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Article
Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil
رابطة إيجابية البروتين التفاعلي C بين مجموعات من المرضى الذين يعانون من التهاب المفاصل في الركبة في أربيل

Authors: Niaz k. Jawad --- Helen Ahmed Pirdawood
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 2 Pages: 1743-1750
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Osteoarthritis is the most common joint disease and a leading cause of disability. Increased circulating levels of C-reactive protein have been associated with prevalent knee osteoarthritis. This study aimed to assess the association between C- reactive protein positivity in patients with knee osteoarthritis in ErbilMethods: Data from100 participants in this case-control study were enrolled from May 1st to December 1st, 2015 in Rizgary Teaching Hospital in Erbil city. Data were divided into two groups. The cases included 50 patients (17 male and 33 female) with a mean age of 58.9 ±3.8 years and diagnosed with primary knee osteoarthritis of one or both knee joints. Controls included 50 persons (17 male and 33 female) with a mean age of 58.1 ±3.9 years without knee osteoarthritis and matched for age, sex, and body mass index. C-reactive protein qualitatively measured. Patients were radiologically assessed by Kellgren and Lawrence grading scale (grade 0-4).Results: C-reactive protein was positive in 41 out of 50 (82%) of knee osteoarthritis patients compared to 3 out of 50 (6%) of healthy controls (P = 0.001). C- reactive protein positivity among knee osteoarthritis patients were significantly associated with body mass index, positive family history of knee osteoarthritis, duration of diseases, and Kellgren and Lawrence grade (P <0.05). No significant association was found with sex, site of knee joint involvement, and knee pain severity (P >0.05).Conclusion: C-reactive protein positivity was significantly associated with knee osteoarthritis compared to healthy controls. Furthermore, body mass index, positive family history of knee osteoarthritis, early osteoarthritis, and Kellgren and Lawrence grade II, were significantly associated with positive C-reactive protein in knee osteoarthritis.


Article
Association of radiological osteoarthritis of the knee joint with locomotor disability

Authors: Nizar Abdulateef Jasim *, --- Husam H. Al-Khafaji ** , --- Zaid Al-Attar ***
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2019 Volume: 15 Issue: 1 Pages: 36-42
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Knee osteoarthritis (KOA) is a common joint disorder leading to considerable pain and locomotor disability in lower limb function. Locomotor disability, which is difficulty in activities of daily living related to lower limb function, can be the consequence of KOA, so early diagnosis and management may improve quality of life. Objective: To assess the contribution of radiological osteoarthritis of the knees to disability in the activities of daily living related to lower limb function. Methods: One hundred twenty Iraqi KOA patients (104 females and 16 males) who were attending to Rheumatology Unit, Full history was taken and complete clinical examination was done for all patients. Wight-bearing X-rays of both knees (anteroposterior and lateral view) were taken for patients and were graded according to Kellgren and Lawrence scale.Results: The frequency of locomotor disability, was 62.50% for men and 72.11% for women (p=0.431). The frequency of radiological osteoarthritis of the knee was 50% for men and 40.37% for women (p=0.651). There was significant statistical differences between; locomotor disability, and increased age, morning stiffness, muscle wasting & BMI (p=0.000, p=0.003, p=0.002 and p=0.028 respectively). There was no statistical significant association between; KOA radiological grading, and gender, morning stiffness, BMI & lower limb locomotor functions disability (p=0.651, p=0.357 and p=0.972 respectively). Conclusion: Radiological osteoarthritis of the knee is only weak independent predictors of locomotor disability. Patient's age, pain of the knees, muscle wasting, morning stiffness and obesity seem to be the most important independent determinants of locomotor disability.


Article
Fibromyalgia Syndrome among Iraqi Patients with Knee Osteoarthritis
متلازمة الالم الليفي العضلي في المرضى العراقيين المصابين بسوفان الركبة

Authors: Ziad S. Al-Rawi زياد الراوي --- Faiq I. Gorial فائق ايشوكوريال --- Wafi H. Ali وافي هادي علي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2014 Volume: 56 Issue: 1 Pages: 45-48
Publisher: Baghdad University جامعة بغداد

