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Article
XRCC1 codon 194 polymorphism in Iraqi population

Author: Luma A. H. Al Obaidy
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 3 Pages: 194-199
Publisher: Baghdad University جامعة بغداد

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Abstract

XRCC1 is one of the DNA repair genes, which play an important role in maintains DNA stability via DNA repair by base excision repair and single strand break, As its acts as a scaffold to other repairing proteins. In this study the polymorphism at the codon 194 had been studied in (202) of Iraqi population, distributed in two groups (106) Arab and (96) Kurdish. The alleles for the 194 codon, were investigates by PCR-RFLP techniques. It's found that (94) represented 88.6% Arab individuals carrying the CC dominant homozygous genotype, while (12) individuals represented 11.4% who carry the CT heterozygous genotype, and no one had the recessive TT genotype. In Kurdish group (94) represented 97.9% individuals had the CC dominant homozygous genotype, while only (2) represented 2.1% had the CT heterozygous genotype, also no one had the recessive TT genotype. The allele frequency for the Arab individuals was 0.9434 for the C which encoding for Arginin and 0.0566 for the T allele which encoding for Tryptophan. In Kurdish individuals the frequency of C allele was 0.99 while the frequency of the T allele was 0.01. These results may indicates that the C allele is the most common allele in Iraqi population in both Arab and Kurdish, and there is a slightly high allele frequency were observed in Kurdish may due intermarriage leading to reduce the recessive allele in the population.


Article
Horizontal and Vertical Position of the Mental Foramen on Panoramic Views of a Selected Iraqi Population

Author: Dr. Salah J. Muhsen, B.D.S.,M.Sc. د. صلاح محسن
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2011 Volume: 8 Issue: 2 Pages: 188-192
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The mental foramen is the opening of the short mental canal, through which themental nerve the terminal branch of the inferior alveolar nerve exits, knowing theexact position of the mental foramen is essential in oral surgical procedures. Thisstudy determines this position in a selected Iraqi population.240 panoramic radiographs of Iraqi population selected from three different oraland maxillofacial centers to identify the normal range of position of the mentalforamen, both horizontal and vertical position were studied, radiographs with anyerrors or taken for patients not co inside with our criteria were excluded.In horizontal position , 51.31% were found apical to the lower second premolar ,43.64% between the first and second premolars, 3.07% were found between secondpremolar and lower first molar, 1.09% were found apical to the lower first premolar,0.87% were found between lower canine and lower first premolar.In vertical position,60.08% were found inferior to the apex of the related tooth,36.84% were found within the apex of the related tooth while 3.07% were foundsuperior to the apex.The mental foramen can be found anywhere from lower canine to the lower firstmolar, although 94.95% of the studied radiographs showed that mental foramen waslocated either between the lower premolars or at the apex of the second premolar.


Article
Revealed of A novel Allele in Wasit – Iraqi Population
الكشف عن اليلات جديدة في المجتمع العراقي / محافظة واسط

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Abstract

The developments in forensic DNA technology have led us to perform this study in Iraqi population as reference database of autosomal Short Tandem Repeat (aSTR) DNA markers . A total of 120 unrelated individuals from Wasit province were analyzed at 15 STR DNA markers. Allele frequencies of DNA typing loci included in the AmpFlSTR1 IdentifilerTM PCR Amplification Kit panel from Applied Biosystems (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, TH01, TPOX, CSF1PO, D19S433, D2S1338, D16S539) and several forensic efficiency statistical parameters were estimated from all the sample. the combined Matching Probability (CMP) using the 15 STR genetic loci in Iraqi population was estimated at 1 in 2.08286E-18 and the Combined Discrimination Power (CDP) was greater than 0.9999999 ,Combined Exclusion Probability (CEP) was 0.98350917 which should be sufficient for the identification of any individual.

