research centers


Search results: Found 23

Listing 1 - 10 of 23 << page
of 3
>>
Sort by

Article
Frequency of Genodermatoses Among Iraqi Patients

Authors: Haider R. Al-Hamami --- Adil A. Noaimi --- Makram M.Al-Waiz --- Abdulkaleq S. Al-Kabraty
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 1 Pages: 62-67
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Genodermatoses are hereditary skin disorders or anomalies which can be grouped into three categories: chromosomal, single gene and multifactorial. Most genodermatoses show single gene or Mendelian inheritance (autosomal dominant, autosomal recessive or X-linked recessive genes).OBJECTIVE:To asses the frequency of genodermatoses among Iraqi patients in outpatients Dermatology and Venereology comparison with other countries.PATIENTS AND METHODS:This case series descriptive epidemiological study included eighty three patients (57males and 26 females) with genodermatoses. They consulted the out patient clinic/ Department of Dermatology and Venereology Baghdad Teaching Hospital fromApril 2005 through April 2006. Their ages ranged from 2months-60 years (Median 10 years),With various genetic diseases.Full history, dermatological and clinical examinations were done to establish the clinical diagnosis of genodermatoses regarding all demographic points related to these disorders.RESULTS:The frequency of genodermatoses among outpatient attendant in Dermatology and Venereology Department was 83/ 20000 (0.42%).This study had shown that the most common genodermatoses were; ichthyosis: 21 (25.3 %) patients and epidermolysis bullosa which contain 16 (19.3 %) patients when taken together they constituted 37 (44.6%) patients of the total, neurofibromatosis 8 (9.6 %), hereditary palmoplantar keratoderma 6 (7.2%), darier's disease 5 (6 %) and xeroderma pigmentosa 4 (4.8 %).Positive family history of the same disease was obtained in; 8 (38.1 %) patients with ichthyosis, 4 (66.6 %) in hereditary palmoplantar keratoderma, 2 (12.5 %) in epidermolysis bullosa and all patients with Hailey-Hailey disease had positive family history of the same condition.Consanguinity was positive in; 13 (61.9 %) patients of ichthyosis, 12 (75 %) epidermolysis bullosa, 2 (33.3 %) hereditary palmoplantar keratoderma and (100 %) patients with xeroderma pigmentosaCONCLUSION:Genodermatoses are frequently encountered among Iraqi dermatological outpatients and more common in families with positive consanguinity and were comparable to other countries


Article
A Survey Of Dermatophytes Isolated From Iraqi Patients In Baghdad City

Loading...
Loading...
Abstract

Dermatophytes infection is a common problem worldwide and frequent in Iraq. Several reports and articles were published on prevalence, distribution, causes and treatment of dermatophytosis . This case study was conducted on fifty patients(31males and 19 females) with suspected dermatophytes were studied . Their ages ranged from one year to fifty years .Patients admitted to Baghdad Teaching Hospital , Dept . of Dermatology , Baghdad during September 2010 to March 2011.Hairs and scales were collected and microscopicall examination using 20% KOH were done. Hair and scales from active outer border of the lesion were inoculated on modified Sabouraud's dextrose agar. Culture was incubated at room temperature(28C°) for 4 - 5 weeks. The identification of dermatophyte species was based on the gross , and microscopical and cultural characteristic according to standard mycological references . The infection of dermatophyte was much higher in children below 10 years of age. Males 31(62%) were affected more than females 19(38%).Tinea capitis 19(47.5%) was the predominant clinical type .The main etiological agents was Trichophyton rubrum 20(50%) followed by Trichophyton mentagrophytes 13(32.5%). The predominant anthropophilic dermatophytic species was Trichophyton rubrum. This study was carried out to determine the prevalence, causative agents of dermatophytosis in group of Iraqi patients in Baghdad.