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Abstract

Back ground: Fibromyalgia syndrome (FMS) is a common chronic musculo-skeletal disorder resulting in chronic widespread pain impacting on quality life.Objectives: To assess the relationship between FMS and knee osteoarthritis (KOA) and to evaluate the predictors of this relationship if present.Patients and Methods: One hundred Iraqi KOA patients and 100 healthy controls were included in this cross-sectional study. Full history was taken and complete clinical examination was done for all patients. Baseline characteristics [age, sex, duration, body mass index (BMI), waist circumference, family history (Hx) of KOA, smoking history, and drug history.] were also documented. Laboratory analysis included complete blood count, erythrocyte sedimentation rate (ESR), thyroid stimulation hormone, serum calcium, serum alkaline phosphatase, serum phosphate, and anti-nuclear antibody were done for all patients. X-rays of both Knees was taken for patients and was graded according Kellgren and Lawrence scale. The American College of Rheumatology (ACR) criteria for classification and reporting osteoarthritis of the knees were applied on both groups. Individuals in both groups were assessed for FMS and the American College of Rheumatology 1990 Criteria for fibromyalgia were applied for both groups. Comparative statistics were done using Chi square test for categorical variables and students' independent 2 samples (t) test for continuous variables.Results: FMS was present in 26 of 100(26%) KOA patients compared to 7(75%) of 100 of controls [odd ratio (OR)=4.6(95% CI(1.92-11.35),p=0.001]. Frequencies of associated features (headache, sleep disturbances, fatigue, depression, anxiety, and parasthesia) were significantly more in patients than that of controls (P<0.05). Longer duration of KOA, higher waist circumference, and positive family Hx of FMS were significant associates with FMS in the patient group (P<0.05). However no significant association was found with age, sex, BMI, grade of KOA, drugs taken marital status, and increased ESR. Conclusions: FMS was significantly increased in Iraqi patients with KOA compared to controls. Longer disease duration of KOA, large waist circumference and family history of FMS were significant predictors. Keywords: Knee osteoarthritis, fibromyalgia, Kellgren and Lawrence scale,osteoarthritis

الخلفية: متلازمة الالم الليفي العضلي هو اضطراب هيكلي عضلي مزمن شائع ينتج الما منتشرا مزمنا مؤثرا على نوعية الحياة.الاهداف: تقييم العلاقة بين متلازمة الالم الليفي و الفصال العظمي وتحديد العوامل المنبئة ان وجدت.المرضى والطرائق: اشتملت الدراسة المقطعية على 100مريض عراقي مصاب بالفصال العظي و100 شخص سوي كمجموعة ضبط.تم اخذ التاريخ المرضي واجراء الفحص السريري الكامل لكل المرضى ووثقت الميزات الاساسية للمرضى(العمر، الجنس، مدة المرض،معيار كتلة الجسم، محيط الخصر، التاريخ العائلي للفصال العظمي، تاريخ التدخين، والتاريخ الدوائي).ثم اجريت الفحوصات المختبرية كفجص صورة الدم، مقدار ترسب الخلايا الحمر، هورمون تحفيز الدرقية، مصل الكالسيوم، مصل الفوسفيت ، مصل انزيم الفوسفاتيز القاعدي،و وفحص الاجسام الضدية( اي ان اي) لكل المرضى. تم اخذ الرقائق الشعاعية للمرضى وتديجها حسب معيار كلكرن-لورانس. وطبقت معايير الكلية الامريكية 1990 لتصنيف مرض الفصال العظمي للركبة ومعايير الكلية الامريكية 1990 لتصنيف متلازمة الالم الليفي العضلي على المجموعتين.اجريت المقارنة الاحصائية باستعمال فحص الكاي سكوير للمتغيرات الصنفية وفحص تي للمتغيرات المستمرة. النتائج: وجدت متلازمة الالم الليفي العضلي في 26 من 100 مريض (26%) مصاب بالفصال العظمي مقارنة ب7 من 100 (7%) من من مجموعة الضبط) القيمة الاحتمالية =0.001). وجد ان مقدار تكرار العلامات المترافقة ( الصداع، اضطرابات النوم،التعب،الاكتئاب ، القلق،والخدر)اكثر في المرضى عما هو في مجموعة الضبط وذو علاقة احصائية ذات جدوى((القيمة الاحتمالية>0.05). كانت مدة مرض فصال الركبة الاطول، محيط الخصر الاعلى، والتاريخ العائلي الموجب لمتلازمة الليفي العضلي مترافقات ذات علاقة احصائية ذي جدوى مع متلازمة الالم الليفي العضلي لمجموعة المرضى (القيمة الاحتمالية>0.05).ولكن لم نجد علاقة احصائية ذات جدوى مع العمر، الجنس، معيار كتلة الجسم، وشدة فصال الركبة.الاستنتاج: كانت متلازمة الالم الليفي العضلي اكثر في مجموعة المرضى مقارنة بمجموعة الضبط.كما ان مرضى فصال الركبة الاطول مدة، محيط الخاصرة الاكبر، والتاريخ العائلي الموجب لمتلازمة الالم الليفي العضلي هي متنبئات لمتلازمة الالم الليفي العضلي.الكلمات المفتاحية:الفصال العظمي للركبة، متلازمة الالم الليفي العضلي

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