التطور السريع الذي حدث في التقنيات المتعلقة بالحمض النووي العدلي في العالم يدفعنا لاجراء البحوث التي تدعم هذا التوجه سيما وان الابحاث في العراق التي تخص هذا الموضوع لا تواكب التطور العالمي الحديث , لذا بدأنا بمحافظة واسط ببناء قاعدة بيانات للكشف عن المؤشرات الجسمية الخاصة بهذه الشريحة من المجتمع العراقي autosomal Short Tandem Repeat (STR) .تم جمع 120 عينة من متطوعين (لا تربطهم اي صلة قرابة ) حصرا من محافظة واسط الجنوبية , المؤشرات التي تم تحليلها هي 15 موقع منتشر على الكروموسومات الجسمية هذه المواقع هي: (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, TH01, TPOX, CSF1PO, D19S433, D2S1338, D16S539). عدة قوانين اساسية استعملت في التحليل النتائج على جميع المواقع منها درجة التقارب بين العينات (CMP), وكانت النتائج تشير الى 1 من اصل 2.08286E-18 وكذلك وقوة التطابق بين العينات 0.999999. كما كانت دقة الاحتمالية كانت 0.98350917 وهذه النتائج يجب ان تكون مطابقة عند اي عمل .


Article
Maxillary Arch Dimensions in an Iraqi Population Sample
ابعاد فك الاسنان العلوي لعينه من سكان العراق

Author: ابعاد فك الاسنان العلوي لعينه من سكان العراق انس قحطان حمدي
Journal: Al- Anbar Medical Journal مجلة الأنبار الطبية ISSN: PISSN: 27066207 / EISSN: 26643154 Year: 2013 Volume: Vol.11 Issue: 1 Pages: 79-84
Publisher: University of Anbar جامعة الانبار

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Abstract

Objectives: To determine the maxillary arch dimensions in an Iraqi (Salah Aldin city) sample aged (17-27) years with CL I(class one) normal occlusion and show the sex difference in this sample and compare these values of this group (males and females) combined with other studies in middle eastern population sample( Saudi and Egyptian population sample).Materials and Methods: The observation concerning maxillary arch dimensions were taken from 80 study models (40males and 40 females) the measurement distances from canine to canine (C-C), molar to molar (M-M), molar to canine (M-C) and molar to incisor (M-I) according to Mack criteria . The measurements were made by means of vernier calipers with sharpened points to the nearest 0.05mm. Statistical analysis of the collected data was performed; the t .test was used when two groups were compared. level of significance was chosen (p<0.05,p<0.01 , p<0,001).Results: The greater mean values of inter cusp distances from canine to canine, molar to molar , molar to canine and molar to incisor were significantly higher in Iraqi males than Iraqi females , and this result is similar to result of sex difference in Saudi and Egyptian samples . While the comparison of the results of Iraqi and Saudi sample reveals no significant difference for Iraqi sample (both males and females )than for the Saudi sample (both males and females ) in all measurements except (C-C) distance which shows significant difference . While higher statistically significant differences in (C-C), (M-M) distances for Egyptian sample than Iraqi sample while (M-I) difference is greater in Iraqi sample than Egyptian sample.Conclusion: The Iraqi maxillary arch dimension was greater in males than in females.There is a similarity between the Iraqi and Saudi maxillary arch dimensions, except a very little difference in (C-C) distance. The Egyptian maxillary arch dimensions (African group)was greater than that of the Iraqi sample (Asian group ) except in (M-C) distance which has no difference ,while (M-I) distance the difference is greater in Iraqi sample than Egyptian sample