اصابات الامراض الجلدية من المشاكل الشائعة في العالم وخاصة العراق . عدة تقارير نشرت لدراستها وخاصة الانتشار والمسببات والمعالجة . وقد اجريت هذة الدراسة حيث تضمنت خمسون مريضا ( 31 ذكر مع 19 انثى ) المشكوك بأصابتهم بالفطريات .وترواحت اعمارهم من سنة واحدة الى خمسون سنة. المرضى من مراجعين لمستشفى بغداد التعليمي و شعبة الامراض الجلدية – في مدينة بغداد للفترة من بداية شهر أيلول 2010 وحتى نهاية شهر أذار 2011 . خضعت النماذج المأخوذة من الشعر والكشطات الجلدية الى الفحص المباشر بمحلول 20%KOH وقد زرعت على وسط السابرويد المطور وتحت درجة حرارة 28م ولمدة 4 -5 اسابيع. وقد شخصت الفطريات المسببة للامراض الجلدية بألاعتماد على الشكل المظهري للنمو الفطري والفحص المجهري لها والتفاعلات الكيموحيوية وبالاعتماد على المصادر الفطرية .وسجلت اعلى اصابة في الاطفال دون سن العاشرة من العمر وكانت اصابة الرجال 31 (62%) اعلى من النساء 19 (38%). الاصابة بسعفة الرأس( (Tinea capitisوالتي كانت سائدة أكثر من بقية الحالات الجلدية الاخرى حيث شكلت نسبة أصابة47.5 %.اما المسببات الرئيسية للاصابات الفطريات الجلدية في البشر هي: Trichophyton rubrum 20 عزلة ( (%50, Trichophyton menatgrophytes 13 عزلة (%32.5) , Microsporum canis 4 عزلة (%10) , Trichophyton sudanese 1عزلة(%2.5) , Trichophyton schoenleinii 1عزلة (%2.5) Epidermophyton floccosum and 1 عزلة (%2.5). واثبتت الدراسة ان الفطريات المحبة للبشرAnthropophilicهي السائدة.


Article
Perniosis: Clinical and Epidemiological Study in Iraqi Patients

Author: Adil A. Al-Nuaimy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 1 Pages: 11-13
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Perniosis(chilblains) is a common skin problem. This condition results from abnormal reaction to cold which is usually seen during the cold months of year.OBJECTIVE:The aim of the present study is to shed a light on different clinical and epidemiological aspects of perniosis in Iraq.METHODS:A total of 40 patients with perniosis were seen between January to march 2008 in the department of dermatology and venereology of Baghdad Teaching Hospital.A detailed history was taken from each patient regarding age, sex, occupation, duration of attack, family history, smoking, drug history, medical history, relieving and aggrevating factors and previous treatment modality.Full examination was done to each patient to assess the distribution and extent and morphology of the lesions and to see if there other skin diseases. Biopsies was done for 6 patients for histopathological study.RESULTS:A total of 40 patients were assessed. Their ages ranged from 5-60 years with a mean age of 22 SD± 6.2, 31 females and 9 males (3.5:1).Main sites of involvemnt were; toes 39% , fingers 22% ,heals 10% and nose 2.5% .Main types of lesions were ; erythematous cyanotic swellings 82% , vesicular lesions 23% ,ulcerations 10% and erythema multiforme like lesions 15%. Family history was positive in 22.5% of patients.CONCLUSION:Perniosis occur mainly in females between 10-20 years . Most common sites of involvement are toes and fingers . genetic susceptibility is an important factor in the development of the disease. Majority of patients are healthy without any medical or dermatological diseases .Majority are non smokers and did not have any history of drug intake.


