لمسببات الحساسية واحد وفي 67.4٪ من المرضى كانت إيجابية للحساسية متعددة. اثنين من المواد المسببة للحساسية اختبار الجلد إيجابيا تشكل 41٪، في حين أن الاختبار كان ايجابيا لمدة ثلاثة أو أكثر المواد المسببة للحساسية في 26.4٪ من المرضى. وكان منزل عث الغبار المستنشق للحساسية السائدة التي أعطت إيجابية اختبار الجلد في الربو. وكانت تمثل 26.9٪ تليها حساسية غبار المنزل 18.2٪

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