الهدف :من الدراسة هو مقارنة ابعاد الفك العلوي في عينه من سكان العراق (محافظة صلاح الدين ) ذكور واناث تتراوح اعمارهم من (17-27) سنه ومن ذوي الاطباق الطبيعي من الصنف الاول ومقارنة نتائج هذه العينات ككل (ذكور واناث) مع دراسات لعينات من سكان السعودية ومصر .طريقة العمل : المشاهدات المتعلقة بأبعاد الفك العلوي اخذت من 80 عينه من القوالب السنيه (40 ذكور و40 اناث) .المسافة المقاسة من الناب الى الناب ,الرحى الى الرحى , الرحى الى الناب والرحى الى السن القاطع .القياسات اجريت بواسطة مقياس ابعاد(فيرنيا) دقيق الى حد 0,05 ملم . التحليلات الاحصائية للعينات اجريت حسب المقياس الاحصائي t-test للمقارنة بين المجموعات .النتائج : اعلى معدل قيمه للمسافة من الناب الى الناب ,الرحى الى الرحى ,الرحى الى الناب والرحى الى السن القاطع الامامي وجدت عالية وبصوره ملحوظه للذكور العراقيين مقارنة بالإناث العراقيات وهذا مشابه لنتائج الفرق بين الذكور والاناث في العينات السعودية والمصرية. مقارنة النتائج للعينات العراقية والسعودية اظهرت انه ليس هناك فرق ملحوظ بأبعاد الفك العلوي لكلا الجنسين الذكور والاناث العراقيين والسعوديين في كل الابعاد ماعدا المسافة بين الناب الى الناب والتي اظهرت فرق ملحوظ. بينما وجد فرق عالي ملحوظ للأبعاد الناب الى الناب ,الرحى الى الرحى للعينات المصرية قياسا بالعينات العراقية ,والمسافة بين الرحى الى السن القاطع الامامي هي اعلى في العينات العراقية مقارنة مع العينات المصرية.الاستنتاجات : ابعاد الفك العلوي في العينات العراقية كانت اكبر في الذكور منها في الاناث .وهناك تشابه بين ابعاد الفك العلوي في العينات السعودية والعراقية ماعدا فرق قليل للمسافة من الناب الى الناب . ابعاد الفك العلوي في العينات المصرية (المجموعة الافريقية) كانت اكبر من العينات العراقية (المجموعة الاسيوية) ما عدا في المسافة من الرحى الى الناب والتي لا توجد فيها فرق .بينما المسافة من الرحى الى القاطع كانت اكبر في العينات العراقية مقارنة مع العينات المصرية


Article
Allele Frequency of 15 Autosomal Short Tandem Repeat (STR) Loci in Al Anbar - Iraqi Population

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Abstract

Abstract:Allele frequencies for 15 STR loci (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317,D16S539, D18S51, D21S11, FGA, TH01, TPOX, VWA, D2S1338, D19S433) included in the AmpFlSTR Identifiler kit were determined in a sample of 132 unrelated people originating From Al Anbar - Iraqi Population, samples were extracted using a Prep Filer Forensic DNA Extraction Kit. DNA concentration measured using Nano drop Simultaneous amplifications of 15 STR loci and a gender determination marker (multiplexed PCR) were done by using the AmpFlSTR® Identifiler® PCR Amplification Kitaccording to the user’s manual recommendations . The separation and detection of amplified products were conducted with the 3130 xl Genetic Analyzer 16-capillary array system following manufacturer’s protocols,A different number of alleles were observed with frequencies ranging between 0.0038 (FGA- allele 18, 19.2, 23.2, 27 and 28 - , D18S51 - allele 20 and 23, D19S433 - allele 9.2,11 and 12.2, D2S1338 – allele 27, D13S317 – allele 16, D3S1358 – allele 13 and 19 CSF1PO – allele 14, D21S11– allele 30.2 and 32 and D8S1179 - allele 9 and 17) and 0.5795 (TPOX-allele 8). The highest heterozygosity is observed for FGA (85.60 %) where the smallest heterozygosity value is obtained for TPOX (61.36 %). The loci were observed to have high discriminating power, as the power of discrimination of each loci varied from 0.812 (TPOX) to 0.973 (D2S1338). All loci but D21S11 (<0.001), D19S433 (<0.001), D5S818 0.00204 and FGA (<0.00024) met Hardy- Weinberg expectations (P > 0.05).Significant departure from Hardy Weinberg Equilibrium (HWE) expectations were observed in loci D21S11 (0.001), D19S433 (0.001), D5S818 (0.002) and FGA (0.00).The results of the population genetics tests and pairwise comparisons suggest that these allele frequency databases are suitable for the purpose of identification in paternity or forensic investigations.

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