Article
Insight on the Side Effects of Lipid Lowering Agents (Statin) in Iraqi Patients with Ischemic Heart Diseases

Author: Basil N. Saeed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 3 Pages: 266-269
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:3-hydroxy-3methyl glutaryl co enzyme inhibitor (MMG-COA) (statin) is a very common drug used in many medical conditions regardless of the presence or absence of dyslipidemia. One of these conditions is the cardiac disorders.OBJECTIVE:Throwing a light on the prevalence of their side effects in Iraqi patients.PATIENTS AND METHODS:Two hundred seventy patients with ischemic heart disease from the period of November 2006-November 2007 referred to Baghdad teaching hospital (the medical city). Those cases were using statin and grouped into two groups.Group A: patients admitted with acute coronary syndrome (myocardial infarction and unstable angina) (230 patients 77%).Group B: patients with associated risk factors (Hypertension, diabetes mellitus, smoking and secondary lipidemia) 40 cases 23%, have history of ischemic heart disease on treatment they use the drug in range of (10-40) daily with review monthly for the side effects. All 270 cases were free from other organic disorders (i.e. renal, thyroid, malignancy, or any longstanding disease). All patients went through a questionnaire which includes: age, gender, risk factors (Hypertension, diabetes mellitus, smoking, and lipidemia), routine blood tests, lipid profile, liver function tests, C-reactive proteins, thyroid function tests, chest X-ray, electrocardiography and echocardiography done for all patients, all patients used to take drugs in the range of 10-40mg daily for at least one year.RESULT:The side effects noticed in this study were gastric, musculoskeletal, elevated liver enzymes (40%, 28.9%, and 1% respectively from the total number of patients). Other side effects in other systems like skin, respiratory, and cardiac were not encountered.CONCLUSION:This study showed that the side effects of statin were not involving all the body systems.


Article
Treatment of Moderate Acne Vulgaris with 20 mg Isotretinoin/Day in Iraqi Patients
علاج العد الشائع المتوسط الحدة بواسطة عقار الايزوتريتينون بجرعة 20 ملغرام يوميا عند المرضى العراقيين

Loading...
Loading...
Abstract

Background: The efficacy of isotretinoin at 0.5-1 mg/kg per day in the treatment of acne is well established and considered safe, although it is sometimes not easily tolerated because of its side effects. Objective: To determine the effect of treatment of moderate acne with a lowest dose of isotretinoin for a shorter period than the standard higher dose. Patients &Methods: Open label therapeutic study. A total of 34 patients with moderate papulopustular acne were examined in the Department of Dermatology and Venereology, Ramadi Teaching Hospital, Anbar, Iraq from July 2007 to June 2008. Detailed history and clinical examination were performed for all patients, and a thorough laboratory tests were done before and after therapy. Patients were treated with a dosage of 20 mg/ day of isotretinoin for four months. And evaluation was done at each month. Then treatment was stopped and Patients were followed up every two months for another 4 months regarding both clinical and laboratory findings. Results: Thirty patients completed the study. Four dropped out for unknown reasons. There were 24 males and 6 females with male to female ratio of 4:1. Their age ranged between 15 -27 (20.3±3.7) years. Complete improvement was achieved in 28(93.5%) patients at the end of two months. Within four months there were two (6.5%) relapses. The most common side effects were mild cheilitis in all patients beginning with the first week of treatment, Mild xerosis in 20(66.5%) patients and epistaxis in 4(13%) patients. No increase in liver enzymes, serum triglyceride or serum cholesterol. Conclusion: Acne vulgaris can be treated with four months regimen of isotretinon 20 mg once daily with lower cost and less severe side effects than standard higher doses.Keyword: Isotretinoin, Moderate acne, Iraqi patients

