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The Role of Leptin and Insulin like Growth factor-1 in patients with Thyroid dysfunction

Author: Huda H. Hassan
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 58-62
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Aims: To evaluate the relationship between serum Leptin, Growth factor-1 (IGF-1) levels and untreated thyroid dysfunction patients.Patients and Methods: A study was made on 50 untreated goiterous patients (female and males) with range between (25-55) years; and25 controls subjects (females and males) with range between (14-55) years.Serum T3, T4 &TSH were by Radio immune assay (RIA) method. Serum Leptin and Insulin like growth factor-1 (IGF-1) was measured by ELISA method.Results: The mean Serum Leptin level was significantly lowest in hyperthyroidism than control subjects. While Insulin growth factor level was significantly highest in hyperthyroidism than control subjects (3.82 vs. 2.49)Conclusions: the objective of the study was to provide new data on the relationship between serum Leptin, Insulin like Growth Factor-1 levels and thyroid dysfunction.

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