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Molecular Detection of HPVgenotype-16 in a Group of Patients with Grade 1 Invasive Papillary Thyroid Carcinoma

Author: Saad Hasan Mohammed Ali*, Suha Abdullah AL-Fakhar*, Raad A. AL-Asady**, Shakir H. Mohammed***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 3 Pages: 410-418
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية


ABSTRACT:BACKGROUND: Thyroid cancers are neoplasms originating from follicular thyroid cells thought to be related to a number of environmental and genetic predisposing factors. Human Papilloma Virus (HPV) is one among their associated infective agents.OBJECTIVE:To determine the frequency of human papilloma virus genotype-16 in infection in a group of iraqi patients with papillary thyroidcell carcinoma MATERIALS AND METHODS: A total number of 64 patients with different thyroid lesions were collected during 2008-2013; 30 have thyroid cancers, 22 benign thyroid tumors while12 healthy thyroid tissues were used as control group. In situ hybridization(ISH) was used to localize high risk HPV-genotype 16 in these tissues.RESULTS: Among malignant thyroid tumors 53.3% patients had HPV-16 while 27.3% HPV-16 positivity was detected in benign thyroid tumor group. None of healthy thyroid tissues revealed ISH reactions. There was 38.5% female had HPV-16, while there was 28% male had HPV-16. No significant statistical associations were noticed between the presence of HPV-16 and the age of those patients.CONCLUSION: Human papilloma virus genotype-16 could share a role in pathogenesis of this group of patients with thyroid cancers.

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