الخلفية: فعالية علاج عقار الايزوتريتينون بجرعة 0,5-1 ملغرام/ يوميا للعد الشائع تم إثباتها وتعتبر سليمة بالرغم من آثاره الجانبية. الأهداف: لتحديد فعالية علاج الايزوتريتينون في مرض العد الشائع المتوسط الحدة بأقل جرعة واقل فترة ممكنة.الطريقة: أجريت دراسة علاجية مفتوحة ل34 مريضا يعانون من العد الشائع المتوسط الحدة في شعبة الأمراض الجلدية والزهرية في مستشفى الرمادي التعليمي للفترة من تموز 2007 إلى حزيران 2008, وأجري فحص سريري والمختبري للمرضى لجمع معلومات عن كل مايتعلق بالمرض. تم معاجلة المرضى بجرعة عشرون ملغرام من عقار الايزوترتينوين مرة واحدة يوميا ولمدة 4 أشهر, وتمت المراجعة شهريا, وبعد انتهاء فترة العلاج يتابع المريض كل شهرين لمدة 4 شهور أخرى من حيث المشاهدات السريرية والمختبرية.النتائج: 30 مريضا اكملو هذه الدراسة, تراوحت أعمارهم ما بين 15 – 27 سنة, بمعدل( 20,3±3,7) سنة, تراوحت نسبة الذكور للإناث 1:4. في نهاية شهرين من العلاج, 28(93,5%) مريضا حصلوا على استجابة كاملة, 2(6,5%) منهم انتكسوا في فترة المتابعة. الآثار الجانبية الشائعة هي الالتهاب البسيط للشفتين لجميع المرضى خلال الأسبوع الأول, تيبس بسيط في سطح الجلد في20 (66,5 %) مريضا, رعاف في 4 (13%)مريضى. ولم يتم تسجيل أي ارتفاع في مستوى إنزيمات الكبد أو نسبة الكولسترول والدهون في الدم. خاتمة : العد المتوسط الحدة يمكن معالجته بواسطة الايزوتريتينون وبجرعة 20 ملغم مرة واحدة يوميا خلال أربعة أشهر مع اقل كلفة واقل حدة للآثار الجانبية من المألوف لدى مستخدمي الجرعة الكلاسيكية العالية.


Article
Treatment of Facial Vitiligo by 0.1% Topical
معالجة البهاق(الوجه) بواسطة التاكرولمص0.1% الموضعي لدى المرضى العراقيين

Author: Zeyad T. Al-Ani زياد طارق عبد الهادي العاني
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2012 Volume: 25 Issue: 3 Pages: 265-267
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

AbstractBackground: Although the treatment options of vitiligo have been increased during the last decades, therapy is still not satisfactory for many patients. Considering the autoimmune hypothesis of vitiligo pathogenesis, the use of topical calcineurin inhibitors seems reasonable.Objective: To evaluate the effectiveness and safety of 0.1% Tacrolimus ointment in the treatment of vitiliginous lesions on the facePatients and Methods: This is an open therapeutic trial. A total of 50 patients with facial vitiligo were seen and studied in the Department of Dermatology and Venereology, Ramadi Teaching Hospital, Al-Anbar, Iraq from March 2010 February 2011. Patients asked to apply topical Tacrolimus) twice daily for three months then follow up 3 months with weekly application with regular visit each month to estimate the area of reduction and record the side effect.Results: All patients' ages were at least 15 years old with stable vitiligo, (38 females and 12 males). In 85 (70.8%) of 120 treated patches marked repigmentation (Grade III) was noted after 6 months treatment. Side effects were mild burning like sensation at the application site.Conclusion: Facial vitiligo can be successfully treated with topical tacrolimus ointment 0.1% with fewer side effects.

الخلاصةالخلفية:على الرغم من إن علاج مرض بهاق الجلد تطور خلال العقود الأخيرة مازال العلاج غير ناجع لعديد من المرضى وبسبب النظرية المناعية لمرض البهاق أدى إلى تجربة مثبط الكالسينيورين الموضعي للعلاج.الأهداف:لتسليط الضوء على فعالية وأمان التاكرولمص الوضعي0.1% في معالجة مرض البهاق(الوجه).الطريقة:أجريت دراسة علاجيه مفتوحة ل 50 مريضا يعانون من بهاق الوجه في شعبة الأمراض الجلدية والزهرية في مستشفى الرمادي التعليمي ,الانبار,العراق للفترة من آذار 2010 إلى شباط 2011 .يتم استعمال الدهن الموضعي مرتين يوميا لمدة 3 أشهر وبعدها مره أسبوعيا لمدة 3 أشهر أخرى.النتائج: أعمار المرضى أكثر من 15 سنه في 85 من 120 بقعه علاجيه)70.8%) وجدت إعادة اللون الطبيعي بعد 6 أشهر والأعراض الجانبية كانت بسيطة وتمثلت بالحرق البسيط في المنطقة المعالجة.الاستنتاجات: المرضى اللذين يعانون من مرض بهاق الوجه يمكن معالجتهم بنجاح بواسطة التاكرولمص الموضعئ0,1% مع اثار جانبيه بسيطة


Article
Clinico-epidemiological and Histopathological Study of Syringoma in Iraqi Patients
تورم الغدد العرقية التكهفي في المرضى العراقيين (دراسة سريرية ونسيجية)

Authors: Khalifa E. Sharquie د. خليفةعبيد الشرقي --- Hadf A. Hassan د. هدف عبدالامير --- Adil A.Noaimi د. عادل عبد الغفور النعيمي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2010 Volume: 23 Issue: 2 Pages: 101-104
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

AbstractBackground: Syringoma is common benign tumor of sweat glands causing cosmetic disfigurement. It occurs predominantly in women at puberty or later in life.Objective: To determine the clinical, histopathological and epidemiological aspects in syringoma.Patients &Methods: A case-controlled study was conducted in Department of Dermatology and Venereology - Baghdad Teaching Hospital, from Oct. 1991 through June 1991. Fifty patients with Syringoma and 100 individuals as a control group were enrolled in this study. Demographic information and full dermatological examination were done for each patient. Biopsy was carried out for 18 patients and fasting blood sugar was performed in 32 patients.Results: Fifty patients were included in the present work, all showed typical clinical features of syringoma. Their ages ranged from 8 – 50 years with a mean of 30.4, and the highest number of cases 10(20%) were in age group 21– 25 years. Females [41(82%)] were affected more frequently than males [9(18%)], with a male to female ratio of 1:4.5.A high incidence of infertility among married females 8(32%), and 1(16.6%) of married males was found. A positive family history of syringoma was found in 25 (50%) patients, and a positive family history of diabetes mellitus in 20(40%) of patients. The main sites involved were the lower eyelids alone in 23(46%) of cases, and in association with other sites in 100% of cases. The color of lesions in syringoma were mainly fleshy or skin– colored 30 (60%) of cases).Twenty two (44%) patients had lesions ranging between 15– 30 papules. Histopathology of lesions showed the typical histological features of syringoma. Also 13(72.2%) of patients showed a striking superficial perivascular mononuclear infiltrate. Fasting blood sugar was normal in all patients.Conclusion: The present study confirmed that syringoma is disease of female, with a high positive family history of diabetes mellitus, while the histopathological examination showed a striking superficial perivascular monomuclear infiltrate, Keywords: syringoma, Iraqi patients, clinical, histopathological.

اساس البحث: يعتير تورم الغدد العرقية التكهفي من الامراض الشائعة التي تسبب تشويها جماليا للوجة,وهذا المرض عادة يصيب النساء في عمر البلوع اوما بعده.الهدف من الدراسة:لمعرفة نسبة تكرار هذا المرض ولتسليط الضوء علىيه من النواحي السريرية والنسيجية.الطرائق والمرضى: هذه الدراسة الوصفية المقارنة تمت في قسم الامراض الجلدية _مستشفى بغداد التعليمي/مدينة الطب خلال الفترة من تشرين الاول/1991 الى حزيران/1991.خمسون مريضا مصابون بتورم الغدد العرقية التكهفي ومائة شخص (اصحاء)كمجموعة قياس احتوتهم هذه الدراسة.كافة المعلومات المتعلقة بالمرض من التاريخ المرضي والفحص السريري قد اجري لكل مريض.تم اخذ خزعة من الجلد المصاي لغرض الفحص النسيجي من 18 مريض وقياس مستوى السكر بالدم لاثنان وثلاثون مريضا.النتائج:تراوحت اعمار المرضى بين 8-50سنة بمعدل 30,4 وكان العدد الاكبر من المرضئ بالفئة العمرية 21-25سنة.كانت اصابات الاناث اعلى من الذكور وبنسبة 1:4,5. ووجدنا ان نسبة عالية من المرضى المشمولين بالبحث من المتزوجين كانوا يعانون من عقم اولي وبنسبة 25%من الاناث المتزوجات و17%من الذكور المتزوجين.خمسون بالمائة (25)من المرضئ كان لديهم تاريخ عائلي ايجابي للمرض وتاريخ عائلي ايجابي لمرض السكري في20(40%)حالة من الحالات.كانت نسبة كبيرة من المرضى الذين شملتهم الدراسة غير منتبهين الى وجود تورم الغدد العرقية التكهفي لديهم وكانوا قد راجعوا العيادة الخارجية للامراض الجلدية شاكين من امراض اخرى او مرافقين لمرضى اخرين ,على العكس من ذلك فان كثيرا منهم كانوا يشكون من وجود حرقة او حكة في منطقة الاصابة وخاصة في فصل الصيف.تبين ان اكثر مناطق الاصابة شيوعا يالجسم كانت كالاتي:الاجفان السفلى وحدها في 23(46%)مريض,بينما الاجفان السفلى مشتركة مع موضع اخر بالاصابة في كل المرضى (100%).اما اللون السائد على الحبيبات في تورم الغدد العرقية التكهفي فهو لون الجلد عند30(60%).وكان معدل الحبيبات عند اثنان وعشرون مريضا( 44%) هو 15-30حبيبة.اظهر الفحص النسيجي لجميع حالات الاصابة الصفات النسيجية النموذجية لمرضى تورم الغدد العرقية التكهفي ,كذلك في 13(72,2%)مريض اظهروا وجود ترشح الخلايا الالتهابية احادية الخلية حول الاوعية الدموية السطحية بالجلد .كان مستوئ السكر بالدم طبيعي.الاستنتاجات:هذه الدراسة اثبتت ان تورم الغدد العرقية التكهفي هو مرض يصيب الاناث اكثر مع وجود تاريخ عائلي ايجابي لمرض السكري بينما القحص النسيجي اظهر وجود وجود ترشح الخلايا الالتهابية احادية الخلية حول الاوعية الدموية السطحية بالجلد.


Article
The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients

Authors: Khalida M .Al-Moussawy --- Nahla Ghanim --- Wifaq M. AL-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 111-115
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Tinea versicolor is a common dermatological problem ,world wide distribution ,caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal .Many factors play a role in the etiology of TV among these could be the disturbed immune systemwhich may be related to the ability of TV alter the immune system by a process calledImmunomodulation leading to subsequent infection.Immuno-inflammatory activity mediated by different cytokines could have a role in the etiologyof TV.Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients withTV as compared to immunocompramized patients and healthy groups.Patients and methods: This study enrolled 50 total patients, 15 of them were as patients controlgroup who were immunocompramized with evident skin lesion ,to be compared serologically with 15patients who had TV and normal immunity, the control group composed of20 healthy volunteers.Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera ofall groups.Results and discussion: The statistical differences in the rate of detectable IL-4 level between TVand healthy control p< 0.001,while the difference was a highly significant between the healthycontrol and immunocompramized patients with TV,P<0.00338.The difference between twodiseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant.IL-8 the results of our study showed a significant difference between the healthy control and thepatients with tinea versicolor, p-value was( 0.05).In this study there was a nice findings by which the difference between the healthy control and theimmunocompramized patients was highly significant as ,p<0.005.Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it actsas an adjuvant, activates the complement cascade, and elicits both cellular and humoral immuneresponses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast,it also seems to have the ability not only to evade the immune system but actually to suppress theresponse directed against


Article
Clinico-Histopathological Study of Calcinosis Cutis among Iraqi Patients

Author: Adil A. Noaimi د.عادل عبد الغفور النعيمي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2013 Volume: 26 Issue: 2 Pages: 118-123
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Abstract:Background: Cutaneous calcification results from deposition of insoluble calcium phosphorous salts in the cutaneous tissues. There are wide clinical presentations of calcinosis cutis and it's a rare dermatological problem. However serious implication may arise due to delayed diagnosis.Objective: To highlight and elaborate different clinical types of calcinosis cutis among Iraqi patients. Patients and Methods: This observational, descriptive, clinical and histopathological study was done in Department of Dermatology- Baghdad Hospital-Medical City, Baghdad, Iraq during the period from January 1997-Decmber 2012.History, examination and complete investigations if needed were done for each patient including all demographic points related to the disease. Excisional or incisional biopsies from each patient for histopathological evaluation were done. Results: A total of 72 patients were included. They were 46 (63.01%) females and 27(38%) males. Their ages ranged from 3.5– 65(24.74±15.9) years. They were classified into 2 groups: Group A the dystrophic type with 65(89.04%) patients and was subdivided into calcinosis cutis universalis which constituted from 6(8.2%) cases. The 2nd subtype is calcinosis cutis circumscriptum which consist of 58(79.7%) cases. Group B: 8 (11.11%) patients with idiopathic type, 1 (12.5%) with idiopathic scrotal calcinosis and 2(25%) with subepidermal calcified nodule. Conclusion: Calcinosis cutis is a rare medical problem with multiple etiological factors in which we see calcified deposits mainly in the skin. This is the first report appeared from Iraq.Keywords: Calcinosis cutis, pilometricoma, pseudoxanthoma elasticum, Iraqi patients.


Article
The role of TNF-α in the pathogenesis of multiple myeloma “a study in Iraqi patients”
دورعامل نخر الورم الفا (TNF-α) في إمراضية الورم النخاعي المتعدد " دراسة لمرضى عراقيين "

Authors: Mohammed A. Essa محمد أحمدعيسى --- Sabah N. Mohammed صباح نعمة محمد --- Talib A. Hussein طالب عبد الله حسين --- Azhar J. Mohsin أزهار جاسم محسن
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2014 Volume: 11 Issue: 2 عدد خاص بالمؤتمر النسوي الثاني Pages: 853-860
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

During recent years, there has been an increasing interest in the investigation of the cytokines roles in pathogenesis of cancer, thus the study aimed at evaluating the level of tumor necrosis factor-alpha(TNF-α) in sera of Iraqi multiple myeloma (MM) patients. Beta 2-microglobulion (β2-m) was assessed to determine if there was any association between this cytokine and the level of β2- m, as the latter is related to the stage of the disease. In addition, the age and gender were also taken into consideration. Furthermore, we investigated the relationship between IgG and TNF-α in sera of patients. 49 Iraqi patients (27 males and 22 females).The patients were also divided into two groups: the first group included (17) patients who were recently diagnosed and not received any treatment at the time of collecting samples while the second group included (32) patients who received treatment. A further group was also investigated which included (12) apparently healthy individuals (9 males and 3 females), who were regarded as a control group. Serum TNF-α and β2- m were determined using enzyme-linked immunosorbent assay (ELISA).while the concentration of IgG was measured by radial immune diffusion plates The study reached to the following results: TNF-α levels were not significantly elevated in the patients with MM compared to control group (5.98 ± 8.47 SD vs. 4.85 ± 12.1 SD) and no significant differences (P > 0.05) were observed in the mean (6.02 ±8.1SD vs 5.9 ±9.4SD) concentration of TNF-α in patients with MM who received treatment, when compared with those who did not take the treatment .In addition, there are positive significant correlations between TNF-α and β 2 Microglobulin (r = 0.316, P = 0 .027), and no relationship between IgG and TNF-α (r = - 0.032, P = 0.829).Furthermore, the study observed that, there was no correlation between TNF-α on the one hand and factors of age and gender on the other hand.

تزايد الأهتمام خلال السَنَوات الأخيرة، في التحرّي عن أدوارِ الحركيات الخلوية في تولّد مرض السرطان ومنشأه ، وهكذا إستهدفتْ الدراسة الحالية تَقييم مستوى عاملِ نخرِالورمِ الفا (TNF-α) في مصول مجموعة من مرضى الورم النخاعي المتعدد في المرضى العراقيين. كما تمّ تقييم مستوى β2-m والتحري عن العلاقة بين عامل نخر الورم الفا TNF- α و β2-m لإرتباط الأخير بمرحلة المرض.إضافة الى ذلك اُخذت الدراسة بنظر الاعتبار عاملي العمر والجنس.فضلا عن ذلك تمّ التحري عن العلاقة بين تركيز عامل نخر الورم الفا TNF-αمن جانب والغلوبيولين المناعي من نوع (IgG) من جانب آخر.شملت الدراسة 49 مريض (27 ذكر و22 انثى )، هؤلاء المرضى قسموا الى مجموعتين تضمنت المجموعة الاولى (17 مريض ) من المرضى المشخصين حديثا والذين لم يتلقوا اي علاج في وقت جمع العينات ، في حين تضمنت المجموعة الثانية (32 مريضاً) كانوا خاضعين للعلاج. ايضاً تضمنت الدراسة مجموعة اخرى وهي المجموعة الضابطة والتي تشمل 12 شخص من الاصحاء(9 من الذكور و3 من الاناث).تمَّ قياس مستوى عامل نخر الورم الفا TNF- α و β2-mبأستخدام تقنية المُمْتَزِّ المناعي المُرْتَبِطِ بالانزيم ELISAفي حين استخدمت طريقة اطباق الانتشار المناعي الشعاعي لقياس تركيز الغلوبيولين المناعي نوع (IgG).توصلت الدراسةالى النتائج التالية :لايوجد اختلاف في مستوى تركيز عامل نخر الورم الفاTNF- α بين مجموعة المرضى والمجموعة الضابطة ) 5.98± 8.47 مقابل 4.85 ±12.1 بيكو غرام مليلتر) ،كما لايوجد اختلاف ذو دلالة معنوية بين مجموعة المرضى اللذين تلقوا علاج مقابل مجموعة المرضى المشخصين حديثاً (6.02 ± 8.1 مقابل 4.85 ±12.1 ).أضافة الى ذلك لوحظ وجود علاقة معنوية موجبة بين عامل نخر الورم الفاTNF- α وβ2-m حيث كان معامل الارتباط (r =0.316 ، P =0.027) كمـا توصلت الدراسة الى عدم وجود عـلاقة بين عامل نخر الورم الفاTNF- α و الغلوبيولين المناعي من نوع (IgG) حيث كان معامل الارتباط (r = - 0.032،P = 0.829 ) ،أخيراً أثبتت الدراسة عدم وجود علاقة معنوية بين انتاج TNF- α من جهة وعاملي العمر والجنس من جهة اخرى كما لايوجد تأثير للجنس على انتاج هذا النوع من الحركيات الخلوية.

Listing 1 - 10 of 23 << page
of 3
>>
Sort by
Narrow your search

Resource type

article (23)


Language

English (19)

Arabic and English (3)


Year
From To Submit

2019 (1)

2018 (1)

2017 (2)

2016 (2)

2015 (2